Francesc Vidal

Summary

Publications

  1. ncbi request reprint Evaluation of the pharmacogenetics of immune recovery in treated HIV-infected patients
    Joaquim Peraire
    Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain 0034977295833 0034977295833
    Expert Opin Drug Metab Toxicol 10:81-101. 2014
  2. pmc Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants
    Francesc Vidal
    Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    PLoS ONE 7:e47725. 2012
  3. ncbi request reprint Adipogenic/lipid, inflammatory, and mitochondrial parameters in subcutaneous adipose tissue of untreated HIV-1-infected long-term nonprogressors: significant alterations despite low viral burden
    Francesc Vidal
    Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    J Acquir Immune Defic Syndr 61:131-7. 2012
  4. doi request reprint Pharmacogenetics of the lipodystrophy syndrome associated with HIV infection and combination antiretroviral therapy
    Francesc Vidal
    Infectious Diseases and HIV AIDS Section, Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    Expert Opin Drug Metab Toxicol 7:1365-82. 2011
  5. ncbi request reprint Pharmacogenetics of adverse effects due to antiretroviral drugs
    Francesc Vidal
    Sección de Enfermedades Infecciosas y VIH SIDA, Departamento de Medicina Interna, Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    AIDS Rev 12:15-30. 2010
  6. ncbi request reprint Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women
    Alfons Lorenzo
    Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, Institut d Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, C Dr Mallafré Guasch, 4, 43007 Tarragona, Spain
    Drug Alcohol Depend 84:195-200. 2006
  7. ncbi request reprint Effect of genetic variants of CCR2 and CCL2 on the natural history of HIV-1 infection: CCL2-2518GG is overrepresented in a cohort of Spanish HIV-1-infected subjects
    Consuelo Vilades
    Department of Internal Medicine, Infectious Diseases and AIDS Research unit, Hospital Universitari de Tarragona Joan XXIII and Universitat Rovira i Virgili, Tarragona, Spain
    J Acquir Immune Defic Syndr 44:132-8. 2007
  8. pmc Effect of TNF-alpha genetic variants and CCR5 Delta 32 on the vulnerability to HIV-1 infection and disease progression in Caucasian Spaniards
    Sergi Veloso
    Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain
    BMC Med Genet 11:63. 2010
  9. doi request reprint The IL-6 system in HIV-1-infection and in HAART-related fat redistribution syndromes
    Maria Saumoy
    Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain
    AIDS 22:893-6. 2008
  10. doi request reprint Polymorphisms in the interleukin-10 gene promoter and the risk of alcoholism and alcoholic liver disease in Caucasian Spaniard men
    Teresa Auguet
    Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    Alcohol 44:211-6. 2010

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Evaluation of the pharmacogenetics of immune recovery in treated HIV-infected patients
    Joaquim Peraire
    Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain 0034977295833 0034977295833
    Expert Opin Drug Metab Toxicol 10:81-101. 2014
    ..Pharmacogenetic studies have been used to investigate how a patient's genetic predisposition may affect their response to antiretroviral drugs...
  2. pmc Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants
    Francesc Vidal
    Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    PLoS ONE 7:e47725. 2012
    ..2b, both with ribavirin, for 48 weeks, in HCV-HIV coinfected patients...
  3. ncbi request reprint Adipogenic/lipid, inflammatory, and mitochondrial parameters in subcutaneous adipose tissue of untreated HIV-1-infected long-term nonprogressors: significant alterations despite low viral burden
    Francesc Vidal
    Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    J Acquir Immune Defic Syndr 61:131-7. 2012
    ..Our objectives were to determine whether adipocyte differentiation/lipid, inflammatory, and mitochondrial parameters are perturbed in abdominal wall subcutaneous adipose tissue of untreated HIV-1-infected patients LTNPs...
