Kristiina Vuori

Summary

Publications

  1. pmc Novel HTS strategy identifies TRAIL-sensitizing compounds acting specifically through the caspase-8 apoptotic axis
    Darren Finlay
    Cancer Center, Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
    PLoS ONE 5:e13375. 2010
  2. doi Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs
    Darren Finlay
    Corresponding Author Kristiina Vuori, Cancer Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037
    Mol Cancer Ther 13:5-15. 2014
  3. pmc The docking protein p130Cas regulates cell sensitivity to proteasome inhibition
    Ming Zhao
    Cancer Center, Sanford Burnham Medical Research Institute, 10901 N, Torrey Pines Road, La Jolla, CA 92037, USA
    BMC Biol 9:73. 2011
  4. ncbi The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle
    Klára Briknarová
    Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 280:21908-14. 2005
  5. pmc Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP
    Robert J Ardecky
    Program in Apoptosis and Cell Death, NCI Designated Cancer Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 23:4253-7. 2013
  6. pmc Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs)
    Lakshmanane Premkumar
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Biol Chem 285:13211-22. 2010
  7. doi Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP
    Mitchell Vamos
    Program in Apoptosis and Cell Death and NCI Designated Cancer Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    ACS Chem Biol 8:725-32. 2013
  8. pmc Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines
    Angel Cipres
    Cancer Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, La Jolla, California, USA
    ACS Chem Biol 5:195-202. 2010
  9. ncbi Molecular basis for regulation of Src by the docking protein p130Cas
    Fariborz Nasertorabi
    Cancer Center, The Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Mol Recognit 19:30-8. 2006
  10. pmc Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP
    Marcos González-López
    Cancer Research Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 21:4332-6. 2011

Collaborators

  • Kathryn R Ely
  • John C Reed
  • Jean Francois Cote
  • Tomas Mustelin
  • Klára Briknarová
  • Lutz Tautz
  • Ming Zhao
  • Sheng Li
  • Garth Powis
  • Ke Li
  • Kaspars Tars
  • Jing Yuan
  • Jie Wu
  • Robert T Abraham
  • Maurizio Pellecchia
  • Nicholas D P Cosford
  • Jason A Bush
  • Gen Sheng Feng
  • Darren Finlay
  • Robert J Ardecky
  • Santhi Reddy Ganji
  • Kate Welsh
  • Fariborz Nasertorabi
  • Marcos González-López
  • Angel Cipres
  • Mitchell Vamos
  • Peter D Mace
  • Stefan J Riedl
  • Amy L Howes
  • Pooi San Lee
  • Ying Su
  • Hongbin Yuan
  • Lakshmanane Premkumar
  • Jesus Vazquez
  • Celine Derunes
  • Kathleen Becherer
  • Lars Liljas
  • Elena B Pasquale
  • Nathaly Marcoux
  • Monique Dail
  • Yingqing Sun
  • Trina R Cooley
  • Curt T Hauser
  • Monica L Gonzalez
  • Guy S Salvesen
  • Palaniyandi Ravanan
  • Scott J Snipas
  • Peter Teriete
  • Daniel P O'Malley
  • Robyn D Richardson
  • Boguslaw Stec
  • Phil S Baran
  • Andrey A Bobkov
  • Manishha Patel
  • Robert C Liddington
  • Lukasz Jaroszewski
  • Laurie A Bankston
  • Lisa K Landberg
  • Amy Howes
  • Jennifer J Ryan
  • Gary G Chiang
  • Caroline B Ho
  • Elizabeth S Lang
  • Yama A Abassi
  • Robert Kellerer
  • Chris R Gessner
  • Ramadurgam Kodandapani
  • Rosemary Burgess
  • Virgil L Woods
  • Emilio Iraheta
  • Krissi Hewitt
  • Scott W Rogers
  • Andres Alonso
  • Marnie L Havert
  • Jaime A Seddon
  • Miguel Garcia-Guzman
  • Matthew S Kalo
  • Elise Larsen
  • Zhongqing Shi
  • Houqi Liu
  • Kelly Baker

