Short- and long-term outcome of narrowed saphenous vein bypass graft: a comparison of Palmaz-Schatz stent, directional coronary atherectomy, and balloon angioplastyR Waksman
Andreas Gruentzig Cardiovascular Center, Emory University School of Medicine, Atlanta, USA
Am Heart J 134:274-81. 1997
..Although a larger lumen is obtained with PSS and DCA, patients who underwent balloon angioplasty had similar rates of cardiac events and requirements for additional procedures at follow-up...
- Intracoronary radiation with gamma wire inhibits recurrent in-stent restenosis
R Waksman
Washington Hospital Center, 110 Irving Street North West, Suite 4B 1, Washington, DC 20010, USA
Cardiovasc Radiat Med 2:63-8. 2001
..41.8 mm(2); P=.32). Eight patients had a reduction of neointimal intimal tissue at follow-up. These results indicate that intracoronary gamma radiation with the Angiorad source wire is safe and effective in preventing in-stent restenosis...
- Intracoronary radiation therapy for restenosis prevention: status of the clinical trials
R Waksman
Vascular Brachytherapy Institute, Cardiology Research Foundation, Washington Hospital Center, DC 20010, USA
Cardiovasc Radiat Med 1:20-9. 1999
..This novel approach introduced specific vascular radiation biology and radiation physics aspects, new devices, and platforms to deliver the radiation intraluminally...
- Yttrium-90 delivered via a centering catheter and afterloader, given both before and after stent implantation, inhibits neointima formation in porcine coronary arteries
R Waksman
Cardiovascular Research Institute, Washington Hospital Center, Suite 4B1, 110 Irving Street, NW, Washington, DC 20010, USA
Cardiovasc Radiat Med 2:11-7. 2000
....
- Intravascular radiation therapy after balloon angioplasty of narrowed femoropopliteal arteries to prevent restenosis: results of the PARIS feasibility clinical trial
R Waksman
Cardiovascular Research Institute, Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA
J Vasc Interv Radiol 12:915-21. 2001
..To conduct a feasibility study to assess the feasibility, safety, and outcome of endoluminal gamma radiation therapy after balloon angioplasty of superficial femoral artery (SFA) lesions...
- Late total occlusion after intracoronary brachytherapy for patients with in-stent restenosis
R Waksman
Cardiac Catheterization Laboratories, Washington Hospital Center, DC, USA
J Am Coll Cardiol 36:65-8. 2000
..The study sought to determine the incidence and predictors of late total occlusion (LTO, >30 days) in-patients with in-stent restenosis who were treated with intracoronary radiation...
- Intracoronary radiation for patients with refractory in-stent restenosis: an analysis from the WRIST-Crossover Trial. Washington Radiation for In-stent Restenosis Trial
R Waksman
Cardiovascular Research Institute, Washington Hospital Center, 20010 DC, USA
Cardiovasc Radiat Med 1:317-22. 1999
..In-stent restenosis (ISR) is a limitation of intracoronary stent implantation. In animal models and clinical trials, ionizing radiation has been shown to decrease in-stent neointimal formation...
- Intracoronary beta-radiation therapy inhibits recurrence of in-stent restenosis
R Waksman
Vascular Brachytherapy Institute, Washington Hospital Center, Washington, DC 20010, USA
Circulation 101:1895-8. 2000
..This study, BETA WRIST (Washington Radiation for In-Stent restenosis Trial) was designed to examine the efficacy and safety of the beta-emitter 90-yttrium for the prevention of recurrent ISR...
- Vascular brachytherapy: update on clinical trials
R Waksman
Vascular Brachytherapy Institute, Cardiovascular Research Institute, Washington Cardiology Center, Washington, DC, 20010, USA
J Invasive Cardiol 12:18A-28A. 2000
..These data may give a clue to potential side effects and to the ultimate question: will dose radiation therapy be a standard of care for prevention of restenosis?..
- Response to radiation therapy in animal restenosis models
R Waksman
Cardiology Research Foundation, Washington Hospital Center, Washington, DC 20010, USA
Semin Interv Cardiol 2:95-101. 1997
..These studies which were pioneered in this new field and have facilitated the clinical trials of using radiotherapy for prevention of restenosis are reviewed and discussed in this paper...
