Lifu Wang

Summary

Publications

  1. ncbi request reprint Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1
    Lifu Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 281:24293-303. 2006
  2. ncbi request reprint Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885
    Alastair J King
    Department of Oncology, MMPD CEDD, GlaxoSmithKline, Collegeville, Pennsylvania 19426, USA
    Cancer Res 66:11100-5. 2006
  3. pmc Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation
    Lifu Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 283:15619-27. 2008
  4. ncbi request reprint PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
    Lifu Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 282:20036-44. 2007
  5. pmc Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908
    Di Wu
    Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 287:12510-9. 2012
  6. pmc Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors
    Hyun Bae Kim
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Cell Biol 30:3126-39. 2010
  7. pmc Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR
    Lifu Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 284:14693-7. 2009
  8. pmc Protein Ser/Thr phosphatase-6 is required for maintenance of E-cadherin at adherens junctions
    Takashi Ohama
    Center for Cell Signaling and Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Box 800577, West Complex MSB 7225, Charlottesville, Virginia 22908, USA
    BMC Cell Biol 14:42. 2013
  9. pmc α-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKα in vitro
    Lifu Wang
    Department of Microbiology, Immunology and Cancer Biology, Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Nat Commun 4:1559. 2013
  10. ncbi request reprint Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition
    Lifu Wang
    Department of Clinical Pharmacology, University of Bern, Switzerland
    Hepatology 41:1241-51. 2005

Collaborators

  • Guang Hui Liu
  • Richard A Roth
  • Zheng Fu
  • Di Wu
  • Anil Kumar
  • Brian N Finck
  • John Lawrence
  • C J Rhodes
  • Lusong Luo
  • RAKESH F KUMAR
  • Takashi Ohama
  • Hyun Bae Kim
  • Alastair J King
  • David L Brautigan
  • Erin M Griner
  • Susanna R Keller
  • Thurl E Harris
  • Jerry L Adams
  • Pearl S Huang
  • David M Wilson
  • Jae Lee
  • Erin Hugger
  • Michael M Morrissey
  • David Chau
  • Meenhard Herlyn
  • Denis R Patrick
  • Cynthia M Rominger
  • Roberta S Batorsky
  • Maureen L Ho
  • Hieu T Do
  • Michael D Schaber
  • Florian Karreth
  • Shu Yun Zhang
  • Thomas J Stout
  • Earl W May
  • Rooja G Contractor
  • Ami S Lakdawala
  • David W Rusnak
  • Andrew K Takle
  • Julie C Lougheed
  • Keiran S M Smalley
  • David A Tuveson

Detail Information

Publications10

  1. ncbi request reprint Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1
    Lifu Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 281:24293-303. 2006
    ....
  2. ncbi request reprint Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885
    Alastair J King
    Department of Oncology, MMPD CEDD, GlaxoSmithKline, Collegeville, Pennsylvania 19426, USA
    Cancer Res 66:11100-5. 2006
    ....
  3. pmc Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation
    Lifu Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 283:15619-27. 2008
    ..We propose that after mTORC1 kinase activation by upstream regulators, PRAS40 is phosphorylated directly by mTOR, thus contributing to the relief of PRAS40-mediated substrate competition...
  4. ncbi request reprint PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
    Lifu Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 282:20036-44. 2007
    ..We, therefore, propose that PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding...
  5. pmc Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908
    Di Wu
    Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 287:12510-9. 2012
    ..Our findings demonstrate an important role for ICK in modulating the activity of mTORC1 through phosphorylation of Raptor Thr-908 and thus implicate a potential signaling mechanism by which ICK regulates cell proliferation and division...
  6. pmc Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors
    Hyun Bae Kim
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Cell Biol 30:3126-39. 2010
    ..These observations place lipin 1 as a potentially important link between triacylglycerol synthesis and adipose tissue inflammation...
  7. pmc Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR
    Lifu Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 284:14693-7. 2009
    ..Therefore, our findings indicate that mTOR-mediated raptor phosphorylation plays an important role on activation of mTORC1...
  8. pmc Protein Ser/Thr phosphatase-6 is required for maintenance of E-cadherin at adherens junctions
    Takashi Ohama
    Center for Cell Signaling and Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Box 800577, West Complex MSB 7225, Charlottesville, Virginia 22908, USA
    BMC Cell Biol 14:42. 2013
    ..Signaling pathways regulate E-cadherin function and cellular distribution via phosphorylation of the cytoplasmic region by kinases such as casein kinases but the protein phosphatases involved have not been identified...
  9. pmc α-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKα in vitro
    Lifu Wang
    Department of Microbiology, Immunology and Cancer Biology, Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Nat Commun 4:1559. 2013
    ..The mouse α-SNAP mutant hyh (hydrocephalus with hop gait) shows enhanced binding and inhibition of AMPK. By negatively controlling AMPK, α-SNAP therefore potentially coordinates membrane trafficking and metabolism...
  10. ncbi request reprint Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition
    Lifu Wang
    Department of Clinical Pharmacology, University of Bern, Switzerland
    Hepatology 41:1241-51. 2005
    ..In conclusion, TUDCA activates CREB in cholangiocytes, reducing the apoptotic effect of CCI-779. These findings suggest a novel cytoprotective mechanism for this bile acid...