Anxun Wang

Summary

Publications

  1. pmc Bone morphogenetic protein receptor in the osteogenic differentiation of rat bone marrow stromal cells
    Anxun Wang
    Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat Sen University, 58 Zhongshan Road II, Guangzhou, 510080, PR China
    Yonsei Med J 51:740-5. 2010
  2. pmc Hydroxycamptothecin-loaded nanoparticles enhance target drug delivery and anticancer effect
    Anxun Wang
    Department of Oral and Maxillofacial Surgery, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    BMC Biotechnol 8:46. 2008
  3. pmc Suppression of local invasion of ameloblastoma by inhibition of matrix metalloproteinase-2 in vitro
    Anxun Wang
    Department of Oral and Maxillofacial Surgery, Guanghua College of Stomatology, Sun Yat Sen University, Guangzhou, Guangdong, 510055, PR China
    BMC Cancer 8:182. 2008
  4. pmc Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma
    Anxun Wang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, USA
    BMC Cancer 9:167. 2009
  5. pmc MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612 7213, United States
    Cancer Lett 286:217-22. 2009
  6. pmc MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 60612, USA
    Biochem J 432:199-205. 2010
  7. pmc Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling
    Zhonghua Liu
    Department of Oral and Maxillofacial Surgery, Sun Yat Sen University, Guangzhou 510080, China
    Free Radic Biol Med 53:44-50. 2012
  8. pmc MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
    FEBS Lett 584:4115-20. 2010
  9. doi request reprint MicroRNA-181a suppresses salivary adenoid cystic carcinoma metastasis by targeting MAPK-Snai2 pathway
    Qianting He
    Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong 510080, China
    Biochim Biophys Acta 1830:5258-66. 2013
  10. pmc Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma
    Cheng Wang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Mol Carcinog 52:229-36. 2013

