Comprehensive evaluation of cortical structure abnormalities in drug-naïve, adult patients with obsessive-compulsive disorder: a surface-based morphometry studyGanesan Venkatasubramanian
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India
J Psychiatr Res 46:1161-8. 2012
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- Digit ratio (2D:4D) asymmetry and Schneiderian first rank symptoms: implications for cerebral lateralisation theories of schizophrenia
Ganesan Venkatasubramanian
Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, Karnataka, India
Laterality 16:499-512. 2011
..Since 2D:4D is linked with limbic asymmetry, our study findings offer further support to the cerebral lateralisation theories of schizophrenia...
- Inverse relationship between serum high density lipoprotein and negative syndrome in antipsychotic-naive schizophrenia
Ganesan Venkatasubramanian
The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
Clin Chem Lab Med 48:95-8. 2010
..The objective of this study was to examine the correlation between symptom scores and serum HDL in antipsychotic-naive schizophrenia patients...
- A longitudinal study on the impact of antipsychotic treatment on serum leptin in schizophrenia
Ganesan Venkatasubramanian
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
Clin Neuropharmacol 33:288-92. 2010
..The study objective was to explore the biological basis for link between antipsychotic-induced weight gain and therapeutic response in schizophrenia by examining longitudinal changes in serum leptin level after antipsychotic treatment...
- Schneiderian first rank symptoms and inferior parietal lobule cortical thickness in antipsychotic-naïve schizophrenia
Ganesan Venkatasubramanian
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India
Prog Neuropsychopharmacol Biol Psychiatry 35:40-6. 2011
..Deficient cortical thickness involving IPL in FRS(+) schizophrenia patients adds further support to the role of internal monitoring system in the pathogenesis of FRS in schizophrenia...
- Corpus callosum deficits in antipsychotic-naïve schizophrenia: evidence for neurodevelopmental pathogenesis
Ganesan Venkatasubramanian
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
Psychiatry Res 182:141-5. 2010
..Together, these findings suggest neurodevelopmentally mediated hypoconnectivity in schizophrenia...
- Effect of antipsychotic treatment on Insulin-like Growth Factor-1 and cortisol in schizophrenia: a longitudinal study
Ganesan Venkatasubramanian
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India
Schizophr Res 119:131-7. 2010
..These observations suggest a possible link between HPA axis abnormalities and IGF-1 deficits in the neurodevelopmental pathogenesis of schizophrenia...
- High energy phosphate abnormalities normalize after antipsychotic treatment in schizophrenia: a longitudinal 31P MRS study of basal ganglia
Peruvumba N Jayakumar
Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India
Psychiatry Res 181:237-40. 2010
..Findings support the hypothesis that reduction of energy demand or induction of decreased energy-demanding processes might underlie the mechanism of action of antipsychotics in schizophrenia...
- First rank symptoms & facial emotion recognition deficits in antipsychotic naïve schizophrenia: Implications for social threat perception model
Rishikesh V Behere
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
Prog Neuropsychopharmacol Biol Psychiatry 35:1653-8. 2011
..There is a differential pattern of impairment in FERD, which supports the role of heightened threat perception in the evolution of psychopathology in schizophrenia patients...
Insulin and insulin-like growth factor-1 abnormalities in antipsychotic-naive schizophreniaGanesan Venkatasubramanian
Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, Karnataka, India
Am J Psychiatry 164:1557-60. 2007
..The purpose of this study was to examine the evidence for the insulin-like growth factor-1 (IGF-1) deficiency hypothesis in the pathogenesis of schizophrenia...
- Effect of risperidone on emotion recognition deficits in antipsychotic-naïve schizophrenia: a short-term follow-up study
Rishikesh V Behere
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
Schizophr Res 113:72-6. 2009
..Facial emotion recognition deficits [FERD] have been consistently demonstrated in treated schizophrenia patients. FERD in treatment-naïve patients and the effect of antipsychotics are yet to be explored...
- Beta2-microglobulin abnormalities in antipsychotic-naïve schizophrenia: evidence for immune pathogenesis
Seetharamaiah Chittiprol
Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India
Brain Behav Immun 23:189-92. 2009
..32; p=0.035). These novel observations suggest that beta2M abnormalities might have a potential association with the pathogenesis of schizophrenia...
