Gustavo Benaim

Summary

Country: Venezuela

Publications

  1. doi request reprint Identification of a sphingosine-sensitive Ca2+ channel in the plasma membrane of Leishmania mexicana
    Gustavo Benaim
    Instituto de Estudios Avanzados, Caracas, Venezuela
    Biochem Biophys Res Commun 430:1091-6. 2013
  2. doi request reprint The emerging role of amiodarone and dronedarone in Chagas disease
    Gustavo Benaim
    Instituto de Estudios Avanzados IDEA, Sartenejas, Baruta, Caracas 1080, Venezuela
    Nat Rev Cardiol 9:605-9. 2012
  3. pmc In vitro anti-Trypanosoma cruzi activity of dronedarone, a novel amiodarone derivative with an improved safety profile
    Gustavo Benaim
    Instituto de Estudios Avanzados, IDEA, Caracas, Venezuela
    Antimicrob Agents Chemother 56:3720-5. 2012
  4. ncbi request reprint Targeting calcium homeostasis as the therapy of Chagas' disease and leishmaniasis - a review
    B Gustavo Benaim
    Instituto de Estudios Avanzados IDEA, Carretera Nacional Hoyo de la Puerta, Baruta, Caracas, Venezuela
    Trop Biomed 28:471-81. 2011
  5. ncbi request reprint Ceramide-1-P induces Ca2+ mobilization in Jurkat T-cells by elevation of Ins(1,4,5)-P3 and activation of a store-operated calcium channel
    Claudia Colina
    Laboratorio de Permeabilidad Ionica, Instituto Venezolano de Investigaciones Cientificas IVIC, Caracas, Venezuela
    Biochem Biophys Res Commun 336:54-60. 2005
  6. doi request reprint Sodium-calcium exchanger modulates the L-glutamate Ca(i) (2+) signalling in type-1 cerebellar astrocytes
    Hector Rojas
    Laboratorio de Fisiologia Celular, Centro de Biofisica, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Adv Exp Med Biol 961:267-74. 2013
  7. ncbi request reprint [Ca2+ and sphingolipids as modulators for apoptosis and cancer]
    Adriana A Pimentel
    Laboratorio de Señialización Celular y Bioquimica de Parásitos Instituto de Estudios Avanzados IDEA, Carretera Nacional Hoyo de la Puerta, Sartenejas, Baruta
    Invest Clin 53:84-110. 2012
  8. pmc Amiodarone destabilizes intracellular Ca2+ homeostasis and biosynthesis of sterols in Leishmania mexicana
    Xenón Serrano-Martín
    Centro de Biociencias y Medicina Molecular, Instituto de Estudios Avanzados, Carretera Nacional Hoyo de la Puerta, Baruta, Caracas, Venezuela
    Antimicrob Agents Chemother 53:1403-10. 2009
  9. doi request reprint Diacylglycerol regulates the plasma membrane calcium pump from human erythrocytes by direct interaction
    Maria C Pérez-Gordones
    Instituto de Biología Experimental IBE, Facultad de Ciencias, Universidad Central de Venezuela, Caracas, Venezuela
    Arch Biochem Biophys 489:55-61. 2009
  10. ncbi request reprint Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy
    Gustavo Benaim
    Laboratorio de Señalización Celular y Bioquímica de Parásitos, Instituto de Estudios Avanzados IDEA, Caracas, Venezuela
    Antimicrob Agents Chemother 58:2295-303. 2014

Collaborators

  • Alirica I Suarez
  • Anita Israel
  • Cecilia Castillo
  • Antonio Villalobo
  • Francisco Arvelo
  • Alexis Mendoza-León
  • Celia R S Garcia
  • Erica H Jaffe
  • Hector Rojas
  • Claudia Colina
  • Adriana A Pimentel
  • Xenón Serrano-Martín
  • Reinaldo DiPolo
  • Yael Garcia-Marchan
  • B Gustavo Benaim
  • Felipe Sojo
  • Ivan Galindo-Castro
  • Magaly Ramos
  • Carlo Caputo
  • Maria C Pérez-Gordones
  • Vincenza Cervino
  • Adriana Flores
  • Maria del Rosario Garrido
  • Reinaldo Di Polo
  • Adriana Mayora
  • Perla Chirino
  • Pimali Felibertt
  • Reinaldo S Compagnone
  • Laura Colman
  • Juan B De Sanctis
  • May Li Silva
  • Noris Rodriguez
  • Juan Carlos Martinez
  • Milena Salerno
  • Moraima Winkler
  • Caridad Malave
  • Evelyn Rodriguez
  • Noraida Zerpa
  • Miguel R Lugo
  • Marisel De Lucca
  • Gonzalo Visbal
  • Gilberto Payares
  • Alexis Fernandez
  • Angie Acosta

