Lifeng Wang

Summary

Affiliation: National Institutes of Health
Location: Bethesda, USA
Grants:
Research Fellow, MGH Cancer Center, Harvard Medical School, Harvard University. 2013
•Postdoctoral Fellow, Laboratory of Endocrinology and Receptor Biology, NIDDK, National Institutes of Health. 2008
•Ph.D., Molecular Genetics, The State Key Lab of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences. 2000
•B.S., Biochemistry and Cellular Biology, Shandong University. 1996

Publications

  1. pmc Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris
    Wei Qian
    National Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, PR China
    Genome Res 15:757-67. 2005
  2. doi request reprint Two Xanthomonas extracellular polygalacturonases, PghAxc and PghBxc, are regulated by type III secretion regulators HrpX and HrpG and are required for virulence
    LiFeng Wang
    State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, Peoples Republic of China
    Mol Plant Microbe Interact 21:555-63. 2008
  3. pmc Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis
    Young Wook Cho
    Nuclear Receptor Biology Section, CEB, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 10:27-39. 2009
  4. pmc Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis
    LiFeng Wang
    Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:7317-22. 2010
  5. ncbi request reprint The bifunctional effector AvrXccC of Xanthomonas campestris pv. campestris requires plasma membrane-anchoring for host recognition
    LiFeng Wang
    State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China
    Mol Plant Pathol 8:491-501. 2007
  6. pmc Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation
    QiHuang Jin
    Nuclear Receptor Biology Section, CEB, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    EMBO J 30:249-62. 2011
  7. pmc EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR
    Chunxi Wang
    Cell and Molecular Biology Section, National Cancer Institute, NIH, Bethesda, Bethesda, MD 20892, USA
    Cancer Res 72:315-24. 2012

Collaborators

Detail Information

Publications7

  1. pmc Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris
    Wei Qian
    National Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, PR China
    Genome Res 15:757-67. 2005
    ....
  2. doi request reprint Two Xanthomonas extracellular polygalacturonases, PghAxc and PghBxc, are regulated by type III secretion regulators HrpX and HrpG and are required for virulence
    LiFeng Wang
    State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, Peoples Republic of China
    Mol Plant Microbe Interact 21:555-63. 2008
    ..campestris pv. campestris to Arabidopsis. In addition, these PG were confirmed to be secreted via the type II secretion system in an Xps-dependent manner...
  3. pmc Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis
    Young Wook Cho
    Nuclear Receptor Biology Section, CEB, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 10:27-39. 2009
    ..Finally, deletion of PTIP in brown adipose tissue significantly reduces tissue weight. Thus, by regulating PPARgamma and C/EBPalpha expression, PTIP plays a critical role in adipogenesis...
  4. pmc Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis
    LiFeng Wang
    Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:7317-22. 2010
    ..These results indicate that H3K27 methyltransferase Ezh2 directly represses Wnt genes to facilitate adipogenesis and suggest that acetylation and trimethylation on H3K27 play opposing roles in regulating Wnt expression...
  5. ncbi request reprint The bifunctional effector AvrXccC of Xanthomonas campestris pv. campestris requires plasma membrane-anchoring for host recognition
    LiFeng Wang
    State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China
    Mol Plant Pathol 8:491-501. 2007
    ..Moreover, the secretion of AvrXccC displayed hrp-dependency and the core sequence for AvrXccC translocation was defined to the N-terminal 40 amino acids...
  6. pmc Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation
    QiHuang Jin
    Nuclear Receptor Biology Section, CEB, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    EMBO J 30:249-62. 2011
    ....
  7. pmc EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR
    Chunxi Wang
    Cell and Molecular Biology Section, National Cancer Institute, NIH, Bethesda, Bethesda, MD 20892, USA
    Cancer Res 72:315-24. 2012
    ..Together, our findings establish that aberrant upregulation of EZH2 in NB cells silences several tumor suppressors, which contribute to the genesis and maintenance of the undifferentiated phenotype of NB tumors...