Carl F Ware

Summary

Publications

  1. ncbi request reprint Protein therapeutics targeted at the TNF superfamily
    Carl F Ware
    Laboratory of Molecular Immunology, Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Adv Pharmacol 66:51-80. 2013
  2. pmc TNF Superfamily Networks: bidirectional and interference pathways of the herpesvirus entry mediator (TNFSF14)
    Carl F Ware
    Laboratory of Molecular Immunology, Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Immunol 23:627-31. 2011
  3. pmc Unconventional ligand activation of herpesvirus entry mediator signals cell survival
    Timothy C Cheung
    Divisions of Molecular Immunology and Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:6244-9. 2009
  4. pmc Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells
    Ian R Humphreys
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Eur J Immunol 40:2762-8. 2010
  5. pmc Human CD4+CD3- innate-like T cells provide a source of TNF and lymphotoxin-αβ and are elevated in rheumatoid arthritis
    Vasileios Bekiaris
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037
    J Immunol 191:4611-8. 2013
  6. pmc CD160 activation by herpesvirus entry mediator augments inflammatory cytokine production and cytolytic function by NK cells
    John R Sedy
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Immunol 191:828-36. 2013
  7. pmc A crucial role for HVEM and BTLA in preventing intestinal inflammation
    Marcos W Steinberg
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 205:1463-76. 2008
  8. doi request reprint The inhibitory receptor BTLA controls γδ T cell homeostasis and inflammatory responses
    Vasileios Bekiaris
    Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Immunity 39:1082-94. 2013
  9. pmc Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways
    Carl F Ware
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunol Rev 223:186-201. 2008
  10. pmc The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation
    Marcos W Steinberg
    Laboratory of Molecular Immunology, Center for Infectious and Inflammatory Diseases, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Immunol Rev 244:169-87. 2011

Research Grants

  1. Anti-herpesvirus Signaling by LTalphabeta/LIGHT Cytokines
    Carl F Ware; Fiscal Year: 2010
  2. HVEM-BTLA system in inflammation
    Carl F Ware; Fiscal Year: 2010
  3. HVEM-BTLA system in inflammation
    Carl F Ware; Fiscal Year: 2010
  4. Anti-herpesvirus Signaling by LTalphabeta/LIGHT Cytokines
    Carl F Ware; Fiscal Year: 2010

