Peter Vandenabeele

Summary

Publications

  1. pmc Many stimuli pull the necrotic trigger, an overview
    N Vanlangenakker
    Department for Molecular Biomedical Research, VIB, Zwijnaarde Ghent, Belgium
    Cell Death Differ 19:75-86. 2012
  2. pmc Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
    E Wirawan
    VIB, Department for Molecular Biomedical Research, Ghent, Belgium
    Cell Death Dis 1:e18. 2010
  3. pmc TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members
    N Vanlangenakker
    Department for Molecular Biomedical Research, VIB, Zwijnaarde Ghent, Belgium
    Cell Death Dis 2:e230. 2011
  4. doi request reprint The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling
    Peter Vandenabeele
    Department for Molecular Biomedical Research, VIB, B 9052 Ghent, Belgium
    Nat Rev Immunol 12:833-44. 2012
  5. doi request reprint Molecular mechanisms of necroptosis: an ordered cellular explosion
    Peter Vandenabeele
    Department for Molecular Biomedical Research, VIB, Ghent University, Belgium
    Nat Rev Mol Cell Biol 11:700-14. 2010
  6. doi request reprint The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal
    Lieselotte Vande Walle
    VIB, Department for Molecular Biomedical Research, B 9052 Zwijnaarde, Belgium
    Cell Res 20:421-33. 2010
  7. ncbi request reprint A novel caspase-2 complex containing TRAF2 and RIP1
    Mohamed Lamkanfi
    Unit of Molecular Signalling and Cell Death, Department for Molecular Biomedical Research, Ghent University and Flemish Interuniversity Institute for Biotechnology, Technologiepark 927, Zwijnaarde B 9052, Belgium
    J Biol Chem 280:6923-32. 2005
  8. doi request reprint Determination of apoptotic and necrotic cell death in vitro and in vivo
    Tom Vanden Berghe
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium
    Methods 61:117-29. 2013
  9. ncbi request reprint Necrosis is associated with IL-6 production but apoptosis is not
    Tom Vanden Berghe
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, VIB and Ghent University, Technologiepark 927, B 9052, Ghent Zwijnaarde, Belgium
    Cell Signal 18:328-35. 2006
  10. ncbi request reprint More than one way to die: methods to determine TNF-induced apoptosis and necrosis
    Tom Vanden Berghe
    Department of Molecular Biomedical Research, Ghent University, Ghent, Belgium
    Methods Mol Med 98:101-26. 2004

Collaborators

Detail Information

Publications74

  1. pmc Many stimuli pull the necrotic trigger, an overview
    N Vanlangenakker
    Department for Molecular Biomedical Research, VIB, Zwijnaarde Ghent, Belgium
    Cell Death Differ 19:75-86. 2012
    ..The availability of new pharmacological inhibitors and transgenic models will allow us to further document the important role of this form of cell death in degenerative, inflammatory and infectious diseases...
  2. pmc Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
    E Wirawan
    VIB, Department for Molecular Biomedical Research, Ghent, Belgium
    Cell Death Dis 1:e18. 2010
    ..These findings point to a mechanism by which casp-dependent generation of Beclin-1-C creates an amplifying loop enhancing apoptosis upon growth factor withdrawal...
  3. pmc TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members
    N Vanlangenakker
    Department for Molecular Biomedical Research, VIB, Zwijnaarde Ghent, Belgium
    Cell Death Dis 2:e230. 2011
    ..Finally, we also report RIP1-independent but RIP3-mediated necroptosis in the context of TNF signaling in particular conditions...
  4. doi request reprint The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling
    Peter Vandenabeele
    Department for Molecular Biomedical Research, VIB, B 9052 Ghent, Belgium
    Nat Rev Immunol 12:833-44. 2012
    ..Understanding the role of IAPs in innate immunity may open new therapeutic perspectives for the treatment of PRR-dependent inflammatory diseases...
  5. doi request reprint Molecular mechanisms of necroptosis: an ordered cellular explosion
    Peter Vandenabeele
    Department for Molecular Biomedical Research, VIB, Ghent University, Belgium
    Nat Rev Mol Cell Biol 11:700-14. 2010
    ..Necroptosis participates in the pathogenesis of diseases, including ischaemic injury, neurodegeneration and viral infection, thereby representing an attractive target for the avoidance of unwarranted cell death...
