Research Topics
| Carlos SevcikSummaryCountry: Venezuela Publications
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Publications
Initial volume of a drug before it reaches the volume of distribution: pharmacokinetics of F(ab')2 antivenoms and other drugsCarlos Sevcik
Laboratory of Cellular Neuropharmacology, Apartado 21827, Caracas 1020A, Venezuela
Toxicon 50:653-65. 2007..Data from the literature showed that the kinetic considerations for V(sl)(t) also apply to clevidipine, digoxin, digitoxin, lidocaine and thiopentone...- Identification of Enterobacter bacteria as saxitoxin producers in cattle's rumen and surface water from Venezuelan SavannahsC Sevcik
Laboratory on Cellular Neuropharmacology, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, Apartado 21827, Caracas1020A, Venezuela
Toxicon 42:359-66. 2003..asburiae and E. cloacae) and a strain of Klebsiella pneumoniae, were identified using standard biochemical criteria as well as gas chromatography of bacterial lipids. All these bacteria produced STX in aerobic cultures... 
Horse IgG- and ostrich IgY-F(ab')₂ groups have different affinities for mice erythrocytes and lymphocytes. Implications for avian immunoglobulin therapeutic usefulnessCarlos Sevcik
Laboratory on Cellular Neuropharmacology, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 20632, Caracas 1020A, Venezuela
Toxicon 60:1215-21. 2012..Our results suggest that IgY may be a stronger activator of adaptive immunity than horse IgG in mammals. Adaptive immunity against IgY is detrimental to its IV therapeutic use in humans and other mammals...- Scorpion toxins modify phytopathogenic fungus physiology. A possible source of new fungicidesGalax Joya
Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Científicas IVIC, Caracas, Venezuela
J Agric Food Chem 59:6327-37. 2011..However, the antifungal effects at short times are indicative of a direct esterase inhibition, which, with the increased membrane leakiness to Na(+), makes the fungus inviable... - Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changesPatricia Diaz
Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
Toxicon 54:802-17. 2009..We found no evidence of changes of K(+) or Ca(2+) concentrations neither inside nor outside the bacteria in experiments using the fluorescent dyes Fluo 4AM (10 microM) and PBFI (20 microM)... - Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepansGina D'suze
Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
Biochimie 91:1010-9. 2009..The N-terminal amino acid sequence of several peptides is reported here for the first time. A phylogenetic tree analysis is also reported, as well as three three-dimensional models of representative toxins... - On the presence of antibodies against bovine, equine and poultry immunoglobulins in human IgG preparations, and its implications on antivenom productionCarlos Sevcik
Laboratory of Cellular Neuropharmacology, Centro de Biofísica y Bioquímica Instituto Venezolano de Investigaciones Científicas, Apartado 21827, Caracas 1020A, Venezuela
Toxicon 51:10-6. 2008..This suggests that when IgY immunotherapeutics are used in populations with an important dietary component of poultry meat and eggs, there is a risk of producing untoward reactions and less efficient antivenoms... - Effect of leukocyte inhibitors benzydamine and cyclophosphamide, on lung injury caused by Tityus discrepans scorpion venomGina D'suze
Laboratory on Cellular Neuropharmacology, IVIC CBB, Apdo 20632, Caracas 1020 A, Venezuela
Toxicon 50:1116-25. 2007..Blocking pro-inflammatory leukocyte metabolic pathways with BZ diminished FF, suggesting that neutrophil activation, inflammation and coagulation are correlated in the genesis of scorpionism acute lung injury... - High resolution fluorescence microscopy evidence on the transport of immunoglobulins. Differences between mammalian IgG, F(ab')2 and avian IgYCarlos Sevcik
Laboratory on Cellular Neuropharmacology, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, Apartado 20632, Caracas 1020A, Bolivarian Republic of Venezuela
Toxicon 63:7-18. 2013..No IgY was seen in bronchial and alveolar endothelium, in bile ducts or in hepatocytes... - Apoptogenic peptides from Tityus discrepans scorpion venom acting against the SKBR3 breast cancer cell lineGina D'suze
Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas IVIC Caracas, Venezuela
Toxicon 56:1497-505. 2010..3 and 4.1% of SKBR3 apoptosis, respectively, in 5 h of exposure; the effect was larger with more prolonged exposures. Inmunohistochemistry showed that neopladines bind to SKBR3 cell surface inducing FasL and BcL-2 expression... - Tityus discrepans venom produces a respiratory distress syndrome in rabbits through an indirect mechanismG D'suze
Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
Toxicon 37:173-80. 1999..We thus propose that the use of the term pulmonary oedema in scorpionism should abandoned in favor of scorpion venom respiratory distress syndrome... - Antigenic cross-reactivity between sixteen venoms from scorpions belonging to six generaG D'suze
Instituto Venezolano de Investigaciones Cientificas IVIC, Lab de Neurofarmacología Celular, Caracas, Venezuela
Clin Toxicol (Phila) 45:158-63. 2007..Venoms from species from other genera such as Centruroides, Broteas, Diplocentrus, Chactas, and Rhopalurus did not cross-react with Td-antibodies... - Relationship between plasmatic levels of various cytokines, tumour necrosis factor, enzymes, glucose and venom concentration following Tityus scorpion stingG D'suze
Lab de Neurofarmacología Celular, Biochemistry and Biophysics Center, Instituto Venezolano de Investigaciones Cientificas IVIC, Apdo 21827, Caracas 1020 A, Venezuela
Toxicon 41:367-75. 2003..Interleukin 6 (IL6) increased significantly in patients with MS symptoms. IL6 values increased with hyperamylasemia, envenoming severity and time hyperamylasemia... - Histopathological changes and inflammatory response induced by Tityus discrepans scorpion venom in ramsG D'suze
Laboratory of Cellular Neuropharmacology, IVIC CBB, Apdo 21827, Caracas 1020A, Venezuela
Toxicon 44:851-60. 2004..Our results suggest that not all remote targets are directly affected by the venom but that, as proposed earlier, are modified by inflammation by products produced elsewhere... - Modelling Tityus scorpion venom and antivenom pharmacokinetics. Evidence of active immunoglobulin G's F(ab')2 extrusion mechanism from blood to tissuesC Sevcik
Laboratory of Cellular Neuropharmacology, , Apartado 21827, Caracas 1020A, Venezuela
Toxicon 44:731-41. 2004..Only approximately 5% of the venom is eliminated in 10h; approximately 80% of the venom is in the tissues after 2h and remains there for >10h... - Ardiscretin a novel arthropod-selective toxin from Tityus discrepans scorpion venomG D'suze
Laboratory of Cellular Neuropharmacology, Biochemistry and Biophysics Center, Inst venezolano de Inves Cient, Apartado 21827, Caracas 1020 A, Venezuela
Toxicon 43:263-72. 2004.... - [Effect of Tityus discrepans scorpion venom on global coagulation test. Preliminary studies]Josmary Brazón
Laboratorio de Neurofarmacología Celular, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 21827, Caracas 1020 A, Venezuela
Invest Clin 49:49-58. 2008..Td venom contains procoagulant components, able to shorten PTT. In addition, the venom contains anticoagulant components which prolong PT and PTT... - Scorpion venom complexity fractal analysis. Its relevance for comparing venomsGina D'suze
Laboratory on Cellular Neuropharmacology, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, IVIC CBB, Apartado 20632, Caracas 1020A, Venezuela
J Theor Biol 267:405-16. 2010.... - Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K+ -channels (IA currents) of cerebellum granular cellsCesar V F Batista
Laboratory of Cellular Neuropharmacology, Biochemistry and Biophysics Center, Instituto Venezolano de Investigaciones Cientificas, Apartado 21827, Caracas 1020-A, Venezuela
Arch Biochem Biophys 430:256-63. 2004..The K+ -currents are inhibited in an apparently irreversible manner, whose 50% inhibitory effect is reached with a 190 nM toxin concentration. The systematic nomenclature proposed for this toxin is alpha-KTx15.6... - Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxinsCesar V F Batista
Department of Molecular Medicine and Bioprocesses, Biotechnology Institute, UNAM, Cuernavaca, Mexico
Proteomics 6:3718-27. 2006..Additionally, peptides similar to defensins were also identified... - The indirect effect of Tityus discrepans on rabbit pulmonary vasculatureEva Novoa
Unit Of Respiration Physiology, Instituto de Medicina Experimental, Facultad de Medicina, Escuela Luis Razetti, Universidad Central de Venezuela, Apartado 50587, Caracas 1050, Venezuela
Respir Physiol Neurobiol 134:33-41. 2003..These experiments also make it unlikely that vascular endothelium is the source of the humoral factors contained in inflammatory serum... - Pharmacokinetics of whole IgG equine antivenom: comparison between normal and envenomed rabbitsLil Quesada
, Instituto Clodomiro Picado, Universidad de Costa Rica, San Jos, Costa Rica
Toxicon 48:255-63. 2006..However, this corresponds to a low percentage of the administered antivenom and, therefore, this increased local extravasation does not have a significant impact in the overall antivenom pharmacokinetics...