Misaki Wayengera

Summary

Publications

  1. pmc Harnessing pharmacogenomics to tackle resistance to the "nucleoside reverse trancripatse inhibitor" backbone of highly active antiretroviral therapy in resource limited settings
    Misaki Wayengera
    Division of Human and Molecular Genetics Dept of Pathology College of Health Sciences, Makerere University P O Box 7072, Kampala, Uganda
    Open AIDS J 2:78-81. 2008
  2. pmc Zinc finger arrays binding human papillomavirus types 16 and 18 genomic DNA: precursors of gene-therapeutics for in-situ reversal of associated cervical neoplasia
    Misaki Wayengera
    Unit of Genetics, Genomics and Theoretical Biology, Dept of Pathology, School of Biomedical Science, College of Health Sciences, Makerere University, P O Box 7072, Kampala, Uganda
    Theor Biol Med Model 9:30. 2012
  3. pmc Targeting wild-type Erythrocyte receptors for Plasmodium falciparum and vivax Merozoites by Zinc Finger Nucleases In- silico: Towards a Genetic Vaccine against Malaria
    Henry Kajumbula
    Dept of Medical Microbiology, School of Biomedical Science, College of Health Sciences, Makerere University, P O Box 7072, Kampala, Uganda
    Genet Vaccines Ther 10:8. 2012
  4. pmc Zinc finger nucleases for targeted mutagenesis and repair of the sickle-cell disease mutation: An in-silico study
    Misaki Wayengera
    Unit of Genetics, Genomics and Theoretical Biology, Dept of Pathology, School of Biomedical Science, College of Health Sciences, Makerere University, P O Box 7072, Kampala, Uganda
    BMC Blood Disord 12:5. 2012
  5. pmc Proviral HIV-genome-wide and pol-gene specific zinc finger nucleases: usability for targeted HIV gene therapy
    Misaki Wayengera
    Unit of Genetics, Genomics and Theoretical Biology, Dept of Pathology, School of Biomedical Science, College of Health Sciences, Makerere University, P O Box 7072 Kampala, Uganda
    Theor Biol Med Model 8:26. 2011
  6. pmc Identity of zinc finger nucleases with specificity to herpes simplex virus type II genomic DNA: novel HSV-2 vaccine/therapy precursors
    Misaki Wayengera
    Unit of Genetics, Genomics and Theoretical Biology, Dept of Pathology, School of Biomedical Science, College of Health Sciences, Makerere University, P O Box 7072 Kampala, Uganda
    Theor Biol Med Model 8:23. 2011
  7. pmc On the general theory of the origins of retroviruses
    Misaki Wayengera
    Unit of Theoretical Biology, Division of Molecular Pathology, Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makerere University, PO Box 7072, Kampala, Uganda
    Theor Biol Med Model 7:5. 2010
  8. pmc Searching for new clues about the molecular cause of endomyocardial fibrosis by way of in silico proteomics and analytical chemistry
    Misaki Wayengera
    Division of Molecular Pathology, Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda
    PLoS ONE 4:e7420. 2009
  9. pmc Theoretical basis for reducing time-lines to the determination of positive Mycobacterium tuberculosis cultures using thymidylate kinase (TMK) assays
    Misaki Wayengera
    Division of Molecular Pathology, Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makerere University, PO Box 7072, Kampala, Uganda
    Theor Biol Med Model 6:4. 2009
  10. ncbi request reprint Bone marrow transplantation (BMT) and gene replacement therapy (GRT) in sickle cell anemia
    W Misaki
    Makerere University Faculty of Medicine, Kamala, Uganda
    Niger J Med 17:251-6. 2008