  6. doi request reprint The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal
    Lieselotte Vande Walle
    VIB, Department for Molecular Biomedical Research, B 9052 Zwijnaarde, Belgium
    Cell Res 20:421-33. 2010
    ....
  7. ncbi request reprint A novel caspase-2 complex containing TRAF2 and RIP1
    Mohamed Lamkanfi
    Unit of Molecular Signalling and Cell Death, Department for Molecular Biomedical Research, Ghent University and Flemish Interuniversity Institute for Biotechnology, Technologiepark 927, Zwijnaarde B 9052, Belgium
    J Biol Chem 280:6923-32. 2005
    ....
  8. doi request reprint Determination of apoptotic and necrotic cell death in vitro and in vivo
    Tom Vanden Berghe
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium
    Methods 61:117-29. 2013
    ..A particular problem in defining necrosis is that in the absence of phagocytosis, apoptotic cells become secondary necrotic and develop morphologic and biochemical features of primary necrosis...
  9. ncbi request reprint Necrosis is associated with IL-6 production but apoptosis is not
    Tom Vanden Berghe
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, VIB and Ghent University, Technologiepark 927, B 9052, Ghent Zwijnaarde, Belgium
    Cell Signal 18:328-35. 2006
    ..This suggests that the activation of inflammatory pathways is distinct from the activation of necrotic cell death sensu strictu...
  10. ncbi request reprint More than one way to die: methods to determine TNF-induced apoptosis and necrosis
    Tom Vanden Berghe
    Department of Molecular Biomedical Research, Ghent University, Ghent, Belgium
    Methods Mol Med 98:101-26. 2004
    ..Here we describe a selection of techniques used to distinguish both modes of TNFR-1-induced cell death, namely apoptotic or necrotic cell death...
  11. ncbi request reprint INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation
    Mohamed Lamkanfi
    Unit of Molecular Signalling and Cell Death, Department for Molecular Biomedical Research, VIB Ghent University, Technologiepark 927, Zwijnaarde B 9052, Belgium
    J Biol Chem 279:51729-38. 2004
    ..Our data show that INCA is a novel intracellular regulator of procaspase-1 activation, involved in the regulation of pro-IL-1beta processing and its release during inflammation...
  12. doi request reprint The role of the kinases RIP1 and RIP3 in TNF-induced necrosis
    Peter Vandenabeele
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Zwijnaarde, Belgium
    Sci Signal 3:re4. 2010
    ....
  13. doi request reprint Inflammatory mediators in Escherichia coli-induced mastitis in mice
    Sofie Notebaert
    Laboratory of Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Comp Immunol Microbiol Infect Dis 31:551-65. 2008
    ..In conclusion, the current study provides novel insights on the contribution of major regulatory proteins to the acute inflammatory host response at the local and systemic level during E. coli mastitis in mice...
  14. pmc Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis
    Linde Duprez
    Department for Molecular Biomedical Research VIB, Ghent University, Technologiepark 927, Gent Zwijnaarde 9052, Belgium
    J Biol Chem 287:14863-72. 2012
    ....
  15. pmc Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production
    Greet Brouckaert
    Molecular Signalling and Cell Death Unit, Department of Molecular Biomedical Research, VIB, Ghent University, Ghent Belgium
    Mol Biol Cell 15:1089-100. 2004
    ..Uptake of neither apoptotic nor necrotic L929 cells by macrophages modulated the expression of proinflammatory cytokines by the phagocytes...
  16. doi request reprint Methods for distinguishing apoptotic from necrotic cells and measuring their clearance
    Dmitri V Krysko
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    Methods Enzymol 442:307-41. 2008
    ..A selection of techniques that can be used to study internalization mechanisms used by phagocytes to engulf dying cells is also presented, such as scanning and transmission electron microscopy and fluorescence microscopy...
  17. ncbi request reprint Caspase inhibitors promote alternative cell death pathways
    Peter Vandenabeele
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, Flanders Interuniversity Institute of Biotechnology VIB, Ghent, Belgium
    Sci STKE 2006:pe44. 2006
    ....
