Leucyl/cystinyl aminopeptidase gene variants in septic shockTaka aki Nakada
University of British Columbia, Vancouver, BC, Canada
Chest 139:1042-9. 2011
..Vasopressin is an essential peptide hormone regulating cardiovascular homeostasis and an adjunctive vasopressor therapy for septic shock...
- Use of central venous oxygen saturation to guide therapy
Keith R Walley
Critical Care Research Laboratories, Heart and Lung Institute at St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Am J Respir Crit Care Med 184:514-20. 2011
....
- beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock
Taka aki Nakada
Critical Care Research Laboratories, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Am J Respir Crit Care Med 181:143-9. 2010
..Whether this functional haplotype alters outcome in patients receiving adrenergic agonists in septic shock is unknown...
Fibrinogen-beta gene haplotype is associated with mortality in sepsisSanjay Manocha
Critical Care Research Laboratories, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
J Infect 54:572-7. 2007
..Our aim was to determine whether haplotypes of FGB are associated with mortality and organ dysfunction in a cohort of patients with sepsis...
- Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality
John H Boyd
University of British Columbia Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
Crit Care Med 39:259-65. 2011
..To determine whether central venous pressure and fluid balance after resuscitation for septic shock are associated with mortality...
- Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock
James A Russell
St Paul s Hospital, iCAPTURE Centre, Canada
Crit Care Med 37:811-8. 2009
..However, it is unknown whether vasopressin treatment interacts with corticosteroid treatment...
- Vasopressin decreases sepsis-induced pulmonary inflammation through the V2R
John H Boyd
Critical Care Research Laboratories, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada V6Z 1Y6
Resuscitation 79:325-31. 2008
..CONCLUSIONS: Vasopressin exerts a local anti-inflammatory effect on the lung through the V2R in a model of sepsis...
- Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock
Taka aki Nakada
University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
Crit Care Med 39:1641-8. 2011
..The objective of this study was to test the hypothesis that single nucleotide polymorphisms in angiotensin II pathway genes alter outcome of septic shock...
- Protein C -1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis
Keith R Walley
Critical Care Research Laboratories, St Paul s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
Crit Care Med 35:12-7. 2007
..We tested the hypothesis that these polymorphisms are associated with altered outcome in patients having severe sepsis, in which protein C is a central molecule...
Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in miceToonchai Indrambarya
Critical Care Research Laboratories, Heart Lung Institute, University of British Columbia, Vancouver, British Columbia V6Z 1Y6, Canada
Crit Care 13:R98. 2009
..However, the direct effect of arginine vasopressin on the function of the ischemia/reperfusion injured heart has not been clearly elucidated...
- Albumin resuscitation improves ventricular contractility and myocardial tissue oxygenation in rat endotoxemia
Chiho Tokunaga
Critical Care Research Laboratories, University of British Columbia, Vancouver, Canada
Crit Care Med 35:1341-7. 2007
..We hypothesized that albumin resuscitation would improve decreased ventricular contractility and myocardial tissue oxygenation in vivo...
- S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products
John H Boyd
Critical Care Research Laboratories, St Paul Hospital, University of British Columbia, Vancouver, Canada
Circ Res 102:1239-46. 2008
..This finding provides a novel mechanistic link between circulating pathogen-associated molecular products and subsequent cardiac dysfunction...
- Vasopressin versus norepinephrine infusion in patients with septic shock
James A Russell
iCAPTURE Centre, Vancouver, BC, Canada
N Engl J Med 358:877-87. 2008
..We hypothesized that low-dose vasopressin as compared with norepinephrine would decrease mortality among patients with septic shock who were being treated with conventional (catecholamine) vasopressors...
- Fibrinogen decreases cardiomyocyte contractility through an ICAM-1-dependent mechanism
John H Boyd
University of British Columbia Critical Care Research Laboratories, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
Crit Care 12:R2. 2008
..We investigated whether fibrinogen and fibrinogen degradation products, including D-dimer, could alter cardiomyocyte contractile function through interaction with ICAM-1 found on inflamed cardiomyocytes...