Collaborators

Detail Information

Publications32

  1. pmc Bone morphogenetic protein receptor in the osteogenic differentiation of rat bone marrow stromal cells
    Anxun Wang
    Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat Sen University, 58 Zhongshan Road II, Guangzhou, 510080, PR China
    Yonsei Med J 51:740-5. 2010
    ..In the present study, we tested the role of bone morphogenetic protein receptor (BMPR) in the osteogenic differentiation of rat bone marrow stromal cells in osteogenic medium (OM) with or without BMP-2...
  2. pmc Hydroxycamptothecin-loaded nanoparticles enhance target drug delivery and anticancer effect
    Anxun Wang
    Department of Oral and Maxillofacial Surgery, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    BMC Biotechnol 8:46. 2008
    ..A high-performance liquid chromatography (HPLC) detection method for determining HCPT in rabbit plasma was established. The pharmacokinetic parameters of HCPT/PEG-PBLG nanoparticles were compared with those of HCPT...
  3. pmc Suppression of local invasion of ameloblastoma by inhibition of matrix metalloproteinase-2 in vitro
    Anxun Wang
    Department of Oral and Maxillofacial Surgery, Guanghua College of Stomatology, Sun Yat Sen University, Guangzhou, Guangdong, 510055, PR China
    BMC Cancer 8:182. 2008
    ..Ameloblastomas are odontogenic neoplasms characterized by local invasiveness. This study was conducted to address the role of matrix metalloproteinase-2 (MMP-2) in the invasiveness of ameloblastomas...
  4. pmc Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma
    Anxun Wang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, USA
    BMC Cancer 9:167. 2009
    ..In this study, to determine the utility of Hsp27 for prognosis, we focused on oral tongue SCC (OTSCC), one of the most aggressive forms of OSCC...
  5. pmc MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612 7213, United States
    Cancer Lett 286:217-22. 2009
    ..Knockdown of miR-138 enhanced cell invasion and suppressed apoptosis. Thus, our results suggested miR-138 acts as a tumor suppresser and may serve as a therapeutic target for HNSCC patients at risk of metastasis...
  6. pmc MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 60612, USA
    Biochem J 432:199-205. 2010
    ..Our results indicate that miR-7 plays an important role in TSCC and may serve as a novel therapeutic target for TSCC patients...
  7. pmc Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling
    Zhonghua Liu
    Department of Oral and Maxillofacial Surgery, Sun Yat Sen University, Guangzhou 510080, China
    Free Radic Biol Med 53:44-50. 2012
    ....
  8. pmc MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
    FEBS Lett 584:4115-20. 2010
    ..Furthermore, the miR-24-mediated change in DND1 expression suppressed the expression of cyclin-dependent kinase inhibitor 1B (CDKN1B), and also led to enhanced proliferation and reduced apoptosis in TSCC cells...
  9. doi request reprint MicroRNA-181a suppresses salivary adenoid cystic carcinoma metastasis by targeting MAPK-Snai2 pathway
    Qianting He
    Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong 510080, China
    Biochim Biophys Acta 1830:5258-66. 2013
    ..To date microRNAs and their contribution to the onset and propagation of salivary adenoid cystic carcinoma (SACC) are limited. The objective of this study was to identify miR-181a and its mechanism in the metastasis of SACC...
  10. pmc Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma
    Cheng Wang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Mol Carcinog 52:229-36. 2013
    ..Taken together, these data suggest that EZH2 plays major roles in the progression of OTSCC, and may serve as a biomarker or therapeutic target for patients at risk of metastasis...
  11. pmc Down-regulation of the microRNA-99 family members in head and neck squamous cell carcinoma
    Zujian Chen
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
    Oral Oncol 48:686-91. 2012
    ..The objective of this study was to survey the published microRNA profiling studies on HNSCC, and to assess the commonly deregulated microRNAs in an independent sample set...
  12. pmc Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, IL, USA
    BMC Cancer 10:365. 2010
    ..The purpose of this study is to further evaluate whether the expression level of SOD2 is correlated with the metastatic status in TSCC patients...
  13. pmc Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, 801 S Paulina Street, Room 530C, Chicago, IL 60612, USA
    Hum Genet 129:189-97. 2011
    ..In summary, we identified a number of high-confident miR-138 target genes, including proto-oncogene GNAI2, which may play an important role in TSCC initiation and progression...
  14. pmc Tumor budding correlates with poor prognosis and epithelial-mesenchymal transition in tongue squamous cell carcinoma
    Cheng Wang
    Department of Oral and Maxillofacial Surgery, Guanghua School and Research Institute of Stomatology, Sun Yat Sen University, Guangzhou, China
    J Oral Pathol Med 40:545-51. 2011
    ..The purpose of this study was to assess the correlation of tumor budding with the clinicopathologic features, and the known molecular biomarkers (E-cadherin and Vimentin), as well as to evaluate its prognostic significance for TSCC...
  15. pmc Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Cancer 127:505-12. 2010
    ....
  16. doi request reprint Retinoic acid inhibits osteogenic differentiation of rat bone marrow stromal cells
    Anxun Wang
    Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat Sen University, 58 Zhongshan Road II, Guangzhou, Guangdong 510080, PR China
    Biochem Biophys Res Commun 375:435-9. 2008
    ..Thus, ATRA inhibited osteogenesis and promoted adipogenesis of BMSCs. BMP signaling cooperated with ATRA in the differentiation of BMSCs...
  17. pmc Down-regulation of tumor suppressor MTUS1/ATIP is associated with enhanced proliferation, poor differentiation and poor prognosis in oral tongue squamous cell carcinoma
    Xueqiang Ding
    Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Mol Oncol 6:73-80. 2012
    ..Taken together, these data suggest that MTUS1 plays major roles in the progression of OTSCC, and may serve as a biomarker or therapeutic target for patients with OTSCC...
