Jezabel Varadé

Summary

Publications

  1. doi request reprint NO role of NOS2A susceptibility polymorphisms in rheumatoid arthritis
    Jezabel Varadé
    Immunology Department, Hospital Clinico San Carlos, Prof Martin Lagos s n, 28040 Madrid, Spain
    Nitric Oxide 21:171-4. 2009
  2. pmc Polymorphisms in the selenoprotein S gene: lack of association with autoimmune inflammatory diseases
    Alfonso Martinez
    Immunology Department, Hospital Universitario San Carlos, Madrid, Spain
    BMC Genomics 9:329. 2008
  3. pmc Specific association of a CLEC16A/KIAA0350 polymorphism with NOD2/CARD15(-) Crohn's disease patients
    Ana Marquez
    Department of Immunology, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Hum Genet 17:1304-8. 2009
  4. doi request reprint Plasma soluble IL-6 receptor concentration in rheumatoid arthritis: associations with the rs8192284 IL6R polymorphism and with disease activity
    Luis Rodríguez-Rodríguez
    Rheumatology Service, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, 28040, Madrid, Spain
    Rheumatol Int 31:409-13. 2011
  5. ncbi request reprint IL4 in the 5q31 context: association studies of type 1 diabetes and rheumatoid arthritis in the Spanish population
    Concepcion Nunez
    Clinical Immunology Department, Hospital Clinico San Carlos, 28040 Madrid, Spain
    Immunogenetics 60:19-23. 2008
  6. ncbi request reprint Combined influence of genetic and environmental factors in age of rheumatoid arthritis onset
    Luis Rodríguez-Rodríguez
    Rheumatology Service, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, 28040 Madrid, Spain
    Rheumatol Int 32:3097-102. 2012
  7. doi request reprint Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis
    Jose Ramon Lamas
    UGC de Reumatología, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain
    Cytokine 61:720-3. 2013
  8. ncbi request reprint Macrophage migration inhibitory factor gene: influence on rheumatoid arthritis susceptibility
    Alfonso Martinez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    Hum Immunol 68:744-7. 2007
  9. pmc Role of the MHC2TA gene in autoimmune diseases
    Alfonso Martinez
    Immunology Department, Hospital Universitario San Carlos, Martin Lagos s n, 28040 Madrid, Spain
    Ann Rheum Dis 66:325-9. 2007
  10. doi request reprint Influence of IL6R rs8192284 polymorphism status in disease activity in rheumatoid arthritis
    Jose Ramon Lamas
    Rheumatology Service, Hospital Clinico San Carlos, 28040 Madrid, Spain
    J Rheumatol 37:1579-81. 2010

