Chunfeng Wang



  1. Bo F, Yang W, Shonyela S, Jin Y, Huang K, Shao L, et al. Immune responses of mice inoculated with recombinant Lactobacillus plantarum NC8 expressing the fusion gene HA2 and 3M2e of the influenza virus and protection against different subtypes of influenza virus. Virus Res. 2019;: pubmed publisher
    ..Lung tissue pathology was also reduced. Therefore, recombinant L.plantarum NC8-409-2 and NC8-409-1 may be candidate oral vaccines against bird flu. ..
  2. Sun Y, Qian J, Xu X, Tang Y, Xu W, Yang W, et al. Dendritic cell-targeted recombinantLactobacilli induce DC activation and elicit specific immune responses against G57 genotype of avian H9N2 influenza virus infection. Vet Microbiol. 2018;223:9-20 pubmed publisher
  3. Liu J, Cong Y, Yin R, Ding C, Yu S, Liu X, et al. The deletion of an extra six nucleotides in the 5' -untranslated region of the nucleoprotein gene of Newcastle disease virus NA-1 decreases virulence. BMC Vet Res. 2014;10:964 pubmed publisher
    ..However, rNA-1(-) was more virulent in chickens than geese, as seen by the higher intracerebral pathogenicity index value. ..
  4. Yang W, Li Q, Ata E, Jiang Y, Huang H, Shi C, et al. Immune response characterization of mice immunized with Lactobacillus plantarum expressing spike antigen of transmissible gastroenteritis virus. Appl Microbiol Biotechnol. 2018;102:8307-8318 pubmed publisher
    ..Accordingly, surface expression of DC-targeted antigens successfully induced cellular, mucosal, and humoral immunity in mice and could be used as a vaccine. ..
  5. Jin Y, Yang W, Shi C, Feng B, Huang K, Zhao G, et al. Immune responses induced by recombinant Lactobacillus plantarum expressing the spike protein derived from transmissible gastroenteritis virus in piglets. Appl Microbiol Biotechnol. 2018;102:8403-8417 pubmed publisher
  6. Yang W, Yang G, Zhao L, Jin Y, Jiang Y, Huang H, et al. Lactobacillus plantarum displaying conserved M2e and HA2 fusion antigens induces protection against influenza virus challenge. Appl Microbiol Biotechnol. 2018;102:5077-5088 pubmed publisher
    ..Thus, our results indicate that our novel approach is an effective method of vaccine design to promote mucosal immunity. ..
  7. Wang J, Cong Y, Yin R, Feng N, Yang S, Xia X, et al. Generation and evaluation of a recombinant genotype VII Newcastle disease virus expressing VP3 protein of Goose parvovirus as a bivalent vaccine in goslings. Virus Res. 2015;203:77-83 pubmed publisher
    ..This is the first study demonstrating that recombinant NDV has the potential to serve as bivalent live vaccine against Goose parvovirus and Newcastle disease virus infection in birds. ..
  8. Sun Y, Cong Y, Liu Y, Jin B, Si L, Wang A, et al. Schisandrin A and B affect subventricular zone neurogenesis in mouse. Eur J Pharmacol. 2014;740:552-9 pubmed publisher
    ..The present study provides the first evidence that Sch B exerts neuroprotective functions by enhancing neurogenesis, but Sch A mainly negatively regulates neurogenesis, in the adult SVZ-RMS-OB system. ..
  9. Shi S, Yang W, Huang K, Jiang Y, Yang G, Wang C, et al. β-glucans from Coriolus versicolor protect mice against S. typhimurium challenge by activation of macrophages. Int J Biol Macromol. 2016;86:352-61 pubmed publisher
    ..These phenomena indicate the possibility of CVP as a potential alternative for antibiotics against resistant bacteria. ..