- Normal-range blood lactate concentration in septic shock is prognostic and predictive
Petch Wacharasint
University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
Shock 38:4-10. 2012
..05). Lactate concentrations within the "normal" range can be a useful prognostic indicator in septic shock. Furthermore, patients whose lactate level is less than or equal to 1.4 mmol/L may benefit from vasopressin infusion...
- Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry
James A Russell
University of British Columbia Critical Care Research Laboratories, 1081 Burrard Street, Vancouver, BC, Canada
Hum Genet 123:661-3. 2008
..The C allele was associated with increased mortality and organ dysfunction, consistent with Chen et al...
- A single nucleotide polymorphism in NF-κB inducing kinase is associated with mortality in septic shock
Simone A Thair
University of British Columbia Critical Care Research Laboratories, Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
J Immunol 186:2321-8. 2011
..017). This suggests that the CC genotype of NIK rs7222094 is associated with increased mortality and organ dysfunction in septic shock patients, perhaps due to altered regulation of NF-κB pathway genes, including CXCL10...
- Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia
Ryon M Bateman
University of British Columbia Critical Care Research Laboratories, Department of Medicine, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
Am J Physiol Heart Circ Physiol 293:H448-56. 2007
..HIF-1alpha and GLUT1 gene induction are related to a heterogeneous ICAM-1 expression and may be cardioprotective during the onset of septic injury...
- Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response
John H Boyd
Critical Care Research Laboratories, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada, V6Z 1Y6
Cardiovasc Res 72:384-93. 2006
..CONCLUSIONS: Cardiomyocytes express most known Toll-like receptors. Of these, TLR2, TLR4 and TLR5 signal via NF-kappaB, resulting in decreased contractility and a concerted inflammatory response...
- Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery
David M Shaw
Critical Care Research Laboratories, Heart Lung Institute, University of British Columbia, Vancouver, BC, Canada
Crit Care 13:R9. 2009
..We hypothesised that variation in the pro-inflammatory gene IL-18 is associated with adverse clinical outcome because of a more intense inflammatory response...
- Vasoactive drugs for vasodilatory shock in ICU
Cheryl L Holmes
Department of Medicine, Kelowna General Hospital, University of British Columbia, Kelowna, British Columbia, Canada
Curr Opin Crit Care 15:398-402. 2009
..In this review, studies published during the past year that increase our understanding of the use of vasoactive drugs in the ICU are discussed...
- A nonsynonymous polymorphism of IRAK4 associated with increased prevalence of gram-positive infection and decreased response to toll-like receptor ligands
Ainsley M Sutherland
Critical Care Research Laboratories, Providence Heart and Lung Institute at St Paul s Hospital, University of British Columbia, Vancouver, B C, Canada ainsley sutherland utoronto ca
J Innate Immun 3:447-58. 2011
..07). Our data suggest that the IRAK4 haplotype clade marked by 29429A (428Thr) alters susceptibility to Gram-positive bacteria, by decreasing cellular response to TLR ligands...
- IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis
Taka aki Nakada
University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
Crit Care 15:R254. 2011
..Therefore, we hypothesized that SNPs in the IL17A gene alter susceptibility to infection and clinical outcome of severe sepsis...
- Interleukin-10 haplotype associated with increased mortality in critically ill patients with sepsis from pneumonia but not in patients with extrapulmonary sepsis
Anan Wattanathum
Critical Care Research Laboratories, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6
Chest 128:1690-8. 2005
..To test the hypothesis that haplotypes of the interleukin (IL)-10 gene are associated with clinical outcomes, comparing critically ill patients with sepsis from pneumonia vs those with extrapulmonary sepsis...
