John L Wallace

Summary

Publications

  1. ncbi request reprint Exploiting endogenous anti-inflammatory pathways as a therapeutic approach to multiorgan inflammatory disease
    John L Wallace
    Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada Electronic address
    Am J Pathol 184:2154-5. 2014
  2. pmc Enhanced synthesis and diminished degradation of hydrogen sulfide in experimental colitis: a site-specific, pro-resolution mechanism
    Kyle L Flannigan
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 8:e71962. 2013
  3. doi request reprint Hydrogen sulfide-based therapeutics and gastrointestinal diseases: translating physiology to treatments
    Melissa V Chan
    Dept of Physiology and Pharmacology, Univ of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
    Am J Physiol Gastrointest Liver Physiol 305:G467-73. 2013
  4. doi request reprint A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury
    Michela Campolo
    1Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, T2N 4N1, Canada
    FASEB J 27:4489-99. 2013
  5. doi request reprint Polypharmacy of osteoarthritis: the perfect intestinal storm
    John L Wallace
    Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada
    Dig Dis Sci 58:3088-93. 2013
  6. ncbi request reprint Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract
    J L Wallace
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    J Physiol Pharmacol 64:167-75. 2013
  7. pmc Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy
    John L Wallace
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4K1, Canada
    World J Gastroenterol 19:1861-76. 2013
  8. ncbi request reprint Citrobacter rodentium infection causes iNOS-independent intestinal epithelial dysfunction in mice
    Andrew C Skinn
    Mucosal Inflammation Research Group and Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Dr NW, Calgary, AB T2N 4N1, Canada
    Can J Physiol Pharmacol 84:1301-12. 2006
  9. ncbi request reprint Aspirin, but not NO-releasing aspirin (NCX-4016), interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation
    John L Wallace
    Mucosal Inflammation Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Gastrointest Liver Physiol 286:G76-81. 2004
  10. pmc Gastrointestinal-sparing effects of novel NSAIDs in rats with compromised mucosal defence
    Rory Blackler
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 7:e35196. 2012

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Exploiting endogenous anti-inflammatory pathways as a therapeutic approach to multiorgan inflammatory disease
    John L Wallace
    Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada Electronic address
    Am J Pathol 184:2154-5. 2014
    ....
  2. pmc Enhanced synthesis and diminished degradation of hydrogen sulfide in experimental colitis: a site-specific, pro-resolution mechanism
    Kyle L Flannigan
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 8:e71962. 2013
    ..Together, the increased production and decreased inactivation of H₂S at sites of mucosal ulceration would result in higher H₂S levels at these sites, which promotes of resolution of inflammation and repair of damaged tissue...
  3. doi request reprint Hydrogen sulfide-based therapeutics and gastrointestinal diseases: translating physiology to treatments
    Melissa V Chan
    Dept of Physiology and Pharmacology, Univ of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
    Am J Physiol Gastrointest Liver Physiol 305:G467-73. 2013
    ..Encouraging results have already been seen experimentally with a mesalamine derivative and with H2S-releasing derivatives of nonsteroidal anti-inflammatory drugs...
  4. doi request reprint A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury
    Michela Campolo
    1Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, T2N 4N1, Canada
    FASEB J 27:4489-99. 2013
    ..The combination of inhibition of cyclooxygenase and delivery of H2S may offer a promising alternative to existing therapies for traumatic injury...
  5. doi request reprint Polypharmacy of osteoarthritis: the perfect intestinal storm
    John L Wallace
    Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada
    Dig Dis Sci 58:3088-93. 2013
    ....
  6. ncbi request reprint Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract
    J L Wallace
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    J Physiol Pharmacol 64:167-75. 2013
    ..Interestingly, different cannabinoid receptors were involved in some of the effects. MFF may serve as the basis for a simple preparation of cannabis that would produce beneficial effects in the GI tract with reduced systemic toxicity...
  7. pmc Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy
    John L Wallace
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4K1, Canada
    World J Gastroenterol 19:1861-76. 2013
    ..Novel NSAIDs that do not cause small intestinal damage in animal models offer hope for a solution to this serious adverse effect of one of the most widely used classes of drugs...