- Oxidative stress and neopterin abnormalities in schizophrenia: a longitudinal study
Seetharamaiah Chittiprol
Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India
J Psychiatr Res 44:310-3. 2010
..Our study observations support increased oxidative stress in schizophrenia that improves with antipsychotic treatment...
- Physical deformity as sequela of chronic catatonia and response to electroconvulsive therapy: a case report
Sugnyani Devi
Department of Psychiatry, Kasturba Medical College, Manipal, India
J ECT 27:e49-50. 2011
..Early interventions in the form of electroconvulsive therapy and physical rehabilitation can be useful in reversing such potentially disabling complications...
- Developmental reflexes and 31P Magnetic Resonance Spectroscopy of basal ganglia in antipsychotic-naive schizophrenia
Bangalore N Gangadhar
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, India
Prog Neuropsychopharmacol Biol Psychiatry 30:910-3. 2006
..These patients had younger age-at-onset of psychosis. Together, this suggests neurodevelopmental etiopathogenesis in schizophrenia...
- Neuroanatomical correlates of neurological soft signs in antipsychotic-naive schizophrenia
Ganesan Venkatasubramanian
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 5600 29, India
Psychiatry Res 164:215-22. 2008
..Prefrontal and temporal cortices, putamen and cerebellum had significant volume deficits in patients. Cortical and cerebellar correlates of the sub-score MSS support the concept of "cognitive dysmetria" in schizophrenia...
- Successful use of maintenance electroconvulsive therapy in the treatment of clozapine-associated obsessive-compulsive symptoms in schizophrenia: a case report
Naren P Rao
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
J ECT 27:e37-8. 2011
..We report, for the first time, the use of maintenance electroconvulsive therapy, in clozapine-associated OC symptoms, in a patient with schizophrenia...
- Corpus callosum abnormalities associated with greater externalizing behaviors in subjects at high risk for alcohol dependence
Ganesan Venkatasubramanian
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India
Psychiatry Res 156:209-15. 2007
..Smaller CC areas and their negative association with externalizing behaviors may represent yet another marker of susceptibility to alcoholism in high-risk subjects...
- Antithetical asymmetry in schizophrenia and bipolar affective disorder: a line bisection study
Naren P Rao
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
Bipolar Disord 12:221-9. 2010
..For the first time, we report concurrent analyses of asymmetry in BPAD and schizophrenia using a line bisection task...
Inferior parietal lobule volume and schneiderian first-rank symptoms in antipsychotic-naïve schizophrenia: a 3-tesla MRI studyVijay Danivas
Department of Psychiatry, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, India
Indian J Psychol Med 31:82-7. 2009
..The specific role of IPL structural abnormalities in the pathogenesis of FRS is yet to be ascertained...
- Relationship between corpus callosum abnormalities and schneiderian first-rank symptoms in antipsychotic-naive schizophrenia patients
Naren P Rao
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India
J Neuropsychiatry Clin Neurosci 23:155-62. 2011
..A novel finding of the study is that only those without FRS differed from control subjects, but not those with FRS. Study findings support a neuro-developmental hypothesis and possible connectivity abnormalities in symptom-genesis...
- Psychogenic polydipsia in bipolar affective disorder--a case report
Karthik Duraiswamy
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India
Gen Hosp Psychiatry 33:84.e9-10. 2011
..One needs to be cautious in choosing the mood stabilizer while treating this condition. We report the successful treatment of a patient with BPAD and polydipsia on a combination of valproate and risperidone...
- Entorhinal Cortex Volume in Antipsychotic-naïve Schizophrenia
Sam P Jose
Department of Psychiatry, The Schizophrenia Clinic, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
Indian J Psychol Med 34:164-9. 2012
..Several studies have looked at cytoarchitectural and morphometric changes in the ERC, but results have been inconsistent possibly due to the potential confounding effects of antipsychotic treatment...
