Lynn R Webster

Summary

Publications

  1. doi request reprint Overdose deaths demand a new paradigm for opioid rotation
    Lynn R Webster
    Lifetree Clinical Research, Salt Lake City, Utah 84106 6102, USA
    Pain Med 13:571-4. 2012
  2. pmc Tolerability of NGX-4010, a capsaicin 8% patch, in conjunction with three topical anesthetic formulations for the treatment of neuropathic pain
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, Lifetree Medical Inc, Salt Lake City, UT, USA
    J Pain Res 5:7-13. 2012
  3. doi request reprint Oxycodone extended-release using gel-cap technology to resist alteration and abuse for the treatment of moderate-to-severe pain
    Lynn R Webster
    Medical Director of Lifetree Clinical Research, Lifetree Clinical Research, 3838 South 700 East, Suite 202, Salt Lake City, UT 84106, USA
    Pain Manag 1:417-25. 2011
  4. pmc Effects of concurrent intravenous morphine sulfate and naltrexone hydrochloride on end-tidal carbon dioxide
    Veeraindar Goli
    Pfizer Inc, Cary, NC, USA
    Harm Reduct J 9:13. 2012
  5. doi request reprint Review and critique of opioid rotation practices and associated risks of toxicity
    Lynn R Webster
    Lifetree Clinical Research, Salt Lake City, Utah 84106 6102, USA
    Pain Med 13:562-70. 2012
  6. doi request reprint Efficacy and safety of dual-opioid therapy in acute pain
    Lynn Webster
    Lifetree Clinical Research, Salt Lake City, Utah 84106 6102, USA
    Pain Med 13:S12-20. 2012
  7. pmc Tolerability of NGX-4010, a capsaicin 8% dermal patch, following pretreatment with lidocaine 2.5%/prilocaine 2.5% cream in patients with post-herpetic neuralgia
    Lynn R Webster
    Lifetree Clinical Research, Salt Lake City, UT, USA
    BMC Anesthesiol 11:25. 2011
  8. pmc Impact of intravenous naltrexone on intravenous morphine-induced high, drug liking, and euphoric effects in experienced, nondependent male opioid users
    Lynn R Webster
    Lifetree Clinical Research, Salt Lake City, UT 84106, USA
    Drugs R D 11:259-75. 2011
  9. doi request reprint Obtaining adequate data to determine causes of opioid-related overdose deaths
    Lynn R Webster
    Lifetree Clinical Research, Salt Lake City, Utah 84106, USA
    Pain Med 12:S86-92. 2011
  10. doi request reprint An analysis of the root causes for opioid-related overdose deaths in the United States
    Lynn R Webster
    Lifetree Clinical Research, Salt Lake City, Utah, USA
    Pain Med 12:S26-35. 2011

