Kevin J Verstrepen

Summary

Publications

  1. pmc Identification of a complex genetic network underlying Saccharomyces cerevisiae colony morphology
    Karin Voordeckers
    Laboratory for Systems Biology, VIB, Bio Incubator, Gaston Geenslaan 1, B 3001, Leuven, Belgium
    Mol Microbiol 86:225-39. 2012
  2. pmc Distal chromatin structure influences local nucleosome positions and gene expression
    An Jansen
    Laboratory for Systems Biology, VIB, Bio Incubator, Gaston Geenslaan 1, B 3001, Leuven, Belgium
    Nucleic Acids Res 40:3870-85. 2012
  3. pmc Nucleosomes affect local transformation efficiency
    Elham Aslankoohi
    Laboratory for Systems Biology, VIB, Bio Incubator, Gaston Geenslaan 1, B 3001 Leuven, Belgium
    Nucleic Acids Res 40:9506-12. 2012
  4. pmc Functional divergence of gene duplicates through ectopic recombination
    Joaquin F Christiaens
    Department of Microbial and Molecular Systems, Centre of Microbial and Plant Genetics CMPG, KU Leuven, Kasteelpark Arenberg 22, B 3001 Leuven Heverlee, Belgium
    EMBO Rep 13:1145-51. 2012
  5. pmc Different levels of catabolite repression optimize growth in stable and variable environments
    Aaron M New
    VIB Laboratory of Systems Biology, Leuven, Belgium CMPG Laboratory of Genetics and Genomics, KU Leuven, Leuven, Belgium
    PLoS Biol 12:e1001764. 2014
  6. doi request reprint Genetic and epigenetic mechanisms underlying cell-surface variability in protozoa and fungi
    Kevin J Verstrepen
    Laboratory for Systems Biology, VIB, B 3001 Leuven, Belgium
    Annu Rev Genet 43:1-24. 2009
  7. doi request reprint Flavour formation in fungi: characterisation of KlAtf, the Kluyveromyces lactis orthologue of the Saccharomyces cerevisiae alcohol acetyltransferases Atf1 and Atf2
    Stijn D M Van Laere
    Centre for Malting and Brewing Science, Centre for Food and Microbial Technology, Department of Microbial and Molecular Systems, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, 3001 Leuven Heverlee, Belgium
    Appl Microbiol Biotechnol 78:783-92. 2008
  8. pmc Dynamics of the Saccharomyces cerevisiae transcriptome during bread dough fermentation
    Elham Aslankoohi
    VIB Laboratory of Systems Biology, Leuven, Belgium
    Appl Environ Microbiol 79:7325-33. 2013
  9. ncbi request reprint The Saccharomyces cerevisiae alcohol acetyl transferase Atf1p is localized in lipid particles
    Kevin J Verstrepen
    Centre for Malting and Brewing Science, Department of Food and Microbial Technology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, B 3001 Leuven Heverlee, Belgium
    Yeast 21:367-77. 2004
  10. doi request reprint Phenotypic diversity of Flo protein family-mediated adhesion in Saccharomyces cerevisiae
    Sebastiaan E Van Mulders
    Department of Microbial and Molecular Systems, Centre for Malting and Brewing Science, Faculty of Bioscience Engineering, Katholieke Universiteit Leuven, Leuven, Heverlee, Belgium
    FEMS Yeast Res 9:178-90. 2009