Collaborators

Detail Information

Publications12

  1. pmc Harnessing pharmacogenomics to tackle resistance to the "nucleoside reverse trancripatse inhibitor" backbone of highly active antiretroviral therapy in resource limited settings
    Misaki Wayengera
    Division of Human and Molecular Genetics Dept of Pathology College of Health Sciences, Makerere University P O Box 7072, Kampala, Uganda
    Open AIDS J 2:78-81. 2008
    ..CONCLUSION: This paper provides an evidence based account of how the knowledge of pharmacogenomics may be exploited to tackle NRTI resistance within limited resource...
  2. pmc Zinc finger arrays binding human papillomavirus types 16 and 18 genomic DNA: precursors of gene-therapeutics for in-situ reversal of associated cervical neoplasia
    Misaki Wayengera
    Unit of Genetics, Genomics and Theoretical Biology, Dept of Pathology, School of Biomedical Science, College of Health Sciences, Makerere University, P O Box 7072, Kampala, Uganda
    Theor Biol Med Model 9:30. 2012
    ..We aimed to derive model zinc finger nucleases (ZFNs) for mutagenesis of the genomes of two high-risk HPV (types 16 & 18)...
  3. pmc Targeting wild-type Erythrocyte receptors for Plasmodium falciparum and vivax Merozoites by Zinc Finger Nucleases In- silico: Towards a Genetic Vaccine against Malaria
    Henry Kajumbula
    Dept of Medical Microbiology, School of Biomedical Science, College of Health Sciences, Makerere University, P O Box 7072, Kampala, Uganda
    Genet Vaccines Ther 10:8. 2012
    ..abstract:..
  4. pmc Zinc finger nucleases for targeted mutagenesis and repair of the sickle-cell disease mutation: An in-silico study
    Misaki Wayengera
    Unit of Genetics, Genomics and Theoretical Biology, Dept of Pathology, School of Biomedical Science, College of Health Sciences, Makerere University, P O Box 7072, Kampala, Uganda
    BMC Blood Disord 12:5. 2012
    ..abstract:..
  5. pmc Proviral HIV-genome-wide and pol-gene specific zinc finger nucleases: usability for targeted HIV gene therapy
    Misaki Wayengera
    Unit of Genetics, Genomics and Theoretical Biology, Dept of Pathology, School of Biomedical Science, College of Health Sciences, Makerere University, P O Box 7072 Kampala, Uganda
    Theor Biol Med Model 8:26. 2011
    ....
  6. pmc Identity of zinc finger nucleases with specificity to herpes simplex virus type II genomic DNA: novel HSV-2 vaccine/therapy precursors
    Misaki Wayengera
    Unit of Genetics, Genomics and Theoretical Biology, Dept of Pathology, School of Biomedical Science, College of Health Sciences, Makerere University, P O Box 7072 Kampala, Uganda
    Theor Biol Med Model 8:23. 2011
    ..Herein, the therapeutic-potential of zinc finger arrays (ZFAs) and ZFNs is identified and modeled, with unique specificity to the HSV-2 genome...
  7. pmc On the general theory of the origins of retroviruses
    Misaki Wayengera
    Unit of Theoretical Biology, Division of Molecular Pathology, Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makerere University, PO Box 7072, Kampala, Uganda
    Theor Biol Med Model 7:5. 2010
    ..Knowledge of such intertwine could lead to a better understanding of retrovirology and possibly other infectious processes. This study was conducted to derive the mathematical equation of a general theory of the origins of retroviruses...
  8. pmc Searching for new clues about the molecular cause of endomyocardial fibrosis by way of in silico proteomics and analytical chemistry
    Misaki Wayengera
    Division of Molecular Pathology, Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda
    PLoS ONE 4:e7420. 2009
    ..This study aimed to investigate the similarity of C-termini of TcP0/TcP2beta to sequences and molecules of several plants, microbial, viral and chemical elements- most prior thought to be possible causative agents for EMF...
  9. pmc Theoretical basis for reducing time-lines to the determination of positive Mycobacterium tuberculosis cultures using thymidylate kinase (TMK) assays
    Misaki Wayengera
    Division of Molecular Pathology, Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makerere University, PO Box 7072, Kampala, Uganda
    Theor Biol Med Model 6:4. 2009
    ..The aim of this study was to define algorithms for predicting positive TB cultures using antibody-based assays of TMKmyc levels in vitro...
  10. ncbi request reprint Bone marrow transplantation (BMT) and gene replacement therapy (GRT) in sickle cell anemia
    W Misaki
    Makerere University Faculty of Medicine, Kamala, Uganda
    Niger J Med 17:251-6. 2008
    ..The SCA trait is inherited through a recessive autosomal link, with the homozygotes (SS) manifesting clinical disease, while the heterozygoste (AS) are clinically normal-exept in states of hypoxia or severe infection...
  11. pmc Identification of restriction endonuclease with potential ability to cleave the HSV-2 genome: inherent potential for biosynthetic versus live recombinant microbicides
    Misaki Wayengera
    Restrizymes Biotherapeutics Uganda Limited, Kampala, Uganda
    Theor Biol Med Model 5:18. 2008
    ..This paper details the protocol for the isolation of restriction endunucleases (REases) with potent activity against the HSV-2 genome and models two biomedical interventions for preventing HSV-2...
  12. pmc In silico evidence for the species-specific conservation of mosquito retroposons: implications as a molecular biomarker
    Wilson Byarugaba
    Restrizymes Biotherapeutics U LTD, PO Box 16606, Kampala, Uganda
    Theor Biol Med Model 6:14. 2009
    ..REase-like retroposons are thought to be the ancestors of APE retroposons. Our aim in this study was to find evidence for the highly species-specific conservation of the APE subclass of mosquito retroposons...