Luc J C van Loon

Summary

Publications

  1. doi request reprint Leucine as a pharmaconutrient in health and disease
    Luc J C van Loon
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 15:71-7. 2012
  2. pmc Is there a need for protein ingestion during exercise?
    Luc J C van Loon
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Sports Med 44:105-11. 2014
  3. pmc Exercise therapy in type 2 diabetes: is daily exercise required to optimize glycemic control?
    Jan Willem van Dijk
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Diabetes Care 35:948-54. 2012
  4. doi request reprint Disuse impairs the muscle protein synthetic response to protein ingestion in healthy men
    Benjamin T Wall
    PhD, Department of Human Movement Sciences, Maastricht University Medical Center, Maastricht 6200 MD, The Netherlands
    J Clin Endocrinol Metab 98:4872-81. 2013
  5. pmc Effect of moderate-intensity exercise versus activities of daily living on 24-hour blood glucose homeostasis in male patients with type 2 diabetes
    Jan Willem van Dijk
    Corresponding author Luc J C van Loon
    Diabetes Care 36:3448-53. 2013
  6. doi request reprint Elderly men and women benefit equally from prolonged resistance-type exercise training
    Marika Leenders
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    J Gerontol A Biol Sci Med Sci 68:769-79. 2013
  7. pmc Carbohydrate co-ingestion with protein does not further augment post-prandial muscle protein accretion in older men
    Henrike M Hamer
    Department of Human Movement Sciences, Maastricht University Medical Centre, PO Box 616, Maastricht, MD, 6200, The Netherlands
    Nutr Metab (Lond) 10:15. 2013
  8. pmc Prolonged exercise training increases intramuscular lipid content and perilipin 2 expression in type I muscle fibers of patients with type 2 diabetes
    C S Shaw
    School of Sport and Exercise Sciences, The University of Birmingham, Birmingham, United Kingdom
    Am J Physiol Endocrinol Metab 303:E1158-65. 2012
  9. ncbi request reprint Physical activity is the key determinant of skeletal muscle mitochondrial function in type 2 diabetes
    F H J van Tienen
    Department of Genetics and Cell Biology, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 97:3261-9. 2012
  10. pmc Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients
    J W van Dijk
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, The Netherlands
    Diabetologia 55:1273-82. 2012

