Changes in bone resorption and vascular endothelial growth factor after a single zoledronic acid infusion in cancer patients with bone metastases from solid tumoursDaniele Santini
Clinical Oncology, University Campus Bio Medico, 00155 Rome, Italy
Oncol Rep 15:1351-7. 2006
..Future clinical trials should be designed to prospectively evaluate the prognostic role of reduction of betaCTX and VEGF in response to ZOL to predict clinical and skeletal outcome...
- COX-2 expression of ampullary carcinoma: correlation with different histotypes and clinicopathological parameters
Giuseppe Perrone
Surgical Pathology, Campus Bio Medico University, Via Emilio Longoni, Rome, 83 00155, Italy
Virchows Arch 449:334-40. 2006
..Furthermore, the high rate of COX-2 expression in the intestinal subtype of ampullary carcinoma may represent the rational for a histotype-tailored therapy targeting COX-2...
The biological properties of cetuximabBruno Vincenzi
Medical Oncology, Campus Bio Medico University, Via Alvaro del Portillo 200, Rome, Italy
Crit Rev Oncol Hematol 68:93-106. 2008
..This paper will overview all the experimental and pre-clinical data on the biological properties of cetuximab...
- Cetuximab: from bench to bedside
Bruno Vincenzi
Department of Medical Oncology, University Campus Bio Medico, Rome, Italy
Curr Cancer Drug Targets 10:80-95. 2010
..This review will illustrate pre-clinical and clinical data on biological properties of cetuximab focusing on the predictive markers of clinical response to this drug...
- Statins may potentiate bisphosphonates anticancer properties: a new pharmacological approach?
Bruno Vincenzi
Oncology Hematology Department, Campus Bio Medico University, Rome, Italy
Med Hypotheses 61:98-101. 2003
....
- PML as a potential predictive factor of oxaliplatin/fluoropyrimidine-based first line chemotherapy efficacy in colorectal cancer patients
Bruno Vincenzi
Department of Oncology, University Campus Bio Medico, Rome, Italy
J Cell Physiol 227:927-33. 2012
..This study represents the first evidence of a possible correlation between PML protein expression and outcome of metastatic colorectal cancer patients treated with oxaliplatin/fluoropyrimidine-based first line therapy...
- Prognostic role of human equilibrative transporter 1 (hENT1) in patients with resected gastric cancer
Daniele Santini
Medical Oncology, University Campus Bio Medico, Rome, Italy
J Cell Physiol 223:384-8. 2010
..Immunohistochemistry for the hENT1 protein carries prognostic information in patients with resected gastric cancer and holds promise as a predictive factor in chemotherapy decisions...
- Bevacizumab in association with de Gramont 5-fluorouracil/folinic acid in patients with oxaliplatin-, irinotecan-, and cetuximab-refractory colorectal cancer: a single-center phase 2 trial
Bruno Vincenzi
Department of Medical Oncology, Campus Bio Medico University, Rome, Italy
Cancer 115:4849-56. 2009
..The aim of the current study was the investigation of the value of bevacizumab+5-fluorouracil(5-FU)/folinic acid in patients with advanced colorectal cancers who have exhausted standard chemotherapy options...
- Circulating VEGF reduction, response and outcome in advanced colorectal cancer patients treated with cetuximab plus irinotecan
Bruno Vincenzi
University Campus Bio Medico, Medical Oncology, Via Emilio Longoni, 69, 00155, Rome, Italy
Pharmacogenomics 8:319-27. 2007
....
- Zoledronic acid-related angiogenesis modifications and survival in advanced breast cancer patients
Bruno Vincenzi
Medical Oncology, University Campus Bio-Medico, Rome, Italy
J Interferon Cytokine Res 25:144-51. 2005
....
Phase I study of intermittent and chronomodulated oral therapy with capecitabine in patients with advanced and/or metastatic cancerDaniele Santini
Medical Oncology, University Campus Bio Medico, Rome, Italy
BMC Cancer 6:42. 2006
....
- Early magnesium reduction in advanced colorectal cancer patients treated with cetuximab plus irinotecan as predictive factor of efficacy and outcome
Bruno Vincenzi
Department of Medical Oncology, Laboratory Medicine, and Radiology, University Campus Bio Medico, Rome, Italy
Clin Cancer Res 14:4219-24. 2008
..We designed this trial to investigate if Mg(2+) serum level modifications may be related with clinical response and outcome in advanced colorectal cancer patients during treatment with cetuximab plus irinotecan...