  18. doi request reprint Caspase substrates: easily caught in deep waters?
    Dieter Demon
    Department for Molecular Biomedical Research, VIB, B 9052 Ghent, Belgium
    Trends Biotechnol 27:680-8. 2009
    ..Here, we critically review recently published procedures used to generate a proteome-wide view of caspase substrates...
  19. doi request reprint Apoptosis and necrosis: detection, discrimination and phagocytosis
    Dmitri V Krysko
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium
    Methods 44:205-21. 2008
    ....
  20. doi request reprint Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock
    Tom Vanden Berghe
    1 Inflammation Research Center, VIB, Ghent, Belgium
    Am J Respir Crit Care Med 189:282-91. 2014
    ..Conclusions: Our data point toward the therapeutic potential of neutralizing IL-1 and IL-18 simultaneously in sepsis, rather than inhibiting the upstream inflammatory caspases. ..
  21. doi request reprint Escherichia coli induces bovine neutrophil cell death independent from caspase-3/-7/-1, but with phosphatidylserine exposure prior to membrane rupture
    Kristel Demeyere
    Laboratory of Biochemistry, Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Immunol Immunopathol 153:45-56. 2013
    ..This indicates that the secretion of the latter pro-inflammatory cytokine is a bystander effect rather than a regulator of PICD in bovine neutrophils, in marked contrast to the IL-1β-dependent pyroptosis reported for macrophages...
  22. doi request reprint Immunogenic cell death and DAMPs in cancer therapy
    Dmitri V Krysko
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, VIB Ghent University Technologiepark 927, B 9052 Ghent Zwijnaarde, Belgium ugent be
    Nat Rev Cancer 12:860-75. 2012
    ..In this Review, we discuss the role of endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in regulating the immunogenicity of dying cancer cells and the effect of therapy-resistant cancer microevolution on ICD...
  23. pmc cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)
    Mathieu J M Bertrand
    Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    PLoS ONE 6:e22356. 2011
    ..Finally, we identified Lys51 and Lys145 of RIP4 as two critical residues for cIAP1-mediated ubiquitination and NF-κB activation...
  24. pmc Caspase-14 reveals its secrets
    Geertrui Denecker
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology VIB, 9052 Ghent, Belgium
    J Cell Biol 180:451-8. 2008
    ..Here, we review the current knowledge on caspase-14 in skin homeostasis and disease...
  25. ncbi request reprint Toxic proteins released from mitochondria in cell death
    Xavier Saelens
    Department for Molecular Biomedical Research, VIB and Ghent University, Fiers Shell Van Montagu Building, Ghent B9052, Belgium
    Oncogene 23:2861-74. 2004
    ..A better understanding of these functions may help to develop new strategies to treat cancer...
  26. ncbi request reprint Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors
    Bart Depuydt
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology VIB and Gent University, 9052 Ghent Zwijnaarde, Belgium
    J Cell Sci 118:497-504. 2005
    ..These data confirm the capacity of TNFR2 to generate an apoptotic cell death signal independent of TNFR1...
  27. ncbi request reprint Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1
    Sigrid Cornelis
    Unit of Molecular Signal Transduction in Inflammation, Department for Molecular Biomedical Research, VIB Ghent University, Technologiepark 927, B 9052 Ghent Zwijnaarde, Belgium
    Oncogene 24:1552-62. 2005
    ..These results suggest an important role for caspase-9 mediated cleavage of Raf-1 in the negative feedback regulation of hematopoietic cell apoptosis induced by growth factor withdrawal...
  28. pmc Protein synthesis persists during necrotic cell death
    Xavier Saelens
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology VIB and Ghent University, B9052 Ghent, Belgium
    J Cell Biol 168:545-51. 2005
    ..Collectively, these results show that, in contrast to apoptotic cells, necrotic dying cells retain the opportunity to synthesize proteins...
  29. doi request reprint Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin
    Esther Hoste
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    J Invest Dermatol 131:2233-41. 2011
    ..Taken together, we identified caspase-14 as a crucial protease in FLG catabolism...
