Keith R Walley

Summary

Publications

  1. doi request reprint Leucyl/cystinyl aminopeptidase gene variants in septic shock
    Taka aki Nakada
    University of British Columbia, Vancouver, BC, Canada
    Chest 139:1042-9. 2011
  2. pmc Clinical review: Update on hemodynamic monitoring--a consensus of 16
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium
    Crit Care 15:229. 2011
  3. doi request reprint Use of central venous oxygen saturation to guide therapy
    Keith R Walley
    Critical Care Research Laboratories, Heart and Lung Institute at St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 184:514-20. 2011
  4. doi request reprint beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock
    Taka aki Nakada
    Critical Care Research Laboratories, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Am J Respir Crit Care Med 181:143-9. 2010
  5. ncbi request reprint Prolonged QTc affects short-term and long-term outcomes in patients with normal left ventricular function undergoing cardiac surgery
    Nattachai Anantasit
    Centre for Heart Lung Innovation, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 147:1627-33. 2014
  6. doi request reprint Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality
    John H Boyd
    University of British Columbia Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:259-65. 2011
  7. ncbi request reprint Fibrinogen-beta gene haplotype is associated with mortality in sepsis
    Sanjay Manocha
    Critical Care Research Laboratories, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    J Infect 54:572-7. 2007
  8. ncbi request reprint Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock
    James A Russell
    St Paul s Hospital, iCAPTURE Centre, Canada
    Crit Care Med 37:811-8. 2009
  9. doi request reprint Vasopressin decreases sepsis-induced pulmonary inflammation through the V2R
    John H Boyd
    Critical Care Research Laboratories, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada V6Z 1Y6
    Resuscitation 79:325-31. 2008
  10. doi request reprint AA genotype of IL-8 -251A/T is associated with low PaO(2)/FiO(2) in critically ill patients and with increased IL-8 expression
    Petch Wacharasint
    University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, BC, Canada
    Respirology 17:1253-60. 2012

Collaborators

Detail Information

Publications64

  1. doi request reprint Leucyl/cystinyl aminopeptidase gene variants in septic shock
    Taka aki Nakada
    University of British Columbia, Vancouver, BC, Canada
    Chest 139:1042-9. 2011
    ..Vasopressin is an essential peptide hormone regulating cardiovascular homeostasis and an adjunctive vasopressor therapy for septic shock...
  2. pmc Clinical review: Update on hemodynamic monitoring--a consensus of 16
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium
    Crit Care 15:229. 2011
    ....
  3. doi request reprint Use of central venous oxygen saturation to guide therapy
    Keith R Walley
    Critical Care Research Laboratories, Heart and Lung Institute at St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 184:514-20. 2011
    ....
  4. doi request reprint beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock
    Taka aki Nakada
    Critical Care Research Laboratories, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Am J Respir Crit Care Med 181:143-9. 2010
    ..Whether this functional haplotype alters outcome in patients receiving adrenergic agonists in septic shock is unknown...
  5. ncbi request reprint Prolonged QTc affects short-term and long-term outcomes in patients with normal left ventricular function undergoing cardiac surgery
    Nattachai Anantasit
    Centre for Heart Lung Innovation, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 147:1627-33. 2014
    ..This study examines whether a prolonged QTc interval is associated with adverse outcomes in patients with preoperative LVEF greater than 40% undergoing cardiac surgery...
  6. doi request reprint Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality
    John H Boyd
    University of British Columbia Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:259-65. 2011
    ..To determine whether central venous pressure and fluid balance after resuscitation for septic shock are associated with mortality...
  7. ncbi request reprint Fibrinogen-beta gene haplotype is associated with mortality in sepsis
    Sanjay Manocha
    Critical Care Research Laboratories, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    J Infect 54:572-7. 2007
    ..Our aim was to determine whether haplotypes of FGB are associated with mortality and organ dysfunction in a cohort of patients with sepsis...
  8. ncbi request reprint Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock
    James A Russell
    St Paul s Hospital, iCAPTURE Centre, Canada
    Crit Care Med 37:811-8. 2009
    ..However, it is unknown whether vasopressin treatment interacts with corticosteroid treatment...