Collaborators

Detail Information

Publications16

  1. doi request reprint NO role of NOS2A susceptibility polymorphisms in rheumatoid arthritis
    Jezabel Varadé
    Immunology Department, Hospital Clinico San Carlos, Prof Martin Lagos s n, 28040 Madrid, Spain
    Nitric Oxide 21:171-4. 2009
    ..The present data do not support a causative role of NOS2A polymorphisms in RA predisposition...
  2. pmc Polymorphisms in the selenoprotein S gene: lack of association with autoimmune inflammatory diseases
    Alfonso Martinez
    Immunology Department, Hospital Universitario San Carlos, Madrid, Spain
    BMC Genomics 9:329. 2008
    ....
  3. pmc Specific association of a CLEC16A/KIAA0350 polymorphism with NOD2/CARD15(-) Crohn's disease patients
    Ana Marquez
    Department of Immunology, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Hum Genet 17:1304-8. 2009
    ..0005; OR (95% CI)=1.52 (1.19-1.93)). These data would suggest that microbial recognition through different pathways seems to converge in the development of these polygenic bowel diseases...
  4. doi request reprint Plasma soluble IL-6 receptor concentration in rheumatoid arthritis: associations with the rs8192284 IL6R polymorphism and with disease activity
    Luis Rodríguez-Rodríguez
    Rheumatology Service, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, 28040, Madrid, Spain
    Rheumatol Int 31:409-13. 2011
    ..Our findings show that the rs8192284 polymorphism is operative in patients with RA. The presence of anti-CCP antibodies determines the relationship between sIL-6R concentration and disease activity...
  5. ncbi request reprint IL4 in the 5q31 context: association studies of type 1 diabetes and rheumatoid arthritis in the Spanish population
    Concepcion Nunez
    Clinical Immunology Department, Hospital Clinico San Carlos, 28040 Madrid, Spain
    Immunogenetics 60:19-23. 2008
    ....
  6. ncbi request reprint Combined influence of genetic and environmental factors in age of rheumatoid arthritis onset
    Luis Rodríguez-Rodríguez
    Rheumatology Service, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, 28040 Madrid, Spain
    Rheumatol Int 32:3097-102. 2012
    ..0001), 12.74 [6.84-18.64] years (P < 0.0001), and 20.87 [10.40-37.17] years (P < 0.0001)). Risk factors for the development of rheumatoid arthritis are also associated, with an additive effect, with a younger age at disease onset...
  7. doi request reprint Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis
    Jose Ramon Lamas
    UGC de Reumatología, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain
    Cytokine 61:720-3. 2013
    ..To describe the relationship between the two mechanisms involved in sIL6R generation in rheumatoid arthritis (RA)...
  8. ncbi request reprint Macrophage migration inhibitory factor gene: influence on rheumatoid arthritis susceptibility
    Alfonso Martinez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    Hum Immunol 68:744-7. 2007
    ..6; OR = 1.09; 95% CI = 0.77-1.55). In conclusion, the -173C allele in the MIF promoter region is associated with increased RA predisposition, mainly in early-onset patients...
  9. pmc Role of the MHC2TA gene in autoimmune diseases
    Alfonso Martinez
    Immunology Department, Hospital Universitario San Carlos, Martin Lagos s n, 28040 Madrid, Spain
    Ann Rheum Dis 66:325-9. 2007
    ..However, no evidence of association of this MHC2TA variant with the two autoimmune diseases could be subsequently detected in independent cohorts...
  10. doi request reprint Influence of IL6R rs8192284 polymorphism status in disease activity in rheumatoid arthritis
    Jose Ramon Lamas
    Rheumatology Service, Hospital Clinico San Carlos, 28040 Madrid, Spain
    J Rheumatol 37:1579-81. 2010
    ..To analyze the influence of IL6R rs8192284 polymorphism on the disease activity of rheumatoid arthritis (RA)...
  11. pmc Role of the human endogenous retrovirus HERV-K18 in autoimmune disease susceptibility: study in the Spanish population and meta-analysis
    Belén de la Hera
    Immunology Department, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain
    PLoS ONE 8:e62090. 2013
    ..We aimed at evaluating the role of HERV-K18 in chromosome 1 on autoimmune disease susceptibility...
  12. pmc Human endogenous retrovirus HERV-Fc1 association with multiple sclerosis susceptibility: a meta-analysis
    Belén de la Hera
    Immunology Dept, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Madrid, Spain
    PLoS ONE 9:e90182. 2014
    ..Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts...
  13. doi request reprint Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes
    Jezabel Varadé
    Immunology Department, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Spain
    Mult Scler 18:959-65. 2012
    ..Ten genes previously showing different evidence of association with multiple sclerosis have been selected to validate...
  14. pmc Interleukin-10 haplotypes in Celiac Disease in the Spanish population
    Concepcion Nunez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    BMC Med Genet 7:32. 2006
    ..Our aim was to study the role of those polymorphisms in susceptibility to CD in our population...
  15. pmc HERV-W polymorphism in chromosome X is associated with multiple sclerosis risk and with differential expression of MSRV
    Marta Garcia-Montojo
    Multiple Sclerosis Unit, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Profesor Martín Lagos s n, 28240, Madrid, Spain
    Retrovirology 11:2. 2014
    ..A possible link between the HERV-W copy on chromosome Xq22.3, that contains an almost complete open reading frame, and the gender differential prevalence in MS has been suggested...
  16. ncbi request reprint Analysis of the essential oil composition from the different parts of Eryngiumglaciale Boiss. from Spain
    Jesús Palá-Paúl
    Dpto Biologia Vegetal I Botánica, Facultad de Biologia, Universidad Complutense de Madrid, 28040 Madrid, Spain
    J Chromatogr A 1094:179-82. 2005
    ..3%) as main one. The oil from the roots presented phyllocladene isomer (49.4%) and linalool (19.1%) as major constituents. This is the first report on the chemical composition of this species...