Fuad Lechin

Summary

Affiliation: Universidad Central de Venezuela
Country: Venezuela

Publications

  1. ncbi Circulating neurotransmitters during the different wake-sleep stages in normal subjects
    Fuad Lechin
    Section of Neuropharmacology, Department of Physiological Sciences, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
    Psychoneuroendocrinology 29:669-85. 2004
  2. ncbi Blood pressure and autonomic system assessment throughout the sleep cycle in normal adults
    Fuad Lechin
    Sleep 28:649. 2005
  3. ncbi Dorsal raphe vs. median raphe serotonergic antagonism. Anatomical, physiological, behavioral, neuroendocrinological, neuropharmacological and clinical evidences: relevance for neuropharmacological therapy
    Fuad Lechin
    Department of Physiological Sciences, Section of Neurochemical, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
    Prog Neuropsychopharmacol Biol Psychiatry 30:565-85. 2006
  4. ncbi Neuropharmacologic treatment of bronchial asthma with the antidepressant tianeptine: a double-blind, crossover placebo-controlled study
    F Lechin
    Section of Psychopharmacology, Institute of Experimental Medicine, Central University of Venezuela, Caracas
    Clin Pharmacol Ther 64:223-32. 1998
  5. ncbi Neuropharmacological treatment of refractory idiopathic thrombocytopenic purpura: roles of circulating catecholamines and serotonin
    Fuad Lechin
    Thromb Haemost 91:1254-6. 2004
  6. ncbi Neurochemical, neuroautonomic and neuropharmacological acute effects of sibutramine in healthy subjects
    Fuad Lechin
    Department of Neurophysiology, Instituto de Medicina Experimental, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Apartado 80 983, Caracas 1080 A, Venezuela
    Neurotoxicology 27:184-91. 2006
  7. ncbi Acute effects of tianeptine on circulating neurotransmitters and cardiovascular parameters
    Fuad Lechin
    Department of Neurophysiology, Instituto de Medicina Experimental, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Venezuela
    Prog Neuropsychopharmacol Biol Psychiatry 30:214-22. 2006
  8. ncbi Central nervous system circuitry and peripheral neural sympathetic activity responsible for essential hypertension
    Fuad Lechin
    Department of Physiological Sciences, Section of Neurochemistry, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
    Curr Neurovasc Res 3:307-25. 2006
  9. doi Central nervous system plus autonomic nervous system disorders responsible for gastrointestinal and pancreatobiliary diseases
    Fuad Lechin
    Department of Neurophysiology, Instituto de Medicina Experimental, Faculty of Medicine, Universidad Central de Venezuela, Apartado 80 983, Caracas, 1080, Venezuela
    Dig Dis Sci 54:458-70. 2009
  10. pmc Effects of amantadine on circulating neurotransmitters in healthy subjects
    Fuad Lechin
    Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
    J Neural Transm 117:293-9. 2010