  4. doi request reprint Pharmacogenetics of the lipodystrophy syndrome associated with HIV infection and combination antiretroviral therapy
    Francesc Vidal
    Infectious Diseases and HIV AIDS Section, Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    Expert Opin Drug Metab Toxicol 7:1365-82. 2011
    ..Pharmacogenetics is the science that studies how the genetic composition of individuals can give rise to interindividual variations in response to drugs and drug toxicity...
  5. ncbi request reprint Pharmacogenetics of adverse effects due to antiretroviral drugs
    Francesc Vidal
    Sección de Enfermedades Infecciosas y VIH SIDA, Departamento de Medicina Interna, Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    AIDS Rev 12:15-30. 2010
    ..Special emphasis is devoted to the studies that have resulted in clinical applications such as that of the pre-screening of HLA B*5701 for avoiding abacavir-related hypersensitivity syndrome...
  6. ncbi request reprint Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women
    Alfons Lorenzo
    Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, Institut d Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, C Dr Mallafré Guasch, 4, 43007 Tarragona, Spain
    Drug Alcohol Depend 84:195-200. 2006
    ..We determined the genotypes of ADH1B, ADH1C, CYP2E1 (Dra-I and Pst-I) and ALDH2 in a group of Caucasian Spanish women...
  7. ncbi request reprint Effect of genetic variants of CCR2 and CCL2 on the natural history of HIV-1 infection: CCL2-2518GG is overrepresented in a cohort of Spanish HIV-1-infected subjects
    Consuelo Vilades
    Department of Internal Medicine, Infectious Diseases and AIDS Research unit, Hospital Universitari de Tarragona Joan XXIII and Universitat Rovira i Virgili, Tarragona, Spain
    J Acquir Immune Defic Syndr 44:132-8. 2007
    ..Our aim was to determine whether functionally active CCR2 and CCL2 genetic variants influence the risk of infection and disease progression in a cohort of white Spaniards...
  8. pmc Effect of TNF-alpha genetic variants and CCR5 Delta 32 on the vulnerability to HIV-1 infection and disease progression in Caucasian Spaniards
    Sergi Veloso
    Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain
    BMC Med Genet 11:63. 2010
    ..Tumor necrosis factor alpha (TNF-alpha) is thought to be involved in the various immunogenetic events that influence HIV-1 infection...
  9. doi request reprint The IL-6 system in HIV-1-infection and in HAART-related fat redistribution syndromes
    Maria Saumoy
    Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain
    AIDS 22:893-6. 2008
    ..The IL-6 -174 G>C genotype distribution and allele frequencies, SAT IL-6 mRNA expression and IL-6 plasma levels were non-significantly different between HIV-1-infected patients with and without lipodystrophy...
  10. doi request reprint Polymorphisms in the interleukin-10 gene promoter and the risk of alcoholism and alcoholic liver disease in Caucasian Spaniard men
    Teresa Auguet
    Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    Alcohol 44:211-6. 2010
    ..55 and P=0.29, respectively). This study failed to detect significant associations of the IL-10 -627C>A SNP and alcoholism or alcoholic liver disease in a cohort of Caucasian male Spaniards...
  11. doi request reprint Lipodystrophy and insulin resistance in combination antiretroviral treated HIV-1-infected patients: implication of resistin
    Xavier Escote
    Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    J Acquir Immune Defic Syndr 57:16-23. 2011
    ..We determined whether the resistin (rest) -420C>G single-nucleotide polymorphism and plasma resistin are associated with the development of lipodystrophy and metabolic disturbances in HIV-1-infected patients treated with cART...
  12. ncbi request reprint Spanish HIV-1-infected long-term nonprogressors of more than 15 years have an increased frequency of the CX3CR1 249I variant allele
    Francesc Vidal
    Hospital Universitari de Tarragona Joan XXIII and Universitat Rovira i Virgili, Tarragona, Catalonia, Spain
    J Acquir Immune Defic Syndr 40:527-31. 2005
    ..This study aimed to determine whether functionally active CX3CR1 genetic variants are associated with long-term nonprogressive infection of >15 years in HIV-1-infected Spanish patients...