- A phase II trial of fixed-dose rate gemcitabine plus capecitabine in metastatic/advanced biliary tract cancer patients
Daniele Santini
Medical Oncology, University Campus Bio Medico, Rome, Italy
Oncology 82:75-82. 2012
..This phase II trial was conducted to determine the activity and safety of the combination of fixed-dose rate (FDR) gemcitabine and capecitabine in metastatic biliary tract cancer (BTC) patients...
- Continuous infusion of oxaliplatin plus chronomodulated capecitabine in 5-fluorouracil- and irinotecan-resistant advanced colorectal cancer patients
Daniele Santini
Medical Oncology, University Campus Bio Medico, Rome, Italy
Oncology 69:27-34. 2005
..The aim of the study was to define the feasibility and efficacy of Xelox (capecitabine and oxaliplatin) administered through a new and original schedule in advanced pretreated colorectal cancer (CRC) patients...
- Patterns of tumor response in canine and feline cancer patients treated with electrochemotherapy: preclinical data for the standardization of this treatment in pets and humans
Enrico P Spugnini
S A F U, Department, Regina Elena Cancer Institute, Rome, Italy
J Transl Med 5:48. 2007
..Further studies on this topic are warranted in companion animals with spontaneous tumors to identify new molecular targets for electrochemotherapy and to the develop new therapeutical protocols to be translated to humans...
- MUC2 but not MUC5 expression correlates with prognosis in radically resected pancreatic cancer patients
Francesco Pantano
Medical Oncology, University Campus Bio Medico of Rome, Rome, Italy
Cancer Biol Ther 8:996-9. 2009
..The present study investigated the prognostic role of MUC2 and MUC5 apomucin expression in a series of surgically resected pancreatic cancer patients...
- Predictive factors for chemotherapy-related toxic effects in patients with colorectal cancer
Bruno Vincenzi
Division of Medical Oncology, University Campus Bio Medico of Rome, Rome, Italy
Nat Clin Pract Oncol 5:455-65. 2008
..We discuss the rationale for tailoring anticancer treatment in patients with colorectal cancer according to individual molecular and clinical features, with the aim of improving response rates and reducing the incidence of toxic events...
- Thymidylate synthase expression in normal colonic mucosa: a predictive marker of toxicity in colorectal cancer patients receiving 5-fluorouracil-based adjuvant chemotherapy
Daniele Santini
Medical Oncology Unit, University Campus Bio-Medico, Rome, Italy
Oncology 67:135-42. 2004
..CONCLUSIONS: Immunohistochemical TS expression in normal colonic mucosa may represent an important predictive parameter for identifying a subset of patients with a high risk of developing severe 5-FU-related toxicities...
- Adjuvant electrochemotherapy for the treatment of incompletely excised spontaneous canine sarcomas
Enrico P Spugnini
SAFU Department, Regina Elena Cancer Institute, Rome, Italy
In Vivo 21:819-22. 2007
..Electrochemotherapy is well tolerated and has effectiveness against incompletely excised sarcomas in companion animals. Further investigations are warranted to improve the currently available protocols...
- Repeated intermittent low-dose therapy with zoledronic acid induces an early, sustained, and long-lasting decrease of peripheral vascular endothelial growth factor levels in cancer patients
Daniele Santini
Medical Oncolog, University Campus Bio Medico, Rome, Italy
Clin Cancer Res 13:4482-6. 2007
....
- Interleukin 1beta-511T gene (IL1beta) polymorphism is correlated with gastric cancer in the Caucasian population: results from a meta-analysis
Bruno Vincenzi
C I R, University Campus Bio Medico, Rome, Italy
Oncol Rep 20:1213-20. 2008
..Hence, the present study contributes to clarify the controversial results on IL1beta polymorphisms and gastric cancer risk correlation evidencing the importance of ethnicity in the generation of the IL1beta polymorphism analysis...
- Aromatase inhibitor exemestane has antiproliferative effects on human mesothelioma cells
Daniela Stoppoloni
Department for the Development of Therapeutic Programs, Regina Elena Cancer Institute, Rome, Italy
J Thorac Oncol 6:583-91. 2011
..The aim of this study was to investigate the expression and biological activity of aromatase (CYP19A1) in malignant mesothelioma (MM)...