  8. ncbi request reprint Citrobacter rodentium infection causes iNOS-independent intestinal epithelial dysfunction in mice
    Andrew C Skinn
    Mucosal Inflammation Research Group and Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Dr NW, Calgary, AB T2N 4N1, Canada
    Can J Physiol Pharmacol 84:1301-12. 2006
    ..Citrobacter rodentium infection causes colonic inflammation, mucosal hyperplasia, and nitric-oxide-independent epithelial dysfunction in association with increased permeability to luminal bacteria...
  9. ncbi request reprint Aspirin, but not NO-releasing aspirin (NCX-4016), interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation
    John L Wallace
    Mucosal Inflammation Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Gastrointest Liver Physiol 286:G76-81. 2004
    ..These studies support the notion that NCX-4016 may be an attractive alternative to aspirin for indications such as cardioprotection, including in individuals also taking selective COX-2 inhibitors...
  10. pmc Gastrointestinal-sparing effects of novel NSAIDs in rats with compromised mucosal defence
    Rory Blackler
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 7:e35196. 2012
    ..Moreover, two novel NSAIDs that release mediators of mucosal defence (hydrogen sulfide and nitric oxide) do not induce significant gastrointestinal damage in these models of impaired mucosal defence...
  11. pmc Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346)
    John L Wallace
    Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Br J Pharmacol 159:1236-46. 2010
    ..We evaluated the gastrointestinal safety and anti-inflammatory efficacy of a novel hydrogen sulphide-releasing derivative of naproxen, ATB-346 [2-(6-methoxy-napthalen-2-yl)-propionic acid 4-thiocarbamoyl-phenyl ester]...
  12. pmc Up-regulation of Annexin-A1 and lipoxin A(4) in individuals with ulcerative colitis may promote mucosal homeostasis
    Linda Vong
    Hospital for Sick Children, Research Institute, Toronto, Ontario, Canada
    PLoS ONE 7:e39244. 2012
    ..To define the contribution of these mediators, we measured their expression in biopsies from individuals with UC...
  13. pmc A role for proteinase-activated receptor-1 in inflammatory bowel diseases
    Nathalie Vergnolle
    Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada
    J Clin Invest 114:1444-56. 2004
    ....
  14. ncbi request reprint Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats
    John L Wallace
    Inflammation Research Network, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Gastroenterology 137:569-78, 578.e1. 2009
    ..The effects of H(2)S during the pathogenesis of colitis have not been established. We analyzed the contribution of H(2)S to inflammation and ulceration of the colon in a rat model of colitis...
  15. ncbi request reprint Mechanisms of nonsteroidal anti-inflammatory drug-induced gastrointestinal injury and repair: a window of opportunity for cyclooxygenase-inhibiting nitric oxide donors
    Rafael Perini
    Mucosal Inflammation Research Group, University of Calgary, Alberta
    Can J Gastroenterol 18:229-36. 2004
    ..Because of their safety profile, CINODs may be particularly useful for long term prevention applications, such as for colon cancer, cardiovascular disease and Alzheimer's disease...
  16. ncbi request reprint Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation
    Renata C O Zanardo
    Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada
    FASEB J 20:2118-20. 2006
    ..These results suggest that endogenous H2S is an important mediator of acute inflammation, acting at the leukocyte-endothelium interface. These findings have important implications for anti-inflammatory drug development...
  17. ncbi request reprint Aspirin-triggered, cyclooxygenase-2-dependent lipoxin synthesis modulates vascular tone
    Pierre Yves von der Weid
    Mucosal Inflammation Research Group, University of Calgary, Calgary, Alberta, Canada
    Circulation 110:1320-5. 2004
    ..In the present study, we have assessed the contribution of ATL to changes in vascular tone induced by aspirin and have examined the role of nitric oxide (NO) as a mediator of such effects...
  18. doi request reprint Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis
    John L Wallace
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 141:1314-22, 1322.e1-5. 2011
    ..However, suppression of gastric acid secretion by PPIs is unlikely to provide any protection against the damage caused by NSAIDs in the more distal small intestine...
