Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of randomized trialsAngela C Webster
Cochrane Renal Group, Children s Hospital at Westmead, Westmead, and School of Public Health, University of Sydney, Sydney, Australia
Transplantation 81:1234-48. 2006
..We performed a systematic review of randomized trials where immunosuppressive regimens containing TOR-I were compared with other regimens as initial therapy for kidney transplant recipients...
- Identifying high risk groups and quantifying absolute risk of cancer after kidney transplantation: a cohort study of 15,183 recipients
A C Webster
NHMRC Centre for Clinical Research Excellence in Renal Medicine, Children s Hospital at Westmead, NSW, Australia
Am J Transplant 7:2140-51. 2007
..Men aged 45-54 surviving 10 years have cancer risks varying from 1 in 13 (non-white, no prior cancer, diabetic ESKD) to 1 in 5 (white, prior cancer, other ESKD)...
- The CARI guidelines. Calcineurin inhibitors in renal transplantation: the addition of anti-CD25 antibody induction to standard immunosuppressive therapy for kidney transplant recipients
Angela C Webster
Department of Renal Medicine, Royal Infirmary of Edinburgh, Old Dalkeith Road, Edinburgh EH16 4SY, UK
Nephrology (Carlton) 12:S75-84. 2007
Managing cancer risk and decision making after kidney transplantationA C Webster
School of Public Health, University of Sydney, Westmead Hospital, NSW Australia
Am J Transplant 8:2185-91. 2008
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- How to get the most from the medical literature: searching the medical literature effectively
Angela C Webster
Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia
Nephrology (Carlton) 15:12-9. 2010
..We illustrate these with sensitive and specific search strategies to answer different clinical questions arising from a hypothetical clinical scenario typical of a nephrologist's everyday practice...
- Validity of registry data: agreement between cancer records in an end-stage kidney disease registry (voluntary reporting) and a cancer register (statutory reporting)
Angela C Webster
School of Public Health, University of Sydney, New South Wales, Australia
Nephrology (Carlton) 15:491-501. 2010
..We assessed agreement between incident cancer reported to the Australian and New Zealand Dialysis and Transplant Registry (ANZDATA) and to the Central Cancer Registry (CCR) in New South Wales...
Effect of reduced immunosuppression after kidney transplant failure on risk of cancer: population based retrospective cohort studyMarina T van Leeuwen
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, 376 Victoria St, Sydney, NSW, 2010, Australia
BMJ 340:c570. 2010
..Incident cancers were ascertained using linkage with national cancer registry records...
- Immunosuppression and other risk factors for early and late non-Hodgkin lymphoma after kidney transplantation
Marina T van Leeuwen
National Centre in HIV Epidemiology and Clinical Research, and School of Public Health and Community Medicine, University of New South Wales, Sydney, Australia
Blood 114:630-7. 2009
..These findings support 2 mechanisms of lymphomagenesis, one predominantly of primary EBV infection in the context of intense immunosuppression, and another of dysregulated lymphoid proliferation in a prolonged immunosuppressed state...
- Immunosuppression and other risk factors for lip cancer after kidney transplantation
Marina T van Leeuwen
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW, Australia
Cancer Epidemiol Biomarkers Prev 18:561-9. 2009
..During transplant function, lip cancer risk is associated with the duration of immunosuppression, receipt of specific immunosuppressive agents, and UV exposure...
- Induction and maintenance treatment of proliferative lupus nephritis: a meta-analysis of randomized controlled trials
Lorna K Henderson
Cochrane Renal Group, Centre for Kidney Research, The Children s Hospital at Westmead, Sydney, Australia
Am J Kidney Dis 61:74-87. 2013
..Treatment regimens combining cyclophosphamide with steroids preserve kidney function but have significant side effects. Newer immunosuppressive agents may have improved toxicity profiles...
- Comparative survival and economic benefits of deceased donor kidney transplantation and dialysis in people with varying ages and co-morbidities
Germaine Wong
Centre for Kidney Research, Children s Hospital at Westmead, Westmead, Australia
PLoS ONE 7:e29591. 2012
..The aim of our study is to estimate the average and incremental survival benefits and health care costs of listing and transplantation compared to dialysis among individuals with varying co-morbidities...