Collaborators

Detail Information

Publications28

  1. pmc Identification of a complex genetic network underlying Saccharomyces cerevisiae colony morphology
    Karin Voordeckers
    Laboratory for Systems Biology, VIB, Bio Incubator, Gaston Geenslaan 1, B 3001, Leuven, Belgium
    Mol Microbiol 86:225-39. 2012
    ..Together, our results provide a first comprehensive look at the complex genetic network that underlies the diversity in the morphologies of yeast colonies...
  2. pmc Distal chromatin structure influences local nucleosome positions and gene expression
    An Jansen
    Laboratory for Systems Biology, VIB, Bio Incubator, Gaston Geenslaan 1, B 3001, Leuven, Belgium
    Nucleic Acids Res 40:3870-85. 2012
    ....
  3. pmc Nucleosomes affect local transformation efficiency
    Elham Aslankoohi
    Laboratory for Systems Biology, VIB, Bio Incubator, Gaston Geenslaan 1, B 3001 Leuven, Belgium
    Nucleic Acids Res 40:9506-12. 2012
    ..Together, our results demonstrate a novel role for nucleosomes and also allow researchers to predict transformation efficiency of a target region and select spots in the genome that are likely to yield higher transformation efficiency...
  4. pmc Functional divergence of gene duplicates through ectopic recombination
    Joaquin F Christiaens
    Department of Microbial and Molecular Systems, Centre of Microbial and Plant Genetics CMPG, KU Leuven, Kasteelpark Arenberg 22, B 3001 Leuven Heverlee, Belgium
    EMBO Rep 13:1145-51. 2012
    ..Our results indicate that intergenic recombination between paralogs can generate a large set of new alleles, thereby providing the raw material for evolutionary adaptation and innovation...
  5. pmc Different levels of catabolite repression optimize growth in stable and variable environments
    Aaron M New
    VIB Laboratory of Systems Biology, Leuven, Belgium CMPG Laboratory of Genetics and Genomics, KU Leuven, Leuven, Belgium
    PLoS Biol 12:e1001764. 2014
    ..Together, our study unmasks how variable and stable environments favor distinct strategies of transcriptional reprogramming and growth. ..
  6. doi request reprint Genetic and epigenetic mechanisms underlying cell-surface variability in protozoa and fungi
    Kevin J Verstrepen
    Laboratory for Systems Biology, VIB, B 3001 Leuven, Belgium
    Annu Rev Genet 43:1-24. 2009
    ....
  7. doi request reprint Flavour formation in fungi: characterisation of KlAtf, the Kluyveromyces lactis orthologue of the Saccharomyces cerevisiae alcohol acetyltransferases Atf1 and Atf2
    Stijn D M Van Laere
    Centre for Malting and Brewing Science, Centre for Food and Microbial Technology, Department of Microbial and Molecular Systems, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, 3001 Leuven Heverlee, Belgium
    Appl Microbiol Biotechnol 78:783-92. 2008
    ..cerevisiae ATF2 and K. lactis ATF overexpression only caused a moderate increase in acetate esters. This study is the first report of the presence of an ester synthesis gene in K. lactis...
  8. pmc Dynamics of the Saccharomyces cerevisiae transcriptome during bread dough fermentation
    Elham Aslankoohi
    VIB Laboratory of Systems Biology, Leuven, Belgium
    Appl Environ Microbiol 79:7325-33. 2013
    ..Together, our results demonstrate that cells embedded in a solid matrix such as bread dough suffer severe osmotic stress and that a proper induction of the HOG pathway is critical for optimal fermentation. ..
  9. ncbi request reprint The Saccharomyces cerevisiae alcohol acetyl transferase Atf1p is localized in lipid particles
    Kevin J Verstrepen
    Centre for Malting and Brewing Science, Department of Food and Microbial Technology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, B 3001 Leuven Heverlee, Belgium
    Yeast 21:367-77. 2004
    ..The localization of Atf1p in lipid particles may indicate that Atf1p has a specific role in the lipid and/or sterol metabolism that takes place in these particles...
  10. doi request reprint Phenotypic diversity of Flo protein family-mediated adhesion in Saccharomyces cerevisiae
    Sebastiaan E Van Mulders
    Department of Microbial and Molecular Systems, Centre for Malting and Brewing Science, Faculty of Bioscience Engineering, Katholieke Universiteit Leuven, Leuven, Heverlee, Belgium
    FEMS Yeast Res 9:178-90. 2009
    ..Taken together, this study reveals how S. cerevisiae carries a small reservoir of FLO genes that allows cells to display a wide variety of adhesive properties...
  11. ncbi request reprint Influence of the brewing process on furfuryl ethyl ether formation during beer aging
    Bart Vanderhaegen
    Centre for Malting and Brewing Science, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, B 3001 Heverlee, Belgium