- The Toll-like receptor 9 ligand CPG-C attenuates acute inflammatory cardiac dysfunction
Sumeet Mathur
Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Shock 36:478-83. 2011
..These may play a role in attenuation of cardiac inflammation. The TLR9 ligand CpG-C attenuates the acute inflammatory cardiac dysfunction induced by both LPS and ischemia-reperfusion of the left anterior descending artery...
- Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults
Ainsley M Sutherland
University of British Columbia Critical Care Research Laboratories, James Hogg iCAPTURE Centre St Paul s Hospital, Vancouver, BC, Canada
Crit Care Med 33:638-44. 2005
....
- The association of interleukin 6 haplotype clades with mortality in critically ill adults
Ainsley M Sutherland
University of British Columbia McDonald Research Laboratories The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
Arch Intern Med 165:75-82. 2005
..We tested the hypothesis that specific haplotype clades of IL-6 may be associated with an outcome of SIRS...
- The prediction of adverse maternal outcomes in preeclampsia
Peter von Dadelszen
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC
J Obstet Gynaecol Can 26:871-9. 2004
..MPV:platelet ratio also showed promise as a marker of platelet consumption. A prospective study is required to develop a clinical prediction model for preeclampsia...
- Extracellular heat shock protein 70 induces cardiomyocyte inflammation and contractile dysfunction via TLR2
Sumeet Mathur
Critical Care Research Laboratories, Heart Lung Institute at St Paul s Hospital, University of British Columbia, Canada
Circ J 75:2445-52. 2011
..Whether endogenous molecules produced by tissue injury (damage associated molecular patterns, DAMPs) can induce cardiomyocyte inflammation via TLR signalling pathways and/or reduce cardiomyocyte contractility is unknown...
- Inhaled beta-2 agonist salbutamol and acute lung injury: an association with improvement in acute lung injury
Sanjay Manocha
Critical Care Research Laboratories, Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, BC, Canada
Crit Care 10:R12. 2006
..A dose greater than 2.2 mg/day of inhaled salbutamol could be a minimal effective dose to evaluate in a randomized controlled trial...
- A common polymorphism in the 5' region of the human protein c gene binds USF1
Katherine R Thain
Critical Care Research Laboratories, Institute for Heart Lung Health at St Paul s Hospital, University of British Columbia, Vancouver, Canada
Thromb Res 130:451-7. 2012
..We tested the hypothesis that common SNPs (minor allele frequency >10%) between the frequently studied promoter SNPs -1654 (rs1799808) and -1641 (rs1799809), and the end of PROC intron 2 alter nuclear transcription factor binding...
- AA genotype of IL-8 -251A/T is associated with low PaO(2)/FiO(2) in critically ill patients and with increased IL-8 expression
Petch Wacharasint
University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, BC, Canada
Respirology 17:1253-60. 2012
..We hypothesized that IL-8 -251A/T SNP is associated with PaO(2)/FiO(2) in critically ill patients...
- Arginine vasopressin in the treatment of vasodilatory septic shock
Cheryl L Holmes
University of British Columbia, Division of Critical Care, Department of Medicine, Kelowna General Hospital, BC, Canada
Best Pract Res Clin Anaesthesiol 22:275-86. 2008
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- Microvascular resuscitation as a therapeutic goal in severe sepsis
Ryon M Bateman
The James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
Crit Care 9:S27-32. 2005
..Thus, attention must be paid to the microcirculation in patients with sepsis, and therapeutic strategies should be employed to resuscitate the microcirculation in order to avoid organ dysfunction and to reduce mortality...
- Molecular mechanisms of sepsis
James A Russell
Heart and Lung Institute, St Paul s Hospital, Vancouver, BC, Canada
Contrib Microbiol 17:48-85. 2011
..Perhaps the paucity of approved therapies for sepsis is related in part to the underevaluation of novel pathways, to lack of understanding of interactions of pathways and to lack of interruption of key pathways of sepsis...
