Effect of fluvoxamine on the pharmokinetics of zolpidem: a two-treatment period study in healthy volunteersLaurian Vlase
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
Clin Exp Pharmacol Physiol 39:9-12. 2012
..The experimental data showed the pharmacokinetic interaction between zolpidem and fluvoxamine, and suggest that the observed interaction might be clinically significant, but its relevance has to be confirmed...
- Pharmacokinetics and comparative bioavailability of two fenofibrate capsule formulations in healthy volunteers
Laurian Vlase
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
Arzneimittelforschung 60:560-3. 2010
..The test product is therefore bioequivalent to the reference product with respect to the rate and extent of fenofibric acid pharmacokinetics...
- Pharmacokinetic interaction between zolpidem and carbamazepine in healthy volunteers
Laurian Vlase
University of Medicine and Pharmacy, Iuliu Hatieganu, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Cluj Napoca, Romania
J Clin Pharmacol 51:1233-6. 2011
..The experimental data demonstrate the pharmacokinetic interaction between zolpidem and carbamazepine and suggest that the observed interaction may be clinically significant, but its relevance has to be confirmed...
- Pharmacokinetic interaction between zolpidem and ciprofloxacin in healthy volunteers
Laurian Vlase
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Emil Isac 13, 400023, Cluj Napoca, Romania
Eur J Drug Metab Pharmacokinet 35:83-7. 2011
..Ciprofloxacin interacts with zolpidem in healthy volunteers, raising its bioavailability by about 46%. This magnitude of effect is likely to be clinically significant...
Pharmacokinetic interaction between fluoxetine and metoclopramide in healthy volunteersLaurian Vlase
Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, Romania
Biopharm Drug Dispos 27:285-9. 2006
..The experimental data demonstrate the pharmacokinetic interaction between fluoxetine and metoclopramide and suggest that the observed interaction may be clinically significant, but its relevance has to be confirmed...
- Pharmacokinetics and comparative bioavailability of two vinpocetine tablet formulations in healthy volunteers by using the metabolite apovincaminic acid as pharmacokinetic parameter
Laurian Vlase
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, Romania
Arzneimittelforschung 55:664-8. 2005
..The test product is therefore bioequivalent to the reference product with respect to the rate and extent of apovincaminic acid pharmacokinetics...
- No effect of short term ranitidine intake on diclofenac pharmacokinetics
Adrian Leucuta
3rd Pediatric Clinic, University of Medicine and Pharmacy, Str Campeni 2 4, Cluj Napoca, Romania
Rom J Gastroenterol 13:306-8. 2004
..The experimental data did not suggest any consistent effects of ranitidine upon the pharmacokinetics of diclofenac sodium...
- Pharmacokinetic interaction between ivabradine and phenytoin in healthy subjects
Laurian Vlase
Department of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
Clin Drug Investig 32:533-8. 2012
..Phenytoin is an inductor of the main metabolizing enzyme of ivabradine and it could influence its pharmacokinetics. Changes in ivabradine pharmacokinetics could have clinical significance regarding the safety of the treatment...
- Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection
Laurian Vlase
Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Emil Isac 13, RO 400023, Cluj Napoca, Romania
J Pharm Biomed Anal 44:652-7. 2007
..Besides its simplicity, the sample treatment allows obtaining a very good recovery of both analytes, around 100%. The validated LC/MS/MS method has been applied to a pharmacokinetic study of loratadine tablets on healthy volunteers...
- Rapid high-performance liquid chromatography-tandem mass spectrometry method for determination of pentoxifylline and its active metabolites M1 and M5 in human plasma and its application in bioavailability study
Laurian Vlase
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, No 8 Victor Babeş, RO 400012, Cluj Napoca, Romania
Talanta 82:945-51. 2010
..The validated method has been successfully applied to a bioequivalence study...
