Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass: a randomized trialEdward D Verrier
Division of Cardiothoracic Surgery, University of Washington School of Medicine, Seattle 98195 6310, USA
JAMA 291:2319-27. 2004
..Inflammation and ischemia-reperfusion injury during coronary artery bypass graft (CABG) surgery requiring cardiopulmonary bypass are associated with postoperative myocardial infarction (MI) and mortality...
- Alpha chemokines regulate direct lung ischemia-reperfusion injury
Alexander S Farivar
University of Washington Medical Center, Division of Cardiothoracic Surgery, Seattle, Washington 98195, USA
J Heart Lung Transplant 23:585-91. 2004
..CONCLUSIONS: CINC and MIP-2 are important mediators involved in direct lung ischemia-reperfusion injury. They appear to function by modulating neutrophil recruitment, but not inflammatory cytokine release...
- Early activation of the alveolar macrophage is critical to the development of lung ischemia-reperfusion injury
Babu V Naidu
Division of Cardiothoracic Surgery, Department of Surgery, University of Washington, Seattle 98195, USA
J Thorac Cardiovasc Surg 126:200-7. 2003
..Depleting alveolar macrophages is protective against injury, supporting its central role in oxidant stress-induced cytokine and chemokine release and the subsequent development of lung injury...
- Crosstalk between thrombosis and inflammation in lung reperfusion injury
Alexander S Farivar
Division of Cardiothoracic Surgery, University of Washington Medical Center, Seattle, Washington 98195, USA
Ann Thorac Surg 81:1061-7. 2006
..We used hirudin, a potent, specific direct thrombin inhibitor, to define the role of thrombin in lung ischemia-reperfusion injury...
- Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart
Albert J Chong
Division of Cardiothoracic Surgery, Department of Surgery, The University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
J Thorac Cardiovasc Surg 128:170-9. 2004
..Inhibition of toll-like receptor 4 activation may be a potential therapeutic target to attenuate ischemia/reperfusion-induced tissue damage in the clinical setting...
- Pexelizumab -- a C5 complement inhibitor for use in both acute myocardial infarction and cardiac surgery with cardiopulmonary bypass
Ani J Fleisig
Division of Cardiothoracic Surgery, University of Washington, 1959 NE Pacific Seattle, Washington, WA 98195, USA
Expert Opin Biol Ther 5:833-9. 2005
..Thus, pexelizumab represents a promising therapeutic option with sustained benefit both in AMI and during CABG with CPB...
- Myocardial infarction following coronary artery bypass graft surgery increases healthcare resource utilization
John C Chen
Division of Cardiothoracic Surgery, University of Hawaii School of Medicine, Honolulu, USA
Crit Care Med 35:1296-301. 2007
..To assess the health economic impact of perioperative myocardial infarction in a cohort of patients undergoing coronary artery bypass graft surgery...
- FR167653 reduces obliterative airway disease in rats
Alexander S Farivar
Department of Surgery, Division of Cardiothoracic Surgery, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, WA 98195, USA
J Heart Lung Transplant 23:985-92. 2004
..These studies assessed whether specific inhibition of p38 with FR167653 (FR) protects against the development of OB in rat tracheal allografts...
Open-chest management after heart transplantationHiroo Takayama
Division of Cardiothoracic Surgery, University of Washington, Seattle, Washington 98195, USA
Tex Heart Inst J 33:306-9. 2006
..No patient had sternal wound infection or impaired wound healing during the follow-up period.We conclude that, when required, open-chest management is an effective and safe measure for hemodynamically unstable heart transplant patients...
- Tissue factor and thrombin mediate myocardial ischemia-reperfusion injury
Albert J Chong
Division of Cardiothoracic Surgery, The University of Washington, Seattle, Washington 98104, USA
Ann Thorac Surg 75:S649-55. 2003
..However, defibrinogenating rabbits with ancrod had no effect on infarct size, suggesting a requirement of thrombin generation but not fibrin deposition in myocardial I/R injury...