  30. doi request reprint RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome
    Linde Duprez
    Department for Molecular Biomedical Research, the Flanders Institute for Biotechnology VIB, 9052 Ghent, Belgium
    Immunity 35:908-18. 2011
    ....
  31. doi request reprint Cell death in the skin
    Saskia Lippens
    Department for Molecular Biomedical Research, Molecular Signaling and Cell Death Unit, VIB, Ghent, Belgium
    Apoptosis 14:549-69. 2009
    ..Deregulation of cell death mechanisms in the skin can lead to diseases such as cancer, necrolysis and graft-versus-host disease. Here we review the apoptotic and the anti-apoptotic mechanisms in skin homeostasis and disease...
  32. doi request reprint Tumor necrosis factor-mediated cell death: to break or to burst, that's the question
    Franky Van Herreweghe
    Unit for Molecular Signalling and Cell Death, Department for Molecular Biomedical Research, VIB, Technologiepark 927, 9052, Ghent Zwijnaarde, Belgium
    Cell Mol Life Sci 67:1567-79. 2010
    ....
  33. pmc Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling
    Kristof Kersse
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology VIB, B 9052 Ghent Zwijnaarde, Belgium
    J Biol Chem 286:35874-82. 2011
    ..These findings indicate that the CARD of procaspase-1 is differently involved in the formation of procaspase-1 activating platforms and procaspase-1-mediated, RIP2-dependent NF-κB activation...
  34. pmc Regulation of the expression and processing of caspase-12
    Michael Kalai
    Department of Molecular Biomedical Research, Unit of Molecular Signalling and Cell Death, Ghent University, Ledeganckstraat 35, B 9000 Ghent, Belgium
    J Cell Biol 162:457-67. 2003
    ..Similar processing occurs in TNF-, LPS-, Fas ligand-, and thapsigargin (Tg)-induced apoptosis. However, B16/B16 melanoma cells die when treated with the ER stress-inducing agent Tg whether they express caspase-12 or not...
  35. doi request reprint Caspase-14-deficient mice are more prone to the development of parakeratosis
    Esther Hoste
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    J Invest Dermatol 133:742-50. 2013
    ....
  36. doi request reprint IP3, a small molecule with a powerful message
    Elke Decrock
    Department of Basic Medical Sciences, Ghent University, Ghent, Belgium
    Biochim Biophys Acta 1833:1772-86. 2013
    ..Finally, we highlight several pathological conditions in which anomalous intercellular IP3/Ca(2+) signaling might play a role. This article is part of a Special Issue entitled:12th European Symposium on Calcium...
  37. doi request reprint The emerging roles of serine protease cascades in the epidermis
    Petra Ovaere
    Department of Biomedical Molecular Biology, Ghent University, Belgium
    Trends Biochem Sci 34:453-63. 2009
    ..Therefore, a deeper knowledge of the regulation of these serine protease cascades could form the basis for development of appropriate treatments for skin disorders such as Netherton syndrome...
  38. pmc Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity
    Dieter Demon
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology VIB, Ghent 9052, Belgium
    Mol Cell Proteomics 8:2700-14. 2009
    ..Interestingly, specific cleavage by caspase-7 relies on excluding recognition by caspase-3 and not on increasing binding for caspase-7...
  39. doi request reprint Expression of calcium-sensing receptor in quail granulosa explants: a key to survival during folliculogenesis
    Araceli Diez-Fraile
    Faculty of Medicine and Health Sciences, Department of Basic Medical Sciences, Ghent University, Ghent, Belgium
    Anat Rec (Hoboken) 293:890-9. 2010
    ..We provide direct evidence for the presence of CaR in preovulatory granulosa explants and suggest a pivotal role for CaR in follicle selection...
  40. ncbi request reprint Inflammatory caspases: targets for novel therapies
    Sigrid Cornelis
    Department for Molecular Biomedical Research, VIB, B9052 Ghent, Belgium
    Curr Pharm Des 13:367-85. 2007
    ..Finally, we point out recent approaches identifying novel peptidomimetic or non-peptide caspase inhibitors with suitable clinical profiles...