- A new, high-throughput high-performance liquid chromatographic/mass spectrometric assay for therapeutic level monitoring of digoxin in human plasma
Laurian Vlase
Iuliu HatieganuUniversity of Medicine and Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Emil Isac 13, RO 400023, Cluj Napoca, Romania
J AOAC Int 92:1390-5. 2009
..9 min). The developed and validated high-throughput method is very simple, rapid, and efficient, with wide applications in clinical level monitoring, pharmacokinetics, and bioequivalence studies...
- Effect of fluoxetine on the pharmacokinetics of lansoprazole: a two-treatment period study in healthy male subjects
Laurian Vlase
Department of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, Cluj, Romania
Clin Drug Investig 31:727-33. 2011
..The changes in lansoprazole pharmacokinetics could have clinical significance concerning the safety of the therapy...
- Pharmacokinetic interaction study between ranitidine and metoclopramide
Adrian Leucuta
3rd Pediatric Clinic, University of Medicine and Pharmacy, Str Campeni 2 4, Cluj Napoca, Romania
Rom J Gastroenterol 13:211-4. 2004
..The experimental data proved the pharmacokinetic interaction between ranitidine of metoclopramide, and suggest monitoring adverse effects in patients...
- Antifungal activity of Aloe vera leaves
Oana Rosca-Casian
Department of Biology, Faculty of Biology and Geology, Babes Bolyai University, 42 Republicii Street, 400015 Cluj Napoca, Romania
Fitoterapia 78:219-22. 2007
..sp. gladioli, Heterosporium pruneti and Penicillium gladioli on Czapek-agar medium. The minimum fungicidal concentration (MFC) varied between 80 and 100 microl/ml, depending on the fungal species...
- Clinical and pharmacokinetics study of oxaliplatin in colon cancer patients
Claudia Burz
Department of Immunology, University of Medicine and Pharmacy Iuliu Hatieganu, Romania
J Gastrointestin Liver Dis 18:39-43. 2009
..to evaluate the therapeutic efficacy of oxaliplatin and to analyze the pharmacokinetics of both ultrafiltrable (free) and protein-bound platinum in patients with metastatic colon cancer...
- Determination of tramadol and O-desmethyltramadol in human plasma by high-performance liquid chromatography with mass spectrometry detection
Laurian Vlase
Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Emil Isac 13, RO 400023, Cluj Napoca, Romania
Talanta 75:1104-9. 2008
..The method is very simple and allows obtaining a very good recovery of both analytes. The validated LC/MS method has been applied to a pharmacokinetic study of 50 mg tramadol tablets on healthy volunteers...
- High-throughput LC/MS/MS analysis of ruscogenin and neoruscogenin in Ruscus aculeatus L
Laurian Vlase
University of Medicine and Pharmacy Iuliu Hatieganu, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, No 13 Emil Isac, RO 400023, Cluj Napoca, Romania
J AOAC Int 92:1055-9. 2009
..The method has been successfully applied to quantify the two sapogenins in aerial (phylloclades) and underground parts (rhizomes, roots) of Ruscus aculeatus L...
- Pharmacokinetics and metabolic drug interactions
Sorin E Leucuta
University of Medicine and Pharmacy Iuliu Hatieganu, Department of Biopharmaceutics and Pharmacokinetics, Cluj Napoca, Romania
Curr Clin Pharmacol 1:5-20. 2006
....
- New HPLC-MS method for quantitative determination of apovincaminic acid in human plasma
Laurian Vlase
Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania
J Sep Sci 29:385-9. 2006
..Accuracy and precision were less than 5.2% for within-run assay and 10% for between-run assay. The method was successfully applied in a bioequivalence study of two pharmaceutical products containing 5 mg vinpocetine...
- Photochemoprotective effect of Calluna vulgaris extract on skin exposed to multiple doses of ultraviolet B in SKH-1 hairless mice
Elena Diana Olteanu
Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
J Environ Pathol Toxicol Oncol 31:233-43. 2012
..001) and sunburn cells (P < 0.001). The administration of Cv via hydrogel may be a viable method for chemoprevention....