- Obsessive compulsive disorder masquerading as psychosis
Dhanya Raveendranathan
Department of Psychiatry, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, Karnataka, India
Indian J Psychol Med 34:179-80. 2012
..This can indeed pose a considerable challenge, especially in a scenario where the phenomenon is difficult to discern. We report a case of OCD, which was initially diagnosed as psychosis...
- Risperidone treatment for polydipsia and hyponatremia in schizophrenia: a case report
Naren Rao
National Institute of Mental Health and Neurosciences, Department of Psychiatry, Bangalore, India
Turk Psikiyatri Derg 22:123-5. 2011
..Herein we present a schizophrenia case with polydipsia and hyponatremia that was successfully treated with risperidone...
- Electroconvulsive therapy in the treatment of delirious mania: a report of 2 patients
Vijay Danivas
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
J ECT 26:278-9. 2010
..Differential diagnosis of the above clinical presentation includes neuroleptic malignant syndrome and malignant catatonia. Delirious mania is clinically important owing to the potential for diagnostic confusion and good response to ECTs...
- Longitudinal study of beta2-microglobulin abnormalities in schizophrenia
Seetharamaiah Chittiprol
Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore, India
Int Immunopharmacol 9:1215-7. 2009
..Moreover, the observations suggest the possibility that the mechanism of action of antipsychotics might involve alteration of immune parameters...
- A Longitudinal Study of Relation between Side-effects and Clinical Improvement in Schizophrenia: Is There a Neuro-metabolic Threshold for Second Generation Antipsychotics?
Ganesan Venkatasubramanian
The Metabolic Clinic in Psychiatry, Department of Psychiatry Translational Psychiatry Laboratory, Cognitive Neurobiology Division, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, India
Clin Psychopharmacol Neurosci 11:24-7. 2013
..This prospective study on antipsychotic-naïve schizophrenia patients, for the first-time, examined concurrently the relationship between clinical improvement and these side-effects NIES and Neuroleptic Induced Metabolic Side-effects...
- Hyperthyroidism presenting as mixed affective state: a case report
Mukund G Rao
Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India
Gen Hosp Psychiatry 34:703.e13-4. 2012
..We present a case of hyperthyroidism presenting as a mixed affective state and the successful resolution of psychiatric symptoms with antithyroid medication along with a mood-stabilizing agent...
- Abnormalities in cortical and transcallosal inhibitory mechanisms in subjects at high risk for alcohol dependence: a TMS study
Kesavan Muralidharan
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
Addict Biol 13:373-9. 2008
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- Volume and asymmetry abnormalities of insula in antipsychotic-naive schizophrenia: a 3-tesla magnetic resonance imaging study
Harve Shanmugam Virupaksha
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
Indian J Psychol Med 34:133-9. 2012
..Existing studies on insula volume abnormalities report inconsistent findings potentially due to the evaluation of 'antipsychotic-treated' schizophrenia patients as well as suboptimal methodology...
- Successful treatment of co-morbid schizophrenia and multiple sclerosis
Eesha Sharma
Department of Psychiatry, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, India
Asian J Psychiatr 3:235-6. 2010
..We, for the first time, report a patient with MS and paranoid schizophrenia successfully treated with concurrent use of clozapine and risperidone with interferon-beta-1a...
- Beneficial effects of add-on raloxifene in schizophrenia
Dhanya Raveendranathan
The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
Arch Womens Ment Health 15:147-148. 2012
..The patient, a 29-year-old woman, over a 7-month followup period, showed significant improvement in sociooccupational functioning, with reduction in symptom severity...
- Acyclovir in bipolar disorder: a mismatched combination?
Naveen Jayaram
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
Indian J Psychol Med 33:208-9. 2011
..Our report suggests that acyclovir is a risk factor for mood episode in vulnerable individual and one need to be cautious while using antiviral agents in patients with psychiatric disorders...
- Has Kahlbaum syndrome disappeared or is it underdiagnosed? Reexamining the nosology of catatonia
Naren P Rao
J ECT 28:62-3. 2012
..Further prospective studies examining the natural course are needed, which could have significant implications on future classificatory systems...