Detail Information

Publications17

  1. doi request reprint Identification of a sphingosine-sensitive Ca2+ channel in the plasma membrane of Leishmania mexicana
    Gustavo Benaim
    Instituto de Estudios Avanzados, Caracas, Venezuela
    Biochem Biophys Res Commun 430:1091-6. 2013
    ..However, different to its human counterpart, sphingosine was able to open this channel, while other well known sphingolipids had no effect. This fact could have important pharmacological implications...
  2. doi request reprint The emerging role of amiodarone and dronedarone in Chagas disease
    Gustavo Benaim
    Instituto de Estudios Avanzados IDEA, Sartenejas, Baruta, Caracas 1080, Venezuela
    Nat Rev Cardiol 9:605-9. 2012
    ..We believe that this 'kill two birds with one stone' approach represents a new tactic for the treatment of Chagas disease using currently approved drugs...
  3. pmc In vitro anti-Trypanosoma cruzi activity of dronedarone, a novel amiodarone derivative with an improved safety profile
    Gustavo Benaim
    Instituto de Estudios Avanzados, IDEA, Caracas, Venezuela
    Antimicrob Agents Chemother 56:3720-5. 2012
    ..Our results suggest a possible future repurposed use of dronedarone for the treatment of Chagas' disease...
  4. ncbi request reprint Targeting calcium homeostasis as the therapy of Chagas' disease and leishmaniasis - a review
    B Gustavo Benaim
    Instituto de Estudios Avanzados IDEA, Carretera Nacional Hoyo de la Puerta, Baruta, Caracas, Venezuela
    Trop Biomed 28:471-81. 2011
    ..All these findings strongly suggest that the alteration of the intracellular Ca(2+) homeostasis of these parasites is a promising strategy as a target of new as well as repurposed old-known drugs...
  5. ncbi request reprint Ceramide-1-P induces Ca2+ mobilization in Jurkat T-cells by elevation of Ins(1,4,5)-P3 and activation of a store-operated calcium channel
    Claudia Colina
    Laboratorio de Permeabilidad Ionica, Instituto Venezolano de Investigaciones Cientificas IVIC, Caracas, Venezuela
    Biochem Biophys Res Commun 336:54-60. 2005
    ..The mechanism of action of Cer-1-P resembles that of the Jurkat anti-TCR antibody, but differs from that of ceramide, since Cer-1-P induced an increase in Ins(1,4,5)-P(3)...
  6. doi request reprint Sodium-calcium exchanger modulates the L-glutamate Ca(i) (2+) signalling in type-1 cerebellar astrocytes
    Hector Rojas
    Laboratorio de Fisiologia Celular, Centro de Biofisica, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Adv Exp Med Biol 961:267-74. 2013
    ....
  7. ncbi request reprint [Ca2+ and sphingolipids as modulators for apoptosis and cancer]
    Adriana A Pimentel
    Laboratorio de Señialización Celular y Bioquimica de Parásitos Instituto de Estudios Avanzados IDEA, Carretera Nacional Hoyo de la Puerta, Sartenejas, Baruta
    Invest Clin 53:84-110. 2012
    ..In this review we discuss new evidences on the effect of several sphingolipids in the intracellular Ca2+ homeostasis and its relationship with apoptosis and cancer...
  8. pmc Amiodarone destabilizes intracellular Ca2+ homeostasis and biosynthesis of sterols in Leishmania mexicana
    Xenón Serrano-Martín
    Centro de Biociencias y Medicina Molecular, Instituto de Estudios Avanzados, Carretera Nacional Hoyo de la Puerta, Baruta, Caracas, Venezuela
    Antimicrob Agents Chemother 53:1403-10. 2009
    ..Taken together, the results obtained in the present work point to a more general effect of amiodarone in trypanosomatids, opening potential therapeutic possibilities for this infectious disease...
  9. doi request reprint Diacylglycerol regulates the plasma membrane calcium pump from human erythrocytes by direct interaction
