Ke Wang



  1. Wang K, Feng C, Li C, Yao J, Xie X, Gong L, et al. Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor. Int J Mol Sci. 2015;16:16454-68 pubmed publisher
    ..In summary, baicalin significantly reduced the disposition of AAI and ameliorated AAI-induced kidney toxicity through AhR-dependent CYP1A1/2 induction in the liver. ..
  2. Zhu X, Wang K, Zhou F, Zhu L. Paeoniflorin attenuates atRAL-induced oxidative stress, mitochondrial dysfunction and endoplasmic reticulum stress in retinal pigment epithelial cells via triggering Ca2+/CaMKII-dependent activation of AMPK. Arch Pharm Res. 2018;41:1009-1018 pubmed publisher
    ..Overall, our findings provided the novel mechanism of PF protecting human RPE cells, which may prevent the progression of retinal degenerative diseases. ..
  3. Zhu X, Wang K, Zhang K, Lin X, Zhu L, Zhou F. Puerarin Protects Human Neuroblastoma SH-SY5Y Cells against Glutamate-Induced Oxidative Stress and Mitochondrial Dysfunction. J Biochem Mol Toxicol. 2016;30:22-8 pubmed publisher
    ..These findings may significantly contribute to a better understanding of the neuroprotective effect of puerarin and provide new insights into its application toward neurodegenerative diseases in the future. ..
  4. Zhu X, Wang K, Zhang K, Tan X, Wu Z, Sun S, et al. Tetramethylpyrazine Protects Retinal Capillary Endothelial Cells (TR-iBRB2) against IL-1β-Induced Nitrative/Oxidative Stress. Int J Mol Sci. 2015;16:21775-90 pubmed publisher
    ..These findings significantly contribute to a better understanding of the protective effect of TMP in DR and form the basis of the therapeutic development of TMP in treating such disease in the future. ..
  5. Wang K, Zhu X, Zhang K, Wu Z, Sun S, Zhou F, et al. Neuroprotective Effect of Puerarin on Glutamate-Induced Cytotoxicity in Differentiated Y-79 Cells via Inhibition of ROS Generation and Ca(2+) Influx. Int J Mol Sci. 2016;17: pubmed publisher
    ..The present study supports the notion that puerarin may be a promising neuroprotective agent in the prevention of retinal degenerative diseases. ..
  6. Zhu X, Wang K, Zhang K, Zhou F, Zhu L. Induction of oxidative and nitrosative stresses in human retinal pigment epithelial cells by all-trans-retinal. Exp Cell Res. 2016;348:87-94 pubmed publisher
    ..The results provide better understanding of atRAL-induced toxicity in human RPE cells. ..
  7. Wang K, Zhu X, Zhang K, Zhu L, Zhou F. FoxM1 inhibition enhances chemosensitivity of docetaxel-resistant A549 cells to docetaxel via activation of JNK/mitochondrial pathway. Acta Biochim Biophys Sin (Shanghai). 2016;48:804-9 pubmed publisher
    ..Our results suggest a critical role of FoxM1 in docetaxel-resistance of the A549 cells and form the basis for the development of combined therapy of docetaxel and FoxM1 depletion in treating NSCLC. ..
  8. Wang K, Zhu X, Zhang K, Zhou F, Zhu L. Gas1 Knockdown Increases the Neuroprotective Effect of Glial Cell-Derived Neurotrophic Factor Against Glutamate-Induced Cell Injury in Human SH-SY5Y Neuroblastoma Cells. Cell Mol Neurobiol. 2016;36:603-11 pubmed publisher
  9. Zhu X, Wang K, Zhang K, Zhang T, Yin Y, Xu F. Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis. Int J Mol Sci. 2016;17: pubmed
    ..Our study suggested that ziyuglycoside I-triggered MDA-MB-231 cell cycle arrest and apoptosis were probably mediated by p53. This suggests that ziyuglycoside I might be a potential drug candidate for treating TNBC. ..

More Information


  1. Wu Z, Ding N, Yu M, Wang K, Luo S, Zou W, et al. Identification of Potential Biomarkers for Rhegmatogenous Retinal Detachment Associated with Choroidal Detachment by Vitreous iTRAQ-Based Proteomic Profiling. Int J Mol Sci. 2016;17: pubmed
    ..This study may provide novel insights into the pathogenesis of RRDCD and offer potential opportunities for the diagnosis and treatment of RRDCD. ..
  2. Wang K, Zhu X, Zhang K, Yao Y, Zhuang M, Tan C, et al. Puerarin inhibits amyloid ?-induced NLRP3 inflammasome activation in retinal pigment epithelial cells via suppressing ROS-dependent oxidative and endoplasmic reticulum stresses. Exp Cell Res. 2017;357:335-340 pubmed publisher
    ..Therefore, the significance of the current study is to reveal the novel mechanism of puerarin in the prevention of AMD. ..
  3. Wang K, Zhu X, Zhang K, Zhou F, Zhu L. Neuroprotective effect of tetramethylpyrazine against all-trans-retinal toxicity in the differentiated Y-79 cells via upregulation of IRBP expression. Exp Cell Res. 2017;359:120-128 pubmed publisher
    ..The present study significantly contributes to better understanding the important role of IRBP in retinal degenerative diseases and forms the basis of the therapeutic development of TMP in such diseases in the future. ..