  9. doi request reprint Vasopressin decreases sepsis-induced pulmonary inflammation through the V2R
    John H Boyd
    Critical Care Research Laboratories, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada V6Z 1Y6
    Resuscitation 79:325-31. 2008
    ..Pretreatment with V2R antagonist results in complete attenuation of vasopressin's immunosuppressive effects, with restoration of pulmonary IL-6 and phospho-IkappaB levels to those seen with LPS alone...
  10. doi request reprint AA genotype of IL-8 -251A/T is associated with low PaO(2)/FiO(2) in critically ill patients and with increased IL-8 expression
    Petch Wacharasint
    University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, BC, Canada
    Respirology 17:1253-60. 2012
    ..We hypothesized that IL-8 -251A/T SNP is associated with PaO(2)/FiO(2) in critically ill patients...
  11. doi request reprint Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock
    Taka aki Nakada
    University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:1641-8. 2011
    ..The objective of this study was to test the hypothesis that single nucleotide polymorphisms in angiotensin II pathway genes alter outcome of septic shock...
  12. ncbi request reprint A multibiomarker-based outcome risk stratification model for adult septic shock*
    Hector R Wong
    1Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 3Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 4Intensive Care Units, Division of Anaesthesia and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland 5Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 6University of British Columbia, Vancouver, BC, Canada 7Critical Care Research Laboratories, Centre for Heart Lung Innovation, St Paul s Hospital, Vancouver, BC, Canada 8Department of Intensive Care Medicine, Tampere University Hospital, Tampere, Finland 9Department of Intensive Care Medicine, Kuopio University Hospital, Kuopio, Finland 10Department of Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA
    Crit Care Med 42:781-9. 2014
    ..Investigators advocate that interventional trials in septic shock require effective outcome risk stratification. We derived and tested a multibiomarker-based approach to estimate mortality risk in adults with septic shock...
  13. pmc Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice
    Toonchai Indrambarya
    Critical Care Research Laboratories, Heart Lung Institute, University of British Columbia, Vancouver, British Columbia V6Z 1Y6, Canada
    Crit Care 13:R98. 2009
    ..However, the direct effect of arginine vasopressin on the function of the ischemia/reperfusion injured heart has not been clearly elucidated...
  14. ncbi request reprint Protein C -1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis
    Keith R Walley
    Critical Care Research Laboratories, St Paul s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
    Crit Care Med 35:12-7. 2007
    ..We tested the hypothesis that these polymorphisms are associated with altered outcome in patients having severe sepsis, in which protein C is a central molecule...
  15. doi request reprint Vasopressin compared with norepinephrine augments the decline of plasma cytokine levels in septic shock
    James A Russell
    James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 188:356-64. 2013
    ..Changes in plasma cytokine levels may predict mortality, and therapies (vasopressin versus norepinephrine) could change plasma cytokine levels in early septic shock...
  16. doi request reprint S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products
    John H Boyd
    Critical Care Research Laboratories, St Paul Hospital, University of British Columbia, Vancouver, Canada
    Circ Res 102:1239-46. 2008
    ..This finding provides a novel mechanistic link between circulating pathogen-associated molecular products and subsequent cardiac dysfunction...
  17. ncbi request reprint Albumin resuscitation improves ventricular contractility and myocardial tissue oxygenation in rat endotoxemia
    Chiho Tokunaga
    Critical Care Research Laboratories, University of British Columbia, Vancouver, Canada
    Crit Care Med 35:1341-7. 2007
    ..We hypothesized that albumin resuscitation would improve decreased ventricular contractility and myocardial tissue oxygenation in vivo...
  18. pmc Fibrinogen decreases cardiomyocyte contractility through an ICAM-1-dependent mechanism
    John H Boyd
    University of British Columbia Critical Care Research Laboratories, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Crit Care 12:R2. 2008
    ..We investigated whether fibrinogen and fibrinogen degradation products, including D-dimer, could alter cardiomyocyte contractile function through interaction with ICAM-1 found on inflamed cardiomyocytes...
  19. doi request reprint Vasopressin versus norepinephrine infusion in patients with septic shock
    James A Russell
    iCAPTURE Centre, Vancouver, BC, Canada
    N Engl J Med 358:877-87. 2008
    ..We hypothesized that low-dose vasopressin as compared with norepinephrine would decrease mortality among patients with septic shock who were being treated with conventional (catecholamine) vasopressors...
