Jerrold M Ward

Summary

Publications

  1. pmc Differentiation of rodent immune and hematopoietic system reactive lesions from neoplasias
    Jerrold M Ward
    Global VetPathology and Laboratory of Immunopathology, NIAID, NIH, Bethesda, Maryland 20892, USA
    Toxicol Pathol 40:425-34. 2012
  2. ncbi request reprint Pathology methods for the evaluation of embryonic and perinatal developmental defects and lethality in genetically engineered mice
    J M Ward
    Global VetPathology, Montgomery Village, MD 20886, USA
    Vet Pathol 49:71-84. 2012
  3. doi request reprint The roles of the toxicologic pathologist in cancer research
    Jerrold M Ward
    Global Vet Pathology, Montgomery Village, Maryland, USA
    Toxicol Pathol 38:39-42. 2010
  4. pmc Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge
    Alexander Bukreyev
    National Institute of Allergy and Infectious Diseases, Building 50, Room 6505, NIAID, National Institutes of Health, 50 South Dr MSC 8007, Bethesda, MD 20892 8007, USA
    Virology 383:348-61. 2009
  5. pmc Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
    Insook Kim
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 28:940-6. 2007
  6. pmc Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice
    Miranda S Oakley
    Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics and Evaluation Research, Food and Drug Administration, Bethesda, MD, USA
    PLoS ONE 4:e6793. 2009
  7. ncbi request reprint Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice
    Kimihiko Matsusue
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 18:2751-64. 2004
  8. pmc Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation
    Joshua D Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, Bethesda, MD 20892, USA
    Blood 116:2476-83. 2010
  9. ncbi request reprint Enhanced acetaminophen toxicity by activation of the pregnane X receptor
    Grace L Guo
    Laboratory of Metabolism, CCR, NCI, NIH, Bethesda, Maryland 20892, USA
    Toxicol Sci 82:374-80. 2004
  10. pmc Delivery to the lower respiratory tract is required for effective immunization with Newcastle disease virus-vectored vaccines intended for humans
    Joshua M DiNapoli
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8007, USA
    Vaccine 27:1530-9. 2009

Collaborators

  • Frank J Gonzalez
  • Brian R Murphy
  • Peter L Collins
  • Alexander Bukreyev
  • Shioko Kimura
  • Yan Li
  • Stephen J Marx
  • Ya Hui Chi
  • Kuan Teh Jeang
  • Francis S Collins
  • Gilles Lambert
  • Stephen H Leppla
  • Allen M Spiegel
  • Stanislav V Sosnovtsev
  • Judy S Crabtree
  • Jerold E Rehg
  • Lily I Cheng
  • Lily Cheng
  • Nicolas Collin
  • Mahtab Moayeri
  • Connie Cheung
  • Joshua D Milner
  • Miranda S Oakley
  • Alfonso S Gozalo
  • William R Elkins
  • Kathy A Perdue
  • Olga A Maximova
  • Kim Y Green
  • Christopher J Nicol
  • Lijuan Yang
  • Lawrence J Faucette
  • Grace L Guo
  • Eva N Huter
  • Keiichirou Morimura
  • Mohamed E Moustafa
  • Elyssa L Barron
  • Reiko Kurotani
  • Anjeanette Roberts
  • Elaine W Lamirande
  • Dia Eldin Elnaiem
  • Laurent Fischer
  • Devorah Crown
  • Xizhong Cui
  • Ursula J Buchholz
  • David W Dorward
  • Joshua M DiNapoli
  • Jesus G Valenzuela
  • Qi Liu
  • Jean K Lim
  • Clarissa Teixeira
  • Sayuri Hoshi
  • Peter Eichacker
  • Shaden Kamhawi
  • Andre Laughinghouse
  • Regis Gomes
  • Don Gardner
  • Babita Mahajan
  • Vivek Anantharaman
  • Sanjai Kumar
  • Thomas F McCutchan
  • L Aravind
  • William E Paul
  • Victoria Majam
  • Hong Zheng
  • Cindy L Sood
  • Janet W Hartley
  • Ethan M Shevach
  • Georg H Stummvoll
  • Richard S Bennett
  • Miriam E R Darnell
  • Insook Kim
  • Yoichi Iwanaga
  • Yatrik Shah
  • Philip M Murphy
  • Shihui Liu
  • Sun Hee Yim
  • Oksana Gavrilova
  • Taro E Akiyama
  • Lionel Feigenbaum
  • Kartiki V Desai
  • Sergey V Ivanov
  • Kimihiko Matsusue
  • Peter C Scacheri
  • Steven A Kliewer
  • H Bryan Brewer
  • Li Yuan Chen