  18. pmc Proteomic based identification of manganese superoxide dismutase 2 (SOD2) as a metastasis marker for oral squamous cell carcinoma
    Hui Ye
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois, Chicago, IL 60612 7213, USA
    Cancer Genomics Proteomics 5:85-94. 2008
    ..Our results thus indicated that elevated SOD2 levels is associated with lymph node metastasis in OSCC and may provide predictive values for diagnosis of metastasis...
  19. pmc Molecular characterization of the microRNA-138-Fos-like antigen 1 (FOSL1) regulatory module in squamous cell carcinoma
    Yi Jin
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 286:40104-9. 2011
    ..Our results also provide evidence that microRNAs target both canonical and non-canonical targeting sites located in all areas of the mRNA molecule (e.g. 5'-UTR, coding sequences, and 3'-UTR)...
  20. pmc MicroRNA-222 regulates cell invasion by targeting matrix metalloproteinase 1 (MMP1) and manganese superoxide dismutase 2 (SOD2) in tongue squamous cell carcinoma cell lines
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612 7213, USA
    Cancer Genomics Proteomics 6:131-9. 2009
    ..Our results indicate that hsa-miR-222 plays an important role in OTSCC invasion, and may serve as a novel therapeutic target for OTSCC patients at risk of metastatic disease...
  21. doi request reprint miR-181a-Twist1 pathway in the chemoresistance of tongue squamous cell carcinoma
    Mo Liu
    Department of Oral and Maxillofacial Surgery, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou 510120, PR China Department of Oral and Maxillofacial Surgery, Guanghua School and Research Institute of Stomatology, Sun Yat Sen University, Guangzhou 510055, PR China
    Biochem Biophys Res Commun 441:364-70. 2013
    ..Our study demonstrates that miR-181a-Twist1 pathway may play an important role in the development of cisplatin-chemoresistance, with EMT and an increase the metastatic potential of TSCC cells. ..
  22. pmc Role of microRNA-138 as a potential tumor suppressor in head and neck squamous cell carcinoma
    Yi Jin
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, IL, USA
    Int Rev Cell Mol Biol 303:357-85. 2013
    ..We will then provide a comprehensive review and integrative analysis of the existing studies on miR-138, and aim to define its molecular mechanisms that contribute to the initiation and progression of HNSCC...
  23. pmc Pharmacokinetic characteristics and anticancer effects of 5-fluorouracil loaded nanoparticles
    Su Li
    Department of Medicine, Tumor Hospital, Sun Yat Sen University, Guangzhou, China
    BMC Cancer 8:103. 2008
    ....
  24. ncbi request reprint Antitumor effects of targeting hTERT lentivirus-mediated RNA interference against KB cell lines
    Dan Chen
    Department of Oral and Maxillofacial Surgery, Guanghua College of Stomatology, Sun Yat Sen University, Guangzhou, Guangdong Province, 510055, PR China
    Oncol Res 17:621-30. 2009
    ....
  25. pmc MicroRNA-99 Family Members Suppress Homeobox A1 Expression in Epithelial Cells
    Dan Chen
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, United States of America Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 8:e80625. 2013
    ....
  26. pmc p53 regulates the expression of human angiotensin II AT(2) receptor interacting protein (ATIP1) gene
    Zujian Chen
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
    Oncol Lett 2:919-922. 2011
    ..The results suggest that the ATIP1 gene is regulated by p53 at the transcriptional level, and that it may play an important role in cancer initiation and progression...
  27. ncbi request reprint Combretastatin A4 phosphate induces programmed cell death in vascular endothelial cells
    Xueqiang Ding
    Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, PR China
    Oncol Res 19:303-9. 2011
    ..The current study demonstrates that CA4P is a promising antivascular agent with potent PCD-inducing activities. CA4P may be useful in the treatment of cancer and hemangioma...
  28. doi request reprint PEG-PBLG nanoparticle-mediated HSV-TK/GCV gene therapy for oral squamous cell carcinoma
    Dongsheng Yu
    Department of Oral and Maxillofacial Surgery, Guanghua College of Stomatology, Sun Yat Sen University, Guangzhou, Guangdong, 510055, PR China
    Nanomedicine (Lond) 3:813-21. 2008
    ..In this study, the characteristics and anticancer effect of herpes simplex virus thymidine kinase (HSV-TK)-loaded PEG-PBLG nanoparticles for OSCC were investigated...
  29. ncbi request reprint Retinoic acid and sodium butyrate as cell cycle regulators in the treatment of oral squamous carcinoma cells
    Anxun Wang
    Department of Oral and Maxillofacial Surgery, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, 510080, P R China
    Oncol Res 17:175-82. 2008
    ....
  30. ncbi request reprint Therapeutic effect of AdCMVCD/5-FC system and metabolism of 5-FC in the treatment of human tongue squamous cell carcinoma
    Anxun Wang
    Department of Oral Maxillofacial Surgery, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Chin Med J (Engl) 116:248-52. 2003
    ..To investigate the therapeutic effect and metabolism of 5-fluorocytosine (5-FC) in human tongue squamous carcinoma cells after treatment with adenovirus-mediated cytosine deaminase (AdCMVCD)/5-FC system...
  31. doi request reprint Folic acid rescue of ATRA-induced cleft palate by restoring the TGF-β signal and inhibiting apoptosis
    Zhaoyou Yao
    Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China
    J Oral Pathol Med 40:433-9. 2011
    ..To gain more insight into the molecular pathways affected by FA, TGF-β signaling and apoptosis in mouse embryonic palatal mesenchymal (MEPM) cells of all-trans retinoic acid (ATRA)-induced cleft palate in organ culture were tested...
  32. doi request reprint Simultaneous maxillomandibular distraction osteogenesis in severe progressive hemifacial atrophy with two distractors
    Cheng Wang
    Department of Oral and Maxillofacial Surgery, Guanghua Institute and School of Stomatology, Sun Yat Sen University, Guangzhou, China
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111:292-7. 2011
    ....