Francisco J Vizoso



  1. Fernández Guinea O, Andicoechea A, Gonzalez L, Gonzalez Reyes S, Merino A, Hernández L, et al. Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinico-pathological and biological factors in invasive breast cancer. BMC Cancer. 2010;10:8 pubmed publisher
    ..036). Peritumor inflammation was significantly associated with washout curve type III (p = 0.042). Variations in the early phase of dynamic MRI seem to be associated with parameters indicatives of tumor aggressiveness in breast cancer. ..
  2. Eiró N, Gonzalez L, Martínez Ordóñez A, Fernandez Garcia B, Gonzalez L, Cid S, et al. Cancer-associated fibroblasts affect breast cancer cell gene expression, invasion and angiogenesis. Cell Oncol (Dordr). 2018;41:369-378 pubmed publisher
    ..Our data additionally indicate that CAFs, especially those derived from MMP11+ MIC tumors, can promote breast cancer cell invasion and angiogenesis. ..
  3. Eiró N, Carrión J, Cid S, Andicoechea A, García Muñiz J, Gonzalez L, et al. Toll-Like Receptor 4 and Matrix Metalloproteases 11 and 13 as Predictors of Tumor Recurrence and Survival in Stage II Colorectal Cancer. Pathol Oncol Res. 2019;: pubmed publisher
    ..Our results show that TLR4 expression by tumor cells and MMP11 expression by CAFs may to improve the identification of patients with stage II CRC with a high-risk of relapse. ..
  4. Eiró N, Ovies C, Fernandez Garcia B, Alvarez Cuesta C, Gonzalez L, Gonzalez L, et al. Expression of TLR3, 4, 7 and 9 in cutaneous malignant melanoma: relationship with clinicopathological characteristics and prognosis. Arch Dermatol Res. 2013;305:59-67 pubmed publisher
    ..001). Therefore, TLR4 expression may be a new prognostic factor of unfavorable evolution in cutaneous malignant melanoma. ..
  5. Sendon Lago J, Seoane S, Eiró N, Bermudez M, Macia M, Garcia Caballero T, et al. Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13. Breast Cancer Res. 2014;16:505 pubmed publisher
    ..Our data indicates that Pit-1 regulates MMP-1 and MMP-13, and that inhibition of MMP-13 blocked invasiveness to lung in Pit-1-overexpressed breast cancer cells. ..
  6. González L, Eiró N, Fernandez Garcia B, González L, Dominguez F, Vizoso F. Gene expression profile of normal and cancer-associated fibroblasts according to intratumoral inflammatory cells phenotype from breast cancer tissue. Mol Carcinog. 2016;55:1489-1502 pubmed publisher
    ..2015 Wiley Periodicals, Inc. ..
  7. Cid S, Eiró N, Gonzalez L, Béridze N, Vazquez J, Vizoso F. Expression and Clinical Significance of Metalloproteases and Their Inhibitors by Endothelial Cells From Invasive Breast Carcinomas. Clin Breast Cancer. 2016;16:e83-91 pubmed publisher
    ..High MMP/TIMP expression by ECs from breast carcinomas, which may be consequence of the cross-talk between tumor cells and their surrounding microenvironment. ..
  8. Eiró N, Fernandez Gomez J, Sacristan R, Fernandez Garcia B, Lobo B, Gonzalez Suarez J, et al. Stromal factors involved in human prostate cancer development, progression and castration resistance. J Cancer Res Clin Oncol. 2017;143:351-359 pubmed publisher
  9. Cid S, Eiró N, Fernández B, Sanchez R, Andicoechea A, Fernández Muñiz P, et al. Prognostic Influence of Tumor Stroma on Breast Cancer Subtypes. Clin Breast Cancer. 2018;18:e123-e133 pubmed publisher
    ..Characterization of both tumor stromal CAFs and MICs, with regard to the expression of MMPs and TIMPs, improve the prognostic evaluation of all breast cancer subtypes. ..

More Information


  1. Gonzalez Reyes S, Fernández J, Gonzalez L, Aguirre A, Suarez A, Gonzalez J, et al. Study of TLR3, TLR4, and TLR9 in prostate carcinomas and their association with biochemical recurrence. Cancer Immunol Immunother. 2011;60:217-26 pubmed publisher
    ..TLR expression is associated with prostate cancer with recurrence and the role of TLR receptors in the biology of malignancy merits study. Therapeutic strategies to boost or block TLRs may be of interest. ..
  2. Gonzalez Reyes S, Marín L, Gonzalez L, Gonzalez L, del Casar J, Lamelas M, et al. Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis. BMC Cancer. 2010;10:665 pubmed publisher
    ..The expression levels of TLR3, TLR4 and TLR9 have clinical interest as indicators of tumor aggressiveness in breast cancer. TLRs may represent therapeutic targets in breast cancer. ..
  3. Bermudez M, Sendon Lago J, Seoane S, Eiró N, Gonzalez F, Saa J, et al. Anti-inflammatory effect of conditioned medium from human uterine cervical stem cells in uveitis. Exp Eye Res. 2016;149:84-92 pubmed publisher
    ..In summary, treatment with CM-hUCESCs significantly reduces inflammation in uveitis. Our data indicate that CM-hUCESCs could be regarded as a potential therapeutic agent for patients suffering from ocular inflammation. ..
  4. Vizoso F, Eiró N, Cid S, Schneider J, Perez Fernandez R. Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine. Int J Mol Sci. 2017;18: pubmed publisher
    ..Moreover, due to easy isolation and a high proliferative rate, it is possible to obtain large amounts of hUCESCs or secretome-derived products for research and clinical use. ..