Jason P Weick

Summary

Publications

  1. pmc Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network
    Jason P Weick
    Waisman Center, University of Wisconsin Madison, 647 Waisman Center, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 108:20189-94. 2011
  2. pmc Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
    Bao Yang Hu
    Department of Anatomy, School of Medicine and Public Health, University of Wisconsin, Waisman Center, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 107:4335-40. 2010
  3. pmc Specification of transplantable astroglial subtypes from human pluripotent stem cells
    Robert Krencik
    Neuroscience Training Program, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Biotechnol 29:528-34. 2011
  4. pmc Developmental regulation of human embryonic stem cell-derived neurons by calcium entry via transient receptor potential channels
    Jason P Weick
    Waisman Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    Stem Cells 27:2906-16. 2009
  5. pmc Deficits in human trisomy 21 iPSCs and neurons
    Jason P Weick
    Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 110:9962-7. 2013
  6. pmc Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits
    Yan Liu
    1 Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA 2 Department of Human Anatomy and Histology, Fudan University Shanghai Medical School, Shanghai, China
    Nat Biotechnol 31:440-7. 2013
  7. pmc Regulation of neural specification from human embryonic stem cells by BMP and FGF
    Timothy M LaVaute
    Neuroscience Training Program, School of Medicine, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Stem Cells 27:1741-9. 2009
  8. pmc Functional control of transplantable human ESC-derived neurons via optogenetic targeting
    Jason P Weick
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Stem Cells 28:2008-16. 2010
  9. pmc Functional neural development from human embryonic stem cells: accelerated synaptic activity via astrocyte coculture
    M Austin Johnson
    Neuroscience Training Program, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neurosci 27:3069-77. 2007

Collaborators

Detail Information

Publications9

  1. pmc Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network
    Jason P Weick
    Waisman Center, University of Wisconsin Madison, 647 Waisman Center, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 108:20189-94. 2011
    ..Thus, hESC-derived neurons can participate in and modulate neural network activity through functional synaptic integration, suggesting they are capable of contributing to neural network information processing both in vitro and in vivo...
  2. pmc Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
    Bao Yang Hu
    Department of Anatomy, School of Medicine and Public Health, University of Wisconsin, Waisman Center, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 107:4335-40. 2010
    ..These findings, which show a need for improving differentiation potency of iPSCs, suggest the possibility of employing human iPSCs in pathological studies, therapeutic screening, and autologous cell transplantation...
  3. pmc Specification of transplantable astroglial subtypes from human pluripotent stem cells
    Robert Krencik
    Neuroscience Training Program, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Biotechnol 29:528-34. 2011
    ....
  4. pmc Developmental regulation of human embryonic stem cell-derived neurons by calcium entry via transient receptor potential channels
    Jason P Weick
    Waisman Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    Stem Cells 27:2906-16. 2009
    ....
  5. pmc Deficits in human trisomy 21 iPSCs and neurons
    Jason P Weick
    Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 110:9962-7. 2013
    ..Thus, Ts21 iPSCs and neurons display unique developmental defects that are consistent with cognitive deficits in individuals with Down syndrome and may enable discovery of the underlying causes of and treatments for this disorder...
  6. pmc Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits
    Yan Liu
    1 Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA 2 Department of Human Anatomy and Histology, Fudan University Shanghai Medical School, Shanghai, China
    Nat Biotechnol 31:440-7. 2013
    ..Our findings support the prospect of using human stem cell-derived MGE-like progenitors in developing therapies for neurological disorders of learning and memory...
  7. pmc Regulation of neural specification from human embryonic stem cells by BMP and FGF
    Timothy M LaVaute
    Neuroscience Training Program, School of Medicine, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Stem Cells 27:1741-9. 2009
    ..Blocking FGF signaling inhibited neural induction, but did not alter the phosphorylation of the linker region of Smad1, suggesting that FGF enhances human neural specification independently of BMP signaling...
  8. pmc Functional control of transplantable human ESC-derived neurons via optogenetic targeting
    Jason P Weick
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Stem Cells 28:2008-16. 2010
    ..This pluripotent cell line will allow both in vitro and in vivo analysis of functional development as well as the integration capacity of neuronal populations for cell-replacement strategies...
  9. pmc Functional neural development from human embryonic stem cells: accelerated synaptic activity via astrocyte coculture
    M Austin Johnson
    Neuroscience Training Program, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neurosci 27:3069-77. 2007
    ..These results lay the foundation for future studies examining the functional development of human neurons and provide support for the potential application of human cells in restorative neuronal therapies...