Y Wang

Summary

Publications

  1. ncbi [Cases-Control association study and transmission disequilibrium test of T102C polymorphism in 5HT2A and Tourette syndrome]
    Y Huang
    Institute of Mental Health, The First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan, 610041 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 18:11-3. 2001
  2. ncbi White-matter microstructure in previously drug-naive patients with schizophrenia after 6 weeks of treatment
    Q Wang
    Mental Health Centre and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    Psychol Med 43:2301-9. 2013
  3. ncbi Mutation analysis of the FLCN gene in Chinese patients with sporadic and familial isolated primary spontaneous pneumothorax
    H Z Ren
    Department of Pathology, Nanjing University Medical School, Nanjing, Jiangsu, China
    Clin Genet 74:178-83. 2008
  4. ncbi Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q
    Y Y Shugart
    Department of Epidemiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Mol Psychiatry 11:763-70. 2006
  5. ncbi Dietary factors and smoking as risk factors for PD in a rural population in China: a nested case-control study
    L Ma
    Department of Epidemiology, Dalian Medical University, Dalian, China
    Acta Neurol Scand 113:278-81. 2006
  6. ncbi Microsatellite instability in mitochondrial genome of common female cancers
    Y Wang
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Int J Gynecol Cancer 16:259-66. 2006
  7. ncbi The Ser219-->Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype
    D Qu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Thromb Haemost 4:229-35. 2006
  8. pmc Changes in circulating mesenchymal stem cells, stem cell homing factor, and vascular growth factors in patients with acute ST elevation myocardial infarction treated with primary percutaneous coronary intervention
    Y Wang
    Medical Department B, The Heart Centre, University Hospital, Rigshospitalet, Copenhagen, Denmark
    Heart 92:768-74. 2006
  9. pmc Haplotype analysis of the endothelial nitric oxide synthase gene in relation to acute myocardial infarction
    J Chen
    Heart 91:1217-8. 2005
  10. ncbi FTY720 pharmacokinetics in mild to moderate hepatic impairment
    J M Kovarik
    Novartis Pharma, Building WSJ 27 P081, 4002 Basel, Switzerland
    J Clin Pharmacol 45:446-52. 2005