  • Steven K Libutti
  • Bradley A Carlson
  • Ulrich Schweizer
  • Gerald F Combs

Detail Information

Publications59

  1. pmc Differentiation of rodent immune and hematopoietic system reactive lesions from neoplasias
    Jerrold M Ward
    Global VetPathology and Laboratory of Immunopathology, NIAID, NIH, Bethesda, Maryland 20892, USA
    Toxicol Pathol 40:425-34. 2012
    ..Proliferative lesions may be difficult to differentiate from lymphomas and leukemias. The use of immunohistochemistry, compartmental pathology, and methods for the evaluation of clonality will make interpretation easier...
  2. ncbi request reprint Pathology methods for the evaluation of embryonic and perinatal developmental defects and lethality in genetically engineered mice
    J M Ward
    Global VetPathology, Montgomery Village, MD 20886, USA
    Vet Pathol 49:71-84. 2012
    ..5. These methods include pathology protocols for necropsy and histopathology in addition to references that will provide additional knowledge for embryo assessment including histology atlases and advanced embryo imaging techniques...
  3. doi request reprint The roles of the toxicologic pathologist in cancer research
    Jerrold M Ward
    Global Vet Pathology, Montgomery Village, Maryland, USA
    Toxicol Pathol 38:39-42. 2010
    ..This introductory review to the 2009 STP Symposium on Cancer will identify and discuss the major roles of pathologists in cancer research...
  4. pmc Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge
    Alexander Bukreyev
    National Institute of Allergy and Infectious Diseases, Building 50, Room 6505, NIAID, National Institutes of Health, 50 South Dr MSC 8007, Bethesda, MD 20892 8007, USA
    Virology 383:348-61. 2009
    ..Despite the attenuation, the virus was highly immunogenic, and a single IN dose completely protected the animals against a highly lethal intraperitoneal challenge of guinea pig-adapted EBOV...
  5. pmc Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
    Insook Kim
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 28:940-6. 2007
    ..They also had increased cell proliferation as revealed by increased PCNA mRNA and BrdU incorporation. These studies reveal a potential role for FXR and BAs in hepatocarcinogenesis...
  6. pmc Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice
    Miranda S Oakley
    Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics and Evaluation Research, Food and Drug Administration, Bethesda, MD, USA
    PLoS ONE 4:e6793. 2009
    ..We find that OX40, a marker of both T cell activation and memory, is selectively upregulated in the brain during ECM and its distribution among CD4(+) and CD8(+) T cells accumulated in the brain vasculature is approximately equal...
  7. ncbi request reprint Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice
    Kimihiko Matsusue
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 18:2751-64. 2004
    ..Taken together, these results indicate that hepatic C/EBP alpha plays a critical role in the acceleration of lipogenesis in ob/ob mice and in glucose homeostasis by the indirect regulation of insulin secretion...
  8. pmc Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation
    Joshua D Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, Bethesda, MD 20892, USA
    Blood 116:2476-83. 2010
    ..These data describe a novel pathophysiologic pathway for erythrophagocytosis in the context of tissue macrophage accumulation and inflammation involving elevations in IL-4 and alternative macrophage activation...
  9. ncbi request reprint Enhanced acetaminophen toxicity by activation of the pregnane X receptor
    Grace L Guo
    Laboratory of Metabolism, CCR, NCI, NIH, Bethesda, Maryland 20892, USA
    Toxicol Sci 82:374-80. 2004
    ..Thus, these results suggest that PXR plays a critical role in APAP-induced hepatic toxicity, probably by inducing CYP3A11 expression and hence increasing bioactivation...