  19. ncbi request reprint Lipoxins in gastric mucosal health and disease
    John L Wallace
    Mucosal Inflammation Research Group, Department of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alta, Canada T2N 4N1
    Prostaglandins Leukot Essent Fatty Acids 73:251-5. 2005
    ..These effects may be mediated via lipoxin-induced nitric oxide generation. Lipoxins activate a receptor that can also be activated by annexin-1, another substance involved in resolution of inflammation and gastroprotection...
  20. doi request reprint Annexin-1 modulates repair of gastric mucosal injury
    Gary R Martin
    Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada
    Am J Physiol Gastrointest Liver Physiol 294:G764-9. 2008
    ..These data support the hypothesis that annexin-1 contributes significantly to the process of healing of gastric mucosal damage...
  21. ncbi request reprint A magic bullet for mucosal protection...and aspirin is the trigger!
    John L Wallace
    Department of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Trends Pharmacol Sci 24:323-6. 2003
  22. pmc Predisposition to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2
    Stella R Zamuner
    Mucosal Inflammation Research Group, Department of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Dr NW, Calgary, Alberta, T2N 4N1, and the Division of Gastroenterology, Kelowna General Hospital, British Columbia, Canada
    Am J Pathol 167:1293-300. 2005
    ..PGD2 may therefore represent a rational target for therapies directed at reducing the incidence of colitis-associated colorectal cancer...
  23. ncbi request reprint Enhanced anti-inflammatory potency of a nitric oxide-releasing derivative of flunisolide: role of nuclear factor-kappaB
    John L Wallace
    Mucosal Inflammation Research Group, University of Calgary, 3330 Hospital Dr NW, Calgary, Alberta, T2N 4N1, Canada
    J Pharmacol Exp Ther 310:1096-102. 2004
    ..These studies suggest that NCX-1024 may be an attractive alternative to conventional glucocorticoids, particularly for applications involving topical administration...
  24. ncbi request reprint Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat
    John L Wallace
    Inflammation Research Network, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada
    Gastroenterology 132:261-71. 2007
    ..In this study, we evaluated the gastrointestinal safety and anti-inflammatory effects of a novel "HS-NSAID" (ATB-337) that consists of diclofenac linked to a hydrogen sulfide-releasing moiety...
  25. ncbi request reprint Physiological and pathophysiological roles of hydrogen sulfide in the gastrointestinal tract
    John L Wallace
    Farncombe Family Institute for Digestive Health Research, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Antioxid Redox Signal 12:1125-33. 2010
    ..Recent evidence suggests that these properties of hydrogen sulfide can be exploited in the design of novel therapies for ulcerative and inflammatory diseases of the gastrointestinal tract...
  26. ncbi request reprint Nitric oxide, aspirin-triggered lipoxins and NO-aspirin in gastric protection
    John L Wallace
    Mucosal Inflammation Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada
    Inflamm Allergy Drug Targets 5:133-7. 2006
    ..Lipoxins and nitric oxide are important mediators of mucosal defence in the stomach (and elsewhere in the gastrointestinal tract) and represent attractive therapeutic targets for reducing the incidence of gastric ulceration...
  27. ncbi request reprint NSAID-induced gastrointestinal damage and the design of GI-sparing NSAIDs
    John L Wallace
    University of Calgary, Department of Pharmacology and Therapeutics, Calgary, Alberta T2N 4N1, Canada
    Curr Opin Investig Drugs 9:1151-6. 2008
    ....
  28. ncbi request reprint Gastrointestinal inflammation: a central component of mucosal defense and repair
    Gary R Martin
    Mucosal Inflammation Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Exp Biol Med (Maywood) 231:130-7. 2006
    ..Many of these endogenous factors, or the enzymes involved in their synthesis, are considered potential therapeutic targets for the treatment of diseases of the digestive tract that are characterized by inflammation and ulceration...
  29. pmc A pro-resolution mediator, prostaglandin D(2), is specifically up-regulated in individuals in long-term remission from ulcerative colitis
    Linda Vong
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Proc Natl Acad Sci U S A 107:12023-7. 2010
    ..This is consistent with animal studies showing the importance of PGD(2) in the induction and maintenance of remission from colitis...