- Electrochemotherapy with cisplatin enhances local control after surgical ablation of fibrosarcoma in cats: an approach to improve the therapeutic index of highly toxic chemotherapy drugs
Enrico P Spugnini
SAFU Department, Regina Elena Cancer Institute, Rome, Italy
J Transl Med 9:152. 2011
..In this article we evaluate the capability of ECT to allow the use of cisplatin despite its high toxicity in a spontaneous feline model of soft tissue sarcoma...
- An increase of CA 19.9 as the first clinical sign of ileocecal valve metastasis from breast cancer
Daniele Santini
Department of Medical Oncology, University Campus Bio Medico, Rome, Italy
In Vivo 20:165-8. 2006
..CONCLUSION: This is the first report in the literature of an ileocecal valve metastasis from breast cancer diagnosed by an increase of CA 19.9, which is a marker of primary colorectal carcinoma...
- Cigarette smoking habit does not reduce the benefit from first line trastuzumab-based treatment in advanced breast cancer patients
Daniele Santini
Department of Medical Oncology, University Campus Bio Medico, Rome, Italy
Oncol Rep 25:1545-8. 2011
..This study clearly showed lack of any correlation between cigarette smoking habit and both activity and efficacy of trastuzumab-based first line therapy in metastatic HER2/neu positive breast cancer patients...
- Intraoperative versus postoperative electrochemotherapy in high grade soft tissue sarcomas: a preliminary study in a spontaneous feline model
Enrico P Spugnini
SAFU Department, Regina Elena Cancer Institute, Via delle Messi d oro, 156, 00158, Rome, Italy
Cancer Chemother Pharmacol 59:375-81. 2007
..The results suggest that ECT is a well tolerated and potentially useful addition to surgery in controlling high-grade sarcomas. On the basis of these results, additional evaluations are warranted in pets and in humans...
- Receptor activator of NF-kB (RANK) expression in primary tumors associates with bone metastasis occurrence in breast cancer patients
Daniele Santini
Department of Medical Oncology, University Campus Bio Medico of Rome, Rome, Italy
PLoS ONE 6:e19234. 2011
..RANKL stimulates migration of RANK-expressing tumor cells in vitro, conversely inhibited by OPG...
- Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients
Cristina Raimondi
Division of Medical Oncology, Sapienza University of Rome, Rome, Italy
Breast Cancer Res Treat 130:449-55. 2011
..The detection of cells in mesenchymal transition, retaining EMT and stemness features, may contribute to discover additional therapeutic targets useful to eradicate micrometastatic disease in breast cancer...
- Serum VEGF levels as predictive marker of bisphosphonate-related osteonecrosis of the jaw
Bruno Vincenzi
Department of Medical Oncology, Campus Bio Medico University of Rome, Rome, Italy
J Hematol Oncol 5:56. 2012
..These data demonstrated for the first time that the anti-angiogenic properties of bisphosphonates are directly linked to B-ONJ pathogenesis and serum VEGF levels could represent an effective early predictive marker...
- Premetastatic niche: ready for new therapeutic interventions?
Alice Zoccoli
Campus Bio Medico University, Department of Medical Oncology, Rome, Italy
Expert Opin Ther Targets 16:S119-29. 2012
..Drugs targeting premetastatic niche could represent a new promising therapeutic approach in the treatment of bone metastases...
- Mechanisms of disease: Preclinical reports of antineoplastic synergistic action of bisphosphonates
Daniele Santini
Department of Medical Oncology, University Campus Bio Medico, Rome, Italy
Nat Clin Pract Oncol 3:325-38. 2006
..We briefly discuss identification of new molecular targets of bisphosphonates from genomic and proteomic analysis, and highlight the cellular consequences of drug-related enzyme inhibition...
- A prospective analysis of CT density measurements of bone metastases after treatment with zoledronic acid
Carlo C Quattrocchi
Department of Radiology, Centro Interdisciplinare per la Ricerca Bio Medica, Via Longoni 47, 00155, Rome, Italy
Skeletal Radiol 36:1121-7. 2007
..The objective was to prospectively determine CT density changes in bone metastases, before and after intravenous zoledronic acid for a maximum period of 12 months...
- Early skin toxicity as a predictive factor for tumor control in hepatocellular carcinoma patients treated with sorafenib
Bruno Vincenzi
Department of Surgical and Oncological Sciences, Section of Medical Oncology Università di Palermo, Palermo, Italy, Via del Vespro 127, 90127 Palermo, Italy
Oncologist 15:85-92. 2010
..This study was conducted to assess the link between the antitumor efficacy of sorafenib and its early cutaneous side effects in advanced HCC patients...
