Gina D'suze

Summary

Country: Venezuela

Publications

  1. ncbi Relationship between plasmatic levels of various cytokines, tumour necrosis factor, enzymes, glucose and venom concentration following Tityus scorpion sting
    G D'suze
    Lab de Neurofarmacología Celular, Biochemistry and Biophysics Center, Instituto Venezolano de Investigaciones Cientificas IVIC, Apdo 21827, Caracas 1020 A, Venezuela
    Toxicon 41:367-75. 2003
  2. ncbi Ardiscretin a novel arthropod-selective toxin from Tityus discrepans scorpion venom
    G D'suze
    Laboratory of Cellular Neuropharmacology, Biochemistry and Biophysics Center, Inst venezolano de Inves Cient, Apartado 21827, Caracas 1020 A, Venezuela
    Toxicon 43:263-72. 2004
  3. ncbi Histopathological changes and inflammatory response induced by Tityus discrepans scorpion venom in rams
    G D'suze
    Laboratory of Cellular Neuropharmacology, IVIC CBB, Apdo 21827, Caracas 1020A, Venezuela
    Toxicon 44:851-60. 2004
  4. ncbi Antigenic cross-reactivity between sixteen venoms from scorpions belonging to six genera
    G D'suze
    Instituto Venezolano de Investigaciones Cientificas IVIC, Lab de Neurofarmacología Celular, Caracas, Venezuela
    Clin Toxicol (Phila) 45:158-63. 2007
  5. ncbi Effect of leukocyte inhibitors benzydamine and cyclophosphamide, on lung injury caused by Tityus discrepans scorpion venom
    Gina D'suze
    Laboratory on Cellular Neuropharmacology, IVIC CBB, Apdo 20632, Caracas 1020 A, Venezuela
    Toxicon 50:1116-25. 2007
  6. doi High resolution fluorescence microscopy evidence on the transport of immunoglobulins. Differences between mammalian IgG, F(ab')2 and avian IgY
    Carlos Sevcik
    Laboratory on Cellular Neuropharmacology, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, Apartado 20632, Caracas 1020A, Bolivarian Republic of Venezuela
    Toxicon 63:7-18. 2013
  7. ncbi Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K+ -channels (IA currents) of cerebellum granular cells
    Gina D'suze
    Laboratory of Cellular Neuropharmacology, Biochemistry and Biophysics Center, Instituto Venezolano de Investigaciones Cientificas, Apartado 21827, Caracas 1020 A, Venezuela
    Arch Biochem Biophys 430:256-63. 2004
  8. doi Horse IgG- and ostrich IgY-F(ab')₂ groups have different affinities for mice erythrocytes and lymphocytes. Implications for avian immunoglobulin therapeutic usefulness
    Carlos Sevcik
    Laboratory on Cellular Neuropharmacology, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 20632, Caracas 1020A, Venezuela
    Toxicon 60:1215-21. 2012
  9. ncbi Initial volume of a drug before it reaches the volume of distribution: pharmacokinetics of F(ab')2 antivenoms and other drugs
    Carlos Sevcik
    Laboratory of Cellular Neuropharmacology, Apartado 21827, Caracas 1020A, Venezuela
    Toxicon 50:653-65. 2007
  10. doi Scorpion toxins modify phytopathogenic fungus physiology. A possible source of new fungicides
    Galax Joya
    Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Científicas IVIC, Caracas, Venezuela
    J Agric Food Chem 59:6327-37. 2011