  30. doi request reprint Hydrogen sulphide synthesis in the rat and mouse gastrointestinal tract
    Gary R Martin
    Inflammation Research Network, Department of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Dig Liver Dis 42:103-9. 2010
    ..Little is known about H2S synthesis in the gastrointestinal tract. The aim of this study was to characterize H2S synthesis throughout the gastrointestinal tract...
  31. pmc Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets
    Li Ma
    Mucosal Inflammation Research Group and Diabetes Endocrine Research Group, Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Proc Natl Acad Sci U S A 102:216-20. 2005
    ..These protease-activated receptors could therefore play a crucial role in regulating angiogenesis and in turn could regulate the processes of wound healing and tumor growth...
  32. pmc Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis
    Eric Hyun
    Mucosal Inflammation Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Br J Pharmacol 143:618-25. 2004
    ....
  33. pmc Hydrogen sulfide and resolution of acute inflammation: A comparative study utilizing a novel fluorescent probe
    Neil Dufton
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Sci Rep 2:499. 2012
    ..Our report offers an insight into the profile of hydrogen sulfide synthesis during inflammation and highlight opportunities raised by the development of novel fluorescent hydrogen sulfide probes...
  34. ncbi request reprint Hydrogen sulfide enhances ulcer healing in rats
    John L Wallace
    Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada
    FASEB J 21:4070-6. 2007
    ..The results further suggest that drugs releasing hydrogen sulfide could be employed to accelerate healing of gastric ulcers, and possibly of other wounds...
  35. doi request reprint Cyclooxygenase-inhibiting nitric oxide donators for osteoarthritis
    John L Wallace
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada
    Trends Pharmacol Sci 30:112-7. 2009
    ..We provide an outline of the rationale for CINODs and their activity, in addition to an overview of the pre-clinical and clinical profile of the most advanced CINOD, naproxcinod...
  36. ncbi request reprint A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner
    Genevieve K Dudar
    Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada
    Am J Physiol Gastrointest Liver Physiol 295:G374-81. 2008
    ..The effects of the mimetic were independent of stimulatory effects on angiogenesis and COX-2 activity but were dependent on iNOS-derived NO production...
  37. pmc A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis
    Kristina K Hansen
    Proteinases and Inflammation Network, Mucosal Inflammation Research Group, Department of Pharmacology, University of Calgary, Calgary, AB, Canada T2N 4N1
    Proc Natl Acad Sci U S A 102:8363-8. 2005
    ..rodentium-induced inflammation. These data point to an important role for both pathogen-induced host serine proteinases and PAR2 in the setting of infectious colitis...
  38. pmc Platelets accelerate gastric ulcer healing through presentation of vascular endothelial growth factor
    John L Wallace
    Mucosal Inflammation Research Group, University of Calgary, Calgary, Alberta, Canada
    Br J Pharmacol 148:274-8. 2006
    ..However, as intact (rather than lysed) platelets were required for the accelerated healing, the presentation of VEGF by the platelet at the site of injury appears to be crucial for enhancement of the healing process...
  39. ncbi request reprint Mucosal repair and COX-2 inhibition
    Rafael F Perini
    Mucosal Inflammation Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Curr Pharm Des 9:2207-11. 2003
    ..Given the importance of COX-2 in regulating ulcer healing, caution should be taken in the use of selective inhibitors of COX-2 by patients at risk of ulcer disease...
  40. pmc Muc-2-deficient mice display a sex-specific, COX-2-related impairment of gastric mucosal repair
    John L Wallace
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 178:1126-33. 2011
    ..These results demonstrate a marked impairment of gastric mucosal repair in male Muc-2-deficient mice that may be related to an insufficient induction of cyclooxygenase-2, an enzyme known to contribute to mucosal repair...
  41. ncbi request reprint Recent advances in gastric ulcer therapeutics
    John L Wallace
    Department of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
    Curr Opin Pharmacol 5:573-7. 2005
    ..Recent studies support the notion that platelets make a major contribution to ulcer healing, and the release of several key growth factors from platelets appears to be regulated by proteinase-activated receptors...
