Quantitative structure-activity relationships for the inhibition toxicity to root elongation of Cucumis sativus of selected phenols and interspecies correlation with Tetrahymena pyriformisXiaodong Wang
State Key Laboratory of Pollution Control and Resources Reuse, The School of Environment, Nanjing University, People's Republic of China
Chemosphere 46:153-61. 2002
..93IGC50 + 1.63 n = 21 r2 = 0.87). This suggested that T pyriformis toxicity could serve as a surrogate of C. sativus toxicity for phenols and interspecies correlation also could be established for reactive chemicals...
S-adenosyl-L-methionine decreases the elevated hepatotoxicity induced by Fas agonistic antibody plus acute ethanol pretreatment in miceXiaodong Wang
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L Levy Place, 1468 Madison Avenue, New York, NY 10029, USA
Arch Biochem Biophys 477:1-11. 2008
....
Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagyDefeng Wu
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Free Radic Biol Med 53:1346-57. 2012
..Inhibition of autophagy promotes binge ethanol induced hepatotoxicity, steatosis and oxidant stress via CYP2E1...
- Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase
Xiaodong Wang
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Free Radic Biol Med 47:518-28. 2009
..These results show that chronic ethanol feeding enhances Fas-induced liver injury by a mechanism associated with induction of CYP2E1, elevated serum TNF-alpha levels, and activation of MAPK...
- S-adenosyl-L-methionine attenuates hepatotoxicity induced by agonistic Jo2 Fas antibody following CYP2E1 induction in mice
Xiaodong Wang
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
J Pharmacol Exp Ther 317:44-52. 2006
..These results indicate that SAM can have an important hepatoprotective role as an effective reagent against Fas plus CYP2E1-induced hepatotoxicity by lowering oxidative and nitrosative stress...
- Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice
Xiaodong Wang
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Hepatology 54:1753-66. 2011
..These findings raise the question as to the potential mechanisms of JNK1 activation related to alcoholic liver injury...
- Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice
Yongke Lu
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Free Radic Biol Med 49:1406-16. 2010
....
- Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice
Xiaodong Wang
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
Hepatology 42:400-10. 2005
..In conclusion, enhanced hepatotoxicity of Fas was found in mice with elevated levels of CYP2E1. We speculate that overexpression of CYP2E1 might synergize and increase the susceptibility to Fas induced-liver injury...
- Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
Yongke Lu
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Hepatology 47:1483-94. 2008
....
- Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways
Xiaodong Wang
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Free Radic Biol Med 42:971-84. 2007
..The enhanced hepatotoxicity involves increased oxidative and nitrosative stress, and appears to be mediated by CYP2E1-dependent and also CYP2E1-independent mechanisms...
- Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver
Lili Yang
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
Free Radic Biol Med 53:1170-80. 2012
..The results show that acute alcohol elevation of CYP2E1, oxidative stress, and activation of JNK interact to lower autophagy and increase lipogenic SREBP resulting in fatty liver...
- Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1-induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cells
Lili Yang
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Free Radic Biol Med 51:185-96. 2011
..In conclusion, knockdown of TRX-1 or TRX-2 sensitizes cells to CYP2E1-induced oxidant stress partially via ASK-1 and JNK1 signaling pathways. Both TRX-1 and TRX-2 are important for defense against CYP2E1-induced oxidative stress...
- CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophagy in HepG2 E47 cells
Defeng Wu
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Biochem Biophys Res Commun 402:116-22. 2010
..We hypothesize that CYP2E1-induced oxidative stress promotes the accumulation of lipid droplets by ethanol and this may be responsible for the suppression of autophagy in the liver...
- Production of crocin using Crocus sativus callus by two-stage culture system
Shu An Chen
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, P O Box 353, Beijing 100080, PR China
Biotechnol Lett 25:1235-8. 2003
..5 mg l(-1)) for crocin formation. The maximum crocin production (0.43 g l(-1)) was achieved by this two-stage culture method, which was three times that by a one-stage method...
- Mechanism-based quantitative structure-activity relationships for the inhibition of substituted phenols on germination rate of Cucumis sativus
Xiaodong Wang
State Key Laboratory of Pollution Control and Resources Reuse, School of Environment, Nanjing University, People s Republic of China
Chemosphere 46:241-50. 2002
..70 logKow - 0.66E(lumo) + 2.17, r2 = 0.89, n = 36). Catechol and 2,4-dinitrophenol proved to be outliers of this model and their much high toxicity was explained...
- Molecular hologram derived quantitative structure-property relationships to predict physico-chemical properties of polychlorinated biphenyls
Xiaodong Wang
State Key Laboratory of Pollution Control and Resources Reuse, The School of Environment, Nanjing University, Nanjing 210093, PR China
Chemosphere 51:617-32. 2003
..The results show that this new quantitative structure-activity relationship approach presents highly predictive models for important physico-chemical properties of PCBs...
