The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)Ronald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
JAMA 289:3095-105. 2003
..Uncertainties exist about prevalence and correlates of major depressive disorder (MDD)...
- Failure and delay in initial treatment contact after first onset of mental disorders in the National Comorbidity Survey Replication
Philip S Wang
Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
Arch Gen Psychiatry 62:603-13. 2005
..An understudied crucial step in the help-seeking process is making prompt initial contact with a treatment provider after first onset of a mental disorder...
Variation in the risk of suicide attempts and completed suicides by antidepressant agent in adults: a propensity score-adjusted analysis of 9 years' dataSebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
Arch Gen Psychiatry 67:497-506. 2010
..This prompted a meta-analysis of trials in adults that found no overall increase in risk, but individual agents could not be studied...
- Changing profiles of service sectors used for mental health care in the United States
Philip S Wang
Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
Am J Psychiatry 163:1187-98. 2006
..Redesigning the fragmented U.S. mental health care system requires knowing how service sectors share responsibility for individuals' mental health needs...
Potential causes of higher mortality in elderly users of conventional and atypical antipsychotic medicationsSoko Setoguchi
Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
J Am Geriatr Soc 56:1644-50. 2008
....
- Underuse of ACE inhibitors and angiotensin II receptor blockers in elderly patients with diabetes
Wolfgang C Winkelmayer
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Kidney Dis 46:1080-7. 2005
..However, little is known about the adequacy of adherence to these guidelines in elderly patients with diabetes and predictors of such appropriate ACE-inhibitor or ARB use...
- Individual and societal effects of mental disorders on earnings in the United States: results from the national comorbidity survey replication
Ronald C Kessler
Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
Am J Psychiatry 165:703-11. 2008
..The purpose of this report was to update previous estimates of the association between mental disorders and earnings. Current estimates for 2002 are based on data from the National Comorbidity Survey Replication (NCS-R)...
- Twelve-month use of mental health services in the United States: results from the National Comorbidity Survey Replication
Philip S Wang
Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
Arch Gen Psychiatry 62:629-40. 2005
..Dramatic changes have occurred in mental health treatments during the past decade. Data on recent treatment patterns are needed to estimate the unmet need for services...
- Prevalence and effects of mood disorders on work performance in a nationally representative sample of U.S. workers
Ronald C Kessler
Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
Am J Psychiatry 163:1561-8. 2006
..Bipolar disorder has been overlooked both because of the failure to distinguish between major depressive disorder and bipolar disorder and by the failure to evaluate the workplace costs of mania/hypomania...
- Evaluating the validity of an instrumental variable study of neuroleptics: can between-physician differences in prescribing patterns be used to estimate treatment effects?
M Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
Med Care 45:S116-22. 2007
..We sought to explore the validity of physician-level IV in a comparative study of short-term mortality risk among elderly users of conventional versus atypical antipsychotic medications (APM)...
- Consistency of performance ranking of comorbidity adjustment scores in Canadian and U.S. utilization data
Sebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Gigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
J Gen Intern Med 19:444-50. 2004
..We sought to evaluate and rank the performance of comorbidity scores across selected U.S. and Canadian elderly populations using health care utilization databases...
- Risk of death in elderly users of conventional vs. atypical antipsychotic medications
Philip S Wang
Department of Psychiatry, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
N Engl J Med 353:2335-41. 2005
..However, the advisory did not apply to conventional antipsychotic medications; the risk of death with these older agents is not known...
- Assessing health state utilities in elderly patients at cardiovascular risk
Wolfgang C Winkelmayer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
Med Decis Making 26:247-54. 2006
..Health state preferences can be a crucial component of cost-effectiveness analyses, but off-the-shelf health state utilities specifically for older people are not available...
- The costs and benefits of enhanced depression care to employers
Philip S Wang
Department of Psychiatry, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, USA
Arch Gen Psychiatry 63:1345-53. 2006
..Although outreach and enhanced treatment interventions improve depression outcomes, uptake has been poor in part because purchasers lack information on their return on investment...
- When is pharmacogenetic testing for antidepressant response ready for the clinic? A cost-effectiveness analysis based on data from the STAR*D study
Roy H Perlis
Center for Human Genetics Research, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Neuropsychopharmacology 34:2227-36. 2009
..These circumstances, particularly availability of alternative treatment strategies and test effect sizes, can be estimated and should be considered before these tests are broadly applied in clinical settings...
