Kai Wang

Summary

Publications

  1. pmc ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, PA 19104, USA
    Nucleic Acids Res 38:e164. 2010
  2. pmc Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects
    Kai Wang
    Center for Applied Genomics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:2059-67. 2010
  3. doi request reprint A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24
    Struan F A Grant
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Pediatr 155:909-13. 2009
  4. pmc A genome-wide association study on obesity and obesity-related traits
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e18939. 2011
  5. pmc Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms
    Sharon J Diskin
    Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Nucleic Acids Res 36:e126. 2008
  6. pmc Gene-based interaction analysis by incorporating external linkage disequilibrium information
    Jing He
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Eur J Hum Genet 19:164-72. 2011
  7. pmc Integrative genomics identifies LMO1 as a neuroblastoma oncogene
    Kai Wang
    The Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nature 469:216-20. 2011
  8. pmc Modeling genetic inheritance of copy number variations
    Kai Wang
    Department of Genetics, Division of Human Genetics, Center for Applied Genomics, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucleic Acids Res 36:e138. 2008
  9. pmc Phenotype restricted genome-wide association study using a gene-centric approach identifies three low-risk neuroblastoma susceptibility Loci
    Le B Nguyen
    Division of Oncology and Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    PLoS Genet 7:e1002026. 2011
  10. pmc Large copy-number variations are enriched in cases with moderate to extreme obesity
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 59:2690-4. 2010

Collaborators

Detail Information

Publications20

  1. pmc ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, PA 19104, USA
    Nucleic Acids Res 38:e164. 2010
    ..7 million variants, making it practical to handle hundreds of human genomes in a day. ANNOVAR is freely available at http://www.openbioinformatics.org/annovar/...
  2. pmc Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects
    Kai Wang
    Center for Applied Genomics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:2059-67. 2010
    ....
  3. doi request reprint A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24
    Struan F A Grant
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Pediatr 155:909-13. 2009
    ..To identify, in a non-hypothesis manner, novel genetic factors associated with nonsyndromic cleft lip with or without cleft palate (NSCL/P)...
  4. pmc A genome-wide association study on obesity and obesity-related traits
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e18939. 2011
    ..67 × 10(-9)), previously associated with body weight and fat distribution. Our study demonstrated how a relatively small sample ascertained through extreme phenotypes can detect genuine associations in a GWAS...
  5. pmc Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms
    Sharon J Diskin
    Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Nucleic Acids Res 36:e126. 2008
    ..With the wide application of whole-genome SNP genotyping techniques, our wave adjustment method will be important for taking full advantage of genotyped samples for CNV analysis...
  6. pmc Gene-based interaction analysis by incorporating external linkage disequilibrium information
    Jing He
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Eur J Hum Genet 19:164-72. 2011
    ..As our method operates at the gene level, it can be applied to a genome-wide association setting and used as a screening tool to detect gene-gene interactions...
  7. pmc Integrative genomics identifies LMO1 as a neuroblastoma oncogene
    Kai Wang
    The Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nature 469:216-20. 2011
    ....
  8. pmc Modeling genetic inheritance of copy number variations
    Kai Wang
    Department of Genetics, Division of Human Genetics, Center for Applied Genomics, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucleic Acids Res 36:e138. 2008
    ..In conclusion, our method produces accurate CNV calls, gives probabilistic estimates of CNV transmission and builds a solid foundation for the development of linkage and association tests utilizing CNVs...
  9. pmc Phenotype restricted genome-wide association study using a gene-centric approach identifies three low-risk neuroblastoma susceptibility Loci
    Le B Nguyen
    Division of Oncology and Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    PLoS Genet 7:e1002026. 2011
    ..2 (P = 4.20 × 10⁻⁷) as being associated with the less aggressive form of the disease. These data demonstrate the importance of robust phenotypic data in GWAS analyses and identify additional susceptibility variants for neuroblastoma...
  10. pmc Large copy-number variations are enriched in cases with moderate to extreme obesity
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 59:2690-4. 2010
    ..We investigated whether large and rare copy-number variations (CNVs) differentiate moderate to extreme obesity from never-overweight control subjects...
  11. doi request reprint Analysing biological pathways in genome-wide association studies
    Kai Wang
    Center for Applied Genomics, The Childrens Hospital of Philadelphia, Pennsylvania 19104, USA
    Nat Rev Genet 11:843-54. 2010
    ..Here we review the development of pathway-based approaches for GWA studies, discuss their practical use and caveats, and suggest that pathway-based approaches may also be useful for future GWA studies with sequencing data...
  12. doi request reprint Variants of DENND1B associated with asthma in children
    Patrick M A Sleiman
    Center for Applied Genomics, Philadelphia, PA 19104 4318, USA
    N Engl J Med 362:36-44. 2010
    ..Asthma is a complex disease that has genetic and environmental causes. The genetic factors associated with susceptibility to asthma remain largely unknown...
  13. pmc Common variants at five new loci associated with early-onset inflammatory bowel disease
    Marcin Imielinski
    Center for Applied Genomics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Nat Genet 41:1335-40. 2009
    ....
  14. pmc ATOM: a powerful gene-based association test by combining optimally weighted markers
    Mingyao Li
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Bioinformatics 25:497-503. 2009
    ..One particularly challenging yet important question is how to best use all genetic information to test whether a gene or a region is associated with the trait of interest...
  15. pmc Pathway-based approaches for analysis of genomewide association studies
    Kai Wang
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Hum Genet 81:1278-83. 2007
    ....
  16. pmc Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Hum Genet 84:399-405. 2009
    ..Our study suggests that examination beyond individual SNP hits, by focusing on genetic networks and pathways, is important to unleashing the true power of GWA studies...
  17. pmc Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia Philadelphia, PA, USA
    Front Genet 2:41. 2011
    ....
  18. pmc Interpretation of association signals and identification of causal variants from genome-wide association studies
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Hum Genet 86:730-42. 2010
    ..Our results suggest that thinking beyond common variants is essential in interpreting GWAS signals and identifying causal variants...
  19. pmc Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
    Joseph T Glessner
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nature 459:569-73. 2009
    ....
  20. ncbi request reprint Convergent mechanisms of somatic mutations in polycythemia vera
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Discov Med 12:25-32. 2011
    ..We argue that PV represents a unique disease model to study the interplay between germline risk variants and convergent mechanisms of somatic mutations...