- Olanzapine-induced clinical seizure: a case report
Rishikesh V Behere
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
Clin Neuropharmacol 32:297-8. 2009
..Olanzapine has a profile similar to that of clozapine and shares its seizure-inducing potential. Typical antipsychotics such as haloperidol might be a safer option for such patients...
- Neurohemodynamic correlates of 'OM' chanting: A pilot functional magnetic resonance imaging study
Bangalore G Kalyani
Department of Psychiatry, Advanced Center for Yoga, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India
Int J Yoga 4:3-6. 2011
..This has the potential for vagus nerve stimulation through its auricular branches and the effects on the brain thereof. The neurohemodynamic correlates of 'OM' chanting are yet to be explored...
- Evolutionary genetic analyses of MEF2C gene: implications for learning and memory in Homo sapiens
Sunil V Kalmady
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
Asian J Psychiatr 6:56-9. 2013
..Further research on this gene might unravel the potential role of this gene in learning and memory as well as its pathogenetic effect in certain hippocampal disorders with evolutionary basis like schizophrenia...
- Successful use of add - on topiramate for antipsychotic - induced weight gain
Venkataram Shivakumar
Department of Psychiatry, The Metabolic Clinic in Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
Indian J Psychol Med 34:85-6. 2012
..In this case report, we describe the use of low - dose topiramate as a weight - reducing agent, in a patient with a bipolar affective disorder - mania with psychotic symptoms, who had significant risperidone - induced weight gain...
- Gray matter volume abnormalities and externalizing symptoms in subjects at high risk for alcohol dependence
Vivek Benegal
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
Addict Biol 12:122-32. 2007
..Subjects at HR for alcoholism have reduced volumes of critical areas of brain gray matter, which are associated with increased externalizing symptoms. These represent key endophenotypes of alcoholism...
- Successful use of donepezil in treatment of cognitive impairment caused by maintenance electroconvulsive therapy: a case report
Naren P Rao
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
J ECT 25:216-8. 2009
..The role of cholinesterase inhibitors in the treatment of cognitive deficits caused by ECT needs further studies...
- Clinical correlates of thalamus volume deficits in anti-psychotic-naïve schizophrenia patients: A 3-Tesla MRI study
Naren P Rao
Department of Psychiatry, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore 560 029, India
Indian J Psychiatry 52:229-35. 2010
..The thalamus volume in anti-psychotic-naïve patients determined using high-resolution 3-Tesla magnetic resonance imaging (MRI) has not yet been examined...
- Optimized voxel-based morphometry of gray matter volume in first-episode, antipsychotic-naive schizophrenia
Peruvamba N Jayakumar
Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, India
Prog Neuropsychopharmacol Biol Psychiatry 29:587-91. 2005
..Findings suggest limbic, heteromodal cortical, striatal, thalamic and cerebellar abnormalities in schizophrenia...
- Orbitofrontal Lobe Volume Deficits in Antipsychotic-Naïve Schizophrenia: A 3-Tesla MRI study
Rishikesh V Behere
Department of Psychiatry, The Schizophrenia Clinic, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, India
Indian J Psychol Med 31:77-81. 2009
..While these functional impairments are established in schizophrenia, the OFL volume deficits have not been well studied, especially in antipsychotic-naïve patients...
- Emotional interference in obsessive-compulsive disorder: a neuropsychological study using optimized emotional Stroop test
Naren Prahlada Rao
Department of Psychiatry, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, India
Psychiatry Res 180:99-104. 2010
..Study findings suggest the presence of selective emotional bias for OCD relevant stimuli in these patients and this bias is potentially related to symptomatic status. These observations are in tune with the threat-relatedness hypothesis...
- Chlorpromazine induced cataract in a young patient with schizophrenia
Anjith Divakaran
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India
Indian J Psychol Med 32:69-70. 2010
..We report a patient who developed cataract possibly due to chlorpromazine and reviewed the relevant literature...
- Neuroimaging studies in schizophrenia: an overview of research from Asia
Janardhanan C Narayanaswamy
Schizophrenia Clinic, Department of Psychiatry, Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore, India
Int Rev Psychiatry 24:405-16. 2012
..In addition, theoretically relevant relationships between these brain abnormalities and developmental aberrations suggest possible neurodevelopmental basis for these brain deficits...
