Carbohydrate co-ingestion with protein does not further augment post-prandial muscle protein accretion in older menHenrike M Hamer
Department of Human Movement Sciences, Maastricht University Medical Centre, PO Box 616, Maastricht, MD, 6200, The Netherlands
Nutr Metab (Lond) 10:15. 2013
..We hypothesized that the greater endogenous insulin release following co-ingestion of carbohydrate facilitates post-prandial muscle protein accretion after ingesting a meal-like bolus of protein in older males...
- Prolonged exercise training increases intramuscular lipid content and perilipin 2 expression in type I muscle fibers of patients with type 2 diabetes
C S Shaw
School of Sport and Exercise Sciences, The University of Birmingham, Birmingham, United Kingdom
Am J Physiol Endocrinol Metab 303:E1158-65. 2012
....
Physical activity is the key determinant of skeletal muscle mitochondrial function in type 2 diabetesF H J van Tienen
Department of Genetics and Cell Biology, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands
J Clin Endocrinol Metab 97:3261-9. 2012
..Conflicting data exist on mitochondrial function and physical activity in type 2 diabetes mellitus (T2DM) development...
- Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients
J W van Dijk
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, The Netherlands
Diabetologia 55:1273-82. 2012
..The present study compares the impact of endurance- vs resistance-type exercise on subsequent 24 h blood glucose homeostasis in individuals with impaired glucose tolerance (IGT) and type 2 diabetes...
- Leucine as a pharmaconutrient in health and disease
Luc J C van Loon
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
Curr Opin Clin Nutr Metab Care 15:71-7. 2012
....
Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly menRene Koopman
Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
Br J Nutr 99:571-80. 2008
..Co-ingestion of leucine with carbohydrate and protein following physical activity does not further elevate muscle protein fractional synthetic rate in elderly men when ample protein is ingested...
- Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men
Bart Pennings
Top Institute Food and Nutrition, Wageningen, The Netherlands
Am J Physiol Endocrinol Metab 302:E992-9. 2012
..05) g. We conclude that ingestion of 35 g whey protein results in greater amino acid absorption and subsequent stimulation of de novo muscle protein synthesis compared with the ingestion of 10 or 20 g whey protein in healthy, older men...
- Significant intramyocellular lipid use during prolonged cycling in endurance-trained males as assessed by three different methodologies
Trent Stellingwerff
Department of Movement Science, Maastricht University, Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 292:E1715-23. 2007
..In addition, this study shows differences in resting subcellular intramyocellular lipid deposit distribution and in the subsequent net use of these deposits during exercise...
- Inhibition of adipose tissue lipolysis increases intramuscular lipid and glycogen use in vivo in humans
Luc J C van Loon
Department of Movement Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 289:E482-93. 2005
..This study confirms the hypothesis that plasma FFA availability regulates both intramuscular lipid and glycogen use in vivo in humans...
- Impact of protein coingestion on muscle protein synthesis during continuous endurance type exercise
Milou Beelen
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 300:E945-54. 2011
..Protein coingestion does not further increase muscle protein synthesis rates during continuous endurance type exercise...
- Carbohydrate supplementation during prolonged cycling exercise spares muscle glycogen but does not affect intramyocellular lipid use
Trent Stellingwerff
Department of Movement Sciences, Nutrition Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
Pflugers Arch 454:635-47. 2007
..We conclude that carbohydrate supplementation during prolonged cycling exercise does not modulate IMTG use but spares muscle glycogen use during the initial stages of exercise in endurance-trained men...
- Dietary protein digestion and absorption rates and the subsequent postprandial muscle protein synthetic response do not differ between young and elderly men
Rene Koopman
Department of Human Movement Sciences, Maastricht University, Maastricht 6200 MD, The Netherlands
J Nutr 139:1707-13. 2009
..27). We conclude that protein digestion and absorption kinetics and the subsequent muscle protein synthetic response following the ingestion of a large bolus of intact CAS are not substantially impaired in healthy, elderly men...
- Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men
Suzanne Verhoeven
Department of Human Movement Sciences, Nutrition and Toxicology Research Institute, Maastricht, Maastricht University, Maastricht, Netherlands
Am J Clin Nutr 89:1468-75. 2009
..It has been reported that the blunted muscle protein synthetic response to food intake in the elderly can be normalized by increasing the leucine content of a meal...
- Protein coingestion stimulates muscle protein synthesis during resistance-type exercise
Milou Beelen
Department of Human Movement Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 295:E70-7. 2008
..012 and 0.060 +/- 0.004%/h in CHO + PRO vs. CHO treatment, respectively; P < 0.05). We conclude that, even in a fed state, protein coingestion stimulates whole body and muscle protein synthesis rates during resistance-type exercise...
- Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance-trained males in a fasted state
Luc J C van Loon
Nutrition Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
J Physiol 553:611-25. 2003
....
- Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein
Rene Koopman
Department of Human Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht, Netherlands
Am J Clin Nutr 90:106-15. 2009
..It has been suggested that a protein hydrolysate, as opposed to its intact protein, is more easily digested and absorbed from the gut, which results in greater plasma amino acid availability and a greater muscle protein synthetic response...
- Substrate source use in older, trained males after decades of endurance training
Hanneke Boon
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Med Sci Sports Exerc 39:2160-70. 2007
..The purpose of this study was to compare substrate source use in older, long-term exercising, endurance-trained males with sedentary controls...
- Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type-specific increase in satellite cell content in elderly men
Lex B Verdijk
Department of Human Movement Sciences, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
J Gerontol A Biol Sci Med Sci 64:332-9. 2009
..001). No changes were observed in the Type I muscle fibers. In older adults, skeletal muscle tissue is still capable of inducing SC proliferation and differentiation, resulting in Type II muscle fiber hypertrophy...
- Combined ingestion of protein and carbohydrate improves protein balance during ultra-endurance exercise
Rene Koopman
Department of Human Biology, Maastricht University, PO Box 616, 6200 MD, The Netherlands
Am J Physiol Endocrinol Metab 287:E712-20. 2004
..Combined ingestion of protein and carbohydrate improves net protein balance at rest as well as during exercise and postexercise recovery...
- Protein supplementation before and after exercise does not further augment skeletal muscle hypertrophy after resistance training in elderly men
Lex B Verdijk
Department of Human Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands
Am J Clin Nutr 89:608-16. 2009
..Considerable discrepancy exists in the literature on the proposed benefits of protein supplementation on the adaptive response of skeletal muscle to resistance-type exercise training in the elderly...
- Intragastric protein administration stimulates overnight muscle protein synthesis in elderly men
Bart B L Groen
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 302:E52-60. 2012
..Dietary protein administration during sleep stimulates muscle protein synthesis and improves overnight whole body protein balance. These findings may provide a basis for novel interventional strategies to attenuate muscle mass loss...
- Reduced glycaemic and insulinaemic responses following isomaltulose ingestion: implications for postprandial substrate use
Judith G P van Can
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
Br J Nutr 102:1408-13. 2009
..The metabolic response to isomaltulose co-ingestion suggests that this may represent an effective nutritional strategy to counteract overweight-induced metabolic disturbances...
- Neuromuscular electrical stimulation increases muscle protein synthesis in elderly type 2 diabetic men
Benjamin T Wall
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 303:E614-23. 2012
..NMES likely represents an effective interventional strategy to attenuate muscle loss in elderly individuals during bed rest and/or in other disuse states...
- Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects
Rene Koopman
Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 288:E645-53. 2005
..0820 +/- 0.0104%/h). We conclude that coingestion of protein and leucine stimulates muscle protein synthesis and optimizes whole body protein balance compared with the intake of carbohydrate only...
- Reduced glycaemic and insulinaemic responses following trehalose and isomaltulose ingestion: implications for postprandial substrate use in impaired glucose-tolerant subjects
Judith G P van Can
Department of Human Biology, Maastricht University Medical Centre, Universiteitssingel 50, Maastricht, The Netherlands
Br J Nutr 108:1210-7. 2012
..This suggests that exchange of SUC in the diet for IMU may result in a more favourable metabolic response and may help to reduce the risks associated with obesity and type 2 diabetes...
