Flow and conduit formation in the external fluid-transport system of a suspension feederMichelangelo von Dassow
Department of Integrative Biology, University of California, Berkeley, 3060 VLSB 3140, CA 94720 3140, USA
J Exp Biol 208:2931-8. 2005
..Together, the results suggest that there is a strong correlation between growth and flow in this external fluid-transport system, with new chimneys forming at sites of high flow...
- Function-dependent development in a colonial animal
Michelangelo von Dassow
Integrative Biology Department, University of California, Berkeley, 3060 Valley Life Sciences Building 3140, Berkeley, California 94720 3140, USA
Biol Bull 211:76-82. 2006
..This kind of "function-dependent development" should be differentiated from phenotypic plasticity, since the developing system, not the environment, produces the signals that induce morphological change...
Natural variation in embryo mechanics: gastrulation in Xenopus laevis is highly robust to variation in tissue stiffnessMichelangelo von Dassow
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Dev Dyn 238:2-18. 2009
..Our results indicate that gastrulation in X. laevis is robust to at least twofold variation in tissue stiffness...
- Surprisingly simple mechanical behavior of a complex embryonic tissue
Michelangelo von Dassow
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 5:e15359. 2010
..Furthermore, embryonic tissues have complex structure and composition and undergo large deformations during morphogenesis. Hence we expect highly non-linear and loading-rate dependent tissue mechanical properties in embryos...
- Experimental control of excitable embryonic tissues: three stimuli induce rapid epithelial contraction
Sagar D Joshi
Department of Bioengineering, University of Pittsburgh, 3501 Fifth Ave, Pittsburgh, PA 15260, USA
Exp Cell Res 316:103-14. 2010
..Our methods provide the means to control and study cellular contractility and will allow dissection of molecular mechanisms and biomechanics of cellular contractility...
- Variation and robustness of the mechanics of gastrulation: the role of tissue mechanical properties during morphogenesis
Michelangelo von Dassow
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Birth Defects Res C Embryo Today 81:253-69. 2007
..We discuss methods for measuring embryo-to-embryo variability in tissue mechanics, and for experimentally perturbing those mechanical properties to determine the sensitivity of gastrulation to tissue mechanics...
- Physics and the canalization of morphogenesis: a grand challenge in organismal biology
Michelangelo von Dassow
Department of Bioengineering, University of Pittsburgh, 3501 Fifth Ave, 5059 BST3, Pittsburgh, PA 15213, USA
Phys Biol 8:045002. 2011
..Studying the variation organisms express and the variation organisms experience will aid in deciphering the causes of birth defects...
- Emergent morphogenesis: elastic mechanics of a self-deforming tissue
Lance A Davidson
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Biomech 43:63-70. 2010
..We conclude by presenting a relatively simple "wedge-model" that exhibits key emergent properties of convergent extension such as the coupling between tissue stiffness, cell intercalation forces, and tissue elongation forces...
- Multi-scale mechanics from molecules to morphogenesis
Lance Davidson
Department of Bioengineering, University of Pittsburgh, 3501 Fifth Avenue, 5059 BST3, Pittsburgh, PA, USA
Int J Biochem Cell Biol 41:2147-62. 2009
..Lastly, we pose a series of questions that will need to be addressed if we are to understand the larger integration of molecular and physical mechanical processes during morphogenesis and organogenesis...
- Effects of ambient flow and injury on the morphology of a fluid transport system in a bryozoan
Michelangelo von Dassow
Integrative Biology Department, 3060 VLSB 3140, Berkeley, California 94720 3140, USA
Biol Bull 208:47-59. 2005
..These results suggest that ambient flow, injury, and the pressure under the canopy may have little effect on the remodeling of this fluid transport system...