  10. pmc Delivery to the lower respiratory tract is required for effective immunization with Newcastle disease virus-vectored vaccines intended for humans
    Joshua M DiNapoli
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8007, USA
    Vaccine 27:1530-9. 2009
    ....
  11. ncbi request reprint Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1
    Peter C Scacheri
    National Human Genome Research Institute, National Institutes of Health, Bldg 31, Room 4B09, 31 Center Drive, Bethesda, Maryland 20892, USA
    Mamm Genome 15:872-7. 2004
    ..These results argue against certain hypotheses previously proposed for the tissue specificity of tumor suppressor genes and provide insights to the mechanism of tissue specificity in MEN1...
  12. pmc Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 124:1483-9. 2009
    ..The findings here provide evidence for a cooperative role of Mad1/Mad2 and p53 genes in preventing tumor development...
  13. pmc The secreted form of respiratory syncytial virus G glycoprotein helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects on Fc receptor-bearing leukocytes
    Alexander Bukreyev
    LID, NIAID, NIH, 50 South Drive, Room 6505, Bethesda, MD 20892 8007, USA
    J Virol 82:12191-204. 2008
    ..Thus, sG helps RSV escape the antibody-dependent restriction of replication via effects as an antigen decoy and as a modulator of leukocytes bearing Fc gamma receptors...
  14. ncbi request reprint Sand fly salivary proteins induce strong cellular immunity in a natural reservoir of visceral leishmaniasis with adverse consequences for leishmania
    Nicolas Collin
    Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 5:e1000441. 2009
    ..Their inclusion in an anti-Leishmania vaccine would exploit anti-saliva immunity following an infective sand fly bite and set the stage for a protective anti-Leishmania immune response...
  15. ncbi request reprint Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism
    Steven K Libutti
    Surgery Branch, Center for Cancer Research, National Cancer Institute NIH, 10 Center Drive, Room 2B07, Bethesda, MD 20892, USA
    Cancer Res 63:8022-8. 2003
    ..This model provides a means for dissecting the molecular basis of this familial cancer syndrome and may allow for the development of new strategies to treat related forms of hypercalcemia...
  16. pmc Immunogenicity and protective efficacy in mice and hamsters of a β-propiolactone inactivated whole virus SARS-CoV vaccine
    Anjeanette Roberts
    Laboratory of Infectious Diseases, NIAID, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Viral Immunol 23:509-19. 2010
    ..Enhanced disease was not observed in the lungs or liver of hamsters following SARS-CoV challenge, regardless of the level of serum neutralizing antibodies...
  17. ncbi request reprint The Heart Is an Early Target of Anthrax Lethal Toxin in Mice: A Protective Role for Neuronal Nitric Oxide Synthase (nNOS)
    Mahtab Moayeri
    Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 5:e1000456. 2009
    ..We report the heart as an early target of LT in mice and discuss a protective role for nNOS against LT-mediated cardiac damage...
  18. pmc Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development
    Shihui Liu
    Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 26:3835-41. 2006
    ..These results attest to the physiological importance of Dph3 in development. The biological roles of Dph3 are also discussed...
  19. pmc Cellular inflammatory response to flaviviruses in the central nervous system of a primate host
    Olga A Maximova
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892 3203, USA
    J Histochem Cytochem 57:973-89. 2009
    ....
  20. ncbi request reprint The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity
    Connie Cheung
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Drug Metab Dispos 33:449-57. 2005
    ..They will also function as an important in vivo tool for predicting drug metabolism and disposition and drug-drug interactions of chemicals that are substrates for human CYP2E1...
  21. ncbi request reprint Pathology of immunodeficient mice with naturally occurring murine norovirus infection
    Jerrold M Ward
    Infectious Disease Pathogenesis Section, Comparative Medicine Branch, Division of Intramural Research, NIAID, NIH, Twinbrook III, Bethesda, Maryland 20892 8135, USA
    Toxicol Pathol 34:708-15. 2006
    ..Further studies are needed to determine whether MNV presents a confounding variable in immunological, toxicological and pathological studies in mice naturally infected with MNV...