    Maria C Pérez-Gordones
    Instituto de Biología Experimental IBE, Facultad de Ciencias, Universidad Central de Venezuela, Caracas, Venezuela
    Arch Biochem Biophys 489:55-61. 2009
    ..Additionally, by different fluorescent approaches, we demonstrated a direct binding between PMCA and DAG. The results obtained in this work strongly suggest that DAG is a novel effector of the PMCA, acting by a direct interaction...
  10. ncbi request reprint Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy
    Gustavo Benaim
    Laboratorio de Señalización Celular y Bioquímica de Parásitos, Instituto de Estudios Avanzados IDEA, Caracas, Venezuela
    Antimicrob Agents Chemother 58:2295-303. 2014
    ..Overall, our results suggest the possibility of repurposing dronedarone as a treatment for cutaneous, and perhaps other, leishmaniases...
  11. ncbi request reprint Na+ entry via glutamate transporter activates the reverse Na+/Ca2+ exchange and triggers Ca(i)2+-induced Ca2+ release in rat cerebellar Type-1 astrocytes
    Hector Rojas
    Laboratorio de Fisiologia Celular, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    J Neurochem 100:1188-202. 2007
    ....
  12. ncbi request reprint Ceramide increase cytoplasmic Ca2+ concentration in Jurkat T cells by liberation of calcium from intracellular stores and activation of a store-operated calcium channel
    Claudia Colina
    Centro de Biociencias y Medicina Molecular, Instituto de Estudios Avanzados IDEA, Caracas, Venezuela
    Arch Biochem Biophys 436:333-45. 2005
    ..The opening of a store operated Ca2+ channel by ceramide was corroborated by experiments of Fura-2 quenching, using Mn2+ as a surrogate for Ca2+ and confirmed by whole-cell recording patch clamp techniques...
  13. doi request reprint Trypanosoma cruzi calmodulin: cloning, expression and characterization
    Yael Garcia-Marchan
    Centro de Biociencias y Medicina Molecular, Instituto de Estudios Avanzados IDEA, Universidad Central de Venezuela, Caracas 1080, Bolivarian Republic of Venezuela
    Exp Parasitol 123:326-33. 2009
    ..cruzi CaM...
  14. doi request reprint The marine sponge toxin agelasine B increases the intracellular Ca(2+) concentration and induces apoptosis in human breast cancer cells (MCF-7)
    Adriana A Pimentel
    Instituto de Estudios Avanzados IDEA, Carretera Nacional Hoyo de la Puerta, Sartenejas, Baruta, Caracas, Venezuela
    Cancer Chemother Pharmacol 69:71-83. 2012
    ..In search for new drugs derived from natural products for the possible treatment of cancer, we studied the action of agelasine B, a compound purified from a marine sponge Agelas clathrodes...
  15. pmc Amiodarone and miltefosine act synergistically against Leishmania mexicana and can induce parasitological cure in a murine model of cutaneous leishmaniasis
    Xenón Serrano-Martín
    Centro de Biociencias y Medicina Molecular, Instituto de Estudios Avanzados IDEA, Caracas, Venezuela
    Antimicrob Agents Chemother 53:5108-13. 2009
    ..mexicana...
  16. pmc Ceramide and sphingosine have an antagonistic effect on the plasma-membrane Ca2+-ATPase from human erythrocytes
    Claudia Colina
    Instituto de Biologia Experimental, Facultad de Ciencias, Universidad Central de Venezuela, Apartado 47114, Caracas, Venezuela
    Biochem J 362:247-51. 2002
    ..This is in accordance with the frequently reported opposite effect of these sphingolipids on intracellular Ca(2+) concentration...
  17. ncbi request reprint Phosphorylation of calmodulin. Functional implications
    Gustavo Benaim
    Instituto de Biologia Experimental, Facultad de Ciencias, Universidad Central de Venezuela, Caracas, Venezuela
    Eur J Biochem 269:3619-31. 2002
    ....