Laurian Vlase

Summary

Publications

  1. doi request reprint Effect of fluvoxamine on the pharmokinetics of zolpidem: a two-treatment period study in healthy volunteers
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    Clin Exp Pharmacol Physiol 39:9-12. 2012
  2. doi request reprint Pharmacokinetics and comparative bioavailability of two fenofibrate capsule formulations in healthy volunteers
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    Arzneimittelforschung 60:560-3. 2010
  3. doi request reprint Pharmacokinetic interaction between zolpidem and carbamazepine in healthy volunteers
    Laurian Vlase
    University of Medicine and Pharmacy, Iuliu Hatieganu, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Cluj Napoca, Romania
    J Clin Pharmacol 51:1233-6. 2011
  4. doi request reprint Pharmacokinetic interaction between zolpidem and ciprofloxacin in healthy volunteers
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Emil Isac 13, 400023, Cluj Napoca, Romania
    Eur J Drug Metab Pharmacokinet 35:83-7. 2011
  5. ncbi request reprint Pharmacokinetic interaction between fluoxetine and metoclopramide in healthy volunteers
    Laurian Vlase
    Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, Romania
    Biopharm Drug Dispos 27:285-9. 2006
  6. ncbi request reprint Pharmacokinetics and comparative bioavailability of two vinpocetine tablet formulations in healthy volunteers by using the metabolite apovincaminic acid as pharmacokinetic parameter
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, Romania
    Arzneimittelforschung 55:664-8. 2005
  7. ncbi request reprint No effect of short term ranitidine intake on diclofenac pharmacokinetics
    Adrian Leucuta
    3rd Pediatric Clinic, University of Medicine and Pharmacy, Str Campeni 2 4, Cluj Napoca, Romania
    Rom J Gastroenterol 13:306-8. 2004
  8. doi request reprint Pharmacokinetic interaction between ivabradine and phenytoin in healthy subjects
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    Clin Drug Investig 32:533-8. 2012
  9. ncbi request reprint Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection
    Laurian Vlase
    Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Emil Isac 13, RO 400023, Cluj Napoca, Romania
    J Pharm Biomed Anal 44:652-7. 2007
  10. doi request reprint Rapid high-performance liquid chromatography-tandem mass spectrometry method for determination of pentoxifylline and its active metabolites M1 and M5 in human plasma and its application in bioavailability study
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, No 8 Victor Babeş, RO 400012, Cluj Napoca, Romania
    Talanta 82:945-51. 2010