  22. pmc Role of NKX2-1 in N-bis(2-hydroxypropyl)-nitrosamine-induced thyroid adenoma in mice
    Sayuri Hoshi
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 30:1614-9. 2009
    ..Thus, NKX2-1 may function to control the proliferation of thyroid follicular cells following damage by a genotoxic carcinogen...
  23. pmc Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouse
    Shioko Kimura
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cancer 11:90. 2012
    ..Since multiple C/EBPs are expressed in lung, the combinatorial expression of these C/EBPs on lung carcinogenesis is not known...
  24. ncbi request reprint Naturally occurring murine norovirus infection in a large research institution
    Kathy A Perdue
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Am Assoc Lab Anim Sci 46:39-45. 2007
    ..Histopathologic lesions consisted only of a few hepatic inflammatory foci in each liver section, some of which were immunoreactive with antibodies to MNV. MNV viral antigens also were present in the mesenteric lymph nodes...
  25. pmc Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis
    Keiichirou Morimura
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 27:1074-80. 2006
    ..This mouse model will be useful for human cancer risk assessment of PPARalpha ligands...
  26. pmc Visceral and neural larva migrans in rhesus macaques
    Alfonso S Gozalo
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Am Assoc Lab Anim Sci 47:64-7. 2008
    ..These cases are similar to the low-level or covert cases of Baylisascaris infection described to occur in humans and provide further evidence of the existence of this parasite in the southeastern United States...
  27. pmc Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Development 136:965-73. 2009
    ..These findings raise a heretofore unrecognized role of Sun1 in the selective gene expression of coding and non-coding RNAs needed for gametogenesis...
  28. pmc Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice
    Miranda S Oakley
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Infect Immun 76:4518-29. 2008
    ..Our studies greatly enhance the repertoire of host molecules for use as diagnostics and novel therapeutics in CM...
  29. pmc Deletion of nonstructural proteins NS1 and NS2 from pneumonia virus of mice attenuates viral replication and reduces pulmonary cytokine expression and disease
    Ursula J Buchholz
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 83:1969-80. 2009
    ..In contrast, in the absence of NS2, there was an early, transient innate response involving moderate levels of IFN, IL-6, and CXCL10 that restricted virus replication and prevented disease...
  30. pmc TGF-beta-induced Foxp3+ regulatory T cells rescue scurfy mice
    Eva N Huter
    Laboratory of Immunology, Cellular Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Immunol 38:1814-21. 2008
    ..Thus, TGF-beta-differentiated Foxp3+ Treg appear to possess all of the functional properties of thymic-derived nTreg and represent a potent population for the cellular immunotherapy of autoimmune and inflammatory diseases...
  31. pmc Diversity of murine norovirus strains isolated from asymptomatic mice of different genetic backgrounds within a single U.S. research institute
    Elyssa L Barron
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 6:e21435. 2011
    ..Our study indicates that the murine noroviruses are widespread in these animal facilities, despite rigorous guidelines for animal care and maintenance...
  32. pmc Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice
    Sun Hee Yim
    Laboratory of Metabolism, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 44:550-60. 2006
    ..Adult ArntDeltaEC mice carrying embryonic hepatic defects developed what was possibly an early stage of cirrhosis with consequences of limited oxygen availability and altered lipid metabolism...
  33. pmc Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells
    Georg H Stummvoll
    Laboratory of Immunology, Cellular Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:1908-16. 2008
    ....
  34. pmc Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease
    Joshua D Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:576-81. 2007
    ..Limited repertoire complexity of Tregs may lead to a failure to control induction of immunopathologic responses, and limitation in repertoire complexity of conventional cells may be responsible for the Th2 phenotype...
  35. ncbi request reprint Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha
    Connie Cheung
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Res 64:3849-54. 2004
    ..The PPARalpha-humanized mice should serve as models for use in drug development and human risk assessment and to determine the mechanism of hepatocarcinogenesis of peroxisome proliferators...