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Protein therapeutics targeted at the TNF superfamily
    Carl F Ware
    Laboratory of Molecular Immunology, Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Adv Pharmacol 66:51-80. 2013
    ..Dramatic clinical outcomes with TNF inhibitors are driving investigation and development of biologics toward other members of the TNF superfamily to selectively alter functional properties of the immune system...
  2. pmc TNF Superfamily Networks: bidirectional and interference pathways of the herpesvirus entry mediator (TNFSF14)
    Carl F Ware
    Laboratory of Molecular Immunology, Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Immunol 23:627-31. 2011
    ..The HVEM Network is emerging as a key survival system for effector and memory T cells in mucosal tissues...
  3. pmc Unconventional ligand activation of herpesvirus entry mediator signals cell survival
    Timothy C Cheung
    Divisions of Molecular Immunology and Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:6244-9. 2009
    ..Moreover, Btla(-/-) T cells survived poorly following activation but were rescued with BTLA-Fc, indicating HVEM-BTLA bidirectional signaling may serve as a critical cell-survival system for lymphoid and epithelial cells...
  4. pmc Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells
    Ian R Humphreys
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Eur J Immunol 40:2762-8. 2010
    ..These data highlight the dual nature of the 4-1BB/4-1BBL system in mediating both stimulatory and inhibitory cosignaling activities during the generation of anti-MCMV immunity...
  5. pmc Human CD4+CD3- innate-like T cells provide a source of TNF and lymphotoxin-αβ and are elevated in rheumatoid arthritis
    Vasileios Bekiaris
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037
    J Immunol 191:4611-8. 2013
    ..This CD4(+)CD3(-) population is enriched in the peripheral blood from rheumatoid arthritis patients, suggesting a link to their involvement in chronic inflammatory disease. ..
  6. pmc CD160 activation by herpesvirus entry mediator augments inflammatory cytokine production and cytolytic function by NK cells
    John R Sedy
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Immunol 191:828-36. 2013
    ..Together, our results demonstrate that HVEM functions as a regulator of immune function that activates NK cells via CD160 and limits lymphocyte-induced inflammation via association with BTLA. ..
  7. pmc A crucial role for HVEM and BTLA in preventing intestinal inflammation
    Marcos W Steinberg
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 205:1463-76. 2008
    ..Our experiments emphasize the antiinflammatory role of HVEM and the importance of HVEM expression by innate immune cells in preventing runaway inflammation in the intestine...
  8. doi request reprint The inhibitory receptor BTLA controls γδ T cell homeostasis and inflammatory responses
    Vasileios Bekiaris
    Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Immunity 39:1082-94. 2013
    ..Therefore, by coordinating expression of BTLA, RORγt and IL-7 balance suppressive and activation stimuli to regulate γδ T cell homeostasis and inflammatory responses...
  9. pmc Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways
    Carl F Ware
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunol Rev 223:186-201. 2008
    ..Alternately, agonists directed at their cell surface receptors can restore homeostasis and potentially reset immune and inflammatory processes, which may be useful in treating autoimmune and infectious diseases and cancer...
  10. pmc The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation
    Marcos W Steinberg
    Laboratory of Molecular Immunology, Center for Infectious and Inflammatory Diseases, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Immunol Rev 244:169-87. 2011
    ..Experimental mouse models and human diseases indicate that dysregulation of HVEM network may contribute to autoimmune pathogenesis, making it an attractive target for drug intervention...
  11. pmc Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners
    Marcos W Steinberg
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Semin Immunopathol 31:207-21. 2009
    ..Despite complexity, experiments we and others are carrying out are establishing rules for understanding when and in what cell types these molecules contribute to intestinal inflammation...
  12. pmc The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling
    Taylor A Doherty
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Med 17:596-603. 2011
    ....
  13. pmc Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability
    Timothy C Cheung
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    J Immunol 185:1949-58. 2010
    ..The increased potential for LTbetaR signaling, coupled with increased bioavailability due to lower DcR3 avidity, provides a mechanism of how polymorphic variants in LIGHT could contribute to the pathogenesis of inflammatory diseases...
  14. pmc Clinical targeting of the TNF and TNFR superfamilies
    Michael Croft
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Rev Drug Discov 12:147-68. 2013
    ....
  15. pmc Cross-regulation between herpesviruses and the TNF superfamily members
    John R Sedy
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Rev Immunol 8:861-73. 2008
    ..Despite these strong immune responses, herpesviruses persist in a latent form, which suggests a dynamic relationship between the host immune system and the virus that results in a balance between host survival and viral control...
  16. pmc B7-mediated costimulation of CD4 T cells constrains cytomegalovirus persistence
    Ramon Arens
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Virol 85:390-6. 2011
    ..Together, these data reveal a requirement for B7-mediated signaling in regulating the CMV-specific CD4 T cell response and establishing host-virus equilibrium...
  17. pmc The adaptor molecule MyD88 directly promotes CD8 T cell responses to vaccinia virus
    Yuan Zhao
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 182:6278-86. 2009
    ..Together, our results highlight an important role for MyD88 in initial antiviral CD8 T cell responses and suggest that targeting this pathway may be useful in promoting and sustaining anti-VACV immunity...
  18. pmc TRAIL: not just for tumors anymore?
    Chris A Benedict
    the Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037
    J Exp Med 209:1903-6. 2012
    ..These differentiating results highlight that the context of TRAIL signaling can determine whether the outcome is beneficial or pathogenic for the host...
  19. pmc Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor
    Hideki Sanjo
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    J Biol Chem 285:17148-55. 2010
    ..These results indicate the LTbetaR modifies the ubiquitin:NIK E3 ligase, and also acts as an allosteric regulator of the ubiquitin:TRAF E3 ligase...
  20. pmc Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses
    Wendell Smith
    The La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Cell Host Microbe 13:324-35. 2013
    ..The identification of UL141 as a herpesvirus modulator of the TRAIL DRs strongly implicates this pathway as a regulator of host defense to HCMV and highlights UL141 as a pleiotropic inhibitor of NK cell effector function...
  21. pmc The TNF Superfamily-2008
    Carl F Ware
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, United States
    Cytokine Growth Factor Rev 19:183-6. 2008
  22. pmc T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment
    Timothy C Cheung
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 183:7286-96. 2009
    ..We suggest that the HVEM-BTLA cis-complex competitively inhibits HVEM activation by ligands expressed in the surrounding microenvironment, thus helping maintain T cells in the naive state...
  23. pmc Lymphotoxin-mediated crosstalk between B cells and splenic stroma promotes the initial type I interferon response to cytomegalovirus
    Kirsten Schneider
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology 9420 Athena Circle, La Jolla, CA 92037, USA
    Cell Host Microbe 3:67-76. 2008
    ..These results reveal a TLR-independent innate host defense strategy directed by B cells in communication with stromal cells via the LTalphabeta cytokine system...
  24. doi request reprint Targeting the LIGHT-HVEM pathway
    Carl F Ware
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California, 92037, USA
    Adv Exp Med Biol 647:146-55. 2009
    ..LIGHT is accessible to biologic-based therapeutics, which can be used to target this molecule during inflammation-driven diseases...

Research Grants4

  1. Anti-herpesvirus Signaling by LTalphabeta/LIGHT Cytokines
    Carl F Ware; Fiscal Year: 2010
    ..The experiments here will provide a comprehensive investigation with mouse and humans that may reveal new approaches to altering immune responses to a persistent pathogen. ..
  2. HVEM-BTLA system in inflammation
    Carl F Ware; Fiscal Year: 2010
    ..Altering this communication system may help stop unwanted inflammation that occurs in autoimmune diseases, or to enhance immunity to viruses or cancer. ..
  3. HVEM-BTLA system in inflammation
    Carl F Ware; Fiscal Year: 2010
    ..Altering this communication system may help stop unwanted inflammation that occurs in autoimmune diseases, or to enhance immunity to viruses or cancer. ..
  4. Anti-herpesvirus Signaling by LTalphabeta/LIGHT Cytokines
    Carl F Ware; Fiscal Year: 2010
    ..The experiments here will provide a comprehensive investigation with mouse and humans that may reveal new approaches to altering immune responses to a persistent pathogen. ..