- Dietary protein to support muscle hypertrophy
Luc J C van Loon
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
Nestle Nutr Inst Workshop Ser 69:79-89; discussion 89-95. 2011
..Future research should focus on the relevance of the acute anabolic response following exercise to optimize the skeletal muscle adaptive response to exercise training...
- Coingestion of carbohydrate and protein hydrolysate stimulates muscle protein synthesis during exercise in young men, with no further increase during subsequent overnight recovery
Milou Beelen
Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
J Nutr 138:2198-204. 2008
..Ingestion of protein with carbohydrate during and immediately after exercise improves whole-body protein synthesis but does not further augment muscle protein synthesis rates during 9 h of subsequent overnight recovery...
- The single biopsy approach is reliable for the measurement of muscle protein synthesis rates in vivo in older men
Nicholas A Burd
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre MUMC Maastricht, The Netherlands
J Appl Physiol 113:896-902. 2012
....
- Effects of increasing insulin secretion on acute postexercise blood glucose disposal
Brechje Kaastra
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM, Maastricht University, Maastricht, The Netherlands
Med Sci Sports Exerc 38:268-75. 2006
..8 g.kg.h) substantially augments insulin secretion, but does not affect plasma glucose disposal during the first 3.5 h of postexercise recovery in trained athletes...
- Influence of prolonged endurance cycling and recovery diet on intramuscular triglyceride content in trained males
Luc J C van Loon
Department of Human Biology, Nutrition Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 285:E804-11. 2003
..Data obtained by quantitative fluorescence microscopy correspond well with MRS results, implying that both are valid methods to quantify IMTG content...
- Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy males
Rene Koopman
Department of Human Biology, Maastricht University, P O Box 616, 6200, Maastricht, The Netherlands
Eur J Appl Physiol 96:525-34. 2006
..We conclude that intramyocellular lipid and glycogen stores are readily used during resistance exercise and this is likely associated with the reported increase in whole-body insulin sensitivity following resistance exercise...
- Nutritional interventions to promote post-exercise muscle protein synthesis
Rene Koopman
Department of Movement Sciences, Maastricht University, Maastricht, The Netherlands
Sports Med 37:895-906. 2007
..Exercise interventions combined with specific nutritional modulation provide an effective strategy to counteract or reduce the loss of skeletal muscle mass with aging...
- Glycaemic instability is an underestimated problem in Type II diabetes
Stephan F E Praet
Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
Clin Sci (Lond) 111:119-26. 2006
..Given the macro- and micro-vascular damage caused by postprandial hyperglycaemia, CGMS provides an excellent tool to evaluate alternative therapeutic strategies to reduce hyperglycaemic blood glucose excursions...
- Coingestion of carbohydrate with protein does not further augment postexercise muscle protein synthesis
Rene Koopman
Department of Movement Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 293:E833-42. 2007
..11 +/- 0.01%/h in the PRO, PRO + LCHO, and PRO + HCHO experiments, respectively. In conclusion, coingestion of carbohydrate during recovery does not further stimulate postexercise muscle protein synthesis when ample protein is ingested...
- Nitrate supplementation's improvement of 10-km time-trial performance in trained cyclists
Naomi M Cermak
Department of Human Movement Sciences, Maastricht University Medical Centre, Maastricht, The Netherlands
Int J Sport Nutr Exerc Metab 22:64-71. 2012
..Six days of nitrate supplementation reduced VO₂ during submaximal exercise and improved time-trial performance in trained cyclists...
- The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle
Chamindie Punyadeera
Department of Pathology, Research Institute GROW, Maastricht University, Maastricht, The Netherlands
Eur J Endocrinol 152:427-36. 2005
..Furthermore, we aimed to detect and locate adiponectin in skeletal muscle tissue...