Detail Information

Publications22

  1. pmc Novel HTS strategy identifies TRAIL-sensitizing compounds acting specifically through the caspase-8 apoptotic axis
    Darren Finlay
    Cancer Center, Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
    PLoS ONE 5:e13375. 2010
    ..This screen was performed in the 384-well format, but could easily be further miniaturized, allows easy identification of artifactual false positives, and is highly scalable to accommodate diverse libraries...
  2. doi Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs
    Darren Finlay
    Corresponding Author Kristiina Vuori, Cancer Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037
    Mol Cancer Ther 13:5-15. 2014
    ..Our studies thus describe valuable compounds that allow elucidation of the signaling events occurring in TRAIL resistance, and demonstrate that these agents act as potent TRAIL-sensitizing agents in a variety of cancer cell lines...
  3. pmc The docking protein p130Cas regulates cell sensitivity to proteasome inhibition
    Ming Zhao
    Cancer Center, Sanford Burnham Medical Research Institute, 10901 N, Torrey Pines Road, La Jolla, CA 92037, USA
    BMC Biol 9:73. 2011
    ..Here, we have studied the putative role of Cas in regulating cell survival and death pathways upon proteasome inhibition...
  4. ncbi The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle
    Klára Briknarová
    Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 280:21908-14. 2005
    ..Mapping the degree of amino acid conservation onto the molecular surface reveals a patch of invariant residues near the C terminus of the bundle, which may represent a previously unidentified site for protein interaction...
  5. pmc Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP
    Robert J Ardecky
    Program in Apoptosis and Cell Death, NCI Designated Cancer Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 23:4253-7. 2013
    ..The potent and highly selective IAP antagonist 8q (ML183) sensitized TRAIL-resistant prostate cancer cells to apoptotic cell death, highlighting the merit of this probe compound as a valuable tool to investigate the biology of XIAP. ..
  6. pmc Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs)
    Lakshmanane Premkumar
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Biol Chem 285:13211-22. 2010
    ....
  7. doi Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP
    Mitchell Vamos
    Program in Apoptosis and Cell Death and NCI Designated Cancer Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    ACS Chem Biol 8:725-32. 2013
    ..Furthermore, computational modeling was performed, revealing key contacts between the IAP proteins and antagonists, suggesting a structural basis for the observed potency...
  8. pmc Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines
    Angel Cipres
    Cancer Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, La Jolla, California, USA
    ACS Chem Biol 5:195-202. 2010
    ....
  9. ncbi Molecular basis for regulation of Src by the docking protein p130Cas
    Fariborz Nasertorabi
    Cancer Center, The Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Mol Recognit 19:30-8. 2006
    ....
  10. pmc Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP
    Marcos González-López
    Cancer Research Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 21:4332-6. 2011
    ..Compounds 9h and 9j sensitized TRAIL-resistant breast cancer cells to apoptotic cell death, highlighting the value of these probe compounds as tools to investigate the biology of XIAP...
  11. pmc Critical role for caspase-8 in epidermal growth factor signaling
    Darren Finlay
    Cancer Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Cancer Res 69:5023-9. 2009
    ..As the EGF/Src pathway activity has been shown to promote oncogenic events, our findings that caspase-8 is necessary for these activities may help explain why it is rarely deleted or silenced in tumors...
  12. pmc A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling
    Jean Francois Cote
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Cell Biol 7:797-807. 2005
    ..These results demonstrate that DOCK180, via its DHR-1 and DHR-2 domains, couples PtdIns(3,4,5)P(3) signalling to Rac GTP-loading, which is essential for directional cell movement...
  13. pmc Crystallization of the SH2-binding site of p130Cas in complex with Lck, a Src-family kinase
    Fariborz Nasertorabi
    Cancer Center, The Burnham Institute, La Jolla, CA 92037, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:174-7. 2005
    ..The crystals formed at 295 K in space group P2(1)2(1)2(1), with unit-cell parameters a = 77.4, b = 107.3, c = 166.4 A, and diffract to 2.7 A resolution...
  14. ncbi Molecular determinants for interaction of SHEP1 with Cas localize to a highly solvent-protected region in the complex
    Celine Derunes
    Cancer Center, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    FEBS Lett 580:175-8. 2006
    ..This region is predominately hydrophilic, yet remains protected from solvent in the complex...
  15. ncbi EGF receptor activity is essential for adhesion-induced stress fiber formation and cofilin phosphorylation
    Nathaly Marcoux
    Cancer Center, The Burnham Institute, La Jolla, CA 92037, USA
    Cell Signal 17:1449-55. 2005
    ..These studies demonstrate adhesion-dependent regulation of cofilin phosphorylation, and identify a novel role for EGFR in integrin signaling...
  16. ncbi Novel noncatalytic role for caspase-8 in promoting SRC-mediated adhesion and Erk signaling in neuroblastoma cells
    Darren Finlay
    Cancer Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Cancer Res 67:11704-11. 2007
    ..This protein complex association of caspase-8 and Src, and concomitant downstream signaling events, may help reconcile why a potential tumor suppressor such as caspase-8 is rarely absent in cancers...
  17. ncbi Organization of functional domains in the docking protein p130Cas
    Fariborz Nasertorabi
    Cancer Center, The Burnham Institute, La Jolla, CA 92037, USA
    Biochem Biophys Res Commun 324:993-8. 2004
    ..The protein products are soluble, homogeneous, monodisperse, and highly suitable for structural studies to define the role of Cas in integrin-mediated cell signaling...
  18. ncbi The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures
    Amy L Howes
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cancer Ther 6:2505-14. 2007
    ..In addition, we propose that the use of three-dimensional tumor models is more predictive of in vivo growth inhibition by PI3K inhibitors in cancer cell lines lacking phosphatase and tensin homologue activity or expression...
  19. ncbi Abl functions as a negative regulator of Met-induced cell motility via phosphorylation of the adapter protein CrkII
    Angel Cipres
    Cancer Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, La Jolla, CA, USA
    Cell Signal 19:1662-70. 2007
    ..Taken together, these results demonstrate that the Abl tyrosine kinase functions as a negative regulator of Met-induced cell migration, and that it does so by inducing CrkII phosphorylation at the site Y221...
  20. pmc Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors
    Jesus Vazquez
    Inflammation and Infectious Disease Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 50:2137-43. 2007
    ..Our data demonstrate the value of the derived chemical probes for NMR-based second-site screening in PTPs...
  21. ncbi SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases
    Monique Dail
    The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 279:41892-902. 2004
    ..Furthermore, the SHEP1-Cas complex may have different roles downstream of EphB2 and the EGF receptor...
  22. pmc Role of Gab1 in UV-induced c-Jun NH2-terminal kinase activation and cell apoptosis
    Yingqing Sun
    Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    Mol Cell Biol 24:1531-9. 2004
    ..In aggregate, these observations identify a new function of Gab1 in the response of mammalian cells to UV light...