DANIEL MARTIN WATTERSON

Summary

Publications

  1. pmc Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors
    Adam D Bachstetter
    Sanders Brown Center on Aging, University of Kentucky, 800 S Limestone, Lexington, KY, 40536, USA
    J Neuroimmune Pharmacol 9:454-60. 2014
  2. pmc Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)
    Adam D Bachstetter
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA
    J Neuroinflammation 8:79. 2011

Detail Information

Publications3

  1. pmc Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors
    Adam D Bachstetter
    Sanders Brown Center on Aging, University of Kentucky, 800 S Limestone, Lexington, KY, 40536, USA
    J Neuroimmune Pharmacol 9:454-60. 2014
    ..In vivo validation included demonstration that oral administration of MW181 suppresses lipopolysaccharide-induced increases in mouse brain IL-1β, TNFα, IL-6, IL-10, and CXCL1 but not in a drug-resistant p38α MAPK mutant mouse. ..
  2. pmc Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)
    Adam D Bachstetter
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA
    J Neuroinflammation 8:79. 2011
    ..Therefore, we examined the contribution of microglial p38αMAPK to cytokine up-regulation, with a focus on the potential to suppress the cytokine increase by inhibition of the kinase with pharmacological or genetic approaches...