David M Virshup

Summary

Publications

  1. pmc Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer
    G S Coombs
    Program in Cancer and Stem Cell Biology, Duke NUS Graduate Medical School, Singapore
    Oncogene 31:213-25. 2012
  2. pmc Precise regulation of porcupine activity is required for physiological Wnt signaling
    Kyle D Proffitt
    Program in Cancer and Stem Cell Biology, Duke National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore
    J Biol Chem 287:34167-78. 2012
  3. pmc PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation
    Tracy M Covey
    Cancer and Stem Cell Biology, Duke NUS Graduate Medical School, Singapore, Singapore
    PLoS ONE 7:e34532. 2012
  4. pmc IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation
    J K Cheong
    Cancer and Stem Cell Biology Program, Duke NUS Graduate Medical School, Singapore
    Oncogene 30:2558-69. 2011
  5. doi request reprint From promiscuity to precision: protein phosphatases get a makeover
    David M Virshup
    Program in Cancer and Stem Cell Biology, Duke NUS Graduate Medical School Singapore, Singapore, Republic of Singapore
    Mol Cell 33:537-45. 2009
  6. doi request reprint Keeping the beat in the rising heat
    David M Virshup
    Program in Cancer and Stem Cell Biology, Duke NUS Graduate Medical School, Singapore 169857
    Cell 137:602-4. 2009
  7. doi request reprint Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer
    Kyle David Proffitt
    Program in Cancer and Stem Cell Biology, Duke NUS Graduate Medical School, Singapore, Singapore
    Cancer Res 73:502-7. 2013
  8. ncbi request reprint WLS retrograde transport to the endoplasmic reticulum during Wnt secretion
    Jia Yu
    Program in Cancer and Stem Cell Biology, Duke NUS Graduate Medical School, Singapore 169857, Singapore
    Dev Cell 29:277-91. 2014
  9. pmc WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification
    Gary S Coombs
    Program in Cancer and Stem Cell Biology, Duke NUS Graduate Medical School, 8 College Road, 169857, Singapore
    J Cell Sci 123:3357-67. 2010
  10. pmc Unwinding the Wnt action of casein kinase 1
    Daniel G R Yim
    Program in Cancer and Stem Cell Biology, Duke NUS Graduate Medical School Singapore, Singapore
    Cell Res 23:737-8. 2013

Collaborators

  • C Michael Jones
  • S Pervaiz
  • Jit Kong Cheong
  • Patrick Tan
  • H Wang
  • Daniel B Forger
  • S Shenolikar
  • Claire A Canning
  • Jia Yu
  • Kyle D Proffitt
  • Tracy M Covey
  • Kyle David Proffitt
  • Daniel G R Yim
  • G S Coombs
  • Gary S Coombs
  • Frederic A Bard
  • Joanne Chia
  • Lijun Ding
  • Vishal Pendharkar
  • Babita Madan
  • May Ann Lee
  • Zhiyuan Ke
  • Rami N Hannoush
  • E J Toone
  • A A Schmitt
  • V Utomo
  • S Kaur
  • N Banerjee
  • Simran Kaur
  • I C C Low
  • Yonghui Wu
  • Tina Tan Ong
  • A Alok
  • Raquel C Jadulco
  • Ivana Mihalek
  • Gisela P Concepcion
  • Mary Kay Harper
  • Nikhil Banerjee
  • Tim S Bugni
  • Zong Hong Zhang
  • Chris M Ireland
  • Charles A Veltri
  • Velani Utomo

Detail Information

Publications11

  1. pmc Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer
    G S Coombs
    Program in Cancer and Stem Cell Biology, Duke NUS Graduate Medical School, Singapore
    Oncogene 31:213-25. 2012
    ..HQBA is a promising specific intracellular Fe(2+) chelator with activity against spontaneous mouse mammary cancers...
  2. pmc Precise regulation of porcupine activity is required for physiological Wnt signaling
    Kyle D Proffitt
    Program in Cancer and Stem Cell Biology, Duke National University of Singapore Graduate Medical School, 8 College Road, 169857 Singapore
    J Biol Chem 287:34167-78. 2012
    ..These studies support an essential regulatory role of PORCN in shaping Wnt signaling gradients...
  3. pmc PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation
    Tracy M Covey
    Cancer and Stem Cell Biology, Duke NUS Graduate Medical School, Singapore, Singapore
    PLoS ONE 7:e34532. 2012
    ..PORCN protein thus appears to moonlight in a novel signaling pathway that is rate-limiting for cancer cell growth and tumorigenesis independent of its enzymatic function in Wnt biosynthesis and secretion...
  4. pmc IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation
    J K Cheong
    Cancer and Stem Cell Biology Program, Duke NUS Graduate Medical School, Singapore
    Oncogene 30:2558-69. 2011
    ..This activity accounts for many of the diverse biological effects of IC261 and, most importantly, for its selective cancer cell killing...
  5. doi request reprint From promiscuity to precision: protein phosphatases get a makeover
    David M Virshup
    Program in Cancer and Stem Cell Biology, Duke NUS Graduate Medical School Singapore, Singapore, Republic of Singapore
    Mol Cell 33:537-45. 2009
    ..As recent publications illustrate, these regulatory subunits confer specificity, selectivity, localization, and regulation on these important enzymes...
  6. doi request reprint Keeping the beat in the rising heat
    David M Virshup
    Program in Cancer and Stem Cell Biology, Duke NUS Graduate Medical School, Singapore 169857
    Cell 137:602-4. 2009
    ..Mehra et al. (2009) and Baker et al. (2009) now show that phosphorylation-regulated protein degradation plays a key role in circadian temperature compensation...
  7. doi request reprint Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer
    Kyle David Proffitt
    Program in Cancer and Stem Cell Biology, Duke NUS Graduate Medical School, Singapore, Singapore
    Cancer Res 73:502-7. 2013
    ..These results offer preclinical proof-of-concept that inhibiting mammalian Wnts can be achieved by targeting PORCN with small-molecule inhibitors such as C59, and that this is a safe and feasible strategy in vivo...
  8. ncbi request reprint WLS retrograde transport to the endoplasmic reticulum during Wnt secretion
    Jia Yu
    Program in Cancer and Stem Cell Biology, Duke NUS Graduate Medical School, Singapore 169857, Singapore
    Dev Cell 29:277-91. 2014
    ..ERGIC2 is required for efficient Wnt secretion. ER retrieval is an integral part of the WLS transport cycle. ..
  9. pmc WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification
    Gary S Coombs
    Program in Cancer and Stem Cell Biology, Duke NUS Graduate Medical School, 8 College Road, 169857, Singapore
    J Cell Sci 123:3357-67. 2010
    ....
  10. pmc Unwinding the Wnt action of casein kinase 1
    Daniel G R Yim
    Program in Cancer and Stem Cell Biology, Duke NUS Graduate Medical School Singapore, Singapore
    Cell Res 23:737-8. 2013
    ..A recent study published in Science identifying allosteric activation of CK1 by the DEAD-box RNA helicase DDX3 expands our understanding of the control of this abundant kinase family...
  11. doi request reprint Casein kinase 1: Complexity in the family
    Jit Kong Cheong
    Cancer and Stem Cell Biology Program, Duke NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore
    Int J Biochem Cell Biol 43:465-9. 2011
    ..We provide a brief overview of the fundamentals of CK1 biology with an emphasis on scaffold binding and kinase regulation in Wnt signaling and circadian rhythms...