Jieru Wang

Summary

Publications

  1. pmc Innate immune response of human alveolar macrophages during influenza A infection
    Jieru Wang
    Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 7:e29879. 2012
  2. pmc Innate immune response to influenza A virus in differentiated human alveolar type II cells
    Jieru Wang
    Department of Medicine, National Jewish Health, 1400 Jackson St, A448, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 45:582-91. 2011
  3. pmc Differentiated human alveolar epithelial cells and reversibility of their phenotype in vitro
    Jieru Wang
    Department of Medicine, National Jewish and Medical Research Center, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 36:661-8. 2007
  4. pmc Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus
    Beata Kosmider
    Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Respir Res 13:43. 2012
  5. ncbi Ozone induces oxidative stress in rat alveolar type II and type I-like cells
    Jieru Wang
    Department of Medicine, National Jewish and Medical Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Free Radic Biol Med 40:1914-28. 2006
  6. pmc Infection of human alveolar macrophages by human coronavirus strain 229E
    C Joel Funk
    National Jewish Health, Denver, CO 80206, USA
    J Gen Virol 93:494-503. 2012
  7. pmc Alveolar epithelial cells secrete chemokines in response to IL-1beta and lipopolysaccharide but not to ozone
    Rizwan Manzer
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 34:158-66. 2006
  8. pmc Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence
    Megan K L Macleod
    Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 8:e61775. 2013
  9. ncbi Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection
    Jieru Wang
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 182:1296-304. 2009
  10. pmc A novel function of MUC18: amplification of lung inflammation during bacterial infection
    Qun Wu
    Pulmonary Division, Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
    Am J Pathol 182:819-27. 2013

Collaborators

Detail Information

Publications13

  1. pmc Innate immune response of human alveolar macrophages during influenza A infection
    Jieru Wang
    Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 7:e29879. 2012
    ..Targeting local components of innate immune response might provide a strategy for controlling influenza A infection-induced proinflammatory response in vivo...
  2. pmc Innate immune response to influenza A virus in differentiated human alveolar type II cells
    Jieru Wang
    Department of Medicine, National Jewish Health, 1400 Jackson St, A448, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 45:582-91. 2011
    ..This study provides insights into influenza-induced innate immunity in differentiated human ATII cells, and demonstrates that the alveolar epithelium is a critical part of the initial innate immune response to influenza...
  3. pmc Differentiated human alveolar epithelial cells and reversibility of their phenotype in vitro
    Jieru Wang
    Department of Medicine, National Jewish and Medical Research Center, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 36:661-8. 2007
    ..The expression of the phenotypes is regulated by the culture conditions and is, in part, reversible in vitro...
  4. pmc Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus
    Beata Kosmider
    Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Respir Res 13:43. 2012
    ..Recent studies have shown the importance of lung antioxidant defense systems against injury by IAV. Nuclear factor-erythroid 2 related factor 2 (Nrf2) activates the majority of antioxidant genes...
  5. ncbi Ozone induces oxidative stress in rat alveolar type II and type I-like cells
    Jieru Wang
    Department of Medicine, National Jewish and Medical Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Free Radic Biol Med 40:1914-28. 2006
    ..The type I-like cells were more sensitive to ozone than type II cells. The genome-wide changes observed provide insight into signal pathways activated by ozone and how cellular protection mechanisms are initiated...
  6. pmc Infection of human alveolar macrophages by human coronavirus strain 229E
    C Joel Funk
    National Jewish Health, Denver, CO 80206, USA
    J Gen Virol 93:494-503. 2012
    ..In contrast, there was a modest reduction in infection in AMs by SP-A, but not by SP-D. In summary, AMs are an important target for HCoV-229E, and they can mount a pro-inflammatory innate immune response to infection...
  7. pmc Alveolar epithelial cells secrete chemokines in response to IL-1beta and lipopolysaccharide but not to ozone
    Rizwan Manzer
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 34:158-66. 2006
    ..It is likely that the inflammatory response to ozone in the alveolar compartment is not due to the direct effect of ozone on epithelial cells...
  8. pmc Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence
    Megan K L Macleod
    Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 8:e61775. 2013
    ..Together, these data point towards a vaccine solution for all influenza A subtypes...
  9. ncbi Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection
    Jieru Wang
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 182:1296-304. 2009
    ..These results suggest that IL-29 exerts IFN-beta-independent protection in type II cells through direct activation of antiviral genes during IAV infection...
  10. pmc A novel function of MUC18: amplification of lung inflammation during bacterial infection
    Qun Wu
    Pulmonary Division, Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
    Am J Pathol 182:819-27. 2013
    ..Up-regulated MUC18 expression in lungs (eg, in alveolar macrophages) of COPD and asthma patients may contribute to excessive inflammation during disease exacerbations...
  11. pmc Expression of CINC-2beta is related to the state of differentiation of alveolar epithelial cells
    Kahoru Nishina
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Cell Mol Biol 33:505-12. 2005
    ..We conclude that CINC-2beta is regulated differently from most other chemokines and that its expression is related to the state of alveolar type II cell differentiation...
  12. ncbi KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells
    Yongsheng Chang
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Lipid Res 46:2624-35. 2005
    ..In summary, we conclude that KGF requires both PI3K and JNK signaling pathways to induce SREBP-1, which in turn induces SCD-1 and FAS expression in H292 cells...
  13. pmc Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells
    Megan K L Macleod
    The Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 108:7914-9. 2011
    ..CD8 memory T cells generated by antigen delivered with both aluminum salts and MPL provided significant protection from influenza A challenge. These adjuvants could be used in human vaccines to prime protective memory CD8 T cells...