- Effects of noncardiovascular comorbidities on antihypertensive use in elderly hypertensives
Philip S Wang
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Hypertension 46:273-9. 2005
..Highly prevalent, noncardiovascular conditions appear to deter use of antihypertensives in elderly with hypertension...
- Comparative safety of antidepressant agents for children and adolescents regarding suicidal acts
Sebastian Schneeweiss
Harvard Medical School, Brigham and Women s Hospital, Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Boston, MA 02120, USA
Pediatrics 125:876-88. 2010
..The objective of this study was to assess the risk of suicide attempts and suicides after initiation of antidepressant medication use by children and adolescents, for individual agents...
- Effects of major depression on moment-in-time work performance
Philip S Wang
Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
Am J Psychiatry 161:1885-91. 2004
..The authors used the experience sampling method to address this problem by collecting comparative data on moment-in-time work performance among service workers who were depressed and those who were not depressed...
- Self-management education programs in chronic disease: a systematic review and methodological critique of the literature
Asra Warsi
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02120, USA
Arch Intern Med 164:1641-9. 2004
..In light of evidence of publication bias, further trials that adhere to a standard methodology would help clarify whether self-management education is worthwhile...
- Prevalence, comorbidity, and service utilization for mood disorders in the United States at the beginning of the twenty-first century
Ronald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
Annu Rev Clin Psychol 3:137-58. 2007
..The article closes with a discussion of future directions for research...
- Racial differences in screening for prostate cancer in the elderly
Timothy Gilligan
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Arch Intern Med 164:1858-64. 2004
..Low screening rates among black men may contribute to these disparities, but there are few data on racial differences in prostate cancer screening...
- Use of the case-crossover design to study prolonged drug exposures and insidious outcomes
Philip S Wang
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Ann Epidemiol 14:296-303. 2004
..We investigated whether case-crossover methods can be used to study prolonged exposures and insidious outcomes...
- Assessing residual confounding of the association between antipsychotic medications and risk of death using survey data
Sebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
CNS Drugs 23:171-80. 2009
..Nonrandomised studies on the causal effects of psychotropic medications may be biased by patient characteristics that are not fully adjusted...
- The descriptive epidemiology of commonly occurring mental disorders in the United States
Ronald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
Annu Rev Public Health 29:115-29. 2008
....
- Prescription opioid use among older adults with arthritis or low back pain
Daniel H Solomon
Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Ste, 3030, Boston, MA 02120, USA
Arthritis Rheum 55:35-41. 2006
..To examine patterns of chronic opioid use in selected groups with arthritis and low back pain and compare them with patterns among persons with ischemic heart disease...
- Pharmacogenetic testing in the clinical management of schizophrenia: a decision-analytic model
Roy H Perlis
Pharmacogenomics Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Psychopharmacol 25:427-34. 2005
..More consistent reporting of test parameters such as sensitivity and specificity would greatly facilitate assessment of future pharmacogenetic studies...
- Simultaneous assessment of short-term gastrointestinal benefits and cardiovascular risks of selective cyclooxygenase 2 inhibitors and nonselective nonsteroidal antiinflammatory drugs: an instrumental variable analysis
Sebastian Schneeweiss
Harvard Medical School, Division of Pharmacoepidemiology and Pharmacoeconomics, Boston, MA 021205, USA
Arthritis Rheum 54:3390-8. 2006
....
- Delays in initial treatment contact after first onset of a mental disorder
Philip S Wang
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
Health Serv Res 39:393-415. 2004
..Interventions are needed to decrease these delays...
- Instrumental variable analysis of secondary pharmacoepidemiologic data
M Alan Brookhart
Division of Pharmacoepidemiology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02120, USA
Epidemiology 17:373-4. 2006
- Selective prescribing led to overestimation of the benefits of lipid-lowering drugs
Robert J Glynn
Division of Pharmacoepidemiology and Pharmacoeconomics, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02120, USA
J Clin Epidemiol 59:819-28. 2006
..Selective use of these drugs in frail people may confound these relationships...
- Chronic medical conditions and work performance in the health and work performance questionnaire calibration surveys
Philip S Wang
Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
J Occup Environ Med 45:1303-11. 2003
..Disease management programs for these conditions might have a positive return on investment (ROI). Health and productivity tracking surveys are needed to evaluate ROI and provide quality assurance...
