Alexander M Walker

..To estimate the rate of new-onset afebrile provoked and unprovoked seizure in a general pediatric population and subgroups of patients with and without psychiatric diagnoses other than attention deficit hyperactivity disorder (ADHD)...

..The literature on the timing of cancer code appearance in general practice records is scanty but suggests that there may be substantial error by comparison with actual dates of clinical onset...

..The Universal Data Warehouse will shortly render moot searches for new databases in which to test...

..The system is potentially much more sensitive to patterns with multiple features than are very large, high-dimension contingency tables...

..The risk of coronary heart disease (CHD) in users of antidiabetic agents must be quantified to permit reasoned therapeutic choices...

..There is conflicting evidence on the reduction of cardiovascular risk in diabetic patients treated with oral antidiabetic agents...

..To refine a preliminary analysis identifying a possibly increased prevalence of malformations among infants born to women exposed to paroxetine in the first trimester...

..To assess the relative incidence of peptic ulcer bleeding and perforation (PUBP) in users of selective cyclooxygenase-2 (COX-2) inhibitors and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs)...

..We sought to quantify the strength of association between exposure to fluoroquinolone antibiotics and the occurrence of ATR, accounting for other risk factors...

..We conducted a study of congenital malformations among infants born to women exposed to bupropion during their first trimester...

..Little attention has been given to how to compare methods in this setting...

..Researchers need to be clear about the population for which an overall treatment estimate is most suitable...

..The purpose of this study was to estimate rates of acute coronary syndrome (ACS), and sudden cardiac death in relation to use of rofecoxib, celecoxib, naproxen, diclofenac, and ibuprofen...

..We conducted a study to assess the risk of GBS after MCV4 vaccination using health plan administrative and claims data together with the review of primary medical records of potential cases...

..Product labeling recommends potassium monitoring in the first month of use for women concurrently receiving medication that may increase serum potassium...

..The purpose of this study was to compare incidence rates of hospitalization associated with rhabdomyolysis, myopathy, renal, or hepatic dysfunction, and of in-hospital death, between initiators of rosuvastatin and other statins...

..Consistent with previous studies, migraineurs in general have an elevated risk of stroke, but not myocardial infarction, compared with nonmigraineurs...

..We sought to quantify the association between tegaserod use and the occurrence of abdominal or pelvic surgery, including cholecystectomy...

..These systems will rely on algorithms to generate alerts about potential safety concerns...

..We also studied whether use of anorexigens and other drugs differed among patients with pulmonary hypertension of different etiologies...

..This study assessed the risk of PTLD in relation to immunosuppression during a period that saw the introduction and eventual market dominance of mycophenolate mofetil (MMF)...

..Nonrheumatic atrial fibrillation (AF) is a common cause of embolic stroke. Warfarin therapy can reduce stroke risk by two-thirds in patients with AF, but therapy may not always be used or always be used optimally...

..This risk was most pronounced in persons with more intense exposure to drugs and appeared to be indistinguishable in users of typical antipsychotics, of atypical products, or of both...

..On June 7, 2002, the Food and Drug Administration approved alosetron for reintroduction in the U.S. market for women with severe diarrhea-related IBS...

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..The resolution for proactive surveillance is sen/cen: high sensitivity to signals and vigorous censoring to filter out the noise...

..0 to 12.9 g/dl. The risk for progression to dialysis was only slightly elevated (7 to 34%) in anemic patients. Anemia raises the risk for cardiovascular disease in patients with elevated serum creatinine...

..Serum low-density lipoprotein levels were reduced by statin therapy, and there were fewer incidents of AMI in statin initiators than in noninitiators...

..Recent data also suggest that other nonsteroidal anti-inflammatory drugs (NSAIDs) may interfere with this benefit of aspirin...

..Studies using a single creatinine measurement have yielded inconsistent results regarding analgesic use and kidney function...

..To measure the association among prescription copayment, drug adherence, and subsequent health outcomes among patients with chronic heart failure (CHF)...

..Complications of influenza are a major cause of morbidity and mortality during the influenza season. Clinical trials of zanamivir have reported a reduced incidence of influenza complications among high-risk patients...

..Inhaled zanamivir is indicated for treatment of uncomplicated acute illness due to influenza A and B viruses in patients aged > or = 12 years who have been symptomatic for no more than 2 days...

..In light of the small hazards and the possibility of residual confounding, these findings should lead to follow-up investigations but not to changes in treatment strategies...

..It remains unclear whether benzodiazepine use increases hip fracture incidence. We studied this relationship in a large cohort, controlling for multiple potential confounders...

..g., smoking and obesity) not captured in claims data in a claims-based cohort study of thromboembolism among matched oral contraceptive (OC) initiators...

..Randomized clinical trials may not accurately predict drug benefit in clinical practice because the patients and conditions of therapy almost always differ between those settings...

..The present study describes the patterns and predictors of treatment persistence and adherence among patients who are diagnosed with glaucoma or as glaucoma suspects (based on claims codes)...

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..This report describes the development and validation of claims-based algorithms to identify colonic ischemia, hospitalized complications of constipation, and irritable bowel syndrome (IBS)...

..In such settings, there will typically be many more variables available for control as potential confounders than traditional epidemiologic techniques will allow...

..We sought to estimate the association between ethinylestradiol/drospirenone and risk of thromboembolism relative to the association among other oral contraceptives...

..Although propensity scores are used increasingly often, their limitations in settings without complete data may not be recognized...

..Aprotinin (Trasylol) is used to mitigate bleeding during coronary-artery bypass grafting (CABG). Accumulating evidence suggests that this practice increases mortality...