  36. pmc Suboptimal ability of dirty-bedding sentinels to detect Spironucleus muris in a colony of mice with genetic manipulations of the adaptive immune system
    Kathy A Perdue
    Comparative Medicine Research, Division of Intramural Research, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    J Am Assoc Lab Anim Sci 47:10-7. 2008
    ..In light of the study results and an extensive literature review, we revised our health surveillance plan so that the age and duration of exposure to dirty bedding among sentinel mice is varied at the time of testing...
  37. pmc Sand fly salivary proteins induce strong cellular immunity in a natural reservoir of visceral leishmaniasis with adverse consequences for Leishmania
    Nicolas Collin
    Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 5:e1000441. 2009
    ..Their inclusion in an anti-Leishmania vaccine would exploit anti-saliva immunity following an infective sand fly bite and set the stage for a protective anti-Leishmania immune response...
  38. ncbi request reprint Evolution of the uses of rats and mice for assessing carcinogenic risk from chemicals in humans
    Jerrold M Ward
    Global VetPathology, Montgomery Village, Maryland, USA
    Asian Pac J Cancer Prev 11:18. 2010
    ..With developments in the philosophy behind animal testing for carcinogenicity and toxicity, with increasing emphasis on Mode of Action analysis, the future usefulness of the 2 year rodent carcinogenesis bioassay is in doubt...
  39. pmc Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    PLoS Pathog 5:e1000321. 2009
    ..0001). Together, these data identify OAS1 SNP rs10774671 as a host genetic risk factor for initial infection with WNV in humans...
  40. pmc Vaccinia virus encodes I5, a small hydrophobic virion membrane protein that enhances replication and virulence in mice
    Cindy L Sood
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Drive, MSC 3210, Bethesda, MD 20892 3210, USA
    J Virol 82:10071-8. 2008
    ..We suggest that I5 is involved in an aspect of host defense that is evolutionarily conserved although a role in cell tropism should also be considered...
  41. pmc Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene
    Sergey V Ivanov
    Basic Research Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute at Frederick, Frederick, Maryland, USA
    Am J Pathol 165:1007-18. 2004
    ....
  42. ncbi request reprint PPARgamma influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis
    Christopher J Nicol
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Carcinogenesis 25:1747-55. 2004
    ..The data also support evidence suggesting a beneficial role for PPARgamma-specific ligands in the chemoprevention of mammary, ovarian and skin carcinogenesis...
  43. pmc La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys
    Richard S Bennett
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virol J 5:25. 2008
    ..As an initial step in the establishment of useful animal models to support vaccine development, we examined LACV infectivity, pathogenesis, and immunogenicity in both weanling mice and rhesus monkeys...
  44. ncbi request reprint Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice
    Yoichi Iwanaga
    Molecular Virology Section, Laboratory of Molecular Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Cancer Res 67:160-6. 2007
    ..Our results indicate an essential MAD1 function in mouse development and correlate Mad1 haploinsufficiency with increased constitutive tumors...
  45. pmc Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation
    Reiko Kurotani
    Laboratory of Metabolism, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:19682-92. 2011
    ..This study suggests the potential utility of SCGB3A2 for targeting TGFβ signaling in the treatment of pulmonary fibrosis...
  46. pmc The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS)
    Mahtab Moayeri
    Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    PLoS Pathog 5:e1000456. 2009
    ..We report the heart as an early target of LT in mice and discuss a protective role for nNOS against LT-mediated cardiac damage...
  47. ncbi request reprint Severe acute respiratory syndrome coronavirus infection in vaccinated ferrets
    Miriam E R Darnell
    Laboratory of Hepatitis and Related Emerging Agents, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, CBER FDA, Bethesda, MD 20892, USA
    J Infect Dis 196:1329-38. 2007
    ..Previous vaccine reports have noted robust neutralizing antibody and inflammatory responses in ferrets, resulting in enhanced hepatitis...