- Human equilibrative nucleoside transporter 1 (hENT1) levels predict response to gemcitabine in patients with biliary tract cancer (BTC)
Daniele Santini
Medical Oncology, University Campus Bio Medico, Rome, Italy
Curr Cancer Drug Targets 11:123-9. 2011
..The aim of this study was to retrospectively determine patients' outcome according to the expression of hENT1 in tumoral cells of patients receiving gemcitabine-based therapy...
- In vivo effects of zoledronic acid on peripheral gammadelta T lymphocytes in early breast cancer patients
Daniele Santini
Medical Oncology, University Campus Bio Medico, Rome, Italy
Cancer Immunol Immunother 58:31-8. 2009
..The aim of our study was to evaluate the immunomodulating properties of a single-dose of zoledronic acid (ZA) on gammadelta T cells in a select group of disease-free breast cancer patients with osteopenia...
- Cigarettes smoking habit may reduce benefit from cetuximab-based treatment in advanced colorectal cancer patients
Bruno Vincenzi
University Campus Bio Medico, Medical Oncology, Rome, Italy
Expert Opin Biol Ther 9:945-9. 2009
..The aim of this study was to evaluate the effect of cigarette smoking on cetuximab efficacy in advanced colorectal cancer patients...
- Apoptotic index or a combination of Bax/Bcl-2 expression correlate with survival after resection of pancreatic adenocarcinoma
Paolo Magistrelli
Department of Surgery, Catholic University School of Medicine, Rome, Italy
J Cell Biochem 97:98-108. 2006
..The contemporary overexpression of Bax and Bcl-2 represents the strongest prognostic factor...
- Endocrine disruptors in utero cause ovarian damages linked to endometriosis
Pietro G Signorile
Fondazione Italiana Endometriosi, Rome, Italy
Front Biosci (Elite Ed) 4:1724-30. 2012
..Considering the high incidence of endometriosis and of the premature ovarian failure associated to infertility in these patients, the data showed prompt a thoroughly reconsideration of the pathological framing of these lesions...
- The role of S-adenosylmethionine in preventing oxaliplatin-induced liver toxicity: a retrospective analysis in metastatic colorectal cancer patients treated with bevacizumab plus oxaliplatin-based regimen
Bruno Vincenzi
Department of Medical Oncology, University Campus Bio Medico, Via Alvaro del Portillo 200, 00128, Rome, Italy
Support Care Cancer 20:135-9. 2012
..S-adenosylmethionine (AdoMet) administration is effective in the treatment of a variety of liver injuries, but it has never been evaluated in the prevention of chemotherapy-induced damage...
- Antiangiogenic properties of metronomic chemotherapy in breast cancer
Giuseppe Tonini
Medical Oncology, University Campus Bio Medico, Rome, Via Emilio Longoni 83, 00155, Rome, Italy
Future Oncol 3:183-90. 2007
..This review aims to explain the rationale behind metronomic and targeted therapies in breast cancer and to examine the main preclinical and clinical (neoadjuvant, adjuvant and advanced settings) studies conducted...
- A new dose-intense epoetin alfa regimen effective in anemic cancer patients receiving chemotherapy: an open-label, non randomized, pilot study
Daniele Santini
Medical Oncology, University Campus Bio-Medico, Rome, Italy
Anticancer Res 25:669-74. 2005
..Moreover, the Hb levels seemed to increase after epoetin therapy discontinuation (d22-29)...
- Reelin expression in human prostate cancer: a marker of tumor aggressiveness based on correlation with grade
Giuseppe Perrone
Department of Surgical Pathology, Campus Bio Medico University, Rome, Italy
Mod Pathol 20:344-51. 2007
..This suggests reelin may behave as a specific histological marker and may represent a useful biomarker to predict aggressive phenotypic behavior of prostatic cancer cells...
- Adjuvant electrochemotherapy for the treatment of incompletely resected canine mast cell tumors
Enrico P Spugnini
S A F U Department, Regina Elena Cancer Institute, Rome, Italy
Anticancer Res 26:4585-9. 2006
..The purpose of this investigation was to assess the adjuvant potentials of ECT for the treatment of incompletely excised mast cell tumors (MCT)...