- Prolonged antiplatelet therapy to prevent late thrombosis after intracoronary gamma-radiation in patients with in-stent restenosis: Washington Radiation for In-Stent Restenosis Trial plus 6 months of clopidogrel (WRIST PLUS)
R Waksman
Washington Hospital Center, Washington, DC, USA
Circulation 103:2332-5. 2001
..Methods and..
- Intracoronary brachytherapy in the Cath Lab. Physics dosimetry, technology and safety considerations
R Waksman
Department of Medicine Cardiology, Washington Hospital Center, Washington DC, USA
Herz 23:401-6. 1998
..These and other issues related to this new exciting field are discussed...
- Late thrombosis following intracoronary brachytherapy
R Waksman
Vascular Brachytherapy Institute, Cardiovascular Research Institute, Washington Cardiology Center, Washington, D C, USA
Catheter Cardiovasc Interv 49:344-7. 2000
..Angiographic study demonstrated late thrombosis, which were treated successfully with the Angiojet thrombectomy device...
- Serial intravascular ultrasound assessment of the efficacy of intracoronary gamma-radiation therapy for preventing recurrence in very long, diffuse, in-stent restenosis lesions
J M Ahmed
Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
Circulation 104:856-9. 2001
..005 for all comparisons). CONCLUSIONS:- Serial IVUS analysis shows that gamma-irradiation reduces recurrent in-stent neointimal hyperplasia in long, diffuse ISR lesions; however, it is even more effective when given at a higher dose...
- A novel 32P deployable balloon system inhibits formation of neointima in porcine coronary arteries after balloon-overstretching injury
H S Kim
Cardiovascular Research Institute, Washington Hospital Center, DC 20010, USA
Coron Artery Dis 12:317-22. 2001
..01). CONCLUSIONS: Intracoronary radiation therapy using a new 32P deployable-balloon system is feasible and safe. A radiation dose of 15 Gy was sufficient to inhibit neointimal response in the porcine coronary-balloon-injury model...
- Serial intravascular ultrasound analysis of edge recurrence after intracoronary gamma radiation treatment of native artery in-stent restenosis lesions
J M Ahmed
Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories Washington Hospital Center, Washington, DC, USA
Am J Cardiol 87:1145-9. 2001
..Thus, edge recurrence after (192)Ir treatment of in-stent restenosis is the result of neointimal hyperplasia (part of generalized treatment failure) and the absence of radiation-induced positive remodeling...
- Acute renal failure requiring dialysis after percutaneous coronary interventions
L Gruberg
Division of Cardiology, Washington Hospital Center, Washington, D C 20010, USA
Catheter Cardiovasc Interv 52:409-16. 2001
..Thus, acute renal failure that requires dialysis after percutaneous coronary interventions is associated with very high in-hospital and 1-year mortality rates and a dramatic increase in hospital resource utilization...
- Comparative efficacy of gamma-irradiation for treatment of in-stent restenosis in saphenous vein graft versus native coronary artery in-stent restenosis: An intravascular ultrasound study
M T Castagna
Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Cardiovascular Research Institute, Washington Hospital Center, Washington, DC, USA
Circulation 104:3020-2. 2001
..1+/-2.1 mm(2) versus 5.6+/-2.2 mm(2), P=0.0067). CONCLUSION: gamma-Irradiation with (192)Ir brachytherapy appears to be as effective in SVGs as it is in native artery ISR lesions...
- Edge stenosis and geographical miss following intracoronary gamma radiation therapy for in-stent restenosis
H S Kim
Cardiovascular Research Institute, Washington Hospital Center, DC, USA
J Am Coll Cardiol 37:1026-30. 2001
..016). CONCLUSIONS: Edge restenosis following gamma irradiation treatment of ISR is related to GM: a mismatch between the segment of artery injured during the primary catheter-based intervention and the length of the radiation source...
- Creatine kinase-MB fraction elevation after percutaneous coronary intervention in patients with chronic renal failure
L Gruberg
Cardiac Catheterization Laboratory, Washington Hospital Center, Washington, DC 20010, USA
Am J Cardiol 87:1356-60. 2001
....