Collaborators

Detail Information

Publications20

  1. ncbi Relationship between plasmatic levels of various cytokines, tumour necrosis factor, enzymes, glucose and venom concentration following Tityus scorpion sting
    G D'suze
    Lab de Neurofarmacología Celular, Biochemistry and Biophysics Center, Instituto Venezolano de Investigaciones Cientificas IVIC, Apdo 21827, Caracas 1020 A, Venezuela
    Toxicon 41:367-75. 2003
    ..Interleukin 6 (IL6) increased significantly in patients with MS symptoms. IL6 values increased with hyperamylasemia, envenoming severity and time hyperamylasemia...
  2. ncbi Ardiscretin a novel arthropod-selective toxin from Tityus discrepans scorpion venom
    G D'suze
    Laboratory of Cellular Neuropharmacology, Biochemistry and Biophysics Center, Inst venezolano de Inves Cient, Apartado 21827, Caracas 1020 A, Venezuela
    Toxicon 43:263-72. 2004
    ....
  3. ncbi Histopathological changes and inflammatory response induced by Tityus discrepans scorpion venom in rams
    G D'suze
    Laboratory of Cellular Neuropharmacology, IVIC CBB, Apdo 21827, Caracas 1020A, Venezuela
    Toxicon 44:851-60. 2004
    ..Our results suggest that not all remote targets are directly affected by the venom but that, as proposed earlier, are modified by inflammation by products produced elsewhere...
  4. ncbi Antigenic cross-reactivity between sixteen venoms from scorpions belonging to six genera
    G D'suze
    Instituto Venezolano de Investigaciones Cientificas IVIC, Lab de Neurofarmacología Celular, Caracas, Venezuela
    Clin Toxicol (Phila) 45:158-63. 2007
    ..Venoms from species from other genera such as Centruroides, Broteas, Diplocentrus, Chactas, and Rhopalurus did not cross-react with Td-antibodies...
  5. ncbi Effect of leukocyte inhibitors benzydamine and cyclophosphamide, on lung injury caused by Tityus discrepans scorpion venom
    Gina D'suze
    Laboratory on Cellular Neuropharmacology, IVIC CBB, Apdo 20632, Caracas 1020 A, Venezuela
    Toxicon 50:1116-25. 2007
    ..Blocking pro-inflammatory leukocyte metabolic pathways with BZ diminished FF, suggesting that neutrophil activation, inflammation and coagulation are correlated in the genesis of scorpionism acute lung injury...
  6. doi High resolution fluorescence microscopy evidence on the transport of immunoglobulins. Differences between mammalian IgG, F(ab')2 and avian IgY
    Carlos Sevcik
    Laboratory on Cellular Neuropharmacology, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, Apartado 20632, Caracas 1020A, Bolivarian Republic of Venezuela
    Toxicon 63:7-18. 2013
    ..No IgY was seen in bronchial and alveolar endothelium, in bile ducts or in hepatocytes...
  7. ncbi Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K+ -channels (IA currents) of cerebellum granular cells
    Gina D'suze
    Laboratory of Cellular Neuropharmacology, Biochemistry and Biophysics Center, Instituto Venezolano de Investigaciones Cientificas, Apartado 21827, Caracas 1020 A, Venezuela
    Arch Biochem Biophys 430:256-63. 2004
    ..The K+ -currents are inhibited in an apparently irreversible manner, whose 50% inhibitory effect is reached with a 190 nM toxin concentration. The systematic nomenclature proposed for this toxin is alpha-KTx15.6...
  8. doi Horse IgG- and ostrich IgY-F(ab')₂ groups have different affinities for mice erythrocytes and lymphocytes. Implications for avian immunoglobulin therapeutic usefulness
    Carlos Sevcik
    Laboratory on Cellular Neuropharmacology, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 20632, Caracas 1020A, Venezuela
    Toxicon 60:1215-21. 2012
    ..Our results suggest that IgY may be a stronger activator of adaptive immunity than horse IgG in mammals. Adaptive immunity against IgY is detrimental to its IV therapeutic use in humans and other mammals...
  9. ncbi Initial volume of a drug before it reaches the volume of distribution: pharmacokinetics of F(ab')2 antivenoms and other drugs
    Carlos Sevcik
    Laboratory of Cellular Neuropharmacology, Apartado 21827, Caracas 1020A, Venezuela
    Toxicon 50:653-65. 2007
    ..Data from the literature showed that the kinetic considerations for V(sl)(t) also apply to clevidipine, digoxin, digitoxin, lidocaine and thiopentone...
  10. doi Scorpion toxins modify phytopathogenic fungus physiology. A possible source of new fungicides
    Galax Joya
    Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Científicas IVIC, Caracas, Venezuela
    J Agric Food Chem 59:6327-37. 2011