    J Agric Food Chem 52:6755-64. 2004
    ..In dark beers, a considerable fraction of furfuryl alcohol may, however, come from the dark malts used. These results lead to important practical conclusions concerning the control over furfuryl ethyl ether in beer...
  12. pmc Reconstruction of ancestral metabolic enzymes reveals molecular mechanisms underlying evolutionary innovation through gene duplication
    Karin Voordeckers
    VIB Laboratory for Systems Biology, Leuven, Belgium
    PLoS Biol 10:e1001446. 2012
    ....
  13. pmc Improved linkage analysis of Quantitative Trait Loci using bulk segregants unveils a novel determinant of high ethanol tolerance in yeast
    Jorge Duitama
    VIB Laboratory of Systems Biology and Laboratory for Genetics and Genomics, Centre of Microbial and Plant Genetics, KU Leuven, Gaston Geenslaan 1, Leuven B 3001, Belgium
    BMC Genomics 15:207. 2014
    ..BSA data analysis is non-trivial due to sequencing, alignment and screening errors...
  14. doi request reprint Flocculation gene variability in industrial brewer's yeast strains
    Sebastiaan E Van Mulders
    Centre for Malting and Brewing Science, Department of Microbial and Molecular Systems, Faculty of Bioscience Engineering, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, 3001 Leuven, Heverlee, Belgium
    Appl Microbiol Biotechnol 88:1321-31. 2010
    ..Taken together, this explicit genetic variation between flocculation genes hampers attempts to understand and control the flocculation behavior in industrial brewer's yeasts...
  15. ncbi request reprint The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity
    Sofie M G Saerens
    Centre for Food and Microbial Technology, Department of Microbial and Molecular Systems, Katholieke Universiteit Leuven, Heverlee, Belgium
    J Biol Chem 281:4446-56. 2006
    ..Hence, our results identify Eht1 and Eeb1 as novel acyl-coenzymeA:ethanol O-acyltransferases/esterases, whereas the third family member, Ymr210w, does not seem to play an important role in medium-chain fatty acid ethyl ester formation...
  16. pdf Production and biological function of volatile esters in Saccharomyces cerevisiae
    Sofie M G Saerens
    Centre for Food and Microbial Technology, Department of Microbial and Molecular Systems, Faculty of Bioscience Engineering, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, B 3001 Leuven Heverlee, Belgium
    Microb Biotechnol 3:165-77. 2010
    ..This paper reviews the current hypotheses of ester synthesis in yeast in relation to the complex regulation of the alcohol acetyl transferases and the different factors that allow ester formation to be controlled during fermentation...
  17. doi request reprint Succinic acid in levels produced by yeast (Saccharomyces cerevisiae) during fermentation strongly impacts wheat bread dough properties
    Vinay B Jayaram
    Laboratory of Food Chemistry and Biochemistry, Leuven Food Science and Nutrition Research Centre LFoRCe KU Leuven, Kasteelpark Arenberg 20 Box 2463, B 3001 Leuven, Belgium
    Food Chem 151:421-8. 2014
    ..These phenomena lead to the reported changes in dough properties. Together, our results establish SA as an important yeast metabolite for dough rheology...
  18. doi request reprint Quantitative trait analysis of yeast biodiversity yields novel gene tools for metabolic engineering
    Georg Hubmann
    Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Belgium
    Metab Eng 17:68-81. 2013
    ..Our results show that polygenic analysis of yeast biodiversity can provide superior novel gene tools for metabolic engineering...
  19. pmc An integrated framework for discovery and genotyping of genomic variants from high-throughput sequencing experiments
    Jorge Duitama
    Agrobiodiversity Research Area, International Center for Tropical Agriculture CIAT, Km 17 recta Cali Palmira, A A 6713 Cali, Colombia, Laboratory of Molecular Cell Biology, Department of Biology, Institute of Botany and Microbiology, KU Leuven, Kasteelpark Arenberg 31, B 3001 Leuven Heverlee, Flanders, Belgium, Department of Molecular Microbiology, VIB, Kasteelpark Arenberg 31, B 3001 Leuven Heverlee, Flanders, Belgium, VIB Laboratory of Systems Biology, KU Leuven, Gaston Geenslaan 1, B 3001 Leuven Heverlee, Flanders, Belgium and Laboratory for Genetics and Genomics, Centre of Microbial and Plant Genetics, KU Leuven, Gaston Geenslaan 1, B 3001 Leuven Heverlee, Flanders, Belgium
    Nucleic Acids Res 42:e44. 2014
    ..We expect that NGSEP will become a strong support tool to empower the analysis of sequencing data in a wide range of research projects on different species. ..
  20. pmc Nucleosome positioning in Saccharomyces cerevisiae