  20. pmc A nonsynonymous polymorphism of IRAK4 associated with increased prevalence of gram-positive infection and decreased response to toll-like receptor ligands
    Ainsley M Sutherland
    Critical Care Research Laboratories, Providence Heart and Lung Institute at St Paul s Hospital, University of British Columbia, Vancouver, B C, Canada ainsley sutherland utoronto ca
    J Innate Immun 3:447-58. 2011
    ..07). Our data suggest that the IRAK4 haplotype clade marked by 29429A (428Thr) alters susceptibility to Gram-positive bacteria, by decreasing cellular response to TLR ligands...
  21. doi request reprint Normal-range blood lactate concentration in septic shock is prognostic and predictive
    Petch Wacharasint
    University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
    Shock 38:4-10. 2012
    ..05). Lactate concentrations within the "normal" range can be a useful prognostic indicator in septic shock. Furthermore, patients whose lactate level is less than or equal to 1.4 mmol/L may benefit from vasopressin infusion...
  22. doi request reprint A single nucleotide polymorphism in NF-κB inducing kinase is associated with mortality in septic shock
    Simone A Thair
    University of British Columbia Critical Care Research Laboratories, Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
    J Immunol 186:2321-8. 2011
    ..017). This suggests that the CC genotype of NIK rs7222094 is associated with increased mortality and organ dysfunction in septic shock patients, perhaps due to altered regulation of NF-κB pathway genes, including CXCL10...
  23. ncbi request reprint Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry
    James A Russell
    University of British Columbia Critical Care Research Laboratories, 1081 Burrard Street, Vancouver, BC, Canada
    Hum Genet 123:661-3. 2008
    ..The C allele was associated with increased mortality and organ dysfunction, consistent with Chen et al...
  24. doi request reprint A common polymorphism in the 5' region of the human protein c gene binds USF1
    Katherine R Thain
    Critical Care Research Laboratories, Institute for Heart Lung Health at St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Thromb Res 130:451-7. 2012
    ..We tested the hypothesis that common SNPs (minor allele frequency >10%) between the frequently studied promoter SNPs -1654 (rs1799808) and -1641 (rs1799809), and the end of PROC intron 2 alter nuclear transcription factor binding...
  25. ncbi request reprint Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response
    John H Boyd
    Critical Care Research Laboratories, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada, V6Z 1Y6
    Cardiovasc Res 72:384-93. 2006
    ..We determined whether Toll-like receptors are expressed in cardiac tissue and whether stimulation with cognate ligands would result in a pro-inflammatory response and decreased cardiomyocyte contractility...
  26. ncbi request reprint Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia
    Ryon M Bateman
    University of British Columbia Critical Care Research Laboratories, Department of Medicine, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Physiol Heart Circ Physiol 293:H448-56. 2007
    ..HIF-1alpha and GLUT1 gene induction are related to a heterogeneous ICAM-1 expression and may be cardioprotective during the onset of septic injury...
  27. doi request reprint Vasoactive drugs for vasodilatory shock in ICU
    Cheryl L Holmes
    Department of Medicine, Kelowna General Hospital, University of British Columbia, Kelowna, British Columbia, Canada
    Curr Opin Crit Care 15:398-402. 2009
    ..In this review, studies published during the past year that increase our understanding of the use of vasoactive drugs in the ICU are discussed...
  28. pmc Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery
    David M Shaw
    Critical Care Research Laboratories, Heart Lung Institute, University of British Columbia, Vancouver, BC, Canada
    Crit Care 13:R9. 2009
    ..We hypothesised that variation in the pro-inflammatory gene IL-18 is associated with adverse clinical outcome because of a more intense inflammatory response...
  29. ncbi request reprint The association of interleukin 6 haplotype clades with mortality in critically ill adults
    Ainsley M Sutherland
    University of British Columbia McDonald Research Laboratories The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
    Arch Intern Med 165:75-82. 2005
    ..We tested the hypothesis that specific haplotype clades of IL-6 may be associated with an outcome of SIRS...
  30. ncbi request reprint Interleukin-10 haplotype associated with increased mortality in critically ill patients with sepsis from pneumonia but not in patients with extrapulmonary sepsis
    Anan Wattanathum
    Critical Care Research Laboratories, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6
    Chest 128:1690-8. 2005
    ..To test the hypothesis that haplotypes of the interleukin (IL)-10 gene are associated with clinical outcomes, comparing critically ill patients with sepsis from pneumonia vs those with extrapulmonary sepsis...
