Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural networkJason P Weick
Waisman Center, University of Wisconsin Madison, 647 Waisman Center, Madison, WI 53705, USA
Proc Natl Acad Sci U S A 108:20189-94. 2011
..Thus, hESC-derived neurons can participate in and modulate neural network activity through functional synaptic integration, suggesting they are capable of contributing to neural network information processing both in vitro and in vivo...
- Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
Bao Yang Hu
Department of Anatomy, School of Medicine and Public Health, University of Wisconsin, Waisman Center, Madison, WI 53705, USA
Proc Natl Acad Sci U S A 107:4335-40. 2010
..These findings, which show a need for improving differentiation potency of iPSCs, suggest the possibility of employing human iPSCs in pathological studies, therapeutic screening, and autologous cell transplantation...
- Specification of transplantable astroglial subtypes from human pluripotent stem cells
Robert Krencik
Neuroscience Training Program, University of Wisconsin Madison, Madison, Wisconsin, USA
Nat Biotechnol 29:528-34. 2011
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- Developmental regulation of human embryonic stem cell-derived neurons by calcium entry via transient receptor potential channels
Jason P Weick
Waisman Center, University of Wisconsin, Madison, Wisconsin 53705, USA
Stem Cells 27:2906-16. 2009
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- Regulation of neural specification from human embryonic stem cells by BMP and FGF
Timothy M LaVaute
Neuroscience Training Program, School of Medicine, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
Stem Cells 27:1741-9. 2009
..Blocking FGF signaling inhibited neural induction, but did not alter the phosphorylation of the linker region of Smad1, suggesting that FGF enhances human neural specification independently of BMP signaling...
- Functional control of transplantable human ESC-derived neurons via optogenetic targeting
Jason P Weick
Waisman Center, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
Stem Cells 28:2008-16. 2010
..This pluripotent cell line will allow both in vitro and in vivo analysis of functional development as well as the integration capacity of neuronal populations for cell-replacement strategies...
- Functional neural development from human embryonic stem cells: accelerated synaptic activity via astrocyte coculture
M Austin Johnson
Neuroscience Training Program, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53705, USA
J Neurosci 27:3069-77. 2007
..These results lay the foundation for future studies examining the functional development of human neurons and provide support for the potential application of human cells in restorative neuronal therapies...