- Effects of rare earth elements on the growth of Cistanche deserticola cells and the production of phenylethanoid glycosides
Jie Ouyang
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, P O Box 353, Beijing, 100080, China
J Biotechnol 102:129-34. 2003
..After 30 day's culture, 0.02 mmoll(-1) MRE gave the highest content (20.8%) and production (1.6 gl(-1)) of PeG, which were 104 and 167% higher than those obtained in control (without rare earth elements)...
- Promotion of the growth of Crocus sativus cells and the production of crocin by rare earth elements
Shu An Chen
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, P O Box 353, Beijing 100080, PR China
Biotechnol Lett 26:27-30. 2004
..4 g l(-1)), crocin content (4.4 mg g(-1)) and crocin production (90 mg l(-1)) which were, respectively, 1.7-fold, 4.2-fold and 7.1-fold of those without additions. Nd3+ (40 microM) only slightly promoted cell growth and crocin production...
- Optimization of cryopreservation of Artemisia annua L. callus
An Chenshu
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China
Biotechnol Lett 25:35-8. 2003
..8% (w/v) sucrose solution...
- Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling
Raquel Urtasun
Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Hepatology 55:594-608. 2012
..CONCLUSION: OPN emerges as a key cytokine within the ECM protein network driving the increase in Collagen-I protein contributing to scarring and liver fibrosis...
- CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases
Arthur I Cederbaum
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, P O Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
Int J Hepatol 2012:582790. 2012
..We hypothesize that similar interactions occur as a result of ethanol induction of CYP2E1 and TNFα...
- Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole
Yongke Lu
Dept. of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, Box 1603, One Gustave L. Levy Place, New York, NY 10029, USA
Am J Physiol Gastrointest Liver Physiol 289:G308-19. 2005
..The enhanced liver necrosis appears to involve an increase in oxidative and nitrosative stress generated by the combination of LPS plus elevated CYP2E1 levels...
- Cytokines in alcoholic liver disease
Leon An
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Arch Toxicol 86:1337-48. 2012
..Interactions between pro- and anti-inflammatory cytokines such as TNFα and adiponectin and other cytokines are likely to play important roles in the development and progression of alcoholic liver disease...
- Cell growth and shikonin production of Arnebia euchroma in a periodically submerged airlift bioreactor
Feng Ge
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, P O Box 353, Beijing 100080, China
Biotechnol Lett 28:525-9. 2006
..Under the optimal submerged/non-submerged period of 10 min/15 h, the shikonin content (4.6%, w/w) and, cell dry mass (16.8 g/l) were 229 and 26% higher than those in suspension culture...
- Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
Sean L Petersen
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Cancer Cell 12:445-56. 2007
..In response to autocrine TNFalpha signaling, the Smac mimetic promotes formation of a RIPK1-dependent caspase-8-activating complex, leading to apoptosis...
- Prediction and application in QSPR of aqueous solubility of sulfur-containing aromatic esters using GA-based MLR with quantum descriptors
Chunsheng Yin
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, People s Republic of China
Water Res 36:2975-82. 2002
..The best QSPR model were obtained by GA-based MLR. Reasonable mechanisms for aqueous solubility of the sulfur-containing carboxylates were investigated and interpreted...
- TNF-alpha induces two distinct caspase-8 activation pathways
Lai Wang
Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Cell 133:693-703. 2008
..These findings revealed that TNF-alpha is able to induce apoptosis via two distinct caspase-8 activation pathways that are differentially regulated by cIAP1/2 and c-FLIP...
- Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division
Gelin Wang
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
Proc Natl Acad Sci U S A 104:2068-73. 2007
..Our experiments reveal an unanticipated, paradoxical role for OAT in mitotic cell division and identify the protein as a target for chemotherapeutic drug development...
- Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2
Xiaodong Wang
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Amherst, NY 14260 1200, USA
Drug Metab Dispos 35:268-74. 2007
..Bcrp1 inhibition by chrysin is likely one potential mechanism for the observed chrysin-nitrofurantoin pharmacokinetic interactions in rats...
- Generation and characterization of Smac/DIABLO-deficient mice
Hitoshi Okada
Amgen Institute and Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada M5G 2C1
Mol Cell Biol 22:3509-17. 2002
..There were also no detectable differences in Fas-mediated apoptosis in the liver in vivo. Our data strongly suggest the existence of a redundant molecule or molecules capable of compensating for a loss of Smac function...