More Information


  1. Jiang Y, Hu J, Guo Y, Yang W, Ye L, Shi C, et al. Construction and immunological evaluation of recombinant Lactobacillus plantarum expressing HN of Newcastle disease virus and DC- targeting peptide fusion protein. J Biotechnol. 2015;216:82-9 pubmed publisher
    ..The results demonstrated the possibility to take use of DCpep as an immune adjuvant in the design of NDV vaccine. ..
  2. Shi S, Yang W, Yang G, Zhang X, Liu Y, Zhang L, et al. Lactobacillus plantarum vaccine vector expressing hemagglutinin provides protection against H9N2 challenge infection. Virus Res. 2016;211:46-57 pubmed publisher
    ..These results revealed that recombinant L. plantarum NC8-pSIP409-HA-DCpep is an effective vaccine candidate against H9N2 AIVs. ..
  3. Wang C, Yang W, Yue L, Qiu J, Zhang L, Wang C, et al. Prominent contribution of Th1, Th17, and Tregs to the host response during M. neoaurum infection. Genet Mol Res. 2016;15: pubmed publisher
    ..The present study may lay the basis for further studies on the mechanisms underlying infection with nontuberculous mycobacteria. ..
  4. Yang G, Jiang Y, Yang W, Du F, Yao Y, Shi C, et al. Effective treatment of hypertension by recombinant Lactobacillus plantarum expressing angiotensin converting enzyme inhibitory peptide. Microb Cell Fact. 2015;14:202 pubmed publisher
    ..These results demonstrated the effectiveness and safety of RLP on the treatment of hypertension. ..
  5. Yang W, Yang G, Wang Q, Huang H, Jiang Y, Shi C, et al. Protective efficacy of Fc targeting conserved influenza virus M2e antigen expressed by Lactobacillus plantarum. Antiviral Res. 2017;138:9-21 pubmed publisher
  6. Ye L, Jiang Y, Yang G, Yang W, Hu J, Cui Y, et al. Murine bone marrow-derived DCs activated by porcine rotavirus stimulate the Th1 subtype response in vitro. Microb Pathog. 2017;110:325-334 pubmed publisher
    ..The PRV-stimulated BMDCs also showed increased stimulatory capacity in mixed lymphocyte reactions and promoted the Th1 subtype response. ..
  7. Jiang Y, Yang G, Wang Q, Wang Z, Yang W, Gu W, et al. Molecular mechanisms underlying protection against H9N2 influenza virus challenge in mice by recombinant Lactobacillus plantarum with surface displayed HA2-LTB. J Biotechnol. 2017;259:6-14 pubmed publisher
    ..In conclusion, this study provides more detail mechanisms underlying the adjuvant effects of LTB on heterologous antigen produced in recombinant lactic acid bacteria. ..
  8. Yang W, Shi S, Jiang Y, Zhao L, Chen H, Huang K, et al. Genetic characterization of a densovirus isolated from great tit (Parus major) in China. Infect Genet Evol. 2016;41:107-112 pubmed publisher
    ..Phylogenetic analysis indicated that the predicted amino acid sequences of capsid (VP) and non-structural domain (NS1) of PmDNV-JL clustered with the BgDNV and were similar to BgDNV-HB within the genus Densovirus. ..
  9. Yang G, Yao J, Yang W, Jiang Y, Du J, Huang H, et al. Construction and immunological evaluation of recombinant Lactobacillus plantarum expressing SO7 of Eimeria tenella fusion DC-targeting peptide. Vet Parasitol. 2017;236:7-13 pubmed publisher
    ..01). Therefore, these results indicate that recombinant L. plantarum NC8-pSIP409-SO7-DCpep could become a promising oral vaccine candidate against E. tenella infection. ..
  10. Huang K, Yang G, Jin Y, Liu J, Chen H, Wang P, et al. Construction and immunogenicity analysis of Lactobacillus plantarum expressing a porcine epidemic diarrhea virus S gene fused to a DC-targeting peptide. Virus Res. 2018;247:84-93 pubmed publisher
    ..The obtained experimental results can provide a theoretical basis that lays the foundation for production of a novel oral vaccine against PED. ..
  11. Xue C, Cong Y, Yin R, Sun Y, Ding C, Yu S, et al. Genetic diversity of the genotype VII Newcastle disease virus: identification of a novel VIIj sub-genotype. Virus Genes. 2017;53:63-70 pubmed publisher
    ..It is worthy of note that the isolation rate of VIIj is increasing recently. It emphasizes the necessity to pay close attention to the epidemiological dynamic of genotype VII NDV and highlights the importance of vaccination program. ..
  12. Yang W, Yang G, Shi S, Liu Y, Huang H, Jiang Y, et al. Protection of chickens against H9N2 avian influenza virus challenge with recombinant Lactobacillus plantarum expressing conserved antigens. Appl Microbiol Biotechnol. 2017;101:4593-4603 pubmed publisher
    ..Taken together, these findings suggest that L. plantarum expressing NP-M1-DCpep has potential as a vaccine to combat H9N2 AIV infection. ..
  13. Yang W, Yang G, Yang X, Shonyela S, Zhao L, Jiang Y, et al. Recombinant Lactobacillus plantarum expressing HA2 antigen elicits protective immunity against H9N2 avian influenza virus in chickens. Appl Microbiol Biotechnol. 2017;101:8475-8484 pubmed publisher
    ..This strategy lays the foundation for the development of recombinant L. plantarum oral vaccines in the prevention of AIV. ..