Antimony-based antileishmanial compounds prolong the cardiac action potential by an increase in cardiac calcium currentsYuri A Kuryshev
Rammelkamp Center, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
Mol Pharmacol 69:1216-25. 2006
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Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older womenLu Wang
Division of Preventive Medicine, Harvard School of Public Health, Boston, Mass, USA harvard edu
Hypertension 51:1073-9. 2008
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Erythrocyte fatty acid composition is associated with the risk of hypertension in middle-aged and older womenLu Wang
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA, USA
J Nutr 141:1691-7. 2011
..However, after controlling for obesity-related metabolic factors, the associations remained significant only for the PS ratio...
Plasma adiponectin and the risk of hypertension in white and black postmenopausal womenLu Wang
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Clin Chem 58:1438-45. 2012
..We conducted a prospective, nested case control study to investigate the relation between baseline plasma adiponectin, measures of adiposity, and subsequent risk of hypertension...
Fruit and vegetable intake and the risk of hypertension in middle-aged and older womenLu Wang
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Am J Hypertens 25:180-9. 2012
..We therefore assessed the prospective association between baseline intake of fruits and vegetables and the risk of hypertension in a large cohort of middle-aged and older women...
Dietary fatty acids and the risk of hypertension in middle-aged and older womenLu Wang
900 Commonwealth Ave East, Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Hypertension 56:598-604. 2010
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Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older womenLu Wang
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Am J Clin Nutr 89:905-12. 2009
..Flavonoids may protect against cancer development through several biological mechanisms. However, epidemiologic studies on dietary flavonoids and cancer risk have yielded inconsistent results...
Plasma lycopene, other carotenoids, and the risk of type 2 diabetes in womenLu Wang
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Am J Epidemiol 164:576-85. 2006
..91 (95% CI: 0.46, 1.81) for beta-cryptoxanthin, and 1.35 (95% CI: 0.68, 2.69) for lutein/zeaxanthin. There was no prospective association between baseline plasma carotenoids and the risk of type 2 diabetes in middle-aged and older women...
Circulating inflammatory and endothelial markers and risk of hypertension in white and black postmenopausal womenLu Wang
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Clin Chem 57:729-36. 2011
..However, epidemiologic studies have yet to compare multiple corresponding biomarkers in relation to risk of hypertension, particularly in multiethnic populations...
Physical activity and the risk of becoming overweight or obese in middle-aged and older womenKathryn A Britton
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Obesity (Silver Spring) 20:1096-103. 2012
..In conclusion, higher amounts of total LTPA should be encouraged to prevent obesity. Among those willing to participate in vigorous LTPA, and for whom such activities are not contraindicated, vigorous LPTA should be encouraged...
Physical activity and weight gain preventionI Min Lee
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
JAMA 303:1173-9. 2010
..In 2008, federal guidelines recommended at least 150 minutes per week (7.5 metabolic equivalent [MET] hours per week) of moderate-intensity activity for "substantial health benefits."..
Whole- and refined-grain intakes and the risk of hypertension in womenLu Wang
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Am J Clin Nutr 86:472-9. 2007
..Prospective studies linking whole- and refined-grain intakes with the risk of hypertension, a major cardiovascular disease risk factor, remain limited...
Associations of plasma carotenoids with risk factors and biomarkers related to cardiovascular disease in middle-aged and older womenLu Wang
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Am J Clin Nutr 88:747-54. 2008
..Cardiovascular disease (CVD) risk factors may potentially influence plasma concentrations of carotenoids. However, data on the association of plasma carotenoids with CVD related biomarkers are only limited...
Meat intake and the risk of hypertension in middle-aged and older womenLu Wang
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
J Hypertens 26:215-22. 2008
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Alcohol consumption, weight gain, and risk of becoming overweight in middle-aged and older womenLu Wang
Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Arch Intern Med 170:453-61. 2010
..Alcohol consumption is a source of energy intake that may contribute to body weight gain and development of obesity. However, previous studies of this relationship have been limited, with inconsistent results...
Endogenous sex hormones, blood pressure change, and risk of hypertension in postmenopausal women: the Multi-Ethnic Study of AtherosclerosisLu Wang
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave, Boston, MA 02215, USA
Atherosclerosis 224:228-34. 2012
..We examine the association of endogenous sex hormone levels with longitudinal change of BP and risk of developing hypertension in initially normotensive postmenopausal women...
Tomato-based food products are related to clinically modest improvements in selected coronary biomarkers in womenHoward D Sesso
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
J Nutr 142:326-33. 2012
..5 servings/wk of tomato-based food products had clinically modest but significant improvements in TC, the TC:HDL cholesterol ratio, and hemoglobin A1c but not other coronary biomarkers...