  31. pmc IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis
    Taka aki Nakada
    University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Crit Care 15:R254. 2011
    ..Therefore, we hypothesized that SNPs in the IL17A gene alter susceptibility to infection and clinical outcome of severe sepsis...
  32. doi request reprint The Toll-like receptor 9 ligand CPG-C attenuates acute inflammatory cardiac dysfunction
    Sumeet Mathur
    Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Shock 36:478-83. 2011
    ..These may play a role in attenuation of cardiac inflammation. The TLR9 ligand CpG-C attenuates the acute inflammatory cardiac dysfunction induced by both LPS and ischemia-reperfusion of the left anterior descending artery...
  33. ncbi request reprint Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults
    Ainsley M Sutherland
    University of British Columbia Critical Care Research Laboratories, James Hogg iCAPTURE Centre St Paul s Hospital, Vancouver, BC, Canada
    Crit Care Med 33:638-44. 2005
    ....
  34. ncbi request reprint Extracellular heat shock protein 70 induces cardiomyocyte inflammation and contractile dysfunction via TLR2
    Sumeet Mathur
    Critical Care Research Laboratories, Heart Lung Institute at St Paul s Hospital, University of British Columbia, Canada
    Circ J 75:2445-52. 2011
    ..Whether endogenous molecules produced by tissue injury (damage associated molecular patterns, DAMPs) can induce cardiomyocyte inflammation via TLR signalling pathways and/or reduce cardiomyocyte contractility is unknown...
  35. pmc Inhaled beta-2 agonist salbutamol and acute lung injury: an association with improvement in acute lung injury
    Sanjay Manocha
    Critical Care Research Laboratories, Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, BC, Canada
    Crit Care 10:R12. 2006
    ..Beta2 agonists have several properties that could be beneficial in acute lung injury (ALI). We therefore chose to study the effect of inhaled beta2 agonist use (salbutamol) on duration and severity of ALI...
  36. ncbi request reprint The prediction of adverse maternal outcomes in preeclampsia
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC
    J Obstet Gynaecol Can 26:871-9. 2004
    ....
  37. pmc Cytokines and signaling molecules predict clinical outcomes in sepsis
    Christopher D Fjell
    James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 8:e79207. 2013
    ..Clinical features relating to both underlying health and the acute organ dysfunction induced by the severe infection were collected during the first 28 days of admission...
  38. ncbi request reprint Arginine vasopressin in the treatment of vasodilatory septic shock
    Cheryl L Holmes
    University of British Columbia, Division of Critical Care, Department of Medicine, Kelowna General Hospital, BC, Canada
    Best Pract Res Clin Anaesthesiol 22:275-86. 2008
    ....
  39. pmc Microvascular resuscitation as a therapeutic goal in severe sepsis
    Ryon M Bateman
    The James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
    Crit Care 9:S27-32. 2005
    ..Thus, attention must be paid to the microcirculation in patients with sepsis, and therapeutic strategies should be employed to resuscitate the microcirculation in order to avoid organ dysfunction and to reduce mortality...
  40. doi request reprint Molecular mechanisms of sepsis
    James A Russell
    Heart and Lung Institute, St Paul s Hospital, Vancouver, BC, Canada
    Contrib Microbiol 17:48-85. 2011
    ..Perhaps the paucity of approved therapies for sepsis is related in part to the underevaluation of novel pathways, to lack of understanding of interactions of pathways and to lack of interruption of key pathways of sepsis...
  41. doi request reprint Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada
    Lancet 377:219-27. 2011
    ..We developed and validated the fullPIERS model with the aim of identifying the risk of fatal or life-threatening complications in women with pre-eclampsia within 48 h of hospital admission for the disorder...
  42. pmc Relative value of multiple plasma biomarkers as risk factors for coronary artery disease and death in an angiography cohort
    Kenny W J Lee
    James Hogg iCAPTURE Centre of Cardiovascular and Pulmonary Research and the Healthy Heart Program, St Paul s Hospital, Department of Pathology and Laboratory Medicine, and the University of British Columbia, Vancouver, BC
    CMAJ 174:461-6. 2006
    ....