- The effect of intracoronary radiation for the treatment of recurrent in-stent restenosis in patients with chronic renal failure
L Gruberg
Washington Hospital Center, Washington, DC 20010, USA
J Am Coll Cardiol 38:1049-53. 2001
..Despite this benefit, patients with renal dysfunction continued to have significantly higher in-hospital and six-month adverse outcomes...
- Intravascular ultrasound assessment of the stenoses location and morphology in the left main coronary artery in relation to anatomic left main length
A Maehara
Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
Am J Cardiol 88:1-4. 2001
..Most ostial left main stenoses were categorized as eccentric (97% vs 76%, p = 0.01). Short and long left main arteries develop stenoses at different locations. Stenosis morphology was significantly different in these 2 locations...
- Excimer laser coronary angioplasty and intracoronary radiation for in-stent restenosis: six-month angiographic and clinical outcomes
A E Ajani
Catheterization Laboratories, Washington Hospital Center, Suite 4B-1, 110 Irving Street Northwest, Washington, DC 20010, USA
Cardiovasc Radiat Med 2:191-6. 2001
..54%, P=.014). CONCLUSION: Radiation therapy with ELCA significantly reduces angiographic binary restenosis at 6 months in patients with diffuse ISR, driven predominantly by reduced percutaneous TVR...
- Treatment of in-stent restenosis
G S Mintz
Intravascular Ultrasound Imaging Laboratory, Washington Hospital Center, Washington, DC, USA
Semin Interv Cardiol 3:117-21. 1998
..Vascular brachytherapy has emerged as the most promising way to treat high-risk lesion subsets...
- Serial intravascular ultrasound analysis of the impact of lesion length on the efficacy of intracoronary gamma-irradiation for preventing recurrent in-stent restenosis
J M Ahmed
Cardiovascular Research Institute, Washington Hospital Center, Washington, DC, USA
Circulation 103:188-91. 2001
..378, P:<0.0001). CONCLUSIONS: Brachytherapy may be less effective in longer ISR lesions because of the greater variability and longer source-to-target distances in diffuse ISR...
- Differential remodeling after balloon overstretch injury and either beta- or gamma-intracoronary radiation of porcine coronary arteries
Y Cottin
Cardiovascular Research Institute, Washington Hospital Center, 110 Irving Street, NW Suite 4B-1, Washington, DC 20010, USA
Cardiovasc Radiat Med 2:75-82. 2001
..These changes in adventitia and neointima appear to contribute to differential vascular remodeling caused by IR in injured vessels...
- An intravascular ultrasound classification of angiographic coronary artery aneurysms
A Maehara
Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Cardiovascular Research Institute, Washington Hospital Center, Washington, DC, USA
Am J Cardiol 88:365-70. 2001
..Instead, most angiographically diagnosed aneurysms had the morphology of complex plaques or normal segments with adjacent stenoses...
- Three-year follow-up after intracoronary gamma radiation therapy for in-stent restenosis. Original WRIST. Washington Radiation for In-Stent Restenosis Trial
A E Ajani
Washington Hospital Center and Washington Cancer Institute at the Washington Hospital Center, Washington, DC 20010, USA
Cardiovasc Radiat Med 2:200-4. 2001
..65%, P=.003). CONCLUSIONS: In WRIST, patients with ISR treated with IRT using 192Ir had a marked reduction in the need for repeat target lesion and vessel revascularization at 6 months, with the clinical benefit maintained at 3 years...
- Decreased adventitial neovascularization after intracoronary irradiation in swine: a time course study
M Kollum
Cardiovascular Research Institute, Washington Hospital Center, Washington, DC, USA
Int J Radiat Oncol Biol Phys 50:1033-9. 2001
..Intimal area and adventitial vessel count were correlated positively. Neointima reduction after intracoronary radiation may depend not only on an antiproliferative effect but also on an anti-angiogenic effect...
- Delayed re-endothelialization and T-cell infiltration following intracoronary radiation therapy in the porcine model
M Kollum
Cardiovascular Research Institute, Washington, DC, USA
Int J Radiat Oncol Biol Phys 50:495-501. 2001
..The elevated apoptosis of these infiltrating T cells may indicate a mechanism for the resolution of inflammation...