Detail Information

Publications91

  1. doi request reprint Leucine as a pharmaconutrient in health and disease
    Luc J C van Loon
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 15:71-7. 2012
    ....
  2. pmc Is there a need for protein ingestion during exercise?
    Luc J C van Loon
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Sports Med 44:105-11. 2014
    ..Therefore, it is concluded that protein ingestion with carbohydrate during exercise does not further improve exercise performance when compared with the ingestion of ample amounts of carbohydrate only. ..
  3. pmc Exercise therapy in type 2 diabetes: is daily exercise required to optimize glycemic control?
    Jan Willem van Dijk
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Diabetes Care 35:948-54. 2012
    ..The current study investigates the impact of daily exercise versus exercise performed every other day on glycemic control in type 2 diabetic patients...
  4. doi request reprint Disuse impairs the muscle protein synthetic response to protein ingestion in healthy men
    Benjamin T Wall
    PhD, Department of Human Movement Sciences, Maastricht University Medical Center, Maastricht 6200 MD, The Netherlands
    J Clin Endocrinol Metab 98:4872-81. 2013
    ..However, it remains to be determined whether muscle disuse also impairs the muscle protein synthetic response to dietary protein ingestion...
  5. pmc Effect of moderate-intensity exercise versus activities of daily living on 24-hour blood glucose homeostasis in male patients with type 2 diabetes
    Jan Willem van Dijk
    Corresponding author Luc J C van Loon
    Diabetes Care 36:3448-53. 2013
    ..To investigate the impact of activities of daily living (ADL) versus moderate-intensity endurance-type exercise on 24-h glycemic control in patients with type 2 diabetes...
  6. doi request reprint Elderly men and women benefit equally from prolonged resistance-type exercise training
    Marika Leenders
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    J Gerontol A Biol Sci Med Sci 68:769-79. 2013
    ..A generic resistance-type exercise training program can be applied for both women and men to effectively counteract the loss of muscle mass and strength with aging...
  7. pmc Carbohydrate co-ingestion with protein does not further augment post-prandial muscle protein accretion in older men
    Henrike M Hamer
    Department of Human Movement Sciences, Maastricht University Medical Centre, PO Box 616, Maastricht, MD, 6200, The Netherlands
    Nutr Metab (Lond) 10:15. 2013
    ..We hypothesized that the greater endogenous insulin release following co-ingestion of carbohydrate facilitates post-prandial muscle protein accretion after ingesting a meal-like bolus of protein in older males...
  8. pmc Prolonged exercise training increases intramuscular lipid content and perilipin 2 expression in type I muscle fibers of patients with type 2 diabetes
    C S Shaw
    School of Sport and Exercise Sciences, The University of Birmingham, Birmingham, United Kingdom
    Am J Physiol Endocrinol Metab 303:E1158-65. 2012
    ....
  9. ncbi request reprint Physical activity is the key determinant of skeletal muscle mitochondrial function in type 2 diabetes
    F H J van Tienen
    Department of Genetics and Cell Biology, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 97:3261-9. 2012
    ..Conflicting data exist on mitochondrial function and physical activity in type 2 diabetes mellitus (T2DM) development...
  10. pmc Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients
    J W van Dijk
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, The Netherlands
    Diabetologia 55:1273-82. 2012
    ..The present study compares the impact of endurance- vs resistance-type exercise on subsequent 24 h blood glucose homeostasis in individuals with impaired glucose tolerance (IGT) and type 2 diabetes...
  11. ncbi request reprint Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men
    Rene Koopman
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Br J Nutr 99:571-80. 2008
    ..Co-ingestion of leucine with carbohydrate and protein following physical activity does not further elevate muscle protein fractional synthetic rate in elderly men when ample protein is ingested...
  12. doi request reprint Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men
    Bart Pennings
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    Am J Physiol Endocrinol Metab 302:E992-9. 2012
    ..05) g. We conclude that ingestion of 35 g whey protein results in greater amino acid absorption and subsequent stimulation of de novo muscle protein synthesis compared with the ingestion of 10 or 20 g whey protein in healthy, older men...
  13. ncbi request reprint Significant intramyocellular lipid use during prolonged cycling in endurance-trained males as assessed by three different methodologies
    Trent Stellingwerff
    Department of Movement Science, Maastricht University, Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 292:E1715-23. 2007
    ..In addition, this study shows differences in resting subcellular intramyocellular lipid deposit distribution and in the subsequent net use of these deposits during exercise...
  14. ncbi request reprint Inhibition of adipose tissue lipolysis increases intramuscular lipid and glycogen use in vivo in humans
    Luc J C van Loon
    Department of Movement Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 289:E482-93. 2005
    ..This study confirms the hypothesis that plasma FFA availability regulates both intramuscular lipid and glycogen use in vivo in humans...
  15. doi request reprint Leucine co-ingestion improves post-prandial muscle protein accretion in elderly men
    Benjamin T Wall
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 616, Maastricht, 6200 MD, The Netherlands
    Clin Nutr 32:412-9. 2013
    ..The present study investigates the impact of leucine co-ingestion on subsequent post-prandial muscle protein accretion following the ingestion of a single bolus of dietary protein in elderly males...
  16. pmc The muscle protein synthetic response to the combined ingestion of protein and carbohydrate is not impaired in healthy older men
    Alexandra Kiskini
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 616, Maastricht, 6200 MD, The Netherlands
    Age (Dordr) 35:2389-98. 2013
    ..05). We conclude that the use of dietary protein-derived amino acids for muscle protein synthesis is not impaired in healthy older men following intake of protein plus carbohydrate...
  17. pmc Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance-trained males in a fasted state
    Luc J C van Loon
    Nutrition Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Physiol 553:611-25. 2003
    ....
  18. pmc Carbohydrate supplementation during prolonged cycling exercise spares muscle glycogen but does not affect intramyocellular lipid use
    Trent Stellingwerff
    Department of Movement Sciences, Nutrition Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Pflugers Arch 454:635-47. 2007
    ..We conclude that carbohydrate supplementation during prolonged cycling exercise does not modulate IMTG use but spares muscle glycogen use during the initial stages of exercise in endurance-trained men...