- New therapies in soft tissue sarcoma
Bruno Vincenzi
University Campus Bio Medico, Medical Oncology, Via Alvaro del Portillo, 200, 00128, Rome, Italy
Expert Opin Emerg Drugs 15:237-48. 2010
..Despite the efforts, overall 5-year survival rate in patients with soft tissue sarcomas of all stages remains only 50 - 60%...
- The new era in the treatment of advanced colorectal cancer patients: the role of monoclonal antibodies
Bruno Vincenzi
University Campus Bio Medico, Medical Oncology, Via Emilio Longoni 69, 00155, Rome, Italy
Expert Opin Emerg Drugs 11:665-83. 2006
..This clinical review focuses on the defining role of the two most clinically advanced novel agents, bevacizumab and cetuximab in metastatic colorectal cancer...
- PML down-regulation in soft tissue sarcomas
Bruno Vincenzi
Department of Oncology, University Campus Bio Medico, Rome, Italy
J Cell Physiol 224:644-8. 2010
..Further investigations are needed to confirm these data and to assess the possible value of PML expression as a prognostic factor in these extremely aggressive diseases...
- Aprepitant for management of severe pruritus related to biological cancer treatments: a pilot study
Daniele Santini
Department of Medical Oncology, Campus Bio Medico University of Rome, Rome, Italy
Lancet Oncol 13:1020-4. 2012
..We designed a pilot single-centre study to assess the effects of aprepitant-a neurokinin receptor inhibitor-for management of severe pruritus induced by biological drugs...
- The role of bone microenvironment, vitamin D and calcium
Daniele Santini
University Campus Bio Medico, Via Alvaro del Portillo, Rome, Italy
Recent Results Cancer Res 192:33-64. 2012
....
- Targeted therapy in sarcomas: mammalian target of rapamycin inhibitors from bench to bedside
Bruno Vincenzi
University Campus Bio Medico, Medical Oncology, Via Alvaro del Portillo, 200, Rome, Italy
Expert Opin Investig Drugs 20:1685-705. 2011
....
- New targets, new drugs for metastatic bone pain: a new philosophy
Francesco Pantano
University Campus Bio Medico, Medical Oncology, Rome, Italy
Expert Opin Emerg Drugs 16:403-5. 2011
..Based on these data, it has been suggested that denosumab has the potential to become a new standard of treatment in bone metastases management...
- Expression of the embryonic lethal abnormal vision-like protein HuR in human mesothelioma: association with cyclooxygenase-2 and prognosis
Daniela Stoppoloni
Laboratory D, Department for the Development of Therapeutic Programs, Centro Ricerca Sperimentale, Regina Elena Cancer Institute, Rome, Italy
Cancer 113:2761-9. 2008
..The human embryonic lethal abnormal vision (ELAV)-like protein HuR is a messenger RNA (mRNA)-binding protein that controls the stability of certain transcripts, including cyclooxygenase2 (COX-2)...
- Complications of therapy in cancer patients: Case 3. Toxic epidermal necrolysis induced by oral phenobarbital and whole-brain radiotherapy in a breast cancer patient
Bruno Vincenzi
University Campus Bio-Medico, Rome, Italy
J Clin Oncol 22:4649-51. 2004
- Expression pattern of receptor activator of NFκB (RANK) in a series of primary solid tumors and related bone metastases
Daniele Santini
Department of Medical Oncology, University Campus Bio Medico, Rome, Italy
J Cell Physiol 226:780-4. 2011
..These data highlight the central role of RANK/RANKL/OPG pathway as potential therapeutic target not only in bone metastasis management, but also in the adjuvant setting...
- Persisting perianal ulcer after radiotherapy for anal cancer: recurrence of disease or late radiation-related complication?
Domenico Borzomati
Department of General Surgery, Campus Bio Medico University, Catholic University, Rome, Italy
Hepatogastroenterology 52:780-4. 2005
..benign post-attinic lesion). In the present article we review this uncommon complication, discuss the technical surgical aspects associated with a very large perianal tissue removal, and data of the most recent literature in this field...
- Circulating tumour cells lacking cytokeratin in breast cancer: the importance of being mesenchymal
Angela Gradilone
Department of Molecular Medicine, Sapienza University, Viale Regina Elena, Rome, Italy
J Cell Mol Med 15:1066-70. 2011
..Thus, there is an urgent need to improve detection methods to identify CTC which undergone epithelial mesenchymal transition program...
