Protein therapeutics targeted at the TNF superfamilyCarl F Ware
Laboratory of Molecular Immunology, Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
Adv Pharmacol 66:51-80. 2013
..Dramatic clinical outcomes with TNF inhibitors are driving investigation and development of biologics toward other members of the TNF superfamily to selectively alter functional properties of the immune system...
TNF Superfamily Networks: bidirectional and interference pathways of the herpesvirus entry mediator (TNFSF14)Carl F Ware
Laboratory of Molecular Immunology, Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
Curr Opin Immunol 23:627-31. 2011
..The HVEM Network is emerging as a key survival system for effector and memory T cells in mucosal tissues...
- Unconventional ligand activation of herpesvirus entry mediator signals cell survival
Timothy C Cheung
Divisions of Molecular Immunology and Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 106:6244-9. 2009
..Moreover, Btla(-/-) T cells survived poorly following activation but were rescued with BTLA-Fc, indicating HVEM-BTLA bidirectional signaling may serve as a critical cell-survival system for lymphoid and epithelial cells...
- Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells
Ian R Humphreys
Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
Eur J Immunol 40:2762-8. 2010
..These data highlight the dual nature of the 4-1BB/4-1BBL system in mediating both stimulatory and inhibitory cosignaling activities during the generation of anti-MCMV immunity...
- A crucial role for HVEM and BTLA in preventing intestinal inflammation
Marcos W Steinberg
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Exp Med 205:1463-76. 2008
..Our experiments emphasize the antiinflammatory role of HVEM and the importance of HVEM expression by innate immune cells in preventing runaway inflammation in the intestine...
- The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation
Marcos W Steinberg
Laboratory of Molecular Immunology, Center for Infectious and Inflammatory Diseases, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
Immunol Rev 244:169-87. 2011
..Experimental mouse models and human diseases indicate that dysregulation of HVEM network may contribute to autoimmune pathogenesis, making it an attractive target for drug intervention...
- Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners
Marcos W Steinberg
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Semin Immunopathol 31:207-21. 2009
..Despite complexity, experiments we and others are carrying out are establishing rules for understanding when and in what cell types these molecules contribute to intestinal inflammation...
- Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways
Carl F Ware
Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Immunol Rev 223:186-201. 2008
..Alternately, agonists directed at their cell surface receptors can restore homeostasis and potentially reset immune and inflammatory processes, which may be useful in treating autoimmune and infectious diseases and cancer...
- The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling
Taylor A Doherty
Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
Nat Med 17:596-603. 2011
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- Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability
Timothy C Cheung
Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
J Immunol 185:1949-58. 2010
..The increased potential for LTbetaR signaling, coupled with increased bioavailability due to lower DcR3 avidity, provides a mechanism of how polymorphic variants in LIGHT could contribute to the pathogenesis of inflammatory diseases...
- Clinical targeting of the TNF and TNFR superfamilies
Michael Croft
Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
Nat Rev Drug Discov 12:147-68. 2013
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- The adaptor molecule MyD88 directly promotes CD8 T cell responses to vaccinia virus
Yuan Zhao
Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Immunol 182:6278-86. 2009
..Together, our results highlight an important role for MyD88 in initial antiviral CD8 T cell responses and suggest that targeting this pathway may be useful in promoting and sustaining anti-VACV immunity...
- Cross-regulation between herpesviruses and the TNF superfamily members
John R Sedy
Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
Nat Rev Immunol 8:861-73. 2008
..Despite these strong immune responses, herpesviruses persist in a latent form, which suggests a dynamic relationship between the host immune system and the virus that results in a balance between host survival and viral control...
- B7-mediated costimulation of CD4 T cells constrains cytomegalovirus persistence
Ramon Arens
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
J Virol 85:390-6. 2011
..Together, these data reveal a requirement for B7-mediated signaling in regulating the CMV-specific CD4 T cell response and establishing host-virus equilibrium...
- TRAIL: not just for tumors anymore?
Chris A Benedict
the Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037
J Exp Med 209:1903-6. 2012
..These differentiating results highlight that the context of TRAIL signaling can determine whether the outcome is beneficial or pathogenic for the host...
- Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor
Hideki Sanjo
Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
J Biol Chem 285:17148-55. 2010
..These results indicate the LTbetaR modifies the ubiquitin:NIK E3 ligase, and also acts as an allosteric regulator of the ubiquitin:TRAF E3 ligase...
- T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment
Timothy C Cheung
Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Immunol 183:7286-96. 2009
..We suggest that the HVEM-BTLA cis-complex competitively inhibits HVEM activation by ligands expressed in the surrounding microenvironment, thus helping maintain T cells in the naive state...
- The TNF Superfamily-2008
Carl F Ware
Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, United States
Cytokine Growth Factor Rev 19:183-6. 2008
- Lymphotoxin-mediated crosstalk between B cells and splenic stroma promotes the initial type I interferon response to cytomegalovirus
Kirsten Schneider
Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology 9420 Athena Circle, La Jolla, CA 92037, USA
Cell Host Microbe 3:67-76. 2008
..These results reveal a TLR-independent innate host defense strategy directed by B cells in communication with stromal cells via the LTalphabeta cytokine system...
- Targeting the LIGHT-HVEM pathway
Carl F Ware
Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California, 92037, USA
Adv Exp Med Biol 647:146-55. 2009
..LIGHT is accessible to biologic-based therapeutics, which can be used to target this molecule during inflammation-driven diseases...