- The prevalence and correlates of workplace depression in the national comorbidity survey replication
Ronald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
J Occup Environ Med 50:381-90. 2008
..To review evidence on the workplace prevalence and correlates of major depressive episodes, with a particular focus on the National Comorbidity Survey Replication, the most recent national survey to focus on these issues...
- Improved comorbidity adjustment for predicting mortality in Medicare populations
Sebastian Schneeweiss
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Health Serv Res 38:1103-20. 2003
..80. CONCLUSIONS: We conclude that in epidemiologic studies of the elderly, a modified diagnosis-based score using empirically derived weights provides improved adjustment for comorbidity and enhances the validity of findings...
- Patterns and correlates of contacting clergy for mental disorders in the United States
Philip S Wang
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
Health Serv Res 38:647-73. 2003
....
- Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients
Sebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 021205, USA
CMAJ 176:627-32. 2007
..We assessed the short-term mortality in a population-based cohort of elderly people in British Columbia who were prescribed conventional and atypical antipsychotic medications...
- The global burden of mental disorders: an update from the WHO World Mental Health (WMH) surveys
Ronald C Kessler
Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
Epidemiol Psichiatr Soc 18:23-33. 2009
..The paper reviews recent findings from the WHO World Mental Health (WMH) surveys on the global burden of mental disorders...
- Disruption of existing mental health treatments and failure to initiate new treatment after Hurricane Katrina
Philip S Wang
Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
Am J Psychiatry 165:34-41. 2008
..The authors examined the disruption of ongoing treatments among individuals with preexisting mental disorders and the failure to initiate treatment among individuals with new-onset mental disorders in the aftermath of Hurricane Katrina...
- Restrictions on antidepressant medications for children: a review of Medicaid policy
Michael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont St, Suite 3030, Boston, MA 02120, USA
Psychiatr Serv 58:135-8. 2007
..This study evaluated Medicaid's prior-authorization policies restricting the prescribing of antidepressant medications for children...
- Identification of hospitalizations for intentional self-harm when E-codes are incompletely recorded
Amanda R Patrick
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
Pharmacoepidemiol Drug Saf 19:1263-75. 2010
..However, rates of E-code completeness in US government and commercial claims databases are low due to issues with hospital billing software...
- Considering the costs of bipolar depression
Ronald C Kessler
Harvard Medical School, USA
Behav Healthc 27:45-7. 2007
- Health advisories and patterns of patient monitoring among new users of antidepressant medications
Joshua J Gagne
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Suite 3030, 1620 Tremont St, Boston, MA 02120, USA
J Clin Psychopharmacol 29:590-4. 2009
..We sought to identify patterns of patient monitoring after antidepressant initiation in British Columbia before and after issuance of health advisories...
- Trends in suicide ideation, plans, gestures, and attempts in the United States, 1990-1992 to 2001-2003
Ronald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, Mass 02115, USA
JAMA 293:2487-95. 2005
..Little is known about trends in suicidal ideation, plans, gestures, or attempts or about their treatment. Such data are needed to guide and evaluate policies to reduce suicide-related behaviors...
- Suboptimal antidepressant use in the elderly
Philip S Wang
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
J Clin Psychopharmacol 25:118-26. 2005
..Suboptimal antidepressant use remains common in the elderly, especially the use of inadequately intensive regimens. Interventions are needed to improve the quality and outcomes of antidepressant use in this vulnerable population...
- Evaluating short-term drug effects using a physician-specific prescribing preference as an instrumental variable
M Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02120, USA
Epidemiology 17:268-75. 2006
..Instrumental variable methods have been proposed as a potential approach to control confounding by indication in nonexperimental studies of treatment effects; however, good instruments are hard to find...
- Lipid levels and bone mineral density
Daniel H Solomon
Division of Pharmacoepidemiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02120, USA
Am J Med 118:1414. 2005
..The aim of this study was to examine the relationship between lipid levels and bone mineral density...
- Medicaid's prior authorization program and access to atypical antipsychotic medications
Jennifer M Polinski
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, Massachusetts, USA
Health Aff (Millwood) 26:750-60. 2007
..More than a year later, no state had changed its PA policy in response. We discuss the roles of Medicaid and other insurers in responding to emerging drug safety issues and their challenges in weighing drug risks and benefits...
- Dopamine antagonists and the development of breast cancer
Philip S Wang
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, 221 Longwood Ave, Boston, MA 02115, USA
Arch Gen Psychiatry 59:1147-54. 2002
..In light of the small hazards and the possibility of residual confounding, these findings should lead to follow-up investigations but not to changes in treatment strategies...