Detail Information

Publications34

  1. ncbi Circulating neurotransmitters during the different wake-sleep stages in normal subjects
    Fuad Lechin
    Section of Neuropharmacology, Department of Physiological Sciences, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
    Psychoneuroendocrinology 29:669-85. 2004
    ..According to the above, we attempted to correlate the profile of circulating neurotransmitters with the very well-known central neurocircuitry functioning during wake-sleep cycle, in experimental mammals...
  2. ncbi Blood pressure and autonomic system assessment throughout the sleep cycle in normal adults
    Fuad Lechin
    Sleep 28:649. 2005
  3. ncbi Dorsal raphe vs. median raphe serotonergic antagonism. Anatomical, physiological, behavioral, neuroendocrinological, neuropharmacological and clinical evidences: relevance for neuropharmacological therapy
    Fuad Lechin
    Department of Physiological Sciences, Section of Neurochemical, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
    Prog Neuropsychopharmacol Biol Psychiatry 30:565-85. 2006
    ....
  4. ncbi Neuropharmacologic treatment of bronchial asthma with the antidepressant tianeptine: a double-blind, crossover placebo-controlled study
    F Lechin
    Section of Psychopharmacology, Institute of Experimental Medicine, Central University of Venezuela, Caracas
    Clin Pharmacol Ther 64:223-32. 1998
    ..The trial lasted 52 weeks. Tianeptine provoked a dramatic and sudden decrease of both clinical rating and free serotonin plasma levels and an increase in pulmonary function...
  5. ncbi Neuropharmacological treatment of refractory idiopathic thrombocytopenic purpura: roles of circulating catecholamines and serotonin
    Fuad Lechin
    Thromb Haemost 91:1254-6. 2004
  6. ncbi Neurochemical, neuroautonomic and neuropharmacological acute effects of sibutramine in healthy subjects
    Fuad Lechin
    Department of Neurophysiology, Instituto de Medicina Experimental, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Apartado 80 983, Caracas 1080 A, Venezuela
    Neurotoxicology 27:184-91. 2006
    ..Further, sibutramine lowers parasympathetic activity. The moderate rise in diastolic blood pressure triggered by sibutramine would be associated with CNS-NA enhancement plus parasympathetic inhibition...
  7. ncbi Acute effects of tianeptine on circulating neurotransmitters and cardiovascular parameters
    Fuad Lechin
    Department of Neurophysiology, Instituto de Medicina Experimental, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Venezuela
    Prog Neuropsychopharmacol Biol Psychiatry 30:214-22. 2006
    ..Other possible neuropharmacological effects are also discussed...
  8. ncbi Central nervous system circuitry and peripheral neural sympathetic activity responsible for essential hypertension
    Fuad Lechin
    Department of Physiological Sciences, Section of Neurochemistry, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
    Curr Neurovasc Res 3:307-25. 2006
    ..Our therapeutical strategy is addressed to enhance the activity of the (A6)-NA + dorsal raphe-5HT binomial circuitry...
  9. doi Central nervous system plus autonomic nervous system disorders responsible for gastrointestinal and pancreatobiliary diseases
    Fuad Lechin
    Department of Neurophysiology, Instituto de Medicina Experimental, Faculty of Medicine, Universidad Central de Venezuela, Apartado 80 983, Caracas, 1080, Venezuela
    Dig Dis Sci 54:458-70. 2009
    ..Serotonin displays hormonal antagonism to the circulating catecholamines...
  10. pmc Effects of amantadine on circulating neurotransmitters in healthy subjects
    Fuad Lechin
    Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
    J Neural Transm 117:293-9. 2010
    ..The above findings supported the postulation that this drug should be a powerful therapeutic tool for treating diseases affected by adrenal sympathetic hyperactivity...
  11. ncbi Enhancement of noradrenergic neural transmission: an effective therapy of myasthenia gravis: a report on 52 consecutive patients
    F Lechin
    Section of Neuropharmacology, Instituto de Medicina Experimental, Universidad Central de Venezuela
    J Med 31:333-61. 2000
    ..Late improvements always paralleled a significant normalization of immunological disorders. Complete normalization was registered only in non-thymectomized MG patients...
  12. ncbi Treatment of bronchial asthma with tianeptine
    F Lechin
    Department of Physiological Sciences, Sections of Neurochemical, Neurophysiology, Neuroimmunology and Neuropharmacology, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
    Methods Find Exp Clin Pharmacol 26:697-701. 2004
    ....
