Liat Vidal

..A number of randomised controlled trials have examined the effect of bendamustine compared to other chemotherapy regimens in these patients. Improved disease control with no survival benefit is shown...

..Eleven of them were eligible for this review and are described herein. These systematic reviews have dramatically influenced the approach to patients with follicular lymphoma...

..67, 95% CI = 1.40 to 2.00). These results further support the use of rituximab maintenance in the standard of care for refractory or relapsed follicular lymphoma...

..This study sought to compare the efficacy and adverse effects of any aminoglycoside as a single antibiotic with other antibiotics for the treatment of patients with infection...

..We aimed to evaluate the effect of maintenance treatment with rituximab on the overall survival of patients with follicular lymphoma...

..Treatment guidelines should address the antibiotic treatment of breakthrough fever...

..Although an advantage is suggested by surrogate parameters, longer follow up is necessary to see if this translates into superior overall survival...

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..Trials have shown the efficacy of antibiotic prophylaxis in reducing the incidence of bacterial infections but not in reducing mortality rates. Our systematic review from 2006 also showed a reduction in mortality...

..However, their safety with regard to disease-related outcomes and survival in AML is unclear. Therefore, we performed a systematic review and meta-analysis to evaluate the impact of CSFs on patient outcomes, including survival...

..53, 95% CI 0.19-1.48). Pediatric-inspired regimens are superior to conventional-adult chemotherapy in AYA ALL patients. Further randomized controlled studies to investigate this approach in adult ALL patients are warranted...

..Extended follow up is needed to evaluate if the superior CCyR and MMolR with higher doses of imatinib will translate to long-term clinical benefit...

..The objective of this study was to compare the various potential therapeutic options for patients who achieved first complete remission...

..To assess the value of empirical anti-Gram-positive antibiotics for the treatment of febrile neutropenia...

..However, their safety with regard to disease-related outcomes and survival in AML is unclear. Therefore, we performed a systematic review and meta-analysis to evaluate the impact of CSFs on patient outcomes, including survival...

..Therefore, it should not be recommended routinely as an adjunct to the immunosuppressive therapy for patients with aplastic anemia...

..We performed a systematic review and meta-analysis of the existing data from randomized controlled trials regarding the efficacy and toxicity of the dose-dense chemotherapy approach in nonmetastatic breast cancer...

..Further studies are needed to establish the exact role of decitabine compared to 5-azacitidine in these patients...

..They probably induce less resistance. Pragmatic large trials are needed to answer open clinical questions on the use of aminoglycosides...

..Patients with poor cytogenetics in whom AZA is prescribed despite low PLT count are particularly at high risk for infections and infection prophylaxis may be considered...

..To date, no sufficient evidence exists to support this broad coverage, while limiting coverage is bound to reduce toxicity, resistance and expense...

..A consensus exists regarding the need for administration of both induction and consolidation treatments, albeit using different approaches. However, there is conflicting evidence for the role of maintenance treatment in APL patients...

..To compare available antifungal treatments for invasive candidiasis, a leading cause of nosocomial bloodstream infections...

..Characteristics predictive for the diagnosis of Burkitt's lymphoma were: younger age, bilateral ovarian involvement, a rapidly progressive course and high LDH levels...

..Current guidelines are inconclusive regarding intravenous (IV) iron for treatment of chemotherapy-induced anaemia (CIA)...

..The methods used to retrieve information and use data should be described and made available to the reader. Advice on drug prescription, dose and dosing interval, contraindications, and adverse effects should be evidence based...

..Oral therapy could be an alternative approach for selected patients...

..To evaluate the effect of Bevacizumab in combination with chemotherapy on overall survival of patients with metastatic solid tumors...

..To assess the efficacy of prophylaxis for Pneumocystis pneumonia (PCP), caused by Pneumocystis jirovecii (formerly Pneumocystis carinii), for immunocompromised non-HIV-infected patients by conducting a systematic review and meta-analysis...