- Prognostic value of cardiac troponin I re-elevation following percutaneous coronary intervention in high-risk patients with acute coronary syndromes
S Fuchs
Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
Am J Cardiol 88:129-33. 2001
..We conclude that troponin I re-elevation after percutaneous coronary intervention in high-risk patients with ACS is associated with a substantial increase in mortality and reduced event-free survival at 6-month follow-up...
- Management of severely calcified right coronary artery
R Lew
Washington Hospital Center, Washington, DC, USA
Cardiovasc Radiat Med 4:116-7. 2003
- Clinical outcomes of compromised side branch (stent jail) after coronary stenting with the NIR stent
B Bhargava
Cardiac Catheterization Laboratory, Division of Cardiology, Washington Hospital Center, Washington, DC, USA
Catheter Cardiovasc Interv 54:295-300. 2001
..However, with the NIR stent, side-branch compromise or occlusion does not influence late (6 month) major adverse events, including death, myocardial infarction, or need for repeat revascularization...
- Effects of 32P radioactive stents on in-stent restenosis in a double stent injury model of the porcine coronary arteries
H S Kim
Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
Int J Radiat Oncol Biol Phys 51:1058-63. 2001
..CONCLUSIONS: 32P radioactive stents may be safe and effective in reducing neointimal formation leading to in-stent restenosis. Longer follow-up will be required to examine whether these positive findings can be maintained...
- Clinical trials of vascular brachytherapy for in-stent restenosis: update
A E Ajani
Experimental Angioplasty and Vascular Brachytherapy, Cardiovascular Research Institute, 110 Irving Street, Northwest, Suite 4B-1, Washington, DC 20010, USA
Cardiovasc Radiat Med 2:107-13. 2001
..This review provides an update of the current status of clinical trials utilizing vascular brachytherapy to prevent the recurrence of in-stent restenosis...
- Novel approaches for the prevention of restenosis
L Gruberg
Cardiac Catheterization Laboratory, Washington Hospital Center, Washington, DC, USA
Expert Opin Investig Drugs 9:2555-78. 2000
..Due to the vast literature on the subject, this review will focus mainly on clinical trials that show the most promise and will highlight those that warrant further investigation...
- Effect of intracoronary gamma-radiation therapy on in-stent restenosis: An intravascular ultrasound analysis from the gamma-1 study
G S Mintz
Intravascular Ultrasound Imaging Laboratory, Washington Hospital Center, Washington, DC, USA
Circulation 102:2915-8. 2000
..The aim of this study was to use serial volumetric intravascular ultrasound to evaluate the effect of gamma-radiation on recurrent in-stent restenosis...
- Perfusion of the left arm via a LIMA graft
R Lew
Washington Hospital Center, 110 Irving Street, NW, Washington, DC 20010, USA
Cardiovasc Radiat Med 3:263. 2002
Intracoronary photodynamic therapy reduces neointimal growth without suppressing re-endothelialisation in a porcine modelR Waksman
Division of Cardiology, Washington Hospital Center, Washington, DC, USA
Heart 92:1138-44. 2006
..To examine the effects of intracoronary PhotoPoint photodynamic therapy (PDT) with a new photosensitiser, MV0611, in the overstretch balloon and stent porcine models of restenosis...
- Progress in clinical trials for coronary arterial restenosis using beta radiation sources
R Waksman
Experimental Angioplasty and Cardiovascular Brachytherapy Program, Washington Hospital Center, DC 20010, USA
Cardiovasc Radiat Med 1:220-6. 1999
..This article updates the current status of clinical trials in vascular brachytherapy utilizing beta emitters, highlighting preliminary results and assessing their implications for the development of this field...
- Intravascular radiation for the prevention of recurrence of restenosis in coronary arteries
L Gruberg
Cardiac Catheterization Laboratory, Cardiovascular Research Institute, Washington Hospital Center, 110 Irving St, NW, Suite 4B 1, Washington, DC 20010, USA
Expert Opin Investig Drugs 10:891-907. 2001
..It is clear that there are still on-going concerns that will eventually be clarified when the long-term results from ongoing clinical trials around the world become available...