Collaborators

Detail Information

Publications33

  1. doi request reprint Overdose deaths demand a new paradigm for opioid rotation
    Lynn R Webster
    Lifetree Clinical Research, Salt Lake City, Utah 84106 6102, USA
    Pain Med 13:571-4. 2012
    ..This new paradigm suggests three easy-to-remember steps in opioid rotation and obviates the need to use a conversion table...
  2. pmc Tolerability of NGX-4010, a capsaicin 8% patch, in conjunction with three topical anesthetic formulations for the treatment of neuropathic pain
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, Lifetree Medical Inc, Salt Lake City, UT, USA
    J Pain Res 5:7-13. 2012
    ..The objective of this study was to assess the safety, tolerability, and preliminary efficacy of NGX-4010, a capsaicin 8% patch, following pretreatment with three different topical anesthetics in patients with peripheral neuropathic pain...
  3. doi request reprint Oxycodone extended-release using gel-cap technology to resist alteration and abuse for the treatment of moderate-to-severe pain
    Lynn R Webster
    Medical Director of Lifetree Clinical Research, Lifetree Clinical Research, 3838 South 700 East, Suite 202, Salt Lake City, UT 84106, USA
    Pain Manag 1:417-25. 2011
    ..Unanswered questions include whether less real-world abuse and increased safety would follow product launch and how this and other formulations aimed at reducing abuse potential might affect adherent patients. ..
  4. pmc Effects of concurrent intravenous morphine sulfate and naltrexone hydrochloride on end-tidal carbon dioxide
    Veeraindar Goli
    Pfizer Inc, Cary, NC, USA
    Harm Reduct J 9:13. 2012
    ..abstract:..
  5. doi request reprint Review and critique of opioid rotation practices and associated risks of toxicity
    Lynn R Webster
    Lifetree Clinical Research, Salt Lake City, Utah 84106 6102, USA
    Pain Med 13:562-70. 2012
    ..The objective of this review was to determine whether the current practice of opioid rotation may be contributing to high rate of unintentional deaths...
  6. doi request reprint Efficacy and safety of dual-opioid therapy in acute pain
    Lynn Webster
    Lifetree Clinical Research, Salt Lake City, Utah 84106 6102, USA
    Pain Med 13:S12-20. 2012
    ..Study results on the coadministration of two or more opioids demonstrate synergistic analgesia with a similar or lower incidence of opioid-related AEs. One such combination is morphine and oxycodone...
  7. pmc Tolerability of NGX-4010, a capsaicin 8% dermal patch, following pretreatment with lidocaine 2.5%/prilocaine 2.5% cream in patients with post-herpetic neuralgia
    Lynn R Webster
    Lifetree Clinical Research, Salt Lake City, UT, USA
    BMC Anesthesiol 11:25. 2011
    ..abstract:..
  8. pmc Impact of intravenous naltrexone on intravenous morphine-induced high, drug liking, and euphoric effects in experienced, nondependent male opioid users
    Lynn R Webster
    Lifetree Clinical Research, Salt Lake City, UT 84106, USA
    Drugs R D 11:259-75. 2011
    ..Should product tampering by crushing occur, the sequestered naltrexone is intended for release to reduce morphine-induced subjective effects...
  9. doi request reprint Obtaining adequate data to determine causes of opioid-related overdose deaths
    Lynn R Webster
    Lifetree Clinical Research, Salt Lake City, Utah 84106, USA
    Pain Med 12:S86-92. 2011
    ..Formulation-specific codes should be added to facilitate consistent recording of findings by death investigators and entry into national vital statistics databases...
  10. doi request reprint An analysis of the root causes for opioid-related overdose deaths in the United States
    Lynn R Webster
    Lifetree Clinical Research, Salt Lake City, Utah, USA
    Pain Med 12:S26-35. 2011
    ..A panel of experts in pain medicine and public policy convened to examine root causes and risk factors for opioid-related poisoning deaths and to propose recommendations to reduce death rates...
  11. ncbi request reprint Efficacy, safety, and tolerability of NGX-4010, capsaicin 8% patch, in an open-label study of patients with peripheral neuropathic pain
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, Salt Lake City, UT, USA
    Diabetes Res Clin Pract 93:187-97. 2011
    ..To assess efficacy, safety, and tolerability of NGX-4010, capsaicin 8% patch, in patients with peripheral neuropathic pain...
  12. doi request reprint Long-term safety and efficacy of morphine sulfate and naltrexone hydrochloride extended release capsules, a novel formulation containing morphine and sequestered naltrexone, in patients with chronic, moderate to severe pain
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, Salt Lake City, Utah 84106, USA
    J Pain Symptom Manage 40:734-46. 2010
    ..Taken whole, as intended, morphine is released to provide pain relief; if tampered with by crushing, naltrexone is released to mitigate subjective effects of morphine...
  13. doi request reprint Opioid titration and conversion in patients receiving morphine sulfate and naltrexone hydrochloride extended release capsules
    Lynn R Webster
    Lifetree Clinical Research, Salt Lake City, UT 84106, USA
    Postgrad Med 123:155-64. 2011
    ..To determine the number of steps and identify characteristics associated with attaining a stable dose of morphine sulfate and sequestered naltrexone extended release capsules (MS-sNT)...
  14. doi request reprint Long-term intrathecal ziconotide for chronic pain: an open-label study
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, Salt Lake City, Utah, USA
    J Pain Symptom Manage 37:363-72. 2009
    ..Long-term treatment with ziconotide appeared to be well tolerated and effective in patients whose response to ziconotide and ability to tolerate the drug had been previously demonstrated...
  15. doi request reprint Sleep-disordered breathing and chronic opioid therapy
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, Salt Lake City, Utah, USA
    Pain Med 9:425-32. 2008
    ..To assess the relation between medications prescribed for chronic pain and sleep apnea...
  16. doi request reprint Open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of morphine in patients receiving ziconotide for severe chronic pain
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, Salt Lake City, Utah, USA
    Pain Med 9:282-90. 2008
    ..To assess the safety and efficacy of adding intrathecal morphine to intrathecal ziconotide in patients treated with stable ziconotide doses...
  17. doi request reprint A multicenter, randomized, double-blind, controlled dose finding study of NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, Salt Lake City, Utah 84106, USA