  42. ncbi request reprint COX-2: a pivotal enzyme in mucosal protection and resolution of inflammation
    John L Wallace
    Inflammation Research Network, Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, T2N 4N1, Canada
    ScientificWorldJournal 6:577-88. 2006
    ..In this review, the roles of COX-2 in mucosal defense and injury are discussed. Furthermore, contributions of COX-2-derived products to the long-term consequences of intestinal inflammation, including cancer, are reviewed...
  43. pmc Commonality of defensive roles of COX-2 in the lung and gut
    John L Wallace
    Department of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Dr NW, Calgary, Alberta, T2N 4N1 Canada
    Am J Pathol 168:1060-3. 2006
  44. pmc Hydrogen sulfide: an endogenous mediator of resolution of inflammation and injury
    John L Wallace
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Antioxid Redox Signal 17:58-67. 2012
    ..Hydrogen sulfide is emerging as an important mediator of many aspects of inflammation, and perhaps most importantly as a factor promoting the resolution of inflammation and repair of injury...
  45. ncbi request reprint Annexin-1 is an endogenous gastroprotective factor against indomethacin-induced damage
    Renata C O Zanardo
    Mucosal Inflammation Research Group, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
    Am J Physiol Gastrointest Liver Physiol 288:G481-6. 2005
    ..We propose that in some circumstances, annexin-1 plays an important role as an endogenous mediator of mucosal defense...
  46. doi request reprint Eukaryotic and prokaryotic contributions to colonic hydrogen sulfide synthesis
    Kyle L Flannigan
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 301:G188-93. 2011
    ..Our results demonstrate that H(2)S production by colonic bacteria does not contribute significantly to what is measured as colonic tissue H(2)S production, using the acetate trapping assay system employed in this study...
  47. ncbi request reprint Nitric oxide as a regulator of inflammatory processes
    John L Wallace
    Mucosal Inflammation Research Group, Department of Pharmacology and Therapeutics, University of Calgary, Alberta T2N 4N1, Canada
    Mem Inst Oswaldo Cruz 100:5-9. 2005
    ..In recent years, NO-releasing drugs have been developed, usually as derivatives of other drugs, which exhibit very powerful anti-inflammatory effects...
  48. ncbi request reprint Gastric tolerability and prolonged prostaglandin inhibition in the brain with a nitric oxide-releasing flurbiprofen derivative, NCX-2216 [3-[4-(2-fluoro-alpha-methyl-[1,1'-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl ester]
    John L Wallace
    Department of Pharmacology and Therapeutics, University of Calgary, Alberta, Canada
    J Pharmacol Exp Ther 309:626-33. 2004
    ..NCX-2216 may represent an attractive alternative to conventional nonsteroidal anti-inflammatory drugs for long-term treatment of a variety of inflammatory disorders, especially those occurring in the central nervous system...
  49. ncbi request reprint Gastritis increases resistance to aspirin-induced mucosal injury via COX-2-mediated lipoxin synthesis
    Marcellus H L P Souza
    Dept of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Am J Physiol Gastrointest Liver Physiol 285:G54-61. 2003
    ..These results support the notion that aspirin-triggered lipoxin synthesis via COX-2 makes an important contribution to mucosal defense in both the normal and inflamed stomach...
  50. ncbi request reprint Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis
    May M Chou
    Department of Biological Sciences, University of Calgary, 2500 University Drive, Calgary, Alberta, Canada, T2N 1N4
    Exp Biol Med (Maywood) 230:255-62. 2005
    ..The benefits of CS and GS in combination are more pronounced than those of CS alone. The reduction of arthritic disease by CS plus GS is associated with a reduction of IL-1beta and MMP-9 synthesis...
  51. ncbi request reprint Roles of platelets and proteinase-activated receptors in gastric ulcer healing
    Rafael Perini
    Mucosal Inflammation Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Dig Dis Sci 50:S12-5. 2005
    ..Taken together, our results suggest that PARs, including those expressed on platelets, are a rational therapeutic target for modulating healing processes and tumor growth...