  19. doi request reprint Impact of protein coingestion on muscle protein synthesis during continuous endurance type exercise
    Milou Beelen
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 300:E945-54. 2011
    ..Protein coingestion does not further increase muscle protein synthesis rates during continuous endurance type exercise...
  20. doi request reprint Dietary protein digestion and absorption rates and the subsequent postprandial muscle protein synthetic response do not differ between young and elderly men
    Rene Koopman
    Department of Human Movement Sciences, Maastricht University, Maastricht 6200 MD, The Netherlands
    J Nutr 139:1707-13. 2009
    ..27). We conclude that protein digestion and absorption kinetics and the subsequent muscle protein synthetic response following the ingestion of a large bolus of intact CAS are not substantially impaired in healthy, elderly men...
  21. doi request reprint Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men
    Suzanne Verhoeven
    Department of Human Movement Sciences, Nutrition and Toxicology Research Institute, Maastricht, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 89:1468-75. 2009
    ..It has been reported that the blunted muscle protein synthetic response to food intake in the elderly can be normalized by increasing the leucine content of a meal...
  22. ncbi request reprint Combined ingestion of protein and carbohydrate improves protein balance during ultra-endurance exercise
    Rene Koopman
    Department of Human Biology, Maastricht University, PO Box 616, 6200 MD, The Netherlands
    Am J Physiol Endocrinol Metab 287:E712-20. 2004
    ..Combined ingestion of protein and carbohydrate improves net protein balance at rest as well as during exercise and postexercise recovery...
  23. doi request reprint Protein coingestion stimulates muscle protein synthesis during resistance-type exercise
    Milou Beelen
    Department of Human Movement Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 295:E70-7. 2008
    ..012 and 0.060 +/- 0.004%/h in CHO + PRO vs. CHO treatment, respectively; P < 0.05). We conclude that, even in a fed state, protein coingestion stimulates whole body and muscle protein synthesis rates during resistance-type exercise...
  24. doi request reprint Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein
    Rene Koopman
    Department of Human Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht, Netherlands
    Am J Clin Nutr 90:106-15. 2009
    ..It has been suggested that a protein hydrolysate, as opposed to its intact protein, is more easily digested and absorbed from the gut, which results in greater plasma amino acid availability and a greater muscle protein synthetic response...
  25. ncbi request reprint Substrate source use in older, trained males after decades of endurance training
    Hanneke Boon
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Med Sci Sports Exerc 39:2160-70. 2007
    ..The purpose of this study was to compare substrate source use in older, long-term exercising, endurance-trained males with sedentary controls...
  26. pmc Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type-specific increase in satellite cell content in elderly men
    Lex B Verdijk
    Department of Human Movement Sciences, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Gerontol A Biol Sci Med Sci 64:332-9. 2009
    ..001). No changes were observed in the Type I muscle fibers. In older adults, skeletal muscle tissue is still capable of inducing SC proliferation and differentiation, resulting in Type II muscle fiber hypertrophy...
  27. ncbi request reprint Glycaemic instability is an underestimated problem in Type II diabetes
    Stephan F E Praet
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Clin Sci (Lond) 111:119-26. 2006
    ..Given the macro- and micro-vascular damage caused by postprandial hyperglycaemia, CGMS provides an excellent tool to evaluate alternative therapeutic strategies to reduce hyperglycaemic blood glucose excursions...
  28. ncbi request reprint Reduced glycaemic and insulinaemic responses following trehalose and isomaltulose ingestion: implications for postprandial substrate use in impaired glucose-tolerant subjects
    Judith G P van Can
    Department of Human Biology, Maastricht University Medical Centre, Universiteitssingel 50, Maastricht, The Netherlands
    Br J Nutr 108:1210-7. 2012
    ..This suggests that exchange of SUC in the diet for IMU may result in a more favourable metabolic response and may help to reduce the risks associated with obesity and type 2 diabetes...
  29. doi request reprint Protein ingestion before sleep improves postexercise overnight recovery
    Peter T Res
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Med Sci Sports Exerc 44:1560-9. 2012
    ..We assessed the effect of protein ingestion immediately before sleep on digestion and absorption kinetics and protein metabolism during overnight recovery from a single bout of resistance-type exercise...
  30. doi request reprint Protein supplementation before and after exercise does not further augment skeletal muscle hypertrophy after resistance training in elderly men
    Lex B Verdijk
    Department of Human Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 89:608-16. 2009
    ..Considerable discrepancy exists in the literature on the proposed benefits of protein supplementation on the adaptive response of skeletal muscle to resistance-type exercise training in the elderly...
  31. doi request reprint Reduced glycaemic and insulinaemic responses following isomaltulose ingestion: implications for postprandial substrate use
    Judith G P van Can
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Br J Nutr 102:1408-13. 2009
    ..The metabolic response to isomaltulose co-ingestion suggests that this may represent an effective nutritional strategy to counteract overweight-induced metabolic disturbances...
  32. doi request reprint Intragastric protein administration stimulates overnight muscle protein synthesis in elderly men
    Bart B L Groen
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 302:E52-60. 2012
    ..Dietary protein administration during sleep stimulates muscle protein synthesis and improves overnight whole body protein balance. These findings may provide a basis for novel interventional strategies to attenuate muscle mass loss...
  33. doi request reprint Dietary protein to support muscle hypertrophy
    Luc J C van Loon
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Nestle Nutr Inst Workshop Ser 69:79-89; discussion 89-95. 2011
    ..Future research should focus on the relevance of the acute anabolic response following exercise to optimize the skeletal muscle adaptive response to exercise training...
  34. ncbi request reprint Neuromuscular electrical stimulation increases muscle protein synthesis in elderly type 2 diabetic men
    Benjamin T Wall
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 303:E614-23. 2012
    ..NMES likely represents an effective interventional strategy to attenuate muscle loss in elderly individuals during