  13. ncbi request reprint A study on the TNF-alpha system in Caucasian Spanish patients with alcoholic liver disease
    Teresa Auguet
    Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain Universitat Rovira i Virgili, Tarragona, Spain
    Drug Alcohol Depend 92:91-9. 2008
    ..We also aimed to elucidate whether functionally active polymorphisms in the promoter region of the TNF-alpha gene modulate the development of ALD...
  14. doi request reprint Leptin and adiponectin, but not IL18, are related with insulin resistance in treated HIV-1-infected patients with lipodystrophy
    Sergi Veloso
    Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    Cytokine 58:253-60. 2012
    ..Plasma IL18 levels are increased in infected patients irrespective of the presence of lipodystrophy. The polymorphisms assessed are not associated with lipodystrophy or metabolic disturbances in treated HIV-1-infected patients...
  15. ncbi request reprint PPARgamma Pro12Ala polymorphism in HIV-1-infected patients with HAART-related lipodystrophy
    Maria Saumoy
    Hospital Universitari Joan XXIII, Tarragona, Spain
    Curr HIV Res 7:533-40. 2009
    ..054). PPARgamma Pro12Ala SNP has no effect on the risk of developing lipodystrophy in HIV-1-infected patients treated with HAART. PPARgamma mRNA SAT expression appears decreased in lipodystrophy...
  16. ncbi request reprint HIV-1-infected long-term non-progressors have milder mitochondrial impairment and lower mitochondrially-driven apoptosis in peripheral blood mononuclear cells than typical progressors
    Joaquim Peraire
    Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain
    Curr HIV Res 5:467-73. 2007
    ..Mitochondrial damage is associated with increased PBMC apoptosis in patients with active HIV-1 replication (TP). These abnormalities are slight or not present in LTNP...
  17. ncbi request reprint Polymorphism of RANTES chemokine gene promoter is not associated with long-term nonprogressive HIV-1 infection of more than 16 years
    Francesc Vidal
    Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain
    J Acquir Immune Defic Syndr 41:17-22. 2006
    ..We conclude that LTNP of more than 16 years is not associated with SNPs in the RANTES gene promoter in white Spanish HIV-1-infected subjects...
  18. doi request reprint No relationship between TNF-α genetic variants and combination antiretroviral therapy-related lipodystrophy syndrome in HIV type 1-infected patients: a case-control study and a meta-analysis
    Sergi Veloso
    Hospital Universitari de Tarragona Joan XXIII, Spain
    AIDS Res Hum Retroviruses 27:143-52. 2011
    ..In HIV-1-infected patients under cART there is a systemic overproduction of sTNF-α R2, which is unrelated to the presence of lipodystrophy...
  19. ncbi request reprint Involvement of the LPS-LPB-CD14-MD2-TLR4 inflammation pathway in HIV-1/HAART-associated lipodystrophy syndrome (HALS)
    Consuelo Vilades
    Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    J Antimicrob Chemother 69:1653-9. 2014
    ....
  20. ncbi request reprint Pharmacogenetics of the metabolic disturbances and atherosclerosis associated with antiretroviral therapy in HIV-infected patients
    Sergi Veloso
    Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    Curr Pharm Des 16:3379-89. 2010
    ..The influence of host genetic variants on dyslipidemia, hyperglycemia and insulin resistance, lipodystrophy and atherosclerosis are presented and discussed...
  21. ncbi request reprint Lack of association of SDF-1 3'A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years
    Francesc Vidal
    Hospital Universitari de Tarragona Joan XXIII and Universitat Rovira i Virgili, Tarragona, Catalonia, Spain
    J Acquir Immune Defic Syndr 40:276-9. 2005
    ..Polymorphism at the SDF-1 locus is not associated with LTNP disease of longer than 16 years in Spanish HIV-1-infected patients. This effect is independent of the CCR5Delta32 allele...
