Virus species polemics: 14 senior virologists oppose a proposed change to the ICTV definition of virus speciesMarc H V Van Regenmortel
Institut de Recherche de l Ecole de Biotechnologie de Strasbourg, Boulevard Sebastien Brant, 67412, Illkirch Cedex, France
Arch Virol 158:1115-9. 2013
..Since the pros and cons of the proposal posted on the ICTV website are not widely consulted, the arguments are summarized here in order to reach a wider audience...
- Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine
Marc H V Van Regenmortel
Stellenbosch Institute of Advanced Study, Wallenberg Research Center at Stellenbosch University, Stellenbosch 7600, South Africa
Arch Virol 157:1-20. 2012
..This means that empirical immunogenicity trials rather than structural analyses of antigens offer the best hope of discovering an HIV-1 vaccine...
- Limitations to the structure-based design of HIV-1 vaccine immunogens
Marc H V Van Regenmortel
Institut de Recherche de l Ecole de Biotechnologie de Strasbourg, CNRS UdS, Strasbourg, France
J Mol Recognit 24:741-53. 2011
..It is concluded that only trial and error, empirical investigations using numerous immunization protocols may eventually allow us to identify which mixtures of immunogens are likely to be the best candidates for an HIV-1 vaccine...
- First Aegean International Conference on Molecular Recognition
Marc H V Van Regenmortel
School of Biotechnology, CNRS, University of Strasbourg, Illkirch, 67412, France
Expert Rev Proteomics 7:639-42. 2010
..A total of 35 oral communications and 15 posters were presented. The second Aegean International Conference on Molecular Recognition is scheduled to take place in the spring of 2012...
- A proposal to change existing virus species names to non-Latinized binomials
Marc H V Van Regenmortel
Institut de Recherche de l Ecole de Biotechnologie de Strasbourg, Illkirch, France
Arch Virol 155:1909-19. 2010
..The rationale for the proposed change is presented...
- Logical puzzles and scientific controversies: the nature of species, viruses and living organisms
Marc H V Van Regenmortel
FRE 3211 Institut de Recherche de l Ecole de Biotechnologie de Strasbourg, CNRS Universite de Strasbourg, Boulevard Sebastien Brant, 67400 Illkirch, France
Syst Appl Microbiol 33:1-6. 2010
..It is argued that viruses are genetic parasites rather than living organisms and that they have no place in the tree of life. This interpretation is based on an analysis of the properties of living agents and living organisms...
Structure-activity relationships in peptide-antibody complexes: implications for epitope prediction and development of synthetic peptide vaccinesShu Wen W Chen
Ecole Superieure de Biotechnologie de Strasbourg, CNRS, F 67412 Illkirch, France
Curr Med Chem 16:953-64. 2009
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Emerging issues in virus taxonomyMarc H V Van Regenmortel
Centre National de la Recherche Scientifique, Biotechnology School, University of Strasbourg, Illkirch, France
Emerg Infect Dis 10:8-13. 2004
..We briefly describe the changes in virus classification that were introduced in that report. We also discuss recent proposals to introduce a nonlatinized binomial nomenclature for virus species...
- What is a B-cell epitope?
Marc H V Van Regenmortel
Ecole Superieure de Biotechnologie de Strasbourg, Illkirch Cedex, France
Methods Mol Biol 524:3-20. 2009
..Methods for predicting the epitopes of proteins are discussed and the reasons for the low success rate of epitope prediction are analyzed...
- Reductionism and the search for structure-function relationships in antibody molecules
Marc H V Van Regenmortel
Biotechnology School, CNRS, University of Strasbourg, France
J Mol Recognit 15:240-7. 2002
..Although knowledge of antibody structure is of little use in vaccine design, it may help to develop therapeutic inhibitors and antibodies effective in the passive immunotherapy of viral infection...