- Time on dialysis and cancer risk after kidney transplantation
Germaine Wong
Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia
Transplantation 95:114-21. 2013
..We aimed to determine if the length of time on maintenance dialysis before the first kidney transplantation was associated with the risk of site-specific and overall incident cancers after transplantation...
- Cancer incidence before and after kidney transplantation
Claire M Vajdic
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
JAMA 296:2823-31. 2006
..Although it is generally accepted that other cancers do not occur at increased rates, there have been few long-term population-based cohort studies performed...
- Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients
Elisabeth M Hodson
Centre for Kidney Research, The Children s Hospital at Westmead, Westmead, Australia
Cochrane Database Syst Rev 2:CD003774. 2013
..This is an update of a review first published in 2005 and updated in 2008...
- Dialysis modality preference of patients with CKD and family caregivers: a discrete-choice study
Rachael L Morton
Sydney School of Public Health, The University of Sydney, NSW, Australia
Am J Kidney Dis 60:102-11. 2012
..Dialysis modality preferences of patients with chronic kidney disease (CKD) and family caregivers are important, yet rarely quantified...
- Factors influencing patient choice of dialysis versus conservative care to treat end-stage kidney disease
Rachael L Morton
Sydney School of Public Health, The University of Sydney, Sydney, Australia
CMAJ 184:E277-83. 2012
..We aimed to determine the most important characteristics of dialysis and the trade-offs patients were willing to make in choosing dialysis instead of conservative care...
- Patient INformation about Options for Treatment (PINOT): a prospective national study of information given to incident CKD Stage 5 patients
Rachael L Morton
Sydney School of Public Health, The University of Sydney, Sydney, Australia
Nephrol Dial Transplant 26:1266-74. 2011
..The aim of this study was to determine the effect of patient and unit characteristics on the type and timing of information provided...
- Monoclonal and polyclonal antibody therapy for treating acute rejection in kidney transplant recipients: a systematic review of randomized trial data
Angela C Webster
Cochrane Renal Group, Children s Hospital, Westmead, New South Wales, Australia
Transplantation 81:953-65. 2006
..We performed a comprehensive systematic review to determine the relative benefits and harms of widely used interventions used to treat acute rejection in kidney transplant recipients: monoclonal or polyclonal antibodies (Ab)...
- No excess risk of follicular lymphoma in kidney transplant and HIV-related immunodeficiency
Claire M Vajdic
UNSW Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
Int J Cancer 127:2732-5. 2010
..82, 95% CI: 0.10-2.96) and in people with HIV (SIR 1.25, 95% CI: 0.41-2.91). The findings argue against an infectious or other immunodeficiency-related etiology for FL and clearly differentiate it from diffuse large B-cell lymphoma...
- Cardiac testing for coronary artery disease in potential kidney transplant recipients
Louis W Wang
Department of Cardiology, St Vincent s Hospital, Darlinghurst, NSW, Australia, 2010
Cochrane Database Syst Rev 12:CD008691. 2011
..There is significant interest in the role of non-invasive cardiac investigations and their ability to identify patients at high risk of CAD. ..
- Association of CKD and cancer risk in older people
Germaine Wong
National Health and Medical Research Council Centre for Clinical Research Excellence in Renal Medicine, Children s Hospital at Westmead, Westmead, New South Wales, Australia
J Am Soc Nephrol 20:1341-50. 2009
..In conclusion, moderate CKD (stage 3) may be an independent risk factor for the development of cancer among older men but not women, and the effect of CKD on risk may vary for different types of cancer...
- Tests for latent tuberculosis in people with ESRD: a systematic review
Thomas E Rogerson
Centre for Kidney Research, The Children s Hospital at Westmead, Westmead, Australia
Am J Kidney Dis 61:33-43. 2013
..TB tests, respectively) and the tuberculin skin test (TST) for latent tuberculosis (TB) infection in people with end-stage kidney disease is uncertain and national guidelines for their use are inconsistent...
- Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data
Angela C Webster
Cochrane Renal Group, Centre for Kidney Research, Children s Hospital at Westmead, Westmead, NSW 2145, Australia
BMJ 331:810. 2005
..To compare the positive and negative effects of tacrolimus and ciclosporin as initial treatment for renal transplant recipients...
- Screening for renal cancer in recipients of kidney transplants
Germaine Wong
Centre for Kidney Research, The Children s Hospital at Westmead, NSW, Australia
Nephrol Dial Transplant 26:1729-39. 2011
..It is uncertain whether routine screening for renal cancer is cost-effective. The aim of our study is to estimate the costs and health benefits of ultrasonographic (US) screening for renal cancer in the kidney transplant population...
- The perspectives of kidney transplant recipients on medicine taking: a systematic review of qualitative studies
Allison Tong
Centre for Kidney Research, The Children s Hospital at Westmead, Westmead, NSW 2145, Australia
Nephrol Dial Transplant 26:344-54. 2011
..This study aimed to describe the beliefs, experiences and perspectives of kidney transplant recipients on medicine taking...
- Characteristics of dialysis important to patients and family caregivers: a mixed methods approach
Rachael L Morton
Sydney School of Public Health, The University of Sydney, Sydney, Australia
Nephrol Dial Transplant 26:4038-46. 2011
..The aim of this study was to rank the most important characteristics of dialysis on which patients and caregivers make decisions about treatment...
- Trial registration and declaration of registration by authors of randomized controlled trials
Richard G McGee
Centre for Kidney Research and Cochrane Renal Group, The Children s Hospital at Westmead, Westmead, NSW, Australia
Transplantation 92:1094-100. 2011
..Trial registration was introduced to reduce research bias by promoting trial transparency and accountability. We aimed to evaluate the frequency of, and factors associated with, trial registration and declaration of trial registration...
- Patient information about options for treatment: Methods of a national audit of information provision in chronic kidney disease
Rachael L Morton
University of Sydney, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Australia
Nephrology (Carlton) 15:649-52. 2010
..PINOT will assess the patient and unit characteristics associated with timely information provision and highlight any regional variation in treatments offered...
- Diagnostic test studies in nephrology: quantity, quality, and scope
Richard G McGee
Centre for Kidney Research and Cochrane Renal Group, The Children s Hospital at Westmead, Westmead, NSW, Australia
Am J Kidney Dis 58:921-7. 2011
..We hypothesized that diagnostic errors are reduced through evidence-based choice, use, and interpretation of diagnostic tests...
- Reported cancer screening practices of nephrologists: results from a national survey
Germaine Wong
NHMRC Centre for Clinical Research Excellence in Renal Medicine, Children s Hospital at Westmead, NSW, Australia
Nephrol Dial Transplant 24:2136-43. 2009
..This study aimed to describe cancer screening practices by nephrologists in Australia and New Zealand, and to identify reasons for a positive recommendation to screen...
- The cost-effectiveness of induction immunosuppression in kidney transplantation
Rachael L Morton
School of Public Health, The University of Sydney, Sydney, NSW, Australia
Nephrol Dial Transplant 24:2258-69. 2009
..This study evaluated the cost-effectiveness of antibody induction comparing interleukin-2 receptor antagonists (IL2Ra) to standard therapy with no induction or induction with polyclonal antibodies...
- Diagnostic accuracy of blood qualitative nucleic acid testing for polyomavirus-associated nephropathy in kidney recipients
Nicholas B Cross
Centre for Kidney Research, Children s Hospital at Westmead, Westmead, NSW 2145, Australia
Nephrology (Carlton) 14:350-6. 2009
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- Interleukin 2 receptor antagonists for renal transplant recipients: a meta-analysis of randomized trials
Angela C Webster
Cochrane Renal Group, Centre for Kidney Research, Children's Hospital at Westmead, Westmead, NSW, Australia
Transplantation 77:166-76. 2004
..There is no apparent difference between basiliximab and daclizumab...