- Electroporation adopting trains of biphasic pulses enhances in vitro and in vivo the cytotoxic effect of doxorubicin on multidrug resistant colon adenocarcinoma cells (LoVo)
Stefania Meschini
Department of Technology and Health, Italian National Institute of Health, Rome, Italy
Eur J Cancer 48:2236-43. 2012
....
- Unusual problems in breast cancer and a rare lung cancer case. Case 1. Clinical complete response of breast cancer metastases after trastuzumab-based immunotherapy
Giuseppe Tonini
, Rome, Italy; and Regina Elena Cancer Institute, Rome, Italy
J Clin Oncol 21:2215-6. 2003
- Cyclooxygenase-2 overexpression is associated with a poor outcome in resected ampullary cancer patients
Daniele Santini
University Campus Bio-Medico, Rome, Italy
Clin Cancer Res 11:3784-9. 2005
..Further studies are required to determine whether Cox-2 inhibitors may be useful for the therapy or prevention of ampullary carcinoma...
- Gemcitabine as single agent chemotherapy in elderly patients with stages III-IV non-small cell lung cancer (NSCLC): a phase II study
Vincenzo Bianco
U.O. Clinical Oncology, Policlinico Umberto I, Department of Experimental Medicine, University of Rome La Sapienza, Rome, Italy
Anticancer Res 22:3053-6. 2002
..045). Toxicity was extremely mild. CONCLUSION: In elderly patients with stages III-IV NSCLC gemcitabine showed good activity with a mild toxicity and could be considered a valid therapeutic option in this setting...
- Bisphosphonate effects in cancer and inflammatory diseases: in vitro and in vivo modulation of cytokine activities
Daniele Santini
Oncology Department, University Campus Bio-Medico, Rome, Italy
BioDrugs 18:269-78. 2004
....
- Piroxicam and cisplatin in a mouse model of peritoneal mesothelioma
Enrico P Spugnini
SAFU Department, CRS, Regina Elena Cancer Institute, Rome, Italy
Clin Cancer Res 12:6133-43. 2006
..Therefore, piroxicam in combination with CDDP might potentially be useful in the treatment of patients with mesothelioma...
- Molecular prognostic factors in patients with pancreatic cancer
Giuseppe Tonini
Campus Bio Medico University, Medical Oncology, Via Emilio Longoni, 83, 00155, Rome, Italy
Expert Opin Ther Targets 11:1553-69. 2007
..The markers with the strongest evidence as independent predictors of patient outcome include, p16, MMP7 and vascular endothelial growth factor...
- S-adenosylmethionine (AdoMet) supplementation for treatment of chemotherapy-induced liver injury
Daniele Santini
Medical Oncology, Center for Biomedical Research (CIR, Laboratory of Internal Medicine and Hepatology, Campus Bio-Medico University, Rome, Italy
Anticancer Res 23:5173-9. 2003
..Further large phase III studies are required to assess the real clinical benefit associated with AdoMet supplementation...
- Fever after zoledronic acid administration is due to increase in TNF-alpha and IL-6
Giordano Dicuonzo
Università Campus Bio Medico, Rome, Italy
J Interferon Cytokine Res 23:649-54. 2003
..The sharp reduction in serum calcium levels observed in patients with fever may be related to zoledronic acid pharmacokinetic modifications...
- Pulse-mediated chemotherapy enhances local control and survival in a spontaneous canine model of primary mucosal melanoma
Enrico P Spugnini
SAFU Department, Regina Elena Cancer Institute, Rome, Italy
Melanoma Res 16:23-7. 2006
..Further studies are needed to characterize this approach and to determine its suitability for head and neck mucosal melanoma...
- High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice
Daniele Santini
Department of Oncology, University Campus Bio Medico, Rome, Italy
Oncologist 13:1270-5. 2008
..Nevertheless, most experiences were conducted on samples from primaries. The aim of this study was to evaluate the grade of concordance in terms of KRAS status between primaries and related metastases...
- Liver harvesting surgical technique for the treatment of retro-hepatic caval thrombosis concomitant to renal cell carcinoma: perioperative and long-term results in 15 patients without mortality
Michele Gallucci
Department of Urology, Regina Elena Institute, Rome, Italy
Eur Urol 45:194-202. 2004
..CONCLUSIONS: Isolation of the retro-hepatic IVC is a safe and effective manoeuvre to significantly reduce perioperative mortality and morbidity in patients affected by Level II caval thrombosis concomitant to renal carcinoma...