    ..However, the antifungal effects at short times are indicative of a direct esterase inhibition, which, with the increased membrane leakiness to Na(+), makes the fungus inviable...
  11. ncbi Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans
    Gina D'suze
    Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Biochimie 91:1010-9. 2009
    ..The N-terminal amino acid sequence of several peptides is reported here for the first time. A phylogenetic tree analysis is also reported, as well as three three-dimensional models of representative toxins...
  12. ncbi [Effect of Tityus discrepans scorpion venom on global coagulation test. Preliminary studies]
    Josmary Brazón
    Laboratorio de Neurofarmacología Celular, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 21827, Caracas 1020 A, Venezuela
    Invest Clin 49:49-58. 2008
    ..Td venom contains procoagulant components, able to shorten PTT. In addition, the venom contains anticoagulant components which prolong PT and PTT...
  13. ncbi On the presence of antibodies against bovine, equine and poultry immunoglobulins in human IgG preparations, and its implications on antivenom production
    Carlos Sevcik
    Laboratory of Cellular Neuropharmacology, Centro de Biofísica y Bioquímica Instituto Venezolano de Investigaciones Científicas, Apartado 21827, Caracas 1020A, Venezuela
    Toxicon 51:10-6. 2008
    ..This suggests that when IgY immunotherapeutics are used in populations with an important dietary component of poultry meat and eggs, there is a risk of producing untoward reactions and less efficient antivenoms...
  14. doi Fibrin(ogen)olytic enzymes in scorpion (Tityus discrepans) venom
    Josmary Brazón
    Laboratorio de Neurofarmacología Celular, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 20632, Caracas, 1020 A, Venezuela Electronic address
    Comp Biochem Physiol B Biochem Mol Biol 168:62-9. 2014
    ..The overall outcome suggests that metalloproteases and serine proteases in TdV are responsible for fibrin(ogen)olytic activity because MPI and SPI inhibited these activities. ..
  15. doi Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes
    Patricia Diaz
    Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Toxicon 54:802-17. 2009
    ..We found no evidence of changes of K(+) or Ca(2+) concentrations neither inside nor outside the bacteria in experiments using the fluorescent dyes Fluo 4AM (10 microM) and PBFI (20 microM)...
  16. doi Scorpion venom complexity fractal analysis. Its relevance for comparing venoms
    Gina D'suze
    Laboratory on Cellular Neuropharmacology, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, IVIC CBB, Apartado 20632, Caracas 1020A, Venezuela
    J Theor Biol 267:405-16. 2010
    ....
  17. doi Apoptogenic peptides from Tityus discrepans scorpion venom acting against the SKBR3 breast cancer cell line
    Gina D'suze
    Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas IVIC Caracas, Venezuela
    Toxicon 56:1497-505. 2010
    ..3 and 4.1% of SKBR3 apoptosis, respectively, in 5 h of exposure; the effect was larger with more prolonged exposures. Inmunohistochemistry showed that neopladines bind to SKBR3 cell surface inducing FasL and BcL-2 expression...
  18. ncbi Discreplasminin, a plasmin inhibitor isolated from Tityus discrepans scorpion venom
    Josmary Brazón
    Laboratorio de Neurofarmacología Celular, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, Apartado, Caracas, Venezuela
    Arch Toxicol 83:669-78. 2009
    ..The presence of discreplasminin and other similar components in scorpion venom could partially explain the generalized fibrin deposition which was found previously in rams...
  19. doi Tityus discrepans scorpion venom activates platelets through GPVI and a novel Src-dependent signaling pathway
    Josmary Brazón
    Laboratorio de Neurofarmacología Celular, Centro de Biofísica y Bioquímica Instituto Venezolano de Investigaciones Científicas IVIC, Apartado 20632, Caracas, 1020 A, Venezuela
    Platelets 22:165-72. 2011
    ..TdV therefore activates platelets through GPVI and a second, as yet unidentified Src kinase-dependent pathway...
  20. ncbi Macrophage alteration induced by inflammatory toxins isolated from Tityus discrepans scorpion venom. The role of Na(+)/Ca(2+) exchangers
    Vanesa Ramírez-Bello
    Laboratory of Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas IVIC, Apdo 20632, Caracas 1020 A, Venezuela
    Toxicon 82:61-75. 2014
    ..A rise of [Ca(2+)]i activates the synthesis and secretion of inflammatory molecules like TNF-α, which in turn, increases the gene transcription for inducible nitric oxide synthase, resulting on NO production. ..