- Antihypertensives for kidney transplant recipients: systematic review and meta-analysis of randomized controlled trials
Nicholas B Cross
Centre for Kidney Research, Children s Hospital at Westmead, Westmead, NSW, Australia
Transplantation 88:7-18. 2009
..2-15.8), and increased hyperkalemia (RR 3.7, 95% CI 1.9-7.7). Graft loss data were inconclusive (RR 7.4, 95% CI 0.4-140). These data suggest that CCB may be preferred as first-line agents for hypertensive kidney transplant recipients...
- Asking the right question and finding the right answers
Nicholas B Cross
Centre for Kidney Research, Children s Hospital at Westmead, New South Wales, Australia
Nephrology (Carlton) 15:8-11. 2010
..We describe a method for rephrasing or 'framing' clinical questions into population, intervention, comparator and outcome terms that helps to determine the best type of study to search for, and aids in the design of search strategies...
- Long-term cancer risk of immunosuppressive regimens after kidney transplantation
Martin P Gallagher
Renal Division, George Institute for International Health, Camperdown, New South Wales, Australia
J Am Soc Nephrol 21:852-8. 2010
..In conclusion, these immunosuppressive regimens, widely used in recent decades, carry similar risks for carcinogenicity after kidney transplantation...
- Treatment for lupus nephritis
Lorna Henderson
Centre for Transplant and Renal Research, Westmead Millennium Institute, The University of Sydney at Westmead, Westmead, Australia
Cochrane Database Syst Rev 12:CD002922. 2012
..Several new agents, including mycophenolate mofetil (MMF), suggest reduced toxicity with equivalent rates of remission. This is an update of a Cochrane review first published in 2004...
- Patients who plan for conservative care rather than dialysis: a national observational study in Australia
Rachael L Morton
School of Public Health, The University of Sydney, Australia
Am J Kidney Dis 59:419-27. 2012
..It is unclear how many incident patients with stage 5 chronic kidney disease (CKD) referred to nephrologists are presented with information about conservative care as a treatment option and how many plan not to dialyze...
- How to write a Cochrane systematic review
Lorna K Henderson
Centre for Kidney Research, Children s Hospital at Westmead Centre for Transplant and Renal Research, Westmead Millennium Institute, University of Sydney at Westmead Hospital Sydney School of Public Health, New South Wales, Australia
Nephrology (Carlton) 15:617-24. 2010
..Here we aim to describe the steps involved to undertake a new or update an existing Cochrane Review...
- Cardiac testing for coronary artery disease in potential kidney transplant recipients: a systematic review of test accuracy studies
Louis W Wang
Sydney School of Public Health, University of Sydney, Sydney, Australia
Am J Kidney Dis 57:476-87. 2011
..Cardiovascular disease is the leading cause of death after kidney transplant. Screening for coronary artery disease is integral to pretransplant evaluation, although the relative performance of different tests is uncertain...
- How to read a report of a randomized controlled trial
Min Jun
The George Institute for International Health, The University of Sydney, PO Box 201, Missenden Road, Sydney, NSW 2050, Australia
Nephrology (Carlton) 15:153-7. 2010
..This paper aims to explain how to approach critical appraisal, by highlighting and illustrating important questions that help determine the reliability of results from randomized trials...
- Expanding the evidence base in transplantation: more and better randomized trials, and extending the value of observational data
Jonathan C Craig
Screening and Diagnostic Test Evaluation Program, School of Public Health, University of Sydney, Sydney, NSW, Australia
Transplantation 86:32-5. 2008
....
- Medical device regulation in Australia: safe and effective?
Richard G McGee
Sydney School of Public Health, University of Sydney, Sydney, NSW
Med J Aust 196:256-60. 2012
..To describe the frequency, characteristics and outcomes of reports of possible harms related to medical devices submitted to the Australian Therapeutic Goods Administration (TGA) using data made publicly available on the TGA website...