  43. doi request reprint The role of echocardiography in hemodynamic monitoring
    John H Boyd
    Critical Care Research Laboratories, Heart and Lung Institute, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    Curr Opin Crit Care 15:239-43. 2009
    ..In this review, we discuss the type of clinical information a trained intensivist can hope to obtain from bedside echocardiography and suggest the ways in which this complements traditional hemodynamic monitoring...
  44. doi request reprint Vasopressin and its immune effects in septic shock
    James A Russell
    Heart and Lung Institute, St Paul s Hospital, University of British Columbia, Vancouver, B C, Canada
    J Innate Immun 2:446-60. 2010
    ..Vasopressin plus corticosteroid treatment may decrease mortality compared to corticosteroids plus norepinephrine. Potential mechanisms are that vasopressin plus corticosteroids beneficially alter immunity in septic shock...
  45. doi request reprint Endotoxemia increases the clearance of mPEGylated 5000-MW quantum dots as revealed by multiphoton microvascular imaging
    Ryon M Bateman
    University of British Columbia, Critical Care Research Laboratories, James Hogg iCAPTURE Centre, St Paul s Hospital, Vancouver, British Colombia, Canada, V6Z 1Y6
    J Biomed Opt 12:064005. 2007
    ..In combination with multiphoton microscopy, quantum dots provide excellent in vivo imaging contrast of deep microvascular structures...
  46. ncbi request reprint Vasopressin in the ICU
    Cheryl L Holmes
    Department of Medicine, University of British Columbia, Vancouver, Department of Medicine, Kelowna General Hospital, Kelowna, BC, Canada
    Curr Opin Crit Care 10:442-8. 2004
    ..Vasopressin is one of the most important endogenously released stress hormones during shock. In this review, studies published in the past year that add to our understanding of the use of vasopressin in the ICU are discussed...
  47. doi request reprint Update in sepsis 2012
    James A Russell
    Critical Care Research Laboratories, Institute for Heart Lung Health, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 187:1303-7. 2013
    ..As a consequence, we suggest that sepsis may be the paradigm disease or condition requiring personalized care first to discover and validate new therapies and second to increase survival...
  48. ncbi request reprint Lack of agreement between thermodilution and fick cardiac output in critically ill patients
    Vinay K Dhingra
    Division of Critical Care Medicine, Vancouver Hospital and Health Sciences Center, University of British Columbia, Vancouver, BC, Canada
    Chest 122:990-7. 2002
    ..s: Individual comparison of cardiac output via intermittent thermodilution and Fick technique over a wide range of cardiac outputs...
  49. ncbi request reprint MACGT: multi-dimensional automated clustering genotyping tool for analysis of microarray-based mini-sequencing data
    David C Walley
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia Vancouver, V6Z 1Y6, Canada
    Bioinformatics 22:1147-9. 2006
    ..Calling accuracy by MACGT exceeds 98% when applied to genotyping data from APEX microarrays, and can be increased to >99.5% by applying thresholds to the confidence measures...
  50. pmc Clinical review: Guyton--the role of mean circulatory filling pressure and right atrial pressure in controlling cardiac output
    William R Henderson
    Critical Care Medicine, Vancouver General Hospital, ICU, JPPN, 2nd Floor, Room 2438, 899 West 12th Avenue, Vancouver, BC, V5Z 1M9, Canada
    Crit Care 14:243. 2010
    ..Further concerns have been raised in regard to the artificial experimental preparations that Guyton used. Recently reported measurements in humans support Guyton's theoretical and animal work...
  51. ncbi request reprint The effects of steroids on the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting surgery: a prospective randomized trial
    Kriengchai Prasongsukarn
    St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    J Thorac Cardiovasc Surg 130:93-8. 2005
    ..A randomized, double-blind, placebo-controlled trial was conducted to determine the effect of steroids on the occurrence of atrial fibrillation after elective coronary artery bypass grafting...
  52. doi request reprint Is there a role for sodium bicarbonate in treating lactic acidosis from shock?
    John H Boyd
    University of British Columbia, Critical Care Research Laboratories, Vancouver, British Columbia, Canada
    Curr Opin Crit Care 14:379-83. 2008
    ..Bicarbonate therapy for severe lactic acidosis remains a controversial therapy...