    An Jansen
    VIB Laboratory for Systems Biology, Bio Incubator, Gaston Geenslaan 1, B 3001 Leuven, Belgium
    Microbiol Mol Biol Rev 75:301-20. 2011
    ..In the last section, we review the biological role of chromatin in gene transcription, the evolution of gene regulation, and epigenetic phenomena...
  21. ncbi request reprint Immobilized yeast cell systems for continuous fermentation applications
    Pieter J Verbelen
    Centre for Malting and Brewing Science, Faculty of Bioscience Engineering, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, 3001 Heverlee, Belgium
    Biotechnol Lett 28:1515-25. 2006
    ..Then, the impact of immobilization on cell physiology and fermentation performance is discussed. In a last part, we focus on the practical use of continuous fermentation and cell immobilization systems for beer production...
  22. pmc Large-scale analysis of tandem repeat variability in the human genome
    Jorge Duitama
    VIB Lab for Systems Biology and CMPG Lab for Genetics and Genomics, KU Leuven, B 3001 Leuven, Belgium Agrobiodiversity Research Area, International Center for Tropical Agriculture CIAT, Cali, Colombia
    Nucleic Acids Res 42:5728-41. 2014
    ..The method opens new routes to look at this underappreciated type of genetic variability, including the identification of novel disease-related repeats. ..
  23. doi request reprint Harvesting yeast (Saccharomyces cerevisiae) at different physiological phases significantly affects its functionality in bread dough fermentation
    Mohammad N Rezaei
    Laboratory of Food Chemistry and Biochemistry and Leuven Food Science and Nutrition Research Centre LFoRCe, Department of Molecular and Microbial Systems, KU Leuven, Kasteelpark Arenberg 20, Box 2463, B 3001 Leuven, Belgium
    Food Microbiol 39:108-15. 2014
    ..Together, our results demonstrate a strong effect of yeast physiology at the time of harvest on subsequent dough fermentation performance, and hint at an important role of yeast metabolites on the subsequent gas holding capacity. ..
  24. doi request reprint Mapping of Saccharomyces cerevisiae metabolites in fermenting wheat straight-dough reveals succinic acid as pH-determining factor
    Vinay B Jayaram
    Laboratory of Food Chemistry and Biochemistry and Leuven Food Science and Nutrition Research Centre LFoRCe, KU Leuven, Kasteelpark Arenberg 20, Box 2463, B 3001 Leuven, Belgium
    Food Chem 136:301-8. 2013
    ..Together, our results provide a comprehensive overview of metabolite production during dough fermentation and yield insight into the importance of some of these metabolites for dough properties...
  25. ncbi request reprint Assessing Genetic Diversity among Brettanomyces Yeasts by DNA Fingerprinting and Whole-Genome Sequencing
    Sam Crauwels
    Laboratory for Process Microbial Ecology and Bioinspirational Management, Cluster for Bioengineering Technology CBeT, Department of Microbial and Molecular Systems M2S, Leuven Food Science and Nutrition Research Centre LFoRCe, Leuven Institute for Beer Research LIBR, KU Leuven, Campus De Nayer, Sint Katelijne Waver, Belgium
    Appl Environ Microbiol 80:4398-413. 2014
    ..12/22. Together, this study provides tools to discriminate Brettanomyces strains and provides a first glimpse at the genetic diversity and genome plasticity of B. bruxellensis. ..
  26. doi request reprint Variable tandem repeats accelerate evolution of coding and regulatory sequences
    Rita Gemayel
    Laboratory for Systems Biology, VIB, B 3001 Heverlee, Belgium
    Annu Rev Genet 44:445-77. 2010
    ..As such, TRs combine characteristics of genetic and epigenetic changes that may facilitate organismal evolvability...
  27. ncbi request reprint Furfuryl ethyl ether: important aging flavor and a new marker for the storage conditions of beer
    Bart Vanderhaegen
    Centre for Malting and Brewing Science, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, B 3001 Heverlee, Belgium
    J Agric Food Chem 52:1661-8. 2004
    ..On the other hand, sulfite clearly reduced furfuryl ethyl ether formation. All results show that the furfuryl ethyl ether concentration is an excellent time-temperature integrator for beer storage...
  28. ncbi request reprint The Saccharomyces cerevisiae alcohol acetyl transferase gene ATF1 is a target of the cAMP/PKA and FGM nutrient-signalling pathways
    Kevin J Verstrepen
    Centre for Malting and Brewing Science, Department of Food and Microbial Technology, K U Leuven, Kasteelpark Arenberg 22, 3001 Heverlee, Leuven, Belgium
    FEMS Yeast Res 4:285-96. 2003
    ..In addition, the complex regulation provides new insights into the physiological role of Atf1p in yeast...