  22. ncbi request reprint LMNA messenger RNA expression in highly active antiretroviral therapy-treated HIV-positive patients
    Merce Miranda
    Endocrinology and Diabetes Unit, Research Department, University Hospital of Tarragona Joan XXIII, Pere Virgili Institute, Rovira i Virgili University, Tarragona, Spain
    J Acquir Immune Defic Syndr 46:384-9. 2007
    ..Hence, in the present study, the lower lamin A expression observed in HIV-positive patients is related to HIV itself or to treatments rather than to the presence of lipodystrophy...
  23. ncbi request reprint A 48-Week Study of Fat Molecular Alterations in HIV Naive Patients Starting Tenofovir/Emtricitabine With Lopinavir/Ritonavir or Efavirenz
    Pere Domingo
    Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain Department of Biochemistry and Molecular Biology, Institute of Biomedicine IBUB, University of Barcelona, Barcelona, Spain CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Spain Biostatistics and Data Management Platform, IDIBAPS, Hospital Clinic Biostatistics Unit, School of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain and Infectious Diseases Unit, Department of Internal Medicine, Hospital Universitari Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    J Acquir Immune Defic Syndr 66:457-65. 2014
    ..Conflicting reports on the effects of efavirenz (EFV) and lopinavir/ritonavir (LPV/r) on subcutaneous adipose tissue (SAT) have been described...
  24. ncbi request reprint [Clinical characteristics and outcome of infective endocarditis in individuals of the general population managed at a teaching hospital without cardiac surgery facilities. Study of 120 cases]
    Miguel López-Dupla
    Servicio de Medicina Interna, Hospital Universitari Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain
    Rev Esp Cardiol 59:1131-9. 2006
    ..To assess the clinical characteristics and management of infective endocarditis at a teaching hospital without cardiac surgery facilities...
  25. ncbi request reprint Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease
    Francesc Vidal
    Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, C Dr Mallafré Guasch, 4, 43007 Tarragona, Spain
    J Hepatol 41:744-50. 2004
    ....
  26. ncbi request reprint [Epidemiology and clinical manifestations of infection due to Nocardia species in Tarragona, 1997-2008: Nocardia cyriacigeorgica is an emerging pathogen]
    Olga Portolá
    Servicio de Medicina Interna, Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili URV, Tarragona, Espana
    Enferm Infecc Microbiol Clin 27:585-8. 2009
    ..Nocardia infections are uncommon, and the clinical experience with this pathogen is limited...
  27. pmc In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells
    Francesc Vidal
    Infectious Diseases and AIDS Section, Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Mallafre Guasch, 4, 43007 Tarragona, Spain
    Antimicrob Agents Chemother 50:3824-32. 2006
    ..Together, these in vitro results indicate that combination with other antiretrovirals does not significantly increase the toxic potential of TFV in RPTECs...
  28. ncbi request reprint Previous ciprofloxacin exposure is associated with resistance to beta-lactam antibiotics in subsequent Pseudomonas aeruginosa bacteremic isolates
    Miguel López-Dupla
    Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain
    Am J Infect Control 37:753-8. 2009
    ..The aim of this study was to assess whether previous exposure to ciprofloxacin influences on the sensitivity of those antibiotics in subsequent P aeruginosa bacteremic isolates...
  29. ncbi request reprint [Persistent vegetative state after meningitis due to Listeria monocytogenes]
    Manuel Mirón
    Servicio de Medicina Interna, Sección de Infecciones, Hospital Universitario de Tarragona Joan XXIII Institut d Estudis AvanCats, Universitat Rovira i Virgili, Tarragona, Spain
    Enferm Infecc Microbiol Clin 20:127-8. 2002
  30. doi request reprint A study of fatty acid binding protein 4 in HIV-1 infection and in combination antiretroviral therapy-related metabolic disturbances and lipodystrophy
    X Escote
    Joan XXIII University Hospital of Tarragona, IISPV, Rovira i Virgili University, Tarragona, Spain
    HIV Med 12:428-37. 2011
    ....