Innate immune response of human alveolar macrophages during influenza A infectionJieru Wang
Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
PLoS ONE 7:e29879. 2012
..Targeting local components of innate immune response might provide a strategy for controlling influenza A infection-induced proinflammatory response in vivo...
- Innate immune response to influenza A virus in differentiated human alveolar type II cells
Jieru Wang
Department of Medicine, National Jewish Health, 1400 Jackson St, A448, Denver, CO 80206, USA
Am J Respir Cell Mol Biol 45:582-91. 2011
..This study provides insights into influenza-induced innate immunity in differentiated human ATII cells, and demonstrates that the alveolar epithelium is a critical part of the initial innate immune response to influenza...
- Differentiated human alveolar epithelial cells and reversibility of their phenotype in vitro
Jieru Wang
Department of Medicine, National Jewish and Medical Research Center, Denver, CO 80206, USA
Am J Respir Cell Mol Biol 36:661-8. 2007
..The expression of the phenotypes is regulated by the culture conditions and is, in part, reversible in vitro...
Ozone induces oxidative stress in rat alveolar type II and type I-like cellsJieru Wang
Department of Medicine, National Jewish and Medical Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Free Radic Biol Med 40:1914-28. 2006
..The type I-like cells were more sensitive to ozone than type II cells. The genome-wide changes observed provide insight into signal pathways activated by ozone and how cellular protection mechanisms are initiated...
- Infection of human alveolar macrophages by human coronavirus strain 229E
C Joel Funk
National Jewish Health, Denver, CO 80206, USA
J Gen Virol 93:494-503. 2012
..In contrast, there was a modest reduction in infection in AMs by SP-A, but not by SP-D. In summary, AMs are an important target for HCoV-229E, and they can mount a pro-inflammatory innate immune response to infection...
- Alveolar epithelial cells secrete chemokines in response to IL-1beta and lipopolysaccharide but not to ozone
Rizwan Manzer
Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Am J Respir Cell Mol Biol 34:158-66. 2006
..It is likely that the inflammatory response to ozone in the alveolar compartment is not due to the direct effect of ozone on epithelial cells...
- Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection
Jieru Wang
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 182:1296-304. 2009
..These results suggest that IL-29 exerts IFN-beta-independent protection in type II cells through direct activation of antiviral genes during IAV infection...
- Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus
Beata Kosmider
Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
Respir Res 13:43. 2012
..Recent studies have shown the importance of lung antioxidant defense systems against injury by IAV. Nuclear factor-erythroid 2 related factor 2 (Nrf2) activates the majority of antioxidant genes...
- Expression of CINC-2beta is related to the state of differentiation of alveolar epithelial cells
Kahoru Nishina
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Am J Respir Cell Mol Biol 33:505-12. 2005
..We conclude that CINC-2beta is regulated differently from most other chemokines and that its expression is related to the state of alveolar type II cell differentiation...
- KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells
Yongsheng Chang
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Lipid Res 46:2624-35. 2005
..In summary, we conclude that KGF requires both PI3K and JNK signaling pathways to induce SREBP-1, which in turn induces SCD-1 and FAS expression in H292 cells...
- Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells
Megan K L Macleod
The Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
Proc Natl Acad Sci U S A 108:7914-9. 2011
..CD8 memory T cells generated by antigen delivered with both aluminum salts and MPL provided significant protection from influenza A challenge. These adjuvants could be used in human vaccines to prime protective memory CD8 T cells...