Comparison of interleukin-6 and C-reactive protein for the risk of developing hypertension in womenHoward D Sesso
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
Hypertension 49:304-10. 2007
..In models simultaneously examining IL-6 and CRP, only CRP remained strongly associated with an increased risk of hypertension...
Calcium intake and risk of cardiovascular disease: a review of prospective studies and randomized clinical trialsLu Wang
Division of Preventive Medicine, Department of Medicine, Brigham and Womens Hospital, Boston, MA 02215, USA
Am J Cardiovasc Drugs 12:105-16. 2012
..More prospective cohort studies and large-scale randomized trials are needed to further evaluate the risks or benefits of calcium supplementation on CVD endpoints as the primary pre-specified outcome...
Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular eventsLu Wang
Brigham and Women s Hospital and Harvard School of Public Health, Boston, Massachusetts 02215, USA
Ann Intern Med 152:315-23. 2010
..Vitamin D and calcium may affect the cardiovascular system independently and interactively...
The consumption of lycopene and tomato-based food products is not associated with the risk of type 2 diabetes in womenLu Wang
Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
J Nutr 136:620-5. 2006
..Our study found little evidence for an association between dietary intake of lycopene or lycopene-containing foods and the risk of type 2 DM...
Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studiesLu Wang
Brigham and Women s Hospital, Boston, MA 02215, USA
Circ Cardiovasc Qual Outcomes 5:819-29. 2012
..Vitamin D status has been linked to the risk of cardiovascular disease (CVD). However, the optimal 25-hydroxy-vitamin D (25[OH]-vitamin D) levels for potential cardiovascular health benefits remain unclear...
Migraine, weight gain and the risk of becoming overweight and obese: a prospective cohort studyAnke C Winter
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, USA
Cephalalgia 32:963-71. 2012
..Some cross-sectional studies have suggested an association between migraine and increased body weight. However, prospective data on the association are lacking...
Relationship between retinal arteriolar narrowing and myocardial perfusion: multi-ethnic study of atherosclerosisLu Wang
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Hypertension 51:119-26. 2008
..This finding suggests that retinal arteriolar narrowing may serve as a marker of coronary microvascular disease...
Fetal window of vulnerability to airborne polycyclic aromatic hydrocarbons on proportional intrauterine growth restrictionHyunok Choi
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS ONE 7:e35464. 2012
..We posited that exposure to PAHs during the first trimester impairs fetal growth more severely than a similar level of exposure during the subsequent trimesters...
Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) StudyLu Wang
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
Am J Clin Nutr 78:91-8. 2003
..Our findings with the use of this biomarker suggest indirectly that the dietary fat profile, particularly that of saturated fat, may contribute to the etiology of diabetes...
Mechanisms of arsenic-induced prolongation of cardiac repolarizationEckhard Ficker
Rammelkamp Center, MetroHealth Medical Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
Mol Pharmacol 66:33-44. 2004
..Other drugs that interfere with proteins in the processing pathway of cardiac ion channels may be proarrhythmic for similar reasons...
Risk factors for postoperative complications after liver resectionHui Chuan Sun
Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China
Hepatobiliary Pancreat Dis Int 4:370-4. 2005
..Liver resection is still a complicated operation with a high risk of postoperative morbidity. This study was undertaken to analyze the risk factors for postoperative complications after liver resection...
Incidence and prognostic values of lymph node metastasis in operable hepatocellular carcinoma and evaluation of routine complete lymphadenectomyHui Chuan Sun
Live Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People s Republic of China
J Surg Oncol 96:37-45. 2007
..To study lymph node metastasis (LNM) and prognosis in patients with operable hepatocellular carcinoma (HCC) as well as the value of routine complete lymphadenectomy. Few studies have been reported on LNM in patients with operable HCC...
'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophagesLu Wang
Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, New York 10021, USA
Nat Immunol 9:186-93. 2008
..Our results associate Pyk2 and Jak kinases with the linkage of signals emanating from cytokine and heterologous ITAM-dependent receptors...
Lysine-rich extracellular rings formed by hbeta2 subunits confer the outward rectification of BK channelsMaorong Chen
Key Laboratory of Molecular Biophysics, Huazhong University of Science and Technology, Ministry of Education, College of Life Science and Technology, Wuhan, Hubei, China
PLoS ONE 3:e2114. 2008
..Furthermore, this study will be helpful to understand the functional diversity of BK channels contributed by different auxiliary beta subunits...
Protein C, antithrombin, and venous thromboembolism incidence: a prospective population-based studyAaron R Folsom
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454 1015, USA
Arterioscler Thromb Vasc Biol 22:1018-22. 2002
..Attributable risk estimates suggest that low protein C levels account for approximately 2.5% of venous thromboembolic events in the ARIC population...