- Clinically significant hoarding in obsessive-compulsive disorder: results from an Indian study
Vaskar Chakraborty
National Institute of Mental Health and Neuro Sciences, Bangalore, India
Compr Psychiatry 53:1153-60. 2012
..Most of the research on hoarding is from the Western countries. This study aimed to provide data on the prevalence and correlates of clinically significant hoarding in a large sample of patients with OCD from the Indian subcontinent...
- Clinical correlates of caudate volume in drug-naïve adult patients with obsessive-compulsive disorder
Janardhanan C Narayanaswamy
Department of Psychiatry, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, India
Psychiatry Res 212:7-13. 2013
..However, it demonstrated a robust relationship between volume of the left caudate body and the severity of OCD. Additionally, there was a sexual dimorphism in caudate volume in OCD...
- White matter abnormalities in children and adolescents with obsessive-compulsive disorder: a diffusion tensor imaging study
Rajan Nishanth Jayarajan
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
Depress Anxiety 29:780-8. 2012
..There is paucity of data on white matter (WM) abnormalities in juvenile obsessive-compulsive disorder (OCD). This study aimed to identify WM microstructure changes in juvenile OCD...
- Neurological soft signs in schizophrenia - The past, the present and the future
Shivarama Varambally
Department of Psychiatry, Schizophrenia Clinic, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
Indian J Psychiatry 54:73-80. 2012
..NSS, by themselves or as a composite index with other neurobiological parameters, hold potential as a candidate endophenotype for schizophrenia...
- Proton magnetic resonance spectroscopy in depression
Naren P Rao
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
Indian J Psychiatry 53:307-11. 2011
..Spectroscopy also has potential implications in predicting the response to treatment and formulating individualized pharmacotherapy...
- Biological investigations in Indian psychiatry
Rishikesh V Behere
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India
Indian J Psychiatry 52:S136-8. 2010
..In this selective overview we summarize findings of various EEG, neuro-imaging and blood related studies that have been reported in the Indian Journal of Psychiatry...
- Do antipsychotics limit disability in schizophrenia? A naturalistic comparative study in the community
Jagadisha Thirthalli
Department of Psychiatry, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, India
Indian J Psychiatry 52:37-41. 2010
..Though antipsychotics are effective against symptoms of schizophrenia and prevent relapses, their effect on disability has not been studied in a comparative design...
- Neuroanatomical, neurochemical, and neurodevelopmental basis of obsessive-compulsive symptoms in schizophrenia
Ganesan Venkatasubramanian
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
Indian J Psychol Med 31:3-10. 2009
..Dopamine may be responsible for the beneficial role of antipsychotics in the treatment of OCD. In summary, we propose that glutamate, serotonin, and dopamine abnormalities may be the probable basis for OCSS...
- Gray matter volume deficits in spinocerebellar ataxia: an optimized voxel based morphometric study
Gaurav Goel
Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, Karnataka, India
Parkinsonism Relat Disord 17:521-7. 2011
..Voxel-based morphometry (VBM) provides an automated unbiased analysis of structural MRI scans and gives a comprehensive assessment of anatomical differences throughout the brain...
- A functional Magnetic Resonance Imaging study of neurohemodynamic abnormalities during emotion processing in subjects at high risk for schizophrenia
Ganesan Venkatasubramanian
Department of Psychiatry, National Institute of Mental Health and Neuro Sciences NIMHANS, Bangalore, Karnataka, India
Indian J Psychiatry 52:308-15. 2010
..The brain functional correlates of emotion processing in these HR subjects in the context of ecologically valid, real-life dynamic images using functional Magnetic Resonance Imaging (fMRI) has not been examined previously...
- Neuropsychological performance in OCD: a study in medication-naïve patients
Rakhee Krishna
National Institute of Mental Health and Neuro Sciences NIMHANS, Bangalore, India
Prog Neuropsychopharmacol Biol Psychiatry 35:1969-76. 2011
..One potential reason for poor replication is the confounding influence of medications. There is limited research on neuropsychological performance in medication-naïve, never treated OCD patients...