  48. pmc p47phox deficiency induces macrophage dysfunction resulting in progressive crystalline macrophage pneumonia
    Qi Liu
    Monocyte Trafficking Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1456, USA
    Am J Pathol 174:153-63. 2009
    ..These results suggest that p47(phox-/-) macrophages are extremely pliable, due in part to an intrinsic dysfunction of macrophage activation pathways that allows for distinct classical or alternative activation phenotypes...
  49. pmc Expression of infectious murine leukemia viruses by RAW264.7 cells, a potential complication for studies with a widely used mouse macrophage cell line
    Janet W Hartley
    Laboratory of Immunopathology, NIAID, NIH, Bethesda, MD 20892, USA
    Retrovirology 5:1. 2008
    ....
  50. ncbi request reprint Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient mice
    Jerrold M Ward
    The National Institute of Allergy and Infectious Diseases, NIH and SoBran, Inc, Twinbrook 3, Room 2W 01A, Bethesda, Maryland 20892 8135, USA
    Toxicol Pathol 32:710-8. 2004
    ..The function of CYP1B1 in histiocytes and macrophages may involve both self-tolerance and tumor suppression...
  51. ncbi request reprint Impaired glucose homeostasis, neutrophil trafficking and function in mice lacking the glucose-6-phosphate transporter
    Li Yuan Chen
    Section on Cellular Differentiation, Heritable Disorders Branch, Natioanl Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1830, USA
    Hum Mol Genet 12:2547-58. 2003
    ..These findings demonstrate that G6PT is not just a G6P transport protein but also an important immunomodulatory protein whose activities need to be addressed in treating the myeloid complications in GSD-Ib patients...
  52. pmc A paramyxovirus-vectored intranasal vaccine against Ebola virus is immunogenic in vector-immune animals
    Lijuan Yang
    Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Rm 6505, Bethesda, Maryland 20892 8007, USA
    Virology 377:255-64. 2008
    ....
  53. ncbi request reprint Gene expression profiling identifies a unique androgen-mediated inflammatory/immune signature and a PTEN (phosphatase and tensin homolog deleted on chromosome 10)-mediated apoptotic response specific to the rat ventral prostate
    Kartiki V Desai
    Laboratory of Cell Regulation and Carcinogenesis, 41 Medlar s Drive, Room C619, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 18:2895-907. 2004
    ..The VP castration model exhibits immune cell infiltration and loss of PTEN that is often observed in progressive PCa, thereby making this model useful for further delineation of androgen-regulated gene expression with relevance to PCa...
  54. pmc Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFα
    Mohamed E Moustafa
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e57389. 2013
    ..4 and 2.25 versus 0.1 ppm of selenium. Thus, selenium and selenoprotein deficiencies led to widespread pyogranuloma formation, while high selenium levels inhibited the size of TGFα-induced liver tumors...
  55. pmc Pathology of captive moustached tamarins (Saguinus mystax)
    Alfonso S Gozalo
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Comp Med 58:188-95. 2008
    ..This species may be a spontaneous animal model for pathogenesis and experimental therapy studies of the analogous human diseases...
  56. pmc Of mice and MEN1: Insulinomas in a conditional mouse knockout
    Judy S Crabtree
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 23:6075-85. 2003
    ..Comparative genomic hybridization of beta cell tumor DNA from these mice reveals duplication of chromosome 11, potentially revealing regions of interest with respect to tumorigenesis...
  57. ncbi request reprint Lymphomas and leukemias in mice
    Jerrold M Ward
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook 3, MSC 8135, Bethesda, MD 20892 8135, USA
    Exp Toxicol Pathol 57:377-81. 2006
    ..This classification follows closely the more detailed human WHO classification and can be used for mouse models of lymphoma and leukemia...
  58. ncbi request reprint Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity
    Grace L Guo
    Laboratory of Metabolism, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:45062-71. 2003
    ..Furthermore, FXR, PXR, and CAR protect against hepatic bile acid toxicity in a complementary manner, suggesting that they serve as redundant but distinct layers of defense to prevent overt hepatic damage by bile acids during cholestasis...
  59. ncbi request reprint Immunohistochemical markers for the rodent immune system
    Jerrold M Ward
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892 8135, USA
    Toxicol Pathol 34:616-30. 2006
    ....