- Relative value of multiple plasma biomarkers as risk factors for coronary artery disease and death in an angiography cohort
Kenny W J Lee
James Hogg iCAPTURE Centre of Cardiovascular and Pulmonary Research and the Healthy Heart Program, St. Paul's Hospital, Department of Pathology and Laboratory Medicine, and the University of British Columbia, Vancouver, BC
CMAJ 174:461-6. 2006
..Elevated levels of multiple biomarkers were associated with an increasing rate of all-cause and CAD-related death...
- Endotoxemia increases the clearance of mPEGylated 5000-MW quantum dots as revealed by multiphoton microvascular imaging
Ryon M Bateman
University of British Columbia, Critical Care Research Laboratories, James Hogg iCAPTURE Centre, St Paul s Hospital, Vancouver, British Colombia, Canada, V6Z 1Y6
J Biomed Opt 12:064005. 2007
..In combination with multiphoton microscopy, quantum dots provide excellent in vivo imaging contrast of deep microvascular structures...
- The role of echocardiography in hemodynamic monitoring
John H Boyd
Critical Care Research Laboratories, Heart and Lung Institute, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
Curr Opin Crit Care 15:239-43. 2009
..In this review, we discuss the type of clinical information a trained intensivist can hope to obtain from bedside echocardiography and suggest the ways in which this complements traditional hemodynamic monitoring...
- Vasopressin and its immune effects in septic shock
James A Russell
Heart and Lung Institute, St Paul s Hospital, University of British Columbia, Vancouver, B C, Canada
J Innate Immun 2:446-60. 2010
..Vasopressin plus corticosteroid treatment may decrease mortality compared to corticosteroids plus norepinephrine. Potential mechanisms are that vasopressin plus corticosteroids beneficially alter immunity in septic shock...
- Vasopressin in the ICU
Cheryl L Holmes
Department of Medicine, University of British Columbia, Vancouver, Department of Medicine, Kelowna General Hospital, Kelowna, BC, Canada
Curr Opin Crit Care 10:442-8. 2004
..Vasopressin is one of the most important endogenously released stress hormones during shock. In this review, studies published in the past year that add to our understanding of the use of vasopressin in the ICU are discussed...
- Lack of agreement between thermodilution and fick cardiac output in critically ill patients
Vinay K Dhingra
Division of Critical Care Medicine, Vancouver Hospital and Health Sciences Center, University of British Columbia, Vancouver, BC, Canada
Chest 122:990-7. 2002
..s: Individual comparison of cardiac output via intermittent thermodilution and Fick technique over a wide range of cardiac outputs...
- MACGT: multi-dimensional automated clustering genotyping tool for analysis of microarray-based mini-sequencing data
David C Walley
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, University of British Columbia Vancouver, V6Z 1Y6, Canada
Bioinformatics 22:1147-9. 2006
..Calling accuracy by MACGT exceeds 98% when applied to genotyping data from APEX microarrays, and can be increased to >99.5% by applying thresholds to the confidence measures...
- Clinical review: Guyton--the role of mean circulatory filling pressure and right atrial pressure in controlling cardiac output
William R Henderson
Critical Care Medicine, Vancouver General Hospital, ICU, JPPN, 2nd Floor, Room 2438, 899 West 12th Avenue, Vancouver, BC, V5Z 1M9, Canada
Crit Care 14:243. 2010
..Further concerns have been raised in regard to the artificial experimental preparations that Guyton used. Recently reported measurements in humans support Guyton's theoretical and animal work...
- The effects of steroids on the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting surgery: a prospective randomized trial
Kriengchai Prasongsukarn
St. Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
J Thorac Cardiovasc Surg 130:93-8. 2005
....
- Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model
Peter von Dadelszen
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada
Lancet 377:219-27. 2011
..We developed and validated the fullPIERS model with the aim of identifying the risk of fatal or life-threatening complications in women with pre-eclampsia within 48 h of hospital admission for the disorder...
- Is there a role for sodium bicarbonate in treating lactic acidosis from shock?