Collaborators

Detail Information

Publications21

  1. doi request reprint Effect of fluvoxamine on the pharmokinetics of zolpidem: a two-treatment period study in healthy volunteers
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    Clin Exp Pharmacol Physiol 39:9-12. 2012
    ..The experimental data showed the pharmacokinetic interaction between zolpidem and fluvoxamine, and suggest that the observed interaction might be clinically significant, but its relevance has to be confirmed...
  2. doi request reprint Pharmacokinetics and comparative bioavailability of two fenofibrate capsule formulations in healthy volunteers
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    Arzneimittelforschung 60:560-3. 2010
    ..The test product is therefore bioequivalent to the reference product with respect to the rate and extent of fenofibric acid pharmacokinetics...
  3. doi request reprint Pharmacokinetic interaction between zolpidem and carbamazepine in healthy volunteers
    Laurian Vlase
    University of Medicine and Pharmacy, Iuliu Hatieganu, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Cluj Napoca, Romania
    J Clin Pharmacol 51:1233-6. 2011
    ..The experimental data demonstrate the pharmacokinetic interaction between zolpidem and carbamazepine and suggest that the observed interaction may be clinically significant, but its relevance has to be confirmed...
  4. doi request reprint Pharmacokinetic interaction between zolpidem and ciprofloxacin in healthy volunteers
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Emil Isac 13, 400023, Cluj Napoca, Romania
    Eur J Drug Metab Pharmacokinet 35:83-7. 2011
    ..Ciprofloxacin interacts with zolpidem in healthy volunteers, raising its bioavailability by about 46%. This magnitude of effect is likely to be clinically significant...
  5. ncbi request reprint Pharmacokinetic interaction between fluoxetine and metoclopramide in healthy volunteers
    Laurian Vlase
    Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, Romania
    Biopharm Drug Dispos 27:285-9. 2006
    ..The experimental data demonstrate the pharmacokinetic interaction between fluoxetine and metoclopramide and suggest that the observed interaction may be clinically significant, but its relevance has to be confirmed...
  6. ncbi request reprint Pharmacokinetics and comparative bioavailability of two vinpocetine tablet formulations in healthy volunteers by using the metabolite apovincaminic acid as pharmacokinetic parameter
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, Romania
    Arzneimittelforschung 55:664-8. 2005
    ..The test product is therefore bioequivalent to the reference product with respect to the rate and extent of apovincaminic acid pharmacokinetics...
  7. ncbi request reprint No effect of short term ranitidine intake on diclofenac pharmacokinetics
    Adrian Leucuta
    3rd Pediatric Clinic, University of Medicine and Pharmacy, Str Campeni 2 4, Cluj Napoca, Romania
    Rom J Gastroenterol 13:306-8. 2004
    ..The experimental data did not suggest any consistent effects of ranitidine upon the pharmacokinetics of diclofenac sodium...
  8. doi request reprint Pharmacokinetic interaction between ivabradine and phenytoin in healthy subjects
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    Clin Drug Investig 32:533-8. 2012
    ..Phenytoin is an inductor of the main metabolizing enzyme of ivabradine and it could influence its pharmacokinetics. Changes in ivabradine pharmacokinetics could have clinical significance regarding the safety of the treatment...
  9. ncbi request reprint Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection
    Laurian Vlase
    Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Emil Isac 13, RO 400023, Cluj Napoca, Romania
    J Pharm Biomed Anal 44:652-7. 2007
    ..Besides its simplicity, the sample treatment allows obtaining a very good recovery of both analytes, around 100%. The validated LC/MS/MS method has been applied to a pharmacokinetic study of loratadine tablets on healthy volunteers...
  10. doi request reprint Rapid high-performance liquid chromatography-tandem mass spectrometry method for determination of pentoxifylline and its active metabolites M1 and M5 in human plasma and its application in bioavailability study
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, No 8 Victor Babeş, RO 400012, Cluj Napoca, Romania
    Talanta 82:945-51. 2010
    ..The validated method has been successfully applied to a bioequivalence study...
  11. ncbi request reprint A new, high-throughput high-performance liquid chromatographic/mass spectrometric assay for therapeutic level monitoring of digoxin in human plasma
    Laurian Vlase
    Iuliu HatieganuUniversity of Medicine and Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Emil Isac 13, RO 400023, Cluj Napoca, Romania
    J AOAC Int 92:1390-5. 2009
    ..9 min). The developed and validated high-throughput method is very simple, rapid, and efficient, with wide applications in clinical level monitoring, pharmacokinetics, and bioequivalence studies...
  12. doi request reprint Effect of fluoxetine on the pharmacokinetics of lansoprazole: a two-treatment period study in healthy male subjects
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, Cluj, Romania
    Clin Drug Investig 31:727-33. 2011
    ..The changes in lansoprazole pharmacokinetics could have clinical significance concerning the safety of the therapy...
  13. ncbi request reprint Pharmacokinetic interaction study between ranitidine and metoclopramide
    Adrian Leucuta
    3rd Pediatric Clinic, University of Medicine and Pharmacy, Str Campeni 2 4, Cluj Napoca, Romania
    Rom J Gastroenterol 13:211-4. 2004
    ..The experimental data proved the pharmacokinetic interaction between ranitidine of metoclopramide, and suggest monitoring adverse effects in patients...
  14. ncbi request reprint Antifungal activity of Aloe vera leaves
    Oana Rosca-Casian
    Department of Biology, Faculty of Biology and Geology, Babes Bolyai University, 42 Republicii Street, 400015 Cluj Napoca, Romania
    Fitoterapia 78:219-22. 2007
    ..sp. gladioli, Heterosporium pruneti and Penicillium gladioli on Czapek-agar medium. The minimum fungicidal concentration (MFC) varied between 80 and 100 microl/ml, depending on the fungal species...
  15. ncbi request reprint Clinical and pharmacokinetics study of oxaliplatin in colon cancer patients
    Claudia Burz
    Department of Immunology, University of Medicine and Pharmacy Iuliu Hatieganu, Romania
    J Gastrointestin Liver Dis 18:39-43. 2009
    ..to evaluate the therapeutic efficacy of oxaliplatin and to analyze the pharmacokinetics of both ultrafiltrable (free) and protein-bound platinum in patients with metastatic colon cancer...
  16. doi request reprint Determination of tramadol and O-desmethyltramadol in human plasma by high-performance liquid chromatography with mass spectrometry detection
    Laurian Vlase
    Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Emil Isac 13, RO 400023, Cluj Napoca, Romania
    Talanta 75:1104-9. 2008
    ..The method is very simple and allows obtaining a very good recovery of both analytes. The validated LC/MS method has been applied to a pharmacokinetic study of 50 mg tramadol tablets on healthy volunteers...
  17. ncbi request reprint High-throughput LC/MS/MS analysis of ruscogenin and neoruscogenin in Ruscus aculeatus L
    Laurian Vlase
    University of Medicine and Pharmacy Iuliu Hatieganu, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, No 13 Emil Isac, RO 400023, Cluj Napoca, Romania
    J AOAC Int 92:1055-9. 2009
    ..The method has been successfully applied to quantify the two sapogenins in aerial (phylloclades) and underground parts (rhizomes, roots) of Ruscus aculeatus L...
  18. ncbi request reprint Pharmacokinetics and metabolic drug interactions
    Sorin E Leucuta
    University of Medicine and Pharmacy Iuliu Hatieganu, Department of Biopharmaceutics and Pharmacokinetics, Cluj Napoca, Romania
    Curr Clin Pharmacol 1:5-20. 2006
    ....
  19. ncbi request reprint New HPLC-MS method for quantitative determination of apovincaminic acid in human plasma
    Laurian Vlase
    Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    J Sep Sci 29:385-9. 2006
    ..Accuracy and precision were less than 5.2% for within-run assay and 10% for between-run assay. The method was successfully applied in a bioequivalence study of two pharmaceutical products containing 5 mg vinpocetine...
  20. doi request reprint Chemical constituents of three Allium species from Romania
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    Molecules 18:114-27. 2012
    ..obliquum. All three species contain glycosides of kaempferol and quercetol. β-Sitosterol and campesterol were identified in all species. The results obtained showed significant differences in the composition of the three Allium species...
  21. ncbi request reprint Photochemoprotective effect of Calluna vulgaris extract on skin exposed to multiple doses of ultraviolet B in SKH-1 hairless mice
    Elena Diana Olteanu
    Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    J Environ Pathol Toxicol Oncol 31:233-43. 2012
    ..001) and sunburn cells (P < 0.001). The administration of Cv via hydrogel may be a viable method for chemoprevention....