  41. ncbi request reprint Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta
    Peter Schotte
    Unit of Molecular Signal Transduction in Inflammation, Flanders Interuniversity Institute for Biotechnology VIB, Ghent Unniversity, Ghent, Belgium
    J Biol Chem 279:25134-42. 2004
    ..These results highlight a previously unknown function of Rho GTPases in the activation of caspase-1 and give new insight on the role of YopE in immune-escape mechanisms of Yersinia...
  42. doi request reprint Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD
    Pieter Hindryckx
    Department of Gastroenterology, Ghent University, Ghent, Belgium
    J Immunol 185:6306-16. 2010
    ..Hydroxylase inhibition could represent a promising alternative treatment strategy for hypoxic inflammatory diseases, including inflammatory bowel disease...
  43. doi request reprint Caspase-14 overexpression in hairless mice is not involved in utricle formation
    Michael Devos
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
    Exp Dermatol 22:484-6. 2013
    ..However, crossing hairless mutant mice with caspase-14-deficient mice revealed that caspase-14 overexpression is not the cause of utricle formation. ..
  44. doi request reprint Calcium and connexin-based intercellular communication, a deadly catch?
    Elke Decrock
    Department of Basic Medical Sciences Physiology group, Faculty of Medicine and Health Sciences, Ghent University, B 9000 Ghent, Belgium
    Cell Calcium 50:310-21. 2011
    ..This review provides a cutting edge overview of the current knowledge and underscores the intimate connection between intercellular communication, Ca(2+) signalling and cell death...
  45. pmc Autophagy: for better or for worse
    Ellen Wirawan
    VIB, Department for Molecular Biomedical Research, Unit for Molecular Signaling and Cell Death, Ghent Zwijnaarde, Belgium
    Cell Res 22:43-61. 2012
    ..In addition, we present a brief overview of the possible contribution of defective autophagic signaling to disease...
  46. pmc Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike
    Magdalena Wejda
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology VIB, Ghent University, B 9052 Ghent Zwijnaarde, Belgium
    J Biol Chem 287:33983-95. 2012
    ....
  47. doi request reprint Beclin1: a role in membrane dynamics and beyond
    Ellen Wirawan
    Unit for Molecular Signalling and Cell Death, Department for Molecular Biomedical Research, Ghent, Belgium
    Autophagy 8:6-17. 2012
    ..In this review, we focus on Beclin1 as a multifunctional protein, discuss the variety of mechanisms by which it is controlled, and give an overview of Beclin1-associated pathologies...
  48. ncbi request reprint Molecular mechanisms and pathophysiology of necrotic cell death
    Nele Vanlangenakker
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium
    Curr Mol Med 8:207-20. 2008
    ....
  49. pmc Caspases leave the beaten track: caspase-mediated activation of NF-kappaB
    Mohamed Lamkanfi
    Unit of Molecular Signaling and Cell Death, Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology, VIB, Ghent University, B 9052 Ghent, Belgium
    J Cell Biol 173:165-71. 2006
    ..Two different mechanisms by which caspases activate the NF-kappaB pathway are discussed...
  50. ncbi request reprint NADPH oxidases: new players in TNF-induced necrotic cell death
    Tom Vanden Berghe
    Department for Molecular Biomedical Research, VIB, Technologiepark 927, B 9052, Ghent, Belgium
    Mol Cell 26:769-71. 2007
    ..In a recent issue of Molecular Cell, Kim et al. (2007) reported on a novel TNF receptor 1 necrotic signaling complex inducing TRADD- and RIP1-dependent recruitment and activation of the ROS-generating Nox1 NADPH oxidase complex...
  51. ncbi request reprint Caspase-containing complexes in the regulation of cell death and inflammation
    Nele Festjens
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, VIB and Ghent University, Fiers Schell Van Montagu Building, Technologiepark 927, B 9052 Ghent, Belgium
    Biol Chem 387:1005-16. 2006
    ..Inhibitory protein families such as FLIPs and CARD-only proteins prevent the recruitment of caspases in these sensing complexes, avoiding inappropriate initiation of cell death or inflammation...
  52. ncbi request reprint Proteome-wide Identification of HtrA2/Omi Substrates
    Lieselotte Vande Walle
    Department of Molecular Biomedical Research, VIB, 9052, Ghent, Belgium
    J Proteome Res 6:1006-15. 2007
    ..Our results suggest that HtrA2/Omi has a rather narrow cleavage site preference and that cytoskeletal proteins are prime targets of this protease...