    J Pain 11:972-82. 2010
    ..Similar results were observed during weeks 2 through 12. Most treatment-emergent adverse events were application-site specific, transient and mostly mild to moderate in severity...
  18. doi request reprint Randomized, double-blind, placebo-controlled study of the abuse potential of different formulations of oral oxycodone
    Lynn R Webster
    Lifetree Clinical Research, Salt Lake City, UT 84106, USA
    Pain Med 13:790-801. 2012
    ..The objective of this study was to evaluate the pharmacokinetics and abuse potential of different formulations of oxycodone...
  19. doi request reprint Opioid pharmacotherapy for chronic non-cancer pain in the United States: a research guideline for developing an evidence-base
    C Richard Chapman
    Department of Anesthesiology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Pain 11:807-29. 2010
    ....
  20. ncbi request reprint Effect of fentanyl buccal tablet on pain-related anxiety: a 4-week open-label study among opioid-tolerant patients with chronic and breakthrough pain
    Lynn R Webster
    Salt Lake Regional Medical Center, Salt Lake City, Utah, USA
    J Opioid Manag 7:297-308. 2011
    ..To evaluate the effect of fentanyl buccal tablet (FBT) on pain-related anxiety in opioid-tolerant patients with chronic pain and breakthrough pain (BTP)...
  21. doi request reprint Fentanyl buccal tablet compared with immediate-release oxycodone for the management of breakthrough pain in opioid-tolerant patients with chronic cancer and noncancer pain: a randomized, double-blind, crossover study followed by a 12-week open-label phase
    Lynn R Webster
    CRI Lifetree, Salt Lake City, Utah
    Pain Med 14:1332-45. 2013
    ..Evaluate analgesic efficacy, functional benefit, and patient satisfaction with fentanyl buccal tablet vs immediate-release oxycodone for breakthrough pain (BTP)...
  22. ncbi request reprint Oxytrex minimizes physical dependence while providing effective analgesia: a randomized controlled trial in low back pain
    Lynn R Webster
    Lifetree Clinical Research, Salt Lake City, Utah, USA
    J Pain 7:937-46. 2006
    ..A cellular mechanism of action has been demonstrated to be the prevention of aberrant G protein signaling by mu opioid receptors caused by chronic opioid administration...
  23. pmc Effect of duration of postherpetic neuralgia on efficacy analyses in a multicenter, randomized, controlled study of NGX-4010, an 8% capsaicin patch evaluated for the treatment of postherpetic neuralgia
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, Salt Lake City, Utah, USA
    BMC Neurol 10:92. 2010
    ..Current treatment options provide only partial relief and are often limited by poor tolerability. We evaluated the safety and efficacy of a single 60-minute application of NGX-4010, an 8% capsaicin patch, in patients with PHN...
  24. doi request reprint Approaches to improve pain relief while minimizing opioid abuse liability
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, Salt Lake City, Utah 84106, USA
    J Pain 11:602-11. 2010
    ..Integration of these formulations in clinical practices based on universal precautions should help further minimize the risk of opioid abuse while fostering appropriate prescribing to patients with indications for opioid therapy...
  25. ncbi request reprint Breakthrough pain in the management of chronic persistent pain syndromes
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, 3838 S 700 E, Ste 200, Salt Lake City, UT 84106, USA
    Am J Manag Care 14:S116-22. 2008
    ..This article reviews the etiology, prevalence, and characteristics of BTP along with assessment of patients and therapeutic strategies available to treat this condition...
  26. ncbi request reprint Pharmacogenetics in pain management: the clinical need
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, 3838 South, 700 East, Suite 200, Salt Lake City, UT 84106, USA
    Clin Lab Med 28:569-79. 2008
    ..As advances continue in the genetics of pain and analgesia, pharmacotherapy will depend more on an individualized, targeted approach and less on empiricism...
  27. doi request reprint Risk factors for drug diversion in a pain clinic patient population
    Mary Jean Walker
    College of Nursing, University of Utah, Salt Lake City, UT, USA
    J Opioid Manag 8:351-62. 2012
    ..Prescription drug abuse and drug diversion have soared at the same time prescribing practices have increased, prompting the pain medicine community to seek more accurate knowledge of the sources of prescription drugs used non medically...
  28. ncbi request reprint Oxytrex: an oxycodone and ultra-low-dose naltrexone formulation
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, Salt Lake City, Utah, USA
    Expert Opin Investig Drugs 16:1277-83. 2007
    ..The agonist/antagonist combination of Oxytrex may reduce the conversion from an inhibitory to an excitatory receptor, thereby decreasing the development of tolerance and physical dependence...
  29. ncbi request reprint Methadone-related deaths
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, Salt Lake City, Utah, USA
    J Opioid Manag 1:211-7. 2005
  30. ncbi request reprint PTI-821: sustained-release oxycodone using gel-cap technology
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, Salt Lake City, Utah, USA
    Expert Opin Investig Drugs 16:359-66. 2007
    ..PTI-821 has demonstrated a statistically significant difference from placebo (p < 0.05) in the efficacy study's primary end point: percentage decrease in pain scores. A further large, clinical study is in progress...
  31. ncbi request reprint Opioid formulations in development designed to curtail abuse: who is the target?
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, 3838 South 700 East, Suite 200, Salt Lake City, Utah 84106, USA
    Expert Opin Investig Drugs 18:255-63. 2009
    ..Formulations are being developed with the intent to curtail abuse through physical barriers that resist alteration, inclusion of excipients that antagonize opioid effects when altered, and other technologies...
  32. ncbi request reprint Safety and efficacy of prolonged outpatient ketamine infusions for neuropathic pain
    Lynn R Webster
    Lifetree Pain Clinic, Salt Lake City, Utah, USA
    Am J Ther 13:300-5. 2006
    ..Prolonged analgesic doses of ketamine infusions were safe for the small sample studied. The results demonstrate that ketamine may provide a reasonable alternative treatment for nonresponsive neuropathic pain in ambulatory outpatients...