  53. pmc Mechanisms of beta-receptor stimulation-induced improvement of acute lung injury and pulmonary edema
    Horacio E Groshaus
    Critical Care Research Laboratories, St Paul s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
    Crit Care 8:234-42. 2004
    ..The available evidence suggests that beta-2 agonists may be efficacious therapy in ALI. Further randomized controlled trials of beta agonists in pulmonary edema and in acute lung injury are necessary...
  54. ncbi request reprint Microarray genotyping resource to determine population stratification in genetic association studies of complex disease
    Scott J Tebbutt
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Biotechniques 37:977-85. 2004
    ..Based on 1141 known genotypes from other research groups, our GC SNP chip has an accuracy of 98.5%, including non-calls...
  55. ncbi request reprint Neutrophil apoptosis in preeclampsia, do steroids confound the relationship?
    Akiko Fuchisawa
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada
    J Obstet Gynaecol Res 30:342-8. 2004
    ..To investigate the influence of maternal corticosteroid administration on neutrophil apoptosis in early onset preeclampsia...
  56. ncbi request reprint Acute hypervolaemia improves arterial oxygen pressure in athletes with exercise-induced hypoxaemia
    Gerald S Zavorsky
    Department of Experimental Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Center, Koerner Pavillion, S154, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
    Exp Physiol 88:555-64. 2003
    ..This suggests that arterial oxygen pressure is only minimally mediated by cardiac output...
  57. ncbi request reprint Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy
    Cheryl L Holmes
    McDonald Research Laboratories The iCapture Centre, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Chest 124:1103-15. 2003
    ....
  58. ncbi request reprint Cardiac ICAM-1 mediates leukocyte-dependent decreased ventricular contractility in endotoxemic mice
    Ehsan Y Davani
    Critical Care Research Laboratories, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Cardiovasc Res 72:134-42. 2006
    ..We tested the hypothesis that signaling via ICAM-1 contributes to decreased left ventricular contractility in an in vivo model of systemic inflammation...
  59. ncbi request reprint Severe acute respiratory distress syndrome (SARS): a critical care perspective
    Sanjay Manocha
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Crit Care Med 31:2684-92. 2003
    ..To review the epidemiology, clinical features, etiology, diagnosis, and management of severe acute respiratory syndrome (SARS) from a critical care perspective...
  60. ncbi request reprint Activated protein C in normal human pregnancy and pregnancies complicated by severe preeclampsia: a therapeutic opportunity?
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, Division of Maternal Fetal Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Crit Care Med 30:1883-92. 2002
    ..To determine which patients would be offered rhAPC, the literature pertaining to fetal/neonatal outcomes for preeclampsia remote from term, transplacental transport of protein C, and pregnancy experience with the compound were reviewed...
  61. ncbi request reprint Albumin resuscitation increases cardiomyocyte contractility and decreases nitric oxide synthase II expression in rat endotoxemia
    Keith R Walley
    University of British Columbia McDonald Research Laboratories iCAPTURE Center, Vancouver, Canada
    Crit Care Med 31:187-94. 2003
    ..Therefore, we hypothesized that crystalloid or colloid resuscitation may alter myocardial dysfunction...
  62. ncbi request reprint Novel regulatory mechanism of cardiomyocyte contractility involving ICAM-1 and the cytoskeleton
    Ehsan Y Davani
    Critical Care Research Laboratories, St Paul s Hospital, University of British Columbia, Vancouver, Canada V6Z 1Y6
    Am J Physiol Heart Circ Physiol 287:H1013-22. 2004
    ..Cardiomyocyte ICAM-1 binding, by PMNs or other ligands, induces decreased cardiomyocyte contractility via this pathway...
  63. ncbi request reprint Circulating white blood cells affect red cell pulmonary transit times in endurance athletes during intense exercise
    Gerald S Zavorsky
    Department of Experimental Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Center, Vancouver, BC, Canada
    Med Sci Sports Exerc 34:954-9. 2002
    ..5 min of exercise via a count-based ratio method from the MUGA technique...
  64. ncbi request reprint Bad medicine: low-dose dopamine in the ICU
    Cheryl L Holmes
    University of British Columbia, McDonald Research Laboratories, Vancouver, Canada
    Chest 123:1266-75. 2003
    ..We conclude that there is no justification for the use of low-dose dopamine administration in the critically ill...