Maciej F Boni
Affiliation: Ho Chi Minh City
- Evolution of antibiotic resistance by human and bacterial niche constructionMaciej F Boni
Department of Biological Sciences, 371 Serra Mall, Stanford University, Stanford, CA 94305, USA
Evolution 59:477-91. 2005..In particular, if antibiotic use is discouraged when resistance levels are high, we observe a classic niche-construction phenomenon of maintaining strain polymorphism even in parameter regions where it would not be expected...
- Clinically immune hosts as a refuge for drug-sensitive malaria parasitesEili Y Klein
Resources for the Future, 1616 P St, NW, Washington, DC 20036, USA
Malar J 7:67. 2008..This model reconsiders the role of immunity in the dynamics of malaria transmission and its impact on the evolution of antimalarial drug resistance under the assumption that immune individuals are infectious...
- Benefits of using multiple first-line therapies against malariaMaciej F Boni
Resources for the Future, Washington, DC 20036, USA
Proc Natl Acad Sci U S A 105:14216-21. 2008..The clinical benefits of using multiple first-line therapies against malaria suggest that MFT policies should play a key role in malaria elimination and control programs...
- Virulence attenuation during an influenza A/H5N1 pandemicMaciej F Boni
Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam
Philos Trans R Soc Lond B Biol Sci 368:20120207. 2013....
- No observed effect of homologous recombination on influenza C virus evolutionGuan Zhu Han
State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai an, Shandong 271018, China
Virol J 7:227. 2010..No recombination signal was found. With the previous evidence in influenza A and B viruses, it seems that homologous recombination has minimal or no effect on influenza virus evolution...
- Guidelines for identifying homologous recombination events in influenza A virusMaciej F Boni
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
PLoS ONE 5:e10434. 2010....
- Modelling the progression of pandemic influenza A (H1N1) in Vietnam and the opportunities for reassortment with other influenza virusesMaciej F Boni
Oxford University Clinical Research Unit, Vietnam
BMC Med 7:43. 2009..This is of greater concern in parts of Southeast Asia, where the population density is high, influenza is less seasonal, human-animal contact is common and avian influenza is still endemic...
- Combined high-resolution genotyping and geospatial analysis reveals modes of endemic urban typhoid fever transmissionStephen Baker
The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam
Open Biol 1:110008. 2011..These findings have implications for typhoid-control strategies, and our innovative approach may be applied to other diseases caused by other monophyletic or emerging pathogens...
- Dengue dynamics in Binh Thuan province, southern Vietnam: periodicity, synchronicity and climate variabilityKhoa T D Thai
Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Amsterdam, The Netherlands
PLoS Negl Trop Dis 4:e747. 2010..The epidemiology is complex with long inter-epidemic intervals and endemic with seasonal fluctuations. This study was initiated to investigate dengue transmission dynamics in Binh Thuan province, southern Vietnam...
- In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, VietnamTinh Hien Tran
Wellcome Trust Major Overseas Programme MOP, Oxford University Clinical Research Unit OUCRU, Ho Chi Minh City, Vietnam
Malar J 11:355. 2012..Therefore, there is an urgent need to investigate whether there is any evidence of a change in the parasitological response to the artemisinin derivatives in Vietnam...
- Early pandemic influenza (2009 H1N1) in Ho Chi Minh City, Vietnam: a clinical virological and epidemiological analysisTran Tinh Hien
Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
PLoS Med 7:e1000277. 2010..In addition, we present detailed systematic viral clearance data on 292 isolated and treated patients and the first three cases of selection of resistant virus during treatment in Vietnam...
- Population-Level Antibody Estimates to Novel Influenza A/H7N9Maciej F Boni
Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City
J Infect Dis 208:554-8. 2013..Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study. ..
- No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swineMaciej F Boni
Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Viet Nam
Gene 494:242-5. 2012..Through rigorous phylogenetic analyses we explain the evolutionary origins of these stains and confirm the lack of any statistical support for intra-segmental recombination...
- Homologous recombination is very rare or absent in human influenza A virusMaciej F Boni
Resources for the Future, 1616 P St NW, Washington, DC 20036, USA
J Virol 82:4807-11. 2008..We therefore conclude that, if it occurs at all, homologous recombination plays only a very minor role in the evolution of human influenza A virus...
- The dynamics of GII.4 Norovirus in Ho Chi Minh City, VietnamPhan Vu Tra My
Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, 764 Vo Van Kiet, District 5, Ho Chi Minh City, Viet Nam Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Wellington Square, Oxford OX1 2JD, United Kingdom
Infect Genet Evol 18:335-43. 2013..4-2010 variant was detected. These data show that NoV GII.4 variants are highly endemic in HCMC and describe a scenario of rapid NoV strain replacement occurring in HCMC in early 2010. ..
- Vaccination and antigenic drift in influenzaMaciej F Boni
Resources for the Future, Washington, DC 20036, USA
Vaccine 26:C8-14. 2008..Improved detection of short-term antigenic drift and epidemic seeding would significantly benefit influenza monitoring efforts and vaccine selection...
- Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infectionsLe Van Tan
Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, South East Asia Infectious Diseases Clinical Research Network, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
MBio 4:e00231-13. 2013..Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus...
- A changing picture of shigellosis in southern Vietnam: shifting species dominance, antimicrobial susceptibility and clinical presentationHa Vinh
The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
BMC Infect Dis 9:204. 2009..Antimicrobial resistance in the genus Shigella is a constant threat, with reports of organisms in Asia being resistant to multiple antimicrobials and new generation therapies...
- Most cases of cryptococcal meningitis in HIV-uninfected patients in Vietnam are due to a distinct amplified fragment length polymorphism-defined cluster of Cryptococcus neoformans var. grubii VN1Jeremy N Day
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
J Clin Microbiol 49:658-64. 2011..Two clusters of C. neoformans var. grubii VN1 are responsible for the majority of cases of cryptococcal meningitis in Vietnam. The distribution of these clusters differs according to the immune status of the host...