Luigi Villa

Summary

Publications

  1. ncbi request reprint [spACE, the last frontier? Renin inhibition in hypertension]
    Luigi Villa
    Struttura Complessa di Nefrologia, Dialisi e Trapianto, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    G Ital Nefrol 25:274. 2008
  2. doi request reprint Effects and mechanisms of angiotensin II receptor blockade with telmisartan in a normotensive model of mesangioproliferative nephritis
    Luigi Villa
    Division of Nephrology, University Hospital RWTH Aachen, Aachen, Germany
    Nephrol Dial Transplant 26:3131-43. 2011
  3. doi request reprint Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms
    Luigi Villa
    Division of Nephrology, RWTH Aachen University Hospital, Germany
    J Pathol 229:672-84. 2013
  4. pmc PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis
    Frank Eitner
    Division of Nephrology and Immunology, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    J Am Soc Nephrol 19:281-9. 2008
  5. ncbi request reprint Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes
    Uta Kunter
    Division of Nephrology, University Hospital RWTH Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Am Soc Nephrol 18:1754-64. 2007
  6. doi request reprint Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D
    Claudia R C van Roeyen
    Division of Nephrology, RWTH Aachen University Hospital, Aachen, Germany
    Kidney Int 80:1292-305. 2011
  7. doi request reprint The peroxisome proliferator-activated receptor-α agonist, BAY PP1, attenuates renal fibrosis in rats
    Peter Boor
    Department of Clinical and Experimental Pharmacotherapy, Research Base of Slovak Medical University, Bratislava, Slovakia
    Kidney Int 80:1182-97. 2011
  8. ncbi request reprint Complement C5 mediates experimental tubulointerstitial fibrosis
    Peter Boor
    Division of Nephrology, Rheinische Westfälische Technische Hochschule, University of Aachen, Aachen, Germany
    J Am Soc Nephrol 18:1508-15. 2007
  9. ncbi request reprint PDGF-D inhibition by CR002 ameliorates tubulointerstitial fibrosis following experimental glomerulonephritis
    Peter Boor
    Division of Nephrology, University Hospital Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Nephrol Dial Transplant 22:1323-31. 2007
  10. doi request reprint The antifibrogenic effect of hepatocyte growth factor (HGF) on renal tubular (HK-2) cells is dependent on cell growth
    Ciro Esposito
    Unit of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Growth Factors 27:173-80. 2009

Collaborators

Detail Information

Publications12

  1. ncbi request reprint [spACE, the last frontier? Renin inhibition in hypertension]
    Luigi Villa
    Struttura Complessa di Nefrologia, Dialisi e Trapianto, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    G Ital Nefrol 25:274. 2008
  2. doi request reprint Effects and mechanisms of angiotensin II receptor blockade with telmisartan in a normotensive model of mesangioproliferative nephritis
    Luigi Villa
    Division of Nephrology, University Hospital RWTH Aachen, Aachen, Germany
    Nephrol Dial Transplant 26:3131-43. 2011
    ..We examined the effect of low-dose telmisartan (LT) and high-dose telmisartan (HT) versus conventional antihypertensive therapy in the rat anti-Thy1.1 model of glomerulonephritis...
  3. doi request reprint Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms
    Luigi Villa
    Division of Nephrology, RWTH Aachen University Hospital, Germany
    J Pathol 229:672-84. 2013
    ..We identified down-regulation of platelet-derived growth factor receptors and CCR6 as potential mediators of telmisartan-related renoprotection. CCR6 may also regulate the renal outcome in human mesangioprolfierative glomerulonephritis...
  4. pmc PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis
    Frank Eitner
    Division of Nephrology and Immunology, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    J Am Soc Nephrol 19:281-9. 2008
  5. ncbi request reprint Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes
    Uta Kunter
    Division of Nephrology, University Hospital RWTH Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Am Soc Nephrol 18:1754-64. 2007
    ..These data suggest that MSC treatment can be a valuable therapeutic approach only if adipogenic maldifferentiation is prevented...
  6. doi request reprint Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D
    Claudia R C van Roeyen
    Division of Nephrology, RWTH Aachen University Hospital, Aachen, Germany
    Kidney Int 80:1292-305. 2011
    ..Hence, podocyte-specific growth factor overexpression can induce paracrine mesangial cell proliferation upstream of the filtration flow...
  7. doi request reprint The peroxisome proliferator-activated receptor-α agonist, BAY PP1, attenuates renal fibrosis in rats
    Peter Boor
    Department of Clinical and Experimental Pharmacotherapy, Research Base of Slovak Medical University, Bratislava, Slovakia
    Kidney Int 80:1182-97. 2011
    ..Hence, potent PPAR-α agonists might be useful in the treatment of renal fibrosis...
  8. ncbi request reprint Complement C5 mediates experimental tubulointerstitial fibrosis
    Peter Boor
    Division of Nephrology, Rheinische Westfälische Technische Hochschule, University of Aachen, Aachen, Germany
    J Am Soc Nephrol 18:1508-15. 2007
    ..Using a combined genetic and pharmacologic approach, C5, in particular C5a, is identified as a novel profibrotic factor in renal disease and as a potential new therapeutic target...
  9. ncbi request reprint PDGF-D inhibition by CR002 ameliorates tubulointerstitial fibrosis following experimental glomerulonephritis
    Peter Boor
    Division of Nephrology, University Hospital Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Nephrol Dial Transplant 22:1323-31. 2007
    ..Administration of the PDGF-D neutralizing fully human monoclonal antibody CR002 in the acute phase of progressive anti-Thy 1.1 glomerulonephritis reduced glomerular and secondary tubulointerstitial damage...
  10. doi request reprint The antifibrogenic effect of hepatocyte growth factor (HGF) on renal tubular (HK-2) cells is dependent on cell growth
    Ciro Esposito
    Unit of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Growth Factors 27:173-80. 2009
    ..Our results demonstrate that the proliferative state of target cells may influence the effects of HGF on extracellular matrix turnover in HK-2 cells...
  11. doi request reprint Different immunohistochemical and ultrastructural phenotypes of squamous differentiation in bladder cancer
    Nadine T Gaisa
    Institute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany
    Virchows Arch 458:301-12. 2011
    ..A staining pattern with CK 5/6- and CK 5/14-positivity plus CK 20- and uroplakin III-negativity identified squamous differentiation in bladder tumours and revealed a third type of squamous transdifferentiation...
  12. ncbi request reprint Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking
    Alessandro Pedretti
    Istituto di Chimica Farmaceutica e Tossicologica, University of Milan, Viale Abruzzi 42, I 20131 Milan, Italy
    J Med Chem 45:1460-5. 2002
    ....