- Creatine supplementation increases glycogen storage but not GLUT-4 expression in human skeletal muscle
Luc J C van Loon
Nutrition Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Clin Sci (Lond) 106:99-106. 2004
..In addition, neither muscle GS-1 nor Gln-1 mRNA expression was affected. We conclude that creatine ingestion itself stimulates muscle glycogen storage, but does not affect muscle GLUT-4 expression...
- Reduced glycaemic and insulinaemic responses following trehalose ingestion: implications for postprandial substrate use
Judith G P van Can
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
Br J Nutr 102:1395-9. 2009
..These differences were accompanied with a reduced carbohydrate oxidation after trehalose when ingested as a drink, whilst no significant differences in fat oxidation between drink were observed...
- Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients
Kristof Vanschoonbeek
Department of Human Biology, Nutrition and Toxicology Research Institute, Maastricht University, Maastricht, The Netherlands
J Nutr 136:977-80. 2006
..More research on the proposed health benefits of cinnamon supplementation is warranted before health claims should be made...
- Responses to acute exercise in type 2 diabetes, with an emphasis on metabolism and interaction with oral hypoglycemic agents and food intake
Henrik Galbo
Copenhagen Muscle Research Centre CMRC and Department of Rheumatology, Bispebjerg Hospital, Copenhagen, Denmark, and Department of Movement Sciences, Nutrition and Toxicology Research Institute, Maastricht University, The Netherlands
Appl Physiol Nutr Metab 32:567-75. 2007
..Finally, in people with type 2 DM, after a high-fat meal, prolonged moderate exercise reduces the exaggerated increases in plasma concentrations of triglycerides contained in chylomicrons and very low-density lipoproteins...
- Use of intramuscular triacylglycerol as a substrate source during exercise in humans
Luc J C van Loon
Nutrition Research Institute Maastricht NUTRIM Dept of Human Biology, Maastricht Univ, PO Box 616, 6200 MD Maastricht, The Netherlands
J Appl Physiol 97:1170-87. 2004
....
- Characteristics of muscle fiber type are predictive of skeletal muscle mass and strength in elderly men
Lex B Verdijk
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
J Am Geriatr Soc 58:2069-75. 2010
..To investigate the relationship between skeletal muscle fiber type-specific characteristics, circulating hormone concentrations, and skeletal muscle mass and strength in older men...
- Exercise therapy in type 2 diabetes: is daily exercise required to optimize glycemic control?
Jan Willem van Dijk
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
Diabetes Care 35:948-54. 2012
..The current study investigates the impact of daily exercise versus exercise performed every other day on glycemic control in type 2 diabetic patients...
- The reliability of using the single-biopsy approach to assess basal muscle protein synthesis rates in vivo in humans
Nicholas A Burd
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre MUMC, PO Box 616, 6200 MD, Maastricht, The Netherlands
Metabolism 61:931-6. 2012
..Our data demonstrate that the single-biopsy approach, irrespective of whether the biopsy is obtained at 2 or 4 hours, can be used as a surrogate for the sequential-biopsy approach to determine basal muscle protein synthesis in a group...
- Increase in S6K1 phosphorylation in human skeletal muscle following resistance exercise occurs mainly in type II muscle fibers
Rene Koopman
Dept of Human Biology, Maastricht Univ, PO Box 616, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 290:E1245-52. 2006
..We conclude that resistance exercise effectively increases the phosphorylation of S6K1 on Thr421/Ser424, which is not associated with a substantial increase in S6 phosphorylation in a fasted state...
- Post-exercise protein synthesis rates are only marginally higher in type I compared with type II muscle fibres following resistance-type exercise
Rene Koopman
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 616, 6200 MD, Maastricht, The Netherlands
Eur J Appl Physiol 111:1871-8. 2011
..05), whereby rates of mixed muscle protein were 0.091 ± 0.005%/h. Muscle protein synthesis rates following resistance-type exercise are only marginally higher in type I compared with type II muscle fibres...
- Eccentric exercise increases satellite cell content in type II muscle fibers
Naomi M Cermak
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
Med Sci Sports Exerc 45:230-7. 2013
..However, little is known about fiber type-specific changes in SC content and their activation status within 24 h of postexercise recovery...
- Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis
Naomi M Cermak
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, Netherlands
Am J Clin Nutr 96:1454-64. 2012
..However, there is much discrepancy in the literature regarding the proposed benefits of protein supplementation during prolonged resistance-type exercise training in younger and older populations...
- A single bout of exercise activates skeletal muscle satellite cells during subsequent overnight recovery
Tim Snijders
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
Exp Physiol 97:762-73. 2012
..A single bout of exercise activates both type I and II skeletal muscle fibre SCs within a single night of postexercise recovery, preceding the subsequent increase in SC content...
- Optimizing the therapeutic benefits of exercise in Type 2 diabetes
Stephan F E Praet
Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
J Appl Physiol 103:1113-20. 2007
..A multidisciplinary individualized approach and continued exercise training under personal supervision is essential to enhance compliance and allow long-term health benefits of an exercise intervention program...
- A single session of resistance exercise induces oxidative damage in untrained men
Saskia J Rietjens
Department of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands
Med Sci Sports Exerc 39:2145-51. 2007
..The aim of the present study was to investigate the effects of a single session of resistance exercise on antioxidant capacity, oxidative damage, and inflammation...
- Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state
Luc J C van Loon
Department of Movement Sciences, Nutrition Research Institute Maastricht, Maastricht University, 616, 6200, Maastricht, MD, The Netherlands
Pflugers Arch 451:606-16. 2006
..Interventions to augment mitochondrial density and/or function are likely to improve the balance between FA uptake and oxidation and should be applied to prevent and/or treat insulin resistance...
- Skeletal muscle lipase content and activity in obesity and type 2 diabetes
Johan W E Jocken
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Centre, P O Box 616, 6200 MD Maastricht, The Netherlands
J Clin Endocrinol Metab 95:5449-53. 2010
..The obese insulin-resistant state is characterized by elevated lipid storage in skeletal muscle tissue...
- Protein ingestion before sleep improves postexercise overnight recovery
Peter T Res
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
Med Sci Sports Exerc 44:1560-9. 2012
..We assessed the effect of protein ingestion immediately before sleep on digestion and absorption kinetics and protein metabolism during overnight recovery from a single bout of resistance-type exercise...
- Carbohydrate mouth rinsing in the fed state: lack of enhancement of time-trial performance
Milou Beelen
Nutrition and Toxicology Research Institute, Maastricht, Maastricht University, The Netherlands
Int J Sport Nutr Exerc Metab 19:400-9. 2009
..Carbohydrate mouth rinsing does not improve time-trial performance when exercise is performed in a practical, postprandial setting...
- Low-intensity exercise reduces the prevalence of hyperglycemia in type 2 diabetes
Ralph J F Manders
Department of Human Movement Sciences NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
Med Sci Sports Exerc 42:219-25. 2010
..Therapeutic targets should aim to reduce postprandial blood glucose excursions. Exercise prescription can effectively improve glucose homeostasis and reduce the risk of cardiovascular complications...
- Aging, exercise, and muscle protein metabolism
Rene Koopman
Department of Human Movement Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands
J Appl Physiol 106:2040-8. 2009
..The latter is needed to define more effective strategies that will maximize the therapeutic benefits of lifestyle intervention in the elderly...
- Continuous endurance-type exercise training does not modulate satellite cell content in obese type 2 diabetes patients
Tim Snijders
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, P O Box 616, Maastricht 6200 MD, The Netherlands
Muscle Nerve 43:393-401. 2011
..No change in SC content was observed after exercise training. Continuous endurance-type exercise training lowers fat mass, but it does not increase leg lean mass and/or modulate muscle fiber characteristics in type 2 diabetes patients...
- Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly
Lex B Verdijk
Dept of Movement Sciences, Faculty of Health Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 292:E151-7. 2007
..The decline in SC content might be an important factor in the etiology of type II muscle fiber atrophy, which accompanies the loss of skeletal muscle with aging...