  13. doi Insulin versus glucagon crosstalk: central plus peripheral mechanisms
    Fuad Lechin
    Department of Pathophysiology, Instituto de Medicina Experimental, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Venezuela
    Am J Ther 20:349-62. 2013
    ....
  14. ncbi Neuropharmacological therapy of polycythemia vera: roles of circulating catecholamines and serotonin
    Fuad Lechin
    Department of Physiological Sciences, Sections of Neurochemical, Neurophysiology, Neuroimmunology and Neuropharmacology, Instituto de Medicina Experimental, Universidad Central de Venzuela, Caracas
    Thromb Haemost 93:175-7. 2005
  15. pmc Amantadine reduces glucagon and enhances insulin secretion throughout the oral glucose tolerance test: central plus peripheral nervous system mechanisms
    Fuad Lechin
    Department of Physiological Sciences, Sections of Neuroendocrinology, Neuropharmacology, and Neurochemistry, Instituto de Medicina Experimental, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Venezuela
    Diabetes Metab Syndr Obes 2:203-13. 2009
    ..These peripheral sympathetic branches depend on the pontine (A(5)-noradrenergic) and the rostral ventrolateral (C(1)-adrenergic) medullary nuclei. They are excited by glutamate axons which act at NMDA postsynaptic receptors...
  16. pmc Anorexia nervosa depends on adrenal sympathetic hyperactivity: opposite neuroautonomic profile of hyperinsulinism syndrome
    Fuad Lechin
    Department of Pathophysiology, Sections of Neuroendocrinology, Neuropharmacology, and Neurochemistry, Instituto de Medicina Experimental, Faculty of Medicine, Universidad Central de Venezuela, Caracas
    Diabetes Metab Syndr Obes 3:311-7. 2010
    ....
  17. pmc Anorexia nervosa versus hyperinsulinism: therapeutic effects of neuropharmacological manipulation
    Fuad Lechin
    Sections of Neuroendocrinology, Neuropharmacology, and Neurochemistry, Department of Pathophysiology, Institute of Experimental Medicine, Faculty of Medicine, Universidad Central de Venezuela, Caracas
    Ther Clin Risk Manag 7:53-8. 2011
    ..Therefore, we prescribed neuropharmacological therapy to reverse this central and autonomic nervous system disorder, in order to normalize the clinical and neuroendocrine profile...
  18. ncbi Plasma catecholamines and chronic congestive heart failure
    Fuad Lechin
    Circulation 106:e222; author reply e222. 2002
  19. ncbi Central nervous system circuitry involved in the hyperinsulinism syndrome
    Fuad Lechin
    Department of Physiological Sciences, Sections of Neurochemistry, Neurophysiology, Neuroimmunology and Neuropharmacology, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
    Neuroendocrinology 84:222-34. 2006
    ....
  20. ncbi Tianeptine, plasma serotonin, and pulmonary hypertension
    Fuad Lechin
    Lancet 361:87. 2003
  21. ncbi Acute effects of sibutramine administration on the autonomic nervous system in obese subjects
    Fuad Lechin
    Clin Pharmacol Ther 81:326; author reply 326-7. 2007
  22. ncbi Neuropharmacological therapy of carcinoid syndrome
    Fuad Lechin
    Neuroendocrinology 81:137-8. 2005
  23. ncbi Tianeptine: a new exploratory therapy for asthma
    Fuad Lechin
    Chest 125:348-9; author reply 349. 2004
  24. ncbi Platelet aggregation, platelet serotonin and pancreatitis
    Fuad Lechin
    JOP 5:237-8; author reply 238-9. 2004
  25. ncbi Noradrenergic hypothesis of schizophrenia
    Fuad Lechin
    Prog Neuropsychopharmacol Biol Psychiatry 29:777-8. 2005
  26. ncbi Plasma serotonin, pulmonary hypertension and bronchial asthma
    Fuad Lechin
    Clin Sci (Lond) 103:345; author reply 346. 2002
  27. ncbi Irritable bowel syndrome, depression, and Th-1 autoimmune diseases
    Fuad Lechin
    Dig Dis Sci 52:103-4. 2007
  28. ncbi Neuroendocrine profiling in PCOS
    Fuad Lechin
    Fertil Steril 82:765-6; author reply 766. 2004
  29. ncbi Neural sympathetic activity in essential hypertension
    Fuad Lechin
    Hypertension 44:e3-4; author reply e3-4. 2004
  30. ncbi Elective stenting, platelet serotonin and thrombotic events
    Fuad Lechin
    Platelets 15:462. 2004
  31. ncbi Natural killer cells activity and neuroimmunological treatment of cancer
    Fuad Lechin
    Clin Cancer Res 10:8120; author reply 8120-1. 2004
  32. ncbi Serotonin bronchial hyperresponsiveness and eosinophilic cholangiopathy
    Fuad Lechin
    Dig Dis Sci 52:3369-70. 2007
  33. ncbi Gallbladder muscle dysfunction and neuroautonomic disorders
    Fuad Lechin
    Gastroenterology 123:1407-8. 2002
  34. pmc Pulmonary hypertension, left ventricular dysfunction and plasma serotonin: commentary on Deuchar et al
    Fuad Lechin
    Br J Pharmacol 137:937-8; author reply 938. 2002