- Structure-activity relationships and response-surface analysis of nitroaromatics toxicity to the yeast (Saccharomyces cerevisiae)
Xiaodong Wang
State Key Laboratory of Pollution Control and Resources Reuse, The School of Environment, Nanjing University, China
Chemosphere 46:1045-51. 2002
..41 log K(ow) - 0.89 E(lumo) - 0.46, r2 = 0.87, Q2 = 0.86, n = 24)...
- [The study on the anti-oxidation effect of root of Mallotus apelta in the rat model of liver fibrosis]
Jinjun Zhao
First Military Medical University, Gunagzhou 510515
Zhong Yao Cai 25:185-7. 2002
..To investigate the effect of root of Mallotus apelta in treatment of liver fibrosis and the effect of anti-oxidation in the rat model of liver fibrosis...
- Acute toxicity of benzene derivatives to the tadpoles (Rana japonica) and QSAR analyses
Hong Huang
State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210093, People's Republic of China
Chemosphere 53:963-70. 2003
..The conventional r2 and cross-validation r2(CV) were 0.914 and 0.785, respectively, indicating that QSAR was both internally consistent and highly predictive...
- [Protective effects of tanshinone IIA on injured primary cultured rat hepatocytes induced by CCl4]
Yongzhong Liu
Center Hospital of Xi'an, Xi'an 710003
Zhong Yao Cai 26:415-7. 2003
....
- Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist
Yanping Xu
Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
J Med Chem 46:5121-4. 2003
..A new series of hPPARalpha agonists containing a 2,4-dihydro-3H-1,2,4-triazol-3-one (triazolone) core is described leading to the discovery of 5 (LY518674), a highly potent and selective PPARalpha agonist...
- Multiple targeting modules on peroxisomal proteins are not redundant: discrete functions of targeting signals within Pmp47 and Pex8p
Xiaodong Wang
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA
Mol Biol Cell 15:1702-10. 2004
..Our results indicate that multiple targeting signals within peroxisomal proteins extend coverage among heterogeneous populations of peroxisomes and increase efficiency of targeting in some metabolic states...
- The interaction of Schwann cells with chitosan membranes and fibers in vitro
Ying Yuan
The Jiangsu Key Laboratory of Neuroregeneration, Nantong Medical College, Nantong, Jiangsu 226001, PR China
Biomaterials 25:4273-8. 2004
..Compared with the chitosan membranes, SCs migrated more easily onto the stereoframe of chitosan fibers. These studies contribute information necessary to enhancing our understanding of biocompatibility of chitosan...
- A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death
Lin Li
Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
Science 305:1471-4. 2004
..The compound is also a lead structure for the development of IAP antagonists potentially useful as therapy for cancer and inflammatory diseases...
- COPII-dependent export of cystic fibrosis transmembrane conductance regulator from the ER uses a di-acidic exit code
Xiaodong Wang
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Cell Biol 167:65-74. 2004
..We propose that the di-acidic exit code plays a key role in linking CFTR to the COPII coat machinery and is the primary defect responsible for CF in DeltaF508-expressing patients...
- Holographic QSAR of selected esters
Da Chen
State Key Laboratory of Pollution Control and Resources Reuse, The School of Environment, Nanjing University, Nanjing 210093, PR China
Chemosphere 57:1739-45. 2004
..912, was developed after optimizing the fragment size and the hologram length. The color coding analysis, which has rarely been reported before, was done here to explain the outlier successfully...
- Characterization of a new class of selective nonsteroidal progesterone receptor agonists
Yu Dong
Department of Metabolic and Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, NJ 08543, USA
Steroids 69:201-17. 2004
..The differential activities observed in the in vivo progestogenic assays in rat models suggest that these analogs can act as selective PR modulators...
- Flavonoids as a novel class of human organic anion-transporting polypeptide OATP1B1 (OATP-C) modulators
Xiaodong Wang
Department of Pharmaceutical Sciences, 517 Hochstetter Hall, University at Buffalo, State University of New York, Amherst, NY 14260-1200, USA
Drug Metab Dispos 33:1666-72. 2005
..2 +/- 1.89 microM. Taken together, these results indicate that flavonoids are a novel class of OATP1B1 modulators, suggesting the potential for diet-drug interactions...
- Physical methods used to study core histone tail structures and interactions in solution
Xiaodong Wang
Department of Biochemistry and Biophysics, Box 712, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester NY, USA
Biochem Cell Biol 84:578-88. 2006
..In addition, post-translational modifications, such as acetylation, can directly alter histone tail structures and interactions...
- Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation
Devrim Acehan
Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA
Mol Cell 9:423-32. 2002
..This complex promotes the efficient activation of procaspase-3. Therefore, the cleavage of procaspase-9 is not required to form an active cell death complex...