- Parenteral versus oral iron therapy for adults and children with chronic kidney disease
Jumana Albaramki
Centre for Kidney Research, The Children sHospital atWestmead, Westmead, Australia
Cochrane Database Syst Rev 1:CD007857. 2012
..Iron can be provided through different routes, with advantages and drawbacks of each route. It remains unclear whether the potential harms and additional costs of intravenous (IV) compared with oral iron are justified...
- How many patients do we need for a clinical trial? Demystifying sample size calculations
Patrick J Kelly
University of Sydney, Sydney, Australia
Nephrology (Carlton) 15:725-31. 2010
..The primary aim is to demystify the sample size section in published clinical trials. Some of the difficulties in determining the sample size correctly are also highlighted and some good practices recommended...
- Antiviral medications to prevent cytomegalovirus disease and early death in recipients of solid-organ transplants: a systematic review of randomised controlled trials
Elisabeth M Hodson
National Health and Medical Research Council Centre for Clinical Research Excellence, Centre for Kidney Research, The Children s Hospital at Westmead, Sydney, Australia
Lancet 365:2105-15. 2005
..We undertook a systematic review to investigate whether this approach affects risks of cytomegalovirus disease and death...
- Proton pump inhibitors and acute interstitial nephritis
Nimeshan Geevasinga
University of Sydney, Sydney, and Department of Medicine, Manly Hospital, Australia
Clin Gastroenterol Hepatol 4:597-604. 2006
..Failure to recognize this entity might have catastrophic long-term consequences including chronic kidney disease. Increased awareness might facilitate more rapid diagnosis and management of this potentially reversible condition...
- Meta-analyses in prevention and treatment of urinary tract infections
Philip Masson
Department of Renal Medicine, Royal Infirmary of Edinburgh, Scotland, UK
Infect Dis Clin North Am 23:355-85; Table of Contents. 2009
..Suggestions are made for future research, because it is apparent that there are evidence gaps for particular subgroups of people...
- Probiotics for patients with hepatic encephalopathy
Richard G McGee
Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia, 2006
Cochrane Database Syst Rev 11:CD008716. 2011
..Probiotics are live microorganisms, which when administered in adequate amounts may confer a health benefit on the host...
- How to get the most from the medical literature: keeping up to date in nephrology
Jeremy Cullis
Medical Sciences Libraries and School of Public Health, University of Sydney, Sydney, Australia
Nephrology (Carlton) 15:269-76. 2010
..In this paper we will examine Web 2.0, including the use of RSS, and suggest a number of different websites that offer free access to nephrology news...
- The views of patients and carers in treatment decision making for chronic kidney disease: systematic review and thematic synthesis of qualitative studies
R L Morton
Sydney School of Public Health, University of Sydney, Sydney, NSW 2006, Australia
BMJ 340:c112. 2010
..To synthesise the views of patients and carers in decision making regarding treatment for chronic kidney disease, and to determine which factors influence those decisions...
- Sirolimus is associated with new-onset diabetes in kidney transplant recipients
Olwyn Johnston
Division of Nephrology, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada
J Am Soc Nephrol 19:1411-8. 2008
..Given the negative impact of NOD on posttransplantation outcomes, these findings should be confirmed in prospective studies or in meta-analyses of existing trials that involved sirolimus...
- Increased incidence of squamous cell carcinoma of eye after kidney transplantation
Claire M Vajdic
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Level 2 376 Victoria St, Darlinghurst NSW 2010, Australia
J Natl Cancer Inst 99:1340-2. 2007
..Our data also support an interaction between immune suppression and sun exposure in the development of ocular SCC after kidney transplantation...
- Antifungal agents for preventing fungal infections in non-neutropenic critically ill and surgical patients: systematic review and meta-analysis of randomized clinical trials
E Geoffrey Playford
Infection Management Services, Princess Alexandra Hospital, Brisbane, Queensland, Australia
J Antimicrob Chemother 57:628-38. 2006
..This study aims to systematically identify and summarize the effects of antifungal prophylaxis in non-neutropenic critically ill adult patients on all-cause mortality and the incidence of invasive fungal infections...