- Intravascular radiation accelerates atherosclerotic lesion formation of hypercholesteremic rabbits
Y Cottin
MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA
Cardiovasc Radiat Med 2:231-40. 2001
..Special care should be taken to minimize radiation exposure in normal vascular segments in hypercholesterolemic patients undergoing radiation therapy...
- Have we solved the problem of late thrombosis?
A E Ajani
Cardiovascular Research Institute, Washington Hospital Center, Washington DC, USA
Minerva Cardioangiol 50:463-8. 2002
..Although we have gained a greater understanding of this complex entity, further research is required to curtail late thrombosis rates...
- Endovascular beta-radiation to reduce restenosis after coronary balloon angioplasty: results of the beta energy restenosis trial (BERT)
S B King
Andreas Gruentzig Cardiovascular Center, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA
Circulation 97:2025-30. 1998
..This study was designed to evaluate the feasibility of the delivery of 12, 14, or 16 Gy at 2 mm after balloon angioplasty of stenoses of native coronary vessels...
- Saphenous vein graft interventions: strategies and devices to minimize distal embolization
M A Gaglia
Department of Cardiology, Washington Hospital Center, Washington, DC, USA
Minerva Cardioangiol 60:157-66. 2012
....
- Severe acute coronary spasm following intracoronary radiation for in-stent restenosis: a case report
L Gruberg
Cardiac Catheterization Laboratory, Washington Hospital Center, Washington, DC 20010, USA
Cardiovasc Radiat Med 2:138-42. 2001
....
Emergence of the concept of platelet reactivity monitoring of response to thienopyridinesL Bonello
Washington Hospital Center, 110 Irving Street, NW, Suite 4B 1, Washington, DC 20010, USA
Heart 95:1214-9. 2009
..This review aims to present the emergence of the concept of PR monitoring in patients undergoing PCI following recent advances in this field...
- A critical appraisal of the safety and efficacy of drug-eluting stents
G Maluenda
Division of Cardiology, Washington Hospital Center, Washington, DC, USA
Clin Pharmacol Ther 85:474-80. 2009
..In this review we provide a critical appraisal, based on published clinical data, of the safety and efficacy of various DESs...
- Intracoronary beta radiation: state of the art
A E Ajani
Vascular Brachytherapy Institute, Cardiology Research Institute, Washington Cardiology Center, Washington, DC, USA
J Interv Cardiol 14:601-9. 2001
..Vascular brachytherapy requires additional "fine-tuning" to achieve full optimization...
- How to approach drug-eluting stent restenosis
P Roy
Division of Cardiology, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010, USA
Minerva Cardioangiol 54:571-6. 2006
..Evidence from randomized controlled trials and large registries is required to establish a formal treatment approach. We provide guidelines based on current available evidence...
- Intravascular ultrasound guidance in drug-eluting stent deployment
P Roy
Division of Cardiology, Washington Hospital Center, Washington, DC 20010, USA
Minerva Cardioangiol 56:67-77. 2008
..The Authors provide a review of the currently available evidence pertaining to the potential clinical benefit of IVUS guidance in DES implantation...
- Percutaneous revascularization in women with coronary artery disease: we've come so far, yet have so far to go
S D Collins
Department of Internal Medicine, Division of Cardiology, Washington Hospital Center, Washington, DC, United States
Nutr Metab Cardiovasc Dis 20:436-44. 2010
..Women with CAD have symptoms that differ from men with CAD. Improved understanding of the symptoms of CAD in women by patients and health care providers may improve treatment and outcomes in women with CAD...
- Evolution of percutaneous balloon aortic valvuloplasty in the treatment of patients with aortic stenosis
L K Pendyala
Interventional Cardiology, Medstar Washington Hospital Center, Washington, DC, USA
Minerva Med 103:415-29. 2012
..BAV can be used as a selection tool to determine if the patient will benefit from valve replacement if they have other comorbidities, such as severe pulmonary hypertension, severe lung disease, very poor ejection fraction, or frailty...
- Persistent right to left shunt post PFO closure for recurrent CVAs
R Lew
Washington Hospital Center, DC 20010, USA
Cardiovasc Radiat Med 4:51. 2003
