Meiselbach H, Vogel N, Langlhofer G, Stangl S, Schleyer B, Bahnassawy L, et al
. Single expressed glycine receptor domains reconstitute functional ion channels without subunit-specific desensitization behavior. J Biol Chem. 2014;289:29135-47 pubmed publisher
..Thus, an intact Î±3 splicing cassette in the TM3-4 loop environment is indispensable for functional rescue, and the quality of receptor restoration can be assessed from desensitization properties. ..
Schaefer N, Kluck C, Price K, Meiselbach H, Vornberger N, Schwarzinger S, et al
. Disturbed neuronal ER-Golgi sorting of unassembled glycine receptors suggests altered subcellular processing is a cause of human hyperekplexia. J Neurosci. 2015;35:422-37 pubmed publisher
..We suggest that loop D/Î²2-3 is an important determinant for GlyR trafficking and functionality, whereas alterations to loop B alter agonist potencies, indicating that residues here are critical elements in ligand binding. ..
Langlhofer G, Janzen D, Meiselbach H, Villmann C. Length of the TM3-4 loop of the glycine receptor modulates receptor desensitization. Neurosci Lett. 2015;600:176-81 pubmed publisher
..We conclude that the TM3-4 loop length is critical for glycine receptor Î±1 desensitization and a direct neighborhood of both basic stretches changes receptor properties from non-desensitizing to desensitizing. ..
Schaefer N, Berger A, van Brederode J, Zheng F, Zhang Y, Leacock S, et al
. Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease. J Neurosci. 2017;37:7948-7961 pubmed publisher
..The GlyR β8-β9 loop is therefore an essential regulator of conformational rearrangements during ion channel opening and closing. ..