  52. pmc A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation
    Hashem N Alshurafa
    Department of Medicine, University of Alberta, Edmonton, AB, Canada, T6G 2S2
    BMC Pharmacol 4:12. 2004
    ..Recent evidence also suggests that MC-induced inflammation can be mediated through PAR. Therefore, we hypothesized that specific PAR-2 agonist peptides (PAR-2ap) induce protease release from PMC...
  53. ncbi request reprint Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself?
    John L Wallace
    Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada
    Physiol Rev 88:1547-65. 2008
    ....
  54. pmc Emerging roles for cyclooxygenase-2 in gastrointestinal mucosal defense
    John L Wallace
    Mucosal Inflammation Research Group, University of Calgary, Alberta T2N 4N1, Canada
    Br J Pharmacol 145:275-82. 2005
    ..COX-2 also contributes to long-term changes in GI function after bouts of inflammation...
  55. pmc Enhanced anti-inflammatory potency of a nitric oxide-releasing prednisolone derivative in the rat
    Fusun Turesin
    Mucosal Inflammation Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Br J Pharmacol 139:966-72. 2003
    ..7. These results support the notion that delivery of NO to a site of inflammation can markedly enhance the anti-inflammatory activity of a glucocorticoid...
  56. ncbi request reprint Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism
    Cathy Nguyen
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Can J Physiol Pharmacol 81:920-7. 2003
    ..These results implicate PAR2 as an important mediator of intestinal neurogenic inflammation...
  57. doi request reprint Acetic acid induced ulceration in rats is not affected by infection with Hymenolepis diminuta
    Derek M McKay
    Gastrointestinal Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    J Parasitol 95:481-2. 2009
    ..While the data do not dismiss the possibility that infection with other helminths could be anti-ulcerogenic, they illustrate that 'helminth therapy' for inflammatory disease is likely to be both disease- and helminth-specific...
  58. doi request reprint New pharmacologic therapies in gastrointestinal disease
    John L Wallace
    Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Gastroenterol Clin North Am 39:709-20. 2010
    ..Although advances have been made in understanding gastrointestinal motility, visceral pain, mucosal inflammation, and tissue repair, the major gastrointestinal diseases remain as significant therapeutic challenges...
  59. pmc NSAID gastropathy and enteropathy: distinct pathogenesis likely necessitates distinct prevention strategies
    John L Wallace
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Br J Pharmacol 165:67-74. 2012
    ..The distinct mechanisms of NSAID-induced injury in the stomach/proximal duodenum versus the more distal small intestine likely dictate distinct strategies for prevention...
  60. pmc Acetaminophen hepatotoxicity: NO to the rescue
    John L Wallace
    Department of Pharmacology and Therapeutics, Mucosal Inflammation Research Group, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Br J Pharmacol 143:1-2. 2004
    ..There is also substantial evidence that a NO-releasing derivative of acetaminophen offers several advantages over acetaminophen itself, including enhanced analgesic potency and reduced liver toxicity...
  61. ncbi request reprint Hydrogen sulfide-releasing anti-inflammatory drugs
    John L Wallace
    Inflammation Research Network, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
    Trends Pharmacol Sci 28:501-5. 2007
    ..Such compounds have now been synthesized and shown to be markedly improved in many respects over the parent anti-inflammatory drugs...
  62. pmc Proteinase-activated receptor 1 activation induces epithelial apoptosis and increases intestinal permeability
    Alex C Chin
    Department of Biological Sciences, University of Calgary, Calgary, AB, Canada T2N 1N4
    Proc Natl Acad Sci U S A 100:11104-9. 2003
    ..These results support a role for proteinases and PARs in intestinal disease and provide new directions for possible therapeutic applications of PAR1 antagonists...
  63. ncbi request reprint Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination
    Joseph M Antony
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Nat Neurosci 7:1088-95. 2004
    ..Thus, syncytin's proinflammatory properties in the nervous system demonstrate a novel role for an endogenous retrovirus protein, which may be a target for therapeutic intervention...