Collaborators

Detail Information

Publications44

  1. ncbi [Cases-Control association study and transmission disequilibrium test of T102C polymorphism in 5HT2A and Tourette syndrome]
    Y Huang
    Institute of Mental Health, The First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan, 610041 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 18:11-3. 2001
    ..To investigate whether T102C polymorphism in 5HT2A (serotonin receptor 2A) is associated with Tourette syndrome...
  2. ncbi White-matter microstructure in previously drug-naive patients with schizophrenia after 6 weeks of treatment
    Q Wang
    Mental Health Centre and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    Psychol Med 43:2301-9. 2013
    ..It is important to explore the longitudinal alterations in white-matter (WM) microstructure in antipsychotic-naive patients with first-episode schizophrenia during the very early phase of treatment when relatively 'free' from chronicity...
  3. ncbi Mutation analysis of the FLCN gene in Chinese patients with sporadic and familial isolated primary spontaneous pneumothorax
    H Z Ren
    Department of Pathology, Nanjing University Medical School, Nanjing, Jiangsu, China
    Clin Genet 74:178-83. 2008
    ..It suggests that mutation analysis and HRCT scan may be recommended for first-degree family members of PSP patients with FLCN mutations, irrespective of their family history status of PSP...
  4. ncbi Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q
    Y Y Shugart
    Department of Epidemiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Mol Psychiatry 11:763-70. 2006
    ..Given probable etiologic heterogeneity in OCD, mapping gene(s) involved in the disorder may be enhanced by replication studies, large-scale family-based linkage studies, and the application of novel statistical methods...
  5. ncbi Dietary factors and smoking as risk factors for PD in a rural population in China: a nested case-control study
    L Ma
    Department of Epidemiology, Dalian Medical University, Dalian, China
    Acta Neurol Scand 113:278-81. 2006
    ..Dietary factors and history of smoking remain elusive in the pathogenesis of Parkinson's disease (PD)...
  6. ncbi Microsatellite instability in mitochondrial genome of common female cancers
    Y Wang
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Int J Gynecol Cancer 16:259-66. 2006
    ..Furthermore, carriers of a germ-line T to C polymorphism at np 16189 could be more susceptible to breast cancer development in light of the higher frequency detected in cancer patients than in normal individuals...
  7. ncbi The Ser219-->Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype
    D Qu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Thromb Haemost 4:229-35. 2006
    ..These results indicate that the A3 haplotype does promote cellular shedding in either 293 or endothelial cells and therefore is likely directly contributory to the higher soluble EPCR levels seen in patients carrying this haplotype...
  8. pmc Changes in circulating mesenchymal stem cells, stem cell homing factor, and vascular growth factors in patients with acute ST elevation myocardial infarction treated with primary percutaneous coronary intervention
    Y Wang
    Medical Department B, The Heart Centre, University Hospital, Rigshospitalet, Copenhagen, Denmark
    Heart 92:768-74. 2006
    ..To investigate the spontaneous occurrence of circulating mesenchymal stem cells (MSC) and angiogenic factors in patients with ST elevation acute myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI)...
  9. pmc Haplotype analysis of the endothelial nitric oxide synthase gene in relation to acute myocardial infarction
    J Chen
    Heart 91:1217-8. 2005
  10. ncbi FTY720 pharmacokinetics in mild to moderate hepatic impairment
    J M Kovarik
    Novartis Pharma, Building WSJ 27 P081, 4002 Basel, Switzerland
    J Clin Pharmacol 45:446-52. 2005
    ..Although hepatic impairment elicited changes in the disposition of FTY720, the magnitude of these changes suggests that the FTY720 dose does not need to be adjusted in mild or moderate hepatic-impaired patients...
  11. pmc Tibial plateau size is related to grade of joint space narrowing and osteophytes in healthy women and in women with osteoarthritis
    A E Wluka
    Department of Epidemiology and Preventive Medicine, Monash University Central and Eastern Clinical School, Alfred Hospital, Commercial Road, Melbourne, VIC 3004, Australia
    Ann Rheum Dis 64:1033-7. 2005
    ..To determine the relation of bone size to radiographic severity in knee osteoarthritis...
  12. ncbi Association of lipoprotein lipase S447X, apolipoprotein E exon 4, and apoC3 -455T>C polymorphisms on the susceptibility to diabetic nephropathy
    M C Y Ng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
    Clin Genet 70:20-8. 2006
    ..61] were protective for DN compared with the most common combination of the respective polymorphisms. Our findings suggest the importance of interactions among lipid genes in modulating the risk of DN...
  13. ncbi Performance of tPSA and f/tPSA for prostate cancer in Chinese. A systematic review and meta-analysis
    Y Wang
    Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China
    Prostate Cancer Prostatic Dis 9:374-8. 2006
    ..tPSA and f/tPSA made an important performance for diagnosis of prostate cancer in decade among Chinese. The use of f/tPSA<0.15 as threshold maintain a high prognostic accuracy for prostate cancer...
  14. pmc Placental anti-oxidant gene polymorphisms, enzyme activity, and oxidative stress in preeclampsia
    J Zhang
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Building 6100 Room 7B03, Bethesda, MD 20892, USA
    Placenta 29:439-43. 2008
    ..8 vs. 27.9 pg/ml, p=0.03). In conclusion, our study showed that polymorphisms of CuZn-SOD, MnSOD, GSTM1 and GSTT1 in the placental tissue were not associated with preeclampsia...