- Azygo-tracheal fistula in a complete implantable central venous system
Carlo Cosimo Quattrocchi
Interdisciplinary Center for Biomedical Research, Department of Radiology, University Campus Bio-Medico of Rome, Via Longoni, Rome, Italy
J Clin Oncol 24:4029-31. 2006
- NOD2/CARD15 polymorphisms impair innate immunity and increase susceptibility to gastric cancer in an Italian population
Silvia Angeletti
Clinical Pathology, University Campus Bio Medico, Rome, Italy
Hum Immunol 70:729-32. 2009
..Meta-analyses of these SNPs and further analyses of additional polymorphisms/haplotypes in NOD genes will help determine their role in carcinogenesis...
- Targeting bone metastases starting from the preneoplastic niche: home sweet home
Daniele Santini
Department of Medical Oncology, University Campus Bio Medico, Via Alvaro del Portillo 200, 00128, Rome, Italy
Breast Cancer Res 13:111. 2011
....
- First-line targeted therapies in the treatment of metastatic colorectal cancer - role of cetuximab
Giuseppe Tonini
Medical Oncology, University Campus, Bio Medico, Rome, Italy
Onco Targets Ther 2:73-82. 2009
..In this review we will focus on the main epidermal growth factor receptor inhibitors demonstrating clinical benefit, and the role of cetuximab in first-line treatment of metastatic CRC...
- New drugs for chemotherapy-induced nausea and vomiting: focus on palonosetron
Giuseppe Tonini
University Campus Bio Medico, Medical Oncology, Via E Longoni 69, 00155, Rome, Italy
Expert Opin Drug Metab Toxicol 1:143-9. 2005
..Further studies incorporating dexamethasone to 5-HT(3) antagonists will be necessary to determine the relative efficacy of palonosetron compared with available agents. These trials could open a new era in the treatment of CINV...
- Emerging anti-cancer molecular mechanisms of aminobisphosphonates
Michele Caraglia
Department of Experimental Oncology, Experimental Pharmacology Unit, National Institute of Tumours, Fondazione G Pascale, Via Mariano Semmola, 80131 Naples, Italy
Endocr Relat Cancer 13:7-26. 2006
..To date, however, the real molecular targets of NBPs are not completely known and new technological platforms are required in order to detect them and to develop new anti-cancer strategies based on the use of NBPs...
- Pamidronate induces modifications of circulating angiogenetic factors in cancer patients
Daniele Santini
, 00155 Rome, Italy
Clin Cancer Res 8:1080-4. 2002
..0001) and a positive correlation between VEGF and IL-8 (P = 0.04). CONCLUSIONS: This study confirms that pamidronate could have antiangiogenic properties through a significant and lasting decrease of VEGF serum levels...
- Last generation of amino-bisphosphonates (N-BPs) and cancer angio-genesis: a new role for these drugs?
Daniele Santini
Medical Oncology, University Campus Bio Medico, Rome
Recent Pat Anticancer Drug Discov 1:383-96. 2006
..The translation into the clinical setting of the preclinical evidence of an antiangiogenic power of these drugs is becoming an imperative need and should represent the objective of future clinical trials...
- Raltitrexed-induced hepatotoxicity: multivariate analysis of predictive factors
Cristian Massacesi
Medical Oncology, Oncology and Radiotherapy Department of Ancona, Ancona, Italy
Anticancer Drugs 14:533-41. 2003
..Predictive and protective factors listed above could assist the management of this toxicity that has probably been underestimated until now...
- Renal-cell carcinoma
Bruno Vincenzi
N Engl J Med 354:1095-6; author reply 1095-6. 2006
- Zoledronic acid delays the onset of skeletal-related events and progression of skeletal disease in patients with advanced renal cell carcinoma
Bruno Vincenzi
Cancer 100:1987-8; author reply 1988. 2004
- Ocular toxicity related to cetuximab monotherapy in an advanced colorectal cancer patient
Giuseppe Tonini
J Natl Cancer Inst 97:606-7. 2005
- Thymidylate synthase expression in colorectal cancer: the never-ending story
Bruno Vincenzi
J Clin Oncol 23:2108; author reply 2108-9. 2005
- Zoledronic acid exhibits inhibitory effects on osteoblastic and osteolytic metastases of prostate cancer
Daniele Santini
Clin Cancer Res 9:3215; author reply 3216. 2003
- Predictive factors for response to chemotherapy in colorectal cancer patients
Bruno Vincenzi
Medical Oncology, Campus Bio-Medico University, Via Emilio Longoni, 69, 00155 Rome, Italy
Crit Rev Oncol Hematol 52:45-60. 2004
..The results of this review provide the rationale basis for personalizing anticancer treatment in colorectal cancer patients by molecular and clinical features, aiming to improve response rate and reduce toxicities...