- Claims data studies of sedative-hypnotics and hip fractures in older people: exploring residual confounding using survey information
Sebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Geriatr Soc 53:948-54. 2005
..To identify the magnitude of confounding bias caused by factors not measured in claims data studies of sedative-hypnotic use and fractures...
- Association between SSRI use and hip fractures and the effect of residual confounding bias in claims database studies
Sebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
J Clin Psychopharmacol 24:632-8. 2004
..Using survey data, we determined the magnitude of such bias and corrected the association between SSRI use and hip fractures accordingly...
- Distinguishing generalized anxiety disorder from major depression: prevalence and impairment from current pure and comorbid disorders in the US and Ontario
Ronald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston MA 02115, USA
Int J Methods Psychiatr Res 11:99-111. 2002
..The paper closes with a discussion of the methodological complexities associated with generalizing to comorbidities that involve rare conditions or more than two disorders...
- Psychotropic medication use for behavioral symptoms of dementia
Philip S Wang
Department of Psychiatry, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
Curr Neurol Neurosci Rep 6:490-5. 2006
..Also, although various psychotropic medications used for behavioral disturbances in dementia patients may be somewhat effective, they have been increasingly associated with important safety risks...
- Measuring the cost-effectiveness of lipid-lowering drugs in the elderly: the outcomes research and economic analysis components of the PROSPER trial
Jerry Avorn
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Control Clin Trials 23:757-73. 2002
....
- Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer
Ann H Partridge
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, D1210, Boston, MA 02215, USA
J Clin Oncol 21:602-6. 2003
..We sought to estimate adherence and predictors of nonadherence in women starting tamoxifen as adjuvant breast cancer therapy...
- How well do patients report noncompliance with antihypertensive medications?: a comparison of self-report versus filled prescriptions
Philip S Wang
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Pharmacoepidemiol Drug Saf 13:11-9. 2004
..Although self-reports are often the only means available in routine practice, their accuracy and agreement with other data sources remain questionable...
- The economic burden of depression and the cost-effectiveness of treatment
Philip S Wang
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Int J Methods Psychiatr Res 12:22-33. 2003
..Further research is needed to overcome these barriers to providing high-quality care for depression and to ultimately reduce the enormous adverse economic impact of depression disorders...
- Urinary antispasmodic use and the risks of ventricular arrhythmia and sudden death in older patients
Philip S Wang
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Geriatr Soc 50:117-24. 2002
..Additional study will be required to confirm these results, exclude the possibility of unmeasured confounders contributing to any lack of an observed relationship, and extend these findings to newer agents such as tolterodine...
- Statin lipid-lowering drugs and bone mineral density
Daniel H Solomon
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
Pharmacoepidemiol Drug Saf 14:219-26. 2005
..We examined the relationship between statin use and bone density among postmenopausal women...
- Effects of efforts to increase response rates on a workplace chronic condition screening survey
Philip S Wang
Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
Med Care 40:752-60. 2002
..Confirmation of these results is required, however, in new samples. Additional research is also needed on innovative and cost-effective strategies to improve HRA response rates...
- Parental anxiety associated with referral of a child to a pediatric cardiologist for evaluation of a Still's murmur
Robert L Geggel
Department of Cardiology, Children's Hospital, Boston, Massachusetts 02115, USA
J Pediatr 140:747-52. 2002
..CONCLUSIONS: Parental anxiety is common among parents of children referred for specialty evaluation. Educational strategies to improve pediatrician communication skills with parents may improve quality of care...
- Arthritis self-management education programs: a meta-analysis of the effect on pain and disability
Asra Warsi
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Suite 341, Boston, MA 02115, USA
Arthritis Rheum 48:2207-13. 2003
..CONCLUSION: The summary effect sizes suggest that arthritis self-management education programs result in small reductions in pain and disability...
- Adequacy of treatment for serious mental illness in the United States
Philip S Wang
Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
Am J Public Health 92:92-8. 2002
..The purpose of this study was to assess the prevalence and correlates of treatment for serious mental illness...
- Clozapine use and risk of diabetes mellitus
Philip S Wang
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Psychopharmacol 22:236-43. 2002
..Additional data from pharmacoepidemiologic studies and randomized controlled trials are needed to exclude the possibility of residual confounding and ensure the appropriate use of this agent...