- Intramyocellular triacylglycerol as a substrate source during exercise
Luc J C van Loon
Nutrition Research Institute Maastricht NUTRIM, Departments of Movement Sciences and Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Proc Nutr Soc 63:301-7. 2004
....
- Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients
Jan Willem van Dijk
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
Diabetes Res Clin Pract 93:31-7. 2011
..Therefore, we assessed the prevalence of hyperglycemia throughout the day in type 2 diabetes patients and healthy controls under standardized dietary, but otherwise free-living conditions...
- Reduced satellite cell numbers with spinal cord injury and aging in humans
Lex B Verdijk
1NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Human Movement Sciences, Maastricht University Medical Centre, Maastricht, THE NETHERLANDS 2Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, THE NETHERLANDS 3Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, THE NETHERLANDS and 4Research Institute for Sports and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
Med Sci Sports Exerc 44:2322-30. 2012
..Despite obvious similarities in atrophy between both models, differences in muscle fiber size and satellite cell content may exist on a muscle fiber type-specific level...
- Amino acid ingestion strongly enhances insulin secretion in patients with long-term type 2 diabetes
Luc J C van Loon
Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
Diabetes Care 26:625-30. 2003
..In this study, we aimed to investigate the insulinotropic capacity of this mixture in long-term type 2 diabetic patients...
- Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes
Luc J C van Loon
Department of Movement Sciences, Nutrition Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 287:E558-65. 2004
..Because structural characteristics and intramyocellular distribution of lipid aggregates seem to be similar between groups, we conclude that elevated IMCL deposits are unlikely to be directly responsible for inducing insulin resistance...
- Protein supplementation during resistance-type exercise training in the elderly
Marika Leenders
Top Institute Food and Nutrition, Wageningen, The Netherlands
Med Sci Sports Exerc 45:542-52. 2013
..We assessed whether dietary protein supplementation can further augment the adaptive response to prolonged resistance-type exercise training in healthy elderly men and women...
- The impact of sarcopenia and exercise training on skeletal muscle satellite cells
Tim Snijders
Department of Human Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands
Ageing Res Rev 8:328-38. 2009
..This review discusses the contribution of skeletal muscle SC in the age-related loss of muscle mass and the efficacy of exercise training as a means to attenuate and/or reverse this process...
- The use of the [1,2-13C]acetate recovery factor in metabolic research
Luc J C van Loon
Nutrition Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Eur J Appl Physiol 89:377-83. 2003
..Therefore, theoretical acetate recovery factors taken from previous literature are not generally applicable...
- The role of membrane fatty-acid transporters in regulating skeletal muscle substrate use during exercise
Maurice M A L Pelsers
Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Sports Med 38:387-99. 2008
..This article will provide an overview on the effects of diet, acute exercise and exercise training on the expression and/or translocation of the various LCFA transporters in skeletal muscle tissue (FAT/CD36, FABPpm, FATP)...
- Poly (ADP-ribose) polymerase-1-inhibiting flavonoids attenuate cytokine release in blood from male patients with chronic obstructive pulmonary disease or type 2 diabetes
Antje R Weseler
Department of Health Risk Analysis and Toxicology, Maastricht University Medical Centre, Maastricht 6200 MD, The Netherlands
J Nutr 139:952-7. 2009
....
- Untreated classical galactosemia patient with mild phenotype
Bianca Panis
Department of Pediatrics, University Hospital Maastricht, Maastricht, The Netherlands
Mol Genet Metab 89:277-9. 2006
..Moreover he has a normal galactose intake from the age of 3 years. This case is probably an example of the important role of yet unknown susceptibility and or modifier genes...
- Thermoregulation during exercise in the heat: strategies for maintaining health and performance
Daniel Wendt
Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
Sports Med 37:669-82. 2007
..The latter should contain moderate amounts of glucose and sodium, which improve both water absorption and retention...
- Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans
Luc J C van Loon
Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, Maastricht, The Netherlands
Clin Sci (Lond) 104:153-62. 2003
..In addition, our findings suggest that prolonged creatine ingestion induces an increase in fat-free mass...
