Bernard Vrijens

Summary

Publications

  1. pmc Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants
    Marc Twagirumukiza
    Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
    Malar J 9:206. 2010
  2. pmc Adherence to prescribed antihypertensive drug treatments: longitudinal study of electronically compiled dosing histories
    Bernard Vrijens
    Pharmionic Research Center, Rue des Cyclistes Frontière 24, 4600 Visé, Belgium
    BMJ 336:1114-7. 2008
  3. ncbi request reprint Effect of intervention through a pharmaceutical care program on patient adherence with prescribed once-daily atorvastatin
    Bernard Vrijens
    AARDEX Ltd, Rue des Cyclistes Frontière 24, Visé, Belgium
    Pharmacoepidemiol Drug Saf 15:115-21. 2006
  4. doi request reprint Analysis and interpretation of 24-h blood pressure profiles: appropriate mathematical models may yield deeper understanding
    Gianfranco Parati
    Am J Hypertens 21:123-5; discussion 127-9. 2008
  5. pmc Adherence to HAART therapy measured by electronic monitoring in newly diagnosed HIV patients in Botswana
    Reinout Vriesendorp
    Centre for Human Drug Research, Department of Clinical Pharmacology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Clin Pharmacol 63:1115-21. 2007
  6. ncbi request reprint Estimation of the comparative therapeutic superiority of QD and BID dosing regimens, based on integrated analysis of dosing history data and pharmacokinetics
    Laetitia Comte
    Department of Mathematics, University of Liege, B37, 12, Grande Traverse, Liege 4000, Belgium
    J Pharmacokinet Pharmacodyn 34:549-58. 2007
  7. ncbi request reprint Effect of monitoring bone turnover markers on persistence with risedronate treatment of postmenopausal osteoporosis
    Pierre D Delmas
    Institut National de la Santé et de la Recherche Médicale Research Unit 403 and University Claude Bernard, Hopital Edouard Herriot, Pavillon F, 69437 Lyon Cedex 03, France
    J Clin Endocrinol Metab 92:1296-304. 2007
  8. ncbi request reprint 'Hedged' prescribing for partially compliant patients
    John Urquhart
    AARDEX Ltd, Zug, Switzerland
    Clin Pharmacokinet 45:105-8. 2006
  9. ncbi request reprint Modelling the association between adherence and viral load in HIV-infected patients
    Bernard Vrijens
    Department of Applied Mathematics and Computer Science, University of Ghent, Belgium
    Stat Med 24:2719-31. 2005
  10. ncbi request reprint Successful projection of the time course of drug concentration in plasma during a 1-year period from electronically compiled dosing-time data used as input to individually parameterized pharmacokinetic models
    Bernard Vrijens
    AARDEX Ltd, Rue des Cyclistes Frontière, 24, B 4600 Visé, Belgium
    J Clin Pharmacol 45:461-7. 2005