John H Boyd
University of British Columbia, Critical Care Research Laboratories, Vancouver, British Columbia, Canada
Curr Opin Crit Care 14:379-83. 2008
..Bicarbonate therapy for severe lactic acidosis remains a controversial therapy...
- Mechanisms of beta-receptor stimulation-induced improvement of acute lung injury and pulmonary edema
Horacio E Groshaus
Critical Care Research Laboratories, St Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada
Crit Care 8:234-42. 2004
..The available evidence suggests that beta-2 agonists may be efficacious therapy in ALI. Further randomized controlled trials of beta agonists in pulmonary edema and in acute lung injury are necessary...
- Neutrophil apoptosis in preeclampsia, do steroids confound the relationship?
Akiko Fuchisawa
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada
J Obstet Gynaecol Res 30:342-8. 2004
..To investigate the influence of maternal corticosteroid administration on neutrophil apoptosis in early onset preeclampsia...
- Acute hypervolaemia improves arterial oxygen pressure in athletes with exercise-induced hypoxaemia
Gerald S Zavorsky
Department of Experimental Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Center, Koerner Pavillion, S154, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
Exp Physiol 88:555-64. 2003
..This suggests that arterial oxygen pressure is only minimally mediated by cardiac output...
- Cardiac ICAM-1 mediates leukocyte-dependent decreased ventricular contractility in endotoxemic mice
Ehsan Y Davani
Critical Care Research Laboratories, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Cardiovasc Res 72:134-42. 2006
..We tested the hypothesis that signaling via ICAM-1 contributes to decreased left ventricular contractility in an in vivo model of systemic inflammation...
- Severe acute respiratory distress syndrome (SARS): a critical care perspective
Sanjay Manocha
Department of Medicine, University of British Columbia, Vancouver, Canada
Crit Care Med 31:2684-92. 2003
..Early recognition is critical for effective management and containment of this disease...
- Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy
Cheryl L Holmes
McDonald Research Laboratories/The iCAPTURE Centre, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Chest 124:1103-15. 2003
....
- Novel regulatory mechanism of cardiomyocyte contractility involving ICAM-1 and the cytoskeleton
Ehsan Y Davani
Critical Care Research Laboratories, St Paul s Hospital, University of British Columbia, Vancouver, Canada V6Z 1Y6
Am J Physiol Heart Circ Physiol 287:H1013-22. 2004
..Cardiomyocyte ICAM-1 binding, by PMNs or other ligands, induces decreased cardiomyocyte contractility via this pathway...
- Circulating white blood cells affect red cell pulmonary transit times in endurance athletes during intense exercise
Gerald S Zavorsky
Department of Experimental Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Center, Vancouver, BC, Canada
Med Sci Sports Exerc 34:954-9. 2002
..5 min of exercise via a count-based ratio method from the MUGA technique...
- Activated protein C in normal human pregnancy and pregnancies complicated by severe preeclampsia: a therapeutic opportunity?
Peter von Dadelszen
Department of Obstetrics and Gynaecology, Division of Maternal Fetal Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Crit Care Med 30:1883-92. 2002
..To determine which patients would be offered rhAPC, the literature pertaining to fetal/neonatal outcomes for preeclampsia remote from term, transplacental transport of protein C, and pregnancy experience with the compound were reviewed...
- Albumin resuscitation increases cardiomyocyte contractility and decreases nitric oxide synthase II expression in rat endotoxemia
Keith R Walley
University of British Columbia McDonald Research Laboratories iCAPTURE Center, Vancouver, Canada
Crit Care Med 31:187-94. 2003
..Therefore, we hypothesized that crystalloid or colloid resuscitation may alter myocardial dysfunction...
- Bad medicine: low-dose dopamine in the ICU
Cheryl L Holmes
University of British Columbia, McDonald Research Laboratories, Vancouver, Canada
Chest 123:1266-75. 2003
..We conclude that there is no justification for the use of low-dose dopamine administration in the critically ill...