- Recurrent episodes of involuntary masticatory spasms induced by continuous infusion of oxaliplatin
Daniele Santini
J Natl Cancer Inst 95:1555-6. 2003
- Chronomodulated administration of oxaliplatin plus capecitabine (XELOX) as first line chemotherapy in advanced colorectal cancer patients: phase II study
Daniele Santini
Medical Oncology, University Campus Bio Medico, Via Emilio Longoni, 69, 00155 Rome, Italy
Cancer Chemother Pharmacol 59:613-20. 2007
..The aim of the present study was to define the feasibility and efficacy of XELOX administered through a new chronomodulated schedule in untreated advanced colorectal cancer (CRC) patients...
- Management of pain in elderly patients receiving infusion of zoledronic acid for bone metastasis: a single-institution report
Raffaele Addeo
UOC Oncologia, S Giovanni di Dio Hospital, ASL Napoli3 Via Giovanni XXIII 80020 Frattaminore, Naples, Italy
Support Care Cancer 16:209-14. 2008
..We studied the safety and the effect of a new bisphosphonate, zoledronic acid (ZA), on pain and on quality of life (QoL) in elderly patients with bone metastases...
- Biological interaction between anti-epidermal growth factor receptor agent cetuximab and magnesium
Bruno Vincenzi
Expert Opin Pharmacother 9:1267-9. 2008
..These reduced magnesium levels in turn contribute to the inhibition of angiogenesis by directly acting on endothelial cells and indirectly affecting EGFR signalling and the production of angiogenic molecules...
- Survey on learning needs and preferred sources of information to meet these needs in Italian oncology patients receiving chemotherapy
Michela Piredda
Università Campus Bio Medico di Roma, Via Alvaro del Portillo, 220 00128 Roma, Italy
Eur J Oncol Nurs 12:120-6. 2008
..In order to meet cancer patients' information needs, health professionals' education and practice should be improved...
- Targeting apoptosis in solid tumors: the role of bortezomib from preclinical to clinical evidence
Antonio Russo
Universita di Palermo, Section of Medical Oncology, Department of Surgical and Oncological Sciences, Italy
Expert Opin Ther Targets 11:1571-86. 2007
....
- Cetuximab: from biology to the care of colorectal cancer patients
Bruno Vincenzi
Future Oncol 3:497-9. 2007
- European Society for Medical Oncology 2006: meeting highlights on targeted therapies. Istanbul, Turkey, 29 September-3 October 2006
Gaia Schiavon
University Campus Bio Medico, Medical Oncology, Via Emilio Longoni, 47, 00155 Rome, Italy
Expert Opin Biol Ther 7:269-78. 2007
....
- Zoledronic acid in the management of metastatic bone disease
Daniele Santini
University Campus Bio Medico, Medical Oncology, Via Emilio Longoni 69, 00155 Rome, Italy
Expert Opin Biol Ther 6:1333-48. 2006
..Renal safety is an important consideration for oncologists who are treating patients with bisphosphonates. This issue and the other topics relating to the safety of bisphosphonates are discussed in this review...
- Chemotherapy-induced steatohepatitis in colorectal cancer patients
Umberto Vespasiani Gentilucci
J Clin Oncol 24:5467; author reply 5467-8. 2006
- New issues on cetuximab mechanism of action in epidermal growth factor receptor-negative colorectal cancer: the role of vascular endothelial growth factor
Bruno Vincenzi
J Clin Oncol 24:1957; author reply 1957-8. 2006
- Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients
Daniele Santini
Medical Oncology, Department of Laboratory Medicine, Campus Bio-Medico University, 00155 Rome, Italy
Clin Cancer Res 9:2893-7. 2003
..CONCLUSIONS: This study confirms that zoledronic acid could have an in vivo antiangiogenic property through a significant and long-lasting reduction in serum VEGF levels...