  53. ncbi request reprint RIP kinases at the crossroads of cell death and survival
    Wim Declercq
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium
    Cell 138:229-32. 2009
    ..Recent studies (Cho et al., 2009; He et al., 2009; Zhang et al., 2009) reveal that the RIP3 kinase functions with RIP1 at the crossroads of apoptosis, necroptosis, and cell survival...
  54. doi request reprint Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation
    Dmitri V Krysko
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Belgium
    Trends Immunol 32:157-64. 2011
    ..Recently, mitochondria have emerged as other organelles that function as a source of DAMPs. Here, we highlight the significance of mitochondrial DAMPs and discuss their contribution to inflammation and development of human pathologies...
  55. ncbi request reprint Gut microbiota affects sensitivity to acute DSS-induced colitis independently of host genotype
    Brigitta M Brinkman
    Department for Molecular Biomedical Research, VIB, Ghent, Belgium Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium Laboratory of Microbiology, Faculty of Sciences, Ghent University, Ghent, Belgium Department of Structural Biology, VIB, Brussels, Belgium Department of Bioscience Engineering, Vrije Universiteit Brussel, Brussels, Belgium and BCCM LMG Bacteria Collection, Faculty of Sciences, Ghent University, Ghent, Belgium
    Inflamm Bowel Dis 19:2560-7. 2013
    ..Our findings also have important implications for the experimental design of disease studies in genetically modified mice and conclusions drawn from them...
  56. ncbi request reprint Necroptosis: the release of damage-associated molecular patterns and its physiological relevance
    Agnieszka Kaczmarek
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium
    Immunity 38:209-23. 2013
    ....
  57. ncbi request reprint Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response
    Nele Festjens
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, VIB and Ghent University, Fiers Schell Van Montagu Building, Technologiepark 927, B 9052 Ghent, Belgium
    Biochim Biophys Acta 1757:1371-87. 2006
    ..Thus detailed knowledge of necrosis may be exploited in therapeutic strategies...
  58. doi request reprint NOD-like receptors and the innate immune system: coping with danger, damage and death
    Kristof Kersse
    Department for Molecular Biomedical Research, Unit for Molecular Signaling and Cell Death, Technologiepark 927, B 9052 Ghent, Belgium
    Cytokine Growth Factor Rev 22:257-76. 2011
    ..We review the roles of NLR family members in health and disease, with emphasis on the signaling mechanisms in cell death and inflammation...
  59. ncbi request reprint Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity
    Mohamed Lamkanfi
    Unit of Molecular Signalling and Cell Death, Department for Molecular Biomedical Research, Flanders Interuniversity Institute of Biotechnology, Ghent University, B 9052 Zwijnaarde, Belgium
    J Biol Chem 279:24785-93. 2004
    ..These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways: proteolysis of pro-IL-1beta, and RIP2-dependent activation of NF-kappaB and p38 MAPK mediated by the caspase recruitment domain...
  60. ncbi request reprint Mechanisms of internalization of apoptotic and necrotic L929 cells by a macrophage cell line studied by electron microscopy
    Dmitri V Krysko
    Department of Human Anatomy, Embryology, Histology and Medical Physics, Ghent University, Godshuizenlaan 4, B 9000 Ghent, Belgium
    J Morphol 258:336-45. 2003
    ..The present report provides a basis for future studies aimed at discovering molecular pathways that precede these diverse mechanisms of uptake...
  61. ncbi request reprint Mitotic catastrophe as a prestage to necrosis in mouse liver cells treated with Helicobacter pullorum sonicates
    Liesbeth M Ceelen
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium
    J Morphol 270:921-8. 2009
    ..The current study shows for the first time that H. pullorum causes mitotic catastrophe resulting in primary necrosis in mouse hepatocytes...
  62. doi request reprint The death-fold superfamily of homotypic interaction motifs
    Kristof Kersse
    Department for Molecular Biomedical Research, VIB, B 9052 Ghent Zwijnaarde, Belgium
    Trends Biochem Sci 36:541-52. 2011
    ..Insights into the mechanisms of interaction of death-fold domains will be useful to design strategies for specific modulation of complex formation and might lead to novel therapeutic applications...