- Activation of the endothelium in cardiac allografts
Edward D Verrier
Division of Cardiothoracic Surgery, Department of Surgery, The University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
J Heart Lung Transplant 23:S229-33. 2004
- Endogenous interleukin-4 and interleukin-10 regulate experimental lung ischemia reperfusion injury
Alexander S Farivar
Division of Cardiothoracic Surgery, University of Washington Medical Center, Seattle, Washington 98195, USA
Ann Thorac Surg 76:253-9. 2003
..These studies were undertaken to investigate the role of two regulatory cytokines, interleukin-4 (IL-4) and IL-10, in an in vivo model of LIRI...
- Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits
Gabriel S Aldea
Division of Cardiothoracic Surgery, Department of Surgery, University of Washington School of Medicine, Seattle, WA 98195 3166, USA
J Thorac Cardiovasc Surg 123:742-55. 2002
..A prospective, randomized study was undertaken to evaluate the specific effects of cardiotomy suction...
- Pexelizumab reduces death and myocardial infarction in higher risk cardiac surgical patients
Axel Haverich
Hannover Medical School, Hannover, Germany
Ann Thorac Surg 82:486-92. 2006
....
- Effect of pexelizumab on mortality in patients with acute myocardial infarction or undergoing coronary artery bypass surgery: a systematic overview
Kenneth W Mahaffey
Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
Am Heart J 152:291-6. 2006
....
- FR167653 diminishes infarct size in a murine model of myocardial ischemia-reperfusion injury
Masaki Yada
Department of Thoracic and Cardiovascular Surgery, Mie University School of Medicine, Tsu, Japan
J Thorac Cardiovasc Surg 128:588-94. 2004
..6%). Thus p38 mitogen-activated protein kinase inhibition may have a role in the treatment of myocardial ischemia-reperfusion...
- A short wholly inside-out reversed vascular graft facilitating difficult aortic anastomosis
Shih Rong Hsieh
Division of Cardiovascular Surgery, Department of Surgery, Taichung Veterans General Hospital, National Yang Ming University, School of Medicine, Taichung, Taiwan, China
Ann Thorac Surg 80:1534-6. 2005
..We present a new technique derived from a modified elephant trunk technique to simplify some laborious situations...
- Inhibition of Toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury
Akira Shimamoto
Department of Thoracic and Cardiovascular Surgery, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
Circulation 114:I270-4. 2006
..To investigate the ligand-activating TLR4 during MI/R injury, we evaluated the effect of eritoran, a specific TLR4 antagonist, on MI/R injury, with the goal of defining better therapeutic options for MI/R injury...
- Unique considerations for the spinal cord injured patient undergoing cardiac surgery utilizing cardiopulmonary bypass
Arnold M Benak
Central Maine Heart and Vascular Institute, Lewiston, Maine 04240, USA
J Extra Corpor Technol 35:230-7. 2003
..Numerous triggering mechanisms may lead to a variety of clinical complications. Consideration of a response/ treatment management plan for potential problems must be exercised by the surgical team...
- HSP70.1 and -70.3 are required for late-phase protection induced by ischemic preconditioning of mouse hearts
Craig R Hampton
Department of Surgery, University of Washington, 1959 N E Pacific Street, Box 356410, Seattle, WA 98195, USA
Am J Physiol Heart Circ Physiol 285:H866-74. 2003
..1/3(-/-) mice. We conclude that inducible HSP70.1 and HSP70.3 are required for late-phase protection against infarction following IP in mice...
- Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy
Rafal Pawlinski
The Scripps Research Institute, Department of Immunology, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
Circulation 116:2298-306. 2007
..The purpose of the present study was to investigate the role of PAR-1 in infarction, cardiac remodeling, and hypertrophy after I/R injury. In addition, we analyzed the effect of overexpression of PAR-1 on cardiomyocytes...