Collaborators

Detail Information

Publications13

  1. pmc Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants
    Marc Twagirumukiza
    Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
    Malar J 9:206. 2010
    ..To compare three methods for evaluating treatment adherence in a 7-day controlled treatment period for malaria in children in Rwanda...
  2. pmc Adherence to prescribed antihypertensive drug treatments: longitudinal study of electronically compiled dosing histories
    Bernard Vrijens
    Pharmionic Research Center, Rue des Cyclistes Frontière 24, 4600 Visé, Belgium
    BMJ 336:1114-7. 2008
    ..To describe characteristics of dosing history in patients prescribed a once a day antihypertensive medication...
  3. ncbi request reprint Effect of intervention through a pharmaceutical care program on patient adherence with prescribed once-daily atorvastatin
    Bernard Vrijens
    AARDEX Ltd, Rue des Cyclistes Frontière 24, Visé, Belgium
    Pharmacoepidemiol Drug Saf 15:115-21. 2006
    ..The objective of this study was to estimate the effect of a pharmaceutical care program on the adherence of once-daily atorvastatin treatment in patients with elevated cholesterol levels...
  4. doi request reprint Analysis and interpretation of 24-h blood pressure profiles: appropriate mathematical models may yield deeper understanding
    Gianfranco Parati
    Am J Hypertens 21:123-5; discussion 127-9. 2008
  5. pmc Adherence to HAART therapy measured by electronic monitoring in newly diagnosed HIV patients in Botswana
    Reinout Vriesendorp
    Centre for Human Drug Research, Department of Clinical Pharmacology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Clin Pharmacol 63:1115-21. 2007
    ....
  6. ncbi request reprint Estimation of the comparative therapeutic superiority of QD and BID dosing regimens, based on integrated analysis of dosing history data and pharmacokinetics
    Laetitia Comte
    Department of Mathematics, University of Liege, B37, 12, Grande Traverse, Liege 4000, Belgium
    J Pharmacokinet Pharmacodyn 34:549-58. 2007
    ..When applied to HIV protease inhibitors, a twice-daily regimen appears to be better than an once-daily regimen in maintaining therapeutically effective drug actions...
  7. ncbi request reprint Effect of monitoring bone turnover markers on persistence with risedronate treatment of postmenopausal osteoporosis
    Pierre D Delmas
    Institut National de la Santé et de la Recherche Médicale Research Unit 403 and University Claude Bernard, Hopital Edouard Herriot, Pavillon F, 69437 Lyon Cedex 03, France
    J Clin Endocrinol Metab 92:1296-304. 2007
    ..Persistence with osteoporosis treatment is poor but is important for maximum benefit...
  8. ncbi request reprint 'Hedged' prescribing for partially compliant patients
    John Urquhart
    AARDEX Ltd, Zug, Switzerland
    Clin Pharmacokinet 45:105-8. 2006
  9. ncbi request reprint Modelling the association between adherence and viral load in HIV-infected patients
    Bernard Vrijens
    Department of Applied Mathematics and Computer Science, University of Ghent, Belgium
    Stat Med 24:2719-31. 2005
    ..The approach is applied to a clinical trial involving 35 patients who were followed over 12 months. Results demonstrate a significant relation between patient adherence and virologic response...
  10. ncbi request reprint Successful projection of the time course of drug concentration in plasma during a 1-year period from electronically compiled dosing-time data used as input to individually parameterized pharmacokinetic models
    Bernard Vrijens
    AARDEX Ltd, Rue des Cyclistes Frontière, 24, B 4600 Visé, Belgium
    J Clin Pharmacol 45:461-7. 2005
    ..This strategy may provide a basis for greatly increasing the informational yield and utility of conventional therapeutic drug monitoring...
  11. ncbi request reprint Patient adherence to prescribed antimicrobial drug dosing regimens
    Bernard Vrijens
    AARDEX Ltd, Zug, Switzerland
    J Antimicrob Chemother 55:616-27. 2005
    ..It is also the basis for sound, measurement-guided steps taken to improve a patient's execution of a prescribed dosing regimen...
  12. ncbi request reprint The odds that clinically unrecognized poor or partial adherence confuses population pharmacokinetic/pharmacodynamic analyses
    Bernard Vrijens
    AARDEX Ltd, Zug, Switzerland
    Basic Clin Pharmacol Toxicol 96:225-7. 2005
    ..With the broadening use of electronic monitoring to estimate longitudinal drug exposure, the need exists for an explicit discipline that concerns itself with "what the patient does with the drug". It is called Pharmionics...
  13. ncbi request reprint Electronic monitoring of variation in drug intakes can reduce bias and improve precision in pharmacokinetic/pharmacodynamic population studies
    Bernard Vrijens
    Department of Applied Mathematics and Computer Science, Ghent University, Belgium
    Stat Med 23:531-44. 2004
    ..We conclude that estimators of PK/PD parameters can benefit greatly from information that enters through greater variation in the drug exposure process...