  63. ncbi request reprint Clearance of apoptotic and necrotic cells and its immunological consequences
    Dmitri V Krysko
    Department for Molecular Biomedical Research, Molecular Signaling and Cell Death Unit, VIB Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
    Apoptosis 11:1709-26. 2006
    ....
  64. doi request reprint Necrotic cell death and 'necrostatins': now we can control cellular explosion
    Peter Vandenabeele
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    Trends Biochem Sci 33:352-5. 2008
    ..In addition, necrostatins are becoming important tools for evaluating the contribution of necrotic cell death in experimental disease models...
  65. doi request reprint Life and death of female gametes during oogenesis and folliculogenesis
    Dmitri V Krysko
    Department for Molecular Biomedical Research, Molecular Signaling and Cell Death Unit, VIB, Technologiepark 927, 9052 Ghent, Zwijnaarde, Belgium
    Apoptosis 13:1065-87. 2008
    ..Potential therapeutic strategies for combating premature ovarian failure are also addressed...
  66. doi request reprint SitePredicting the cleavage of proteinase substrates
    Jelle Verspurten
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology, Ghent, Belgium
    Trends Biochem Sci 34:319-23. 2009
    ..Comparison of the different programs shows that SitePrediction makes it possible to derive more reliable predictions. In addition, this tool allows the use of a wide range of proteinases...
  67. ncbi request reprint Caspase-14 protects against epidermal UVB photodamage and water loss
    Geertrui Denecker
    Department for Molecular Biomedical Research, VIB, Technologie Park 927, B 9052, Ghent, Belgium
    Nat Cell Biol 9:666-74. 2007
    ..Removal of the stratum corneum indicate that caspase-14 controls the UVB scavenging capacity of the stratum corneum...
  68. doi request reprint In vivo imaging of NF-kappaB activity during Escherichia coli-induced mammary gland infection
    Sofie Notebaert
    Laboratory of Biochemistry, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium
    Cell Microbiol 10:1249-58. 2008
    ....
  69. doi request reprint Severity of doxorubicin-induced small intestinal mucositis is regulated by the TLR-2 and TLR-9 pathways
    Agnieszka Kaczmarek
    Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    J Pathol 226:598-608. 2012
    ....
  70. pmc The Pseudomonas aeruginosa type III secretion system has an exotoxin S/T/Y independent pathogenic role during acute lung infection
    Marlies Galle
    Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
    PLoS ONE 7:e41547. 2012
    ..These results demonstrate a T3SS effector toxin independent role for the T3SS, in particular the T3SS translocator protein PopB, in the pathogenicity of P. aeruginosa during acute lung infection...
  71. ncbi request reprint A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand
    Geert van Loo
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology, University of Ghent, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Cytokine 22:62-70. 2003
    ....
  72. ncbi request reprint Major cell death pathways at a glance
    Linde Duprez
    VIB, Department for Molecular Biomedical Research, Unit for Molecular Signaling and Cell Death, Technologiepark 927, B 9052 Ghent Zwijnaarde, Belgium
    Microbes Infect 11:1050-62. 2009
    ..In this review, we will discuss the molecular mechanisms and physiological relevance of four major types of programmed cell death, namely apoptosis, necrosis, autophagic cell death and pyroptosis...
  73. ncbi request reprint Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis
    Wim Declercq
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, B 9052 Ghent, Belgium
    Immunity 35:493-5. 2011
    ..In this issue of Immunity, Bonnet et al. (2011) show that skin-specific ablation of the adaptor protein FADD sensitizes keratinocytes to RIPK3-dependent necrotic cell death, which leads to severe skin inflammation...
  74. ncbi request reprint Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis
    Tom Vanden Berghe
    Molecular Signaling and Cell Death Unit, Department of Molecular Biomedical Research, VIB, Gent University, B 9000 Gent, Belgium
    J Biol Chem 278:5622-9. 2003
    ..Thus, the availability of proteins such as receptor-interacting protein, Fas-associated death domain, and caspase-8 can determine whether TNFR1 activation will lead to apoptosis or to necrosis...