NO role of NOS2A susceptibility polymorphisms in rheumatoid arthritisJezabel Varadé
Immunology Department, Hospital Clinico San Carlos, Prof Martin Lagos s n, 28040 Madrid, Spain
Nitric Oxide 21:171-4. 2009
..The present data do not support a causative role of NOS2A polymorphisms in RA predisposition...
Polymorphisms in the selenoprotein S gene: lack of association with autoimmune inflammatory diseasesAlfonso Martinez
Immunology Department, Hospital Universitario San Carlos, Madrid, Spain
BMC Genomics 9:329. 2008
....
- Specific association of a CLEC16A/KIAA0350 polymorphism with NOD2/CARD15(-) Crohn's disease patients
Ana Marquez
Department of Immunology, Hospital Clinico San Carlos, Madrid, Spain
Eur J Hum Genet 17:1304-8. 2009
..0005; OR (95% CI)=1.52 (1.19-1.93)). These data would suggest that microbial recognition through different pathways seems to converge in the development of these polygenic bowel diseases...
- Plasma soluble IL-6 receptor concentration in rheumatoid arthritis: associations with the rs8192284 IL6R polymorphism and with disease activity
Luis Rodríguez-Rodríguez
Rheumatology Service, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, 28040, Madrid, Spain
Rheumatol Int 31:409-13. 2011
..Our findings show that the rs8192284 polymorphism is operative in patients with RA. The presence of anti-CCP antibodies determines the relationship between sIL-6R concentration and disease activity...
IL4 in the 5q31 context: association studies of type 1 diabetes and rheumatoid arthritis in the Spanish populationConcepcion Nunez
Clinical Immunology Department, Hospital Clinico San Carlos, 28040 Madrid, Spain
Immunogenetics 60:19-23. 2008
....
- Combined influence of genetic and environmental factors in age of rheumatoid arthritis onset
Luis Rodríguez-Rodríguez
Rheumatology Service, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, 28040 Madrid, Spain
Rheumatol Int 32:3097-102. 2012
..0001), 12.74 [6.84-18.64] years (P < 0.0001), and 20.87 [10.40-37.17] years (P < 0.0001)). Risk factors for the development of rheumatoid arthritis are also associated, with an additive effect, with a younger age at disease onset...
- Macrophage migration inhibitory factor gene: influence on rheumatoid arthritis susceptibility
Alfonso Martinez
Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
Hum Immunol 68:744-7. 2007
..6; OR = 1.09; 95% CI = 0.77-1.55). In conclusion, the -173C allele in the MIF promoter region is associated with increased RA predisposition, mainly in early-onset patients...
- Influence of IL6R rs8192284 polymorphism status in disease activity in rheumatoid arthritis
Jose Ramon Lamas
Rheumatology Service, Hospital Clinico San Carlos, 28040 Madrid, Spain
J Rheumatol 37:1579-81. 2010
..To analyze the influence of IL6R rs8192284 polymorphism on the disease activity of rheumatoid arthritis (RA)...
- Role of the MHC2TA gene in autoimmune diseases
Alfonso Martinez
Immunology Department, Hospital Universitario San Carlos, Martin Lagos s n, 28040 Madrid, Spain
Ann Rheum Dis 66:325-9. 2007
..However, no evidence of association of this MHC2TA variant with the two autoimmune diseases could be subsequently detected in independent cohorts...
- Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes
Jezabel Varadé
Immunology Department, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Spain
Mult Scler 18:959-65. 2012
..Ten genes previously showing different evidence of association with multiple sclerosis have been selected to validate...
- Interleukin-10 haplotypes in Celiac Disease in the Spanish population
Concepcion Nunez
Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
BMC Med Genet 7:32. 2006
..Our aim was to study the role of those polymorphisms in susceptibility to CD in our population...
- Analysis of the essential oil composition from the different parts of Eryngiumglaciale Boiss. from Spain
Jesús Palá-Paúl
Dpto Biologia Vegetal I Botánica, Facultad de Biologia, Universidad Complutense de Madrid, 28040 Madrid, Spain
J Chromatogr A 1094:179-82. 2005
..3%) as main one. The oil from the roots presented phyllocladene isomer (49.4%) and linalool (19.1%) as major constituents. This is the first report on the chemical composition of this species...