  15. ncbi Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection
    S J Li
    Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, People s Republic of China
    Lupus 16:875-80. 2007
    ....
  16. pmc Mutations in the glucocerebrosidase gene are associated with early-onset Parkinson disease
    L N Clark
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neurology 69:1270-7. 2007
    ..To evaluate the frequency of glucocerebrosidase (GBA) mutations in cases and controls enrolled in the Genetic Epidemiology of Parkinson's Disease (GEPD) study...
  17. ncbi Characterization of polymorphisms of transferrin receptor and their association with susceptibility to ETEC F4ab/ac in pigs
    Y Wang
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang, China
    J Anim Breed Genet 124:225-9. 2007
    ..The result showed that the 291 C>T polymorphism is not a causal mutation, however, has a significant linkage disequilibrium with the ETEC F4ab/ac, especially F4ac receptor locus...
  18. ncbi Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women
    X Fan
    Hypertension Division, Department of Cardiology, Ministry of Education and Sino German Laboratory for Molecular Medicine, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Clin Pharmacol Ther 82:187-96. 2007
    ..3 mm Hg lower in ACE2 T allele carriers than in CC genotype carriers (P=0.019) in women. We conclude that the ACE2 T allele confers a high risk for hypertension and reduced antihypertensive response to ACE inhibitors...
  19. ncbi Rare plus common SERT variants in obsessive-compulsive disorder
    M A Grados
    Mol Psychiatry 12:422-3. 2007
  20. ncbi Association study of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms and essential hypertension in northern Han Chinese
    W Huang
    Bioinformatics Laboratory and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    J Hum Hypertens 20:968-71. 2006
  21. ncbi Genetic diversity of Picea asperata populations based on RAPDs
    X Xue
    Chengdu Institute of Biology, Chinese Academy of Sciences, P O Box 416, Chengdu 610041, China
    Plant Biol (Stuttg) 9:101-8. 2007
    ..In addition, it was discovered that the geographic distribution is not correlated with the genetic distances among the populations of P. asperata...
  22. ncbi A deletion affecting several gene candidates is present in the Evergrowing peach mutant
    D G Bielenberg
    Department of Horticulture, Clemson University, Clemson, SC 29634, USA
    J Hered 95:436-44. 2004
    ..The deletion was bracketed using RFLP analysis, which showed that it is contained within a segment of the genome no greater than 180 kb...
  23. pmc High frequency of mitochondrial genome instability in human endometrial carcinomas
    V W S Liu
    Department of Obstetrics and Gynaecology, Queen Mary Hospital, University of Hong Kong
    Br J Cancer 89:697-701. 2003
    ..It is suggested that errors in replication may account for the high frequency of mtMSI in human endometrial carcinomas. The relatively high prevalence of mtMSI may be a potential new tool for detection of endometrial cancer...
  24. ncbi [Gene polymorphism at apoB locus and the serum lipids profile in children]
    W Zhu
    Institute of Child and Adolescent Health, Peking University, Beijing 100083, China
    Wei Sheng Yan Jiu 30:280-2. 2001
    ..More studies and analysis on the relationship between serum lipids and multiple genes in multisites should be the next step...
  25. ncbi Association of retinopathy with a microsatellite at 5' end of the aldose reductase gene in Chinese patients with late-onset Type 2 diabetes
    S C Lee
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Ophthalmic Genet 22:63-7. 2001
    ..The aldose reductase gene may be implicated, but is not likely to play a major role...
  26. ncbi Changes of the expression of 5-HT receptor subtype mRNAs in rat dorsal root ganglion by complete Freund's adjuvant-induced inflammation
    S Wu
    Department of Anatomy and K. K. Leung Brain Research Centre, The Fourth Military Medical University, No. 17, West Chang-le Road, 710032, People's Republic of, Xi'an, China
    Neurosci Lett 307:183-6. 2001
    ..The present results suggest the important roles for these 5-HT receptor subtypes in generating peripheral nociceptive signaling and provide evidence to elucidate the mechanism of 5-HT in nociception...
  27. ncbi [Relationship between delta-aminolevulinic acid dehydratase gene polymorphism and blood levels of lead and zinc protoporphyrin in children exposed to lead]
    Y Zheng
    Department of Toxicology, Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing 100050, China
    Zhonghua Yu Fang Yi Xue Za Zhi 35:96-7. 2001
    ..To explore the associations of polymorphism of delta-aminolevulinic acid dehydratase (ALAD) gene with blood levels of lead and zinc protoporphyrin (ZPP)...
  28. ncbi Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients
    M R Spitz
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 61:1354-7. 2001
    ..These results suggest that the two XPD polymorphisms have a modulating effect on DRC, especially in the cases...
  29. ncbi Allelic loss of distal chromosome 4 in mouse lung tumors localize a putative tumor suppressor gene to a region homologous with human chromosome 1p36
    C R Herzog
    Department of Pathology, Medical College of Ohio, Toledo 43699, USA
    Oncogene 11:1811-5. 1995
    ..In contrast, retention of heterozygosity was observed at all markers tested in each of the adenomas studied, which suggests that the inactivation of this tumor suppressor gene participates in mouse lung tumor progression...
  30. ncbi Refinement of the locus for autosomal dominant hereditary gingival fibromatosis (GINGF) to a 3.8-cM region on 2p21
    S Xiao
    Shanghai Research Center of Biotechnology, Chinese Academy of Science, Shanghai, 200233, People s Republic of China
    Genomics 68:247-52. 2000
    ..This region overlaps by 3.8 cM with the previously reported HGF region. Single-strand conformation polymorphism and sequence analysis of the coding region of cytochrome P450 1B1 (CYP1B1) excluded it as a likely candidate gene...
  31. ncbi The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins
    Y Wang
    Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9111, USA
    J Biol Chem 275:20033-44. 2000
    ..With the RIM-BPs, we have identified a partner for RIMs that may bind to RIMs at the synapse in addition to Rab3...
  32. ncbi p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    A Yang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 2:305-16. 1998
    ..We demonstrate that these truncated p63 variants can act as dominant-negative agents toward transactivation by p53 and p63, and we suggest the possibility of physiological interactions among members of the p53 family...
  33. ncbi A polymorphism in the promoter region of catalase is associated with blood pressure levels
    Z Jiang
    Laboratory of Human Population Genetics and Complex Diseases, Institute of Genetics, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai, China 200443
    Hum Genet 109:95-8. 2001
    ..13, P=0.002). This is the first study to implicate genetic variation in catalase in susceptibility to EHYT and suggests that polymorphisms in promoter regions may be particularly relevant to the study of complex diseases...
  34. pmc The role of central 5-HT(1A) receptors in the control of B-fibre cardiac and bronchoconstrictor vagal preganglionic neurones in anaesthetized cats
    Y Wang
    Department of Pharmacology, University College London, Royal Free Campus, Rowland Hill Street, Hampstead, London NW3 2PF, UK
    J Physiol 536:753-67. 2001
    ....
  35. ncbi [Schizophrenia and dopamine D4 gene polymorphism in Chinese population: association analysis]
    Y Tang
    Institute of Mental Health, Peking University, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 81:995-8. 2001
    ..To investigate the association of the 48 bp variable number tandem repeat (VNTR) polymorphism in the dopamine D4 receptor (DRD4) gene exon III with schizophrenia in Chinese Han population...
  36. ncbi Genetic mapping of the evergrowing gene in peach [Prunus persica (L.) Batsch]
    Y Wang
    Department of Horticulture, Clemson University, Clemson SC 29634, USA
    J Hered 93:352-8. 2002
    ..Three AFLP markers from the rootstock genetic linkage map were found linked to the evg locus...
  37. ncbi [The human alpha(2A)-AR gene and the genotype of site -1296 and the susceptibility to motion sickness]
    L Liu
    Key Laboratory of Molecular Biology, General Hospital of Airforce, Beijing 100036, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34:291-7. 2002
    ..01 ). All the populations were in Hardy-Weinberg equilibrium. The results suggested that gg genotype and g allele at site -1296 in alpha(2A)-AR gene could associate with the susceptibility to motion sickness...
  38. ncbi Chromosome mapping and sequence variation of the murine Ras effector gene Nore1
    R Yao
    Division of Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Cytogenet Cell Genet 95:126-8. 2001
  39. ncbi [The gene polymorphism of delta-aminolevulinate dehydratase (ALAD) in 530 cases of Chinese Han population]
    Y Zheng
    Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing 100050, China
    Zhonghua Yu Fang Yi Xue Za Zhi 35:16-8. 2001
    ..To explore the distribution of allele and genotype frequencies of delta-aminolevulinate dehydratase (ALAD) gene in Chinese Han population...
  40. ncbi [Distribution of HIV resistance CCR5-delta 32, CCR2-64 I and SDF1-3'A alleles and their polymorphisms in the Han population in China]
    F Wang
    302nd Hospital of PLA, Beijing 100039, China
    Zhonghua Liu Xing Bing Xue Za Zhi 21:256-60. 2000
    ..To study the frequency and polymorphism of three mutations (CCR5(Delta)32, CCR2-64I and SDF1-3'A alleles) conferring resistance to determined HIV-1/AIDS in the indigenous Han population in China...
  41. ncbi Changes of serum selenium in pregnant women with gestational diabetes mellitus
    M Tan
    Shanghai Institute of Nuclear Research, People's Republic of China
    Biol Trace Elem Res 83:231-7. 2001
    ..Furthermore, an inverse correlation between the serum selenium concentration and the gestational period was also observed. Selenium supplementation during gestation for pregnant women, especially with IGT and GDM, should be considered...
  42. ncbi [Relationship between gene polymorphism at the apolipoprotein E locus and serum lipid profile in urban children of school age in Beijing]
    W Zhu
    Institute of Child and Adolescent Health, Peking University, Beijing 100083, China
    Zhonghua Yu Fang Yi Xue Za Zhi 35:297-300. 2001
    ..To study the relationship between gene polymorphism at the apolipoprotein E (ApoE) locus and serum lipid levels in children of school age...
  43. ncbi Genotypes and polymorphisms of mutant CCR5-delta 32, CCR2-64I and SDF1-3' a HIV-1 resistance alleles in indigenous Han Chinese
    F Wang
    Division of Biological Engineering, Beijing Institute of Infectious Diseases, 302 PLA Hospital, Beijing 100039, China
    Chin Med J (Engl) 114:1162-6. 2001
    ..To evaluate the frequencies and polymorphisms of CCR5-delta 32, CCR2-64I and SDF1-3' A alleles conferring resistance to HIV-1 infection in Chinese population from Han ethnic origin...
  44. ncbi Tissue-specific expression of the K-ras allele from the A/J parent in (A/J x TSG-p53) F1 mice
    S A Matzinger
    Department of Pathology, Medical College of Ohio, Toledo 43699, USA
    Gene 188:261-9. 1997
    ..These data demonstrate tissue-specific allele-specific transcription of the K-ras gene and provide further support to the thesis that K-ras allele itself is a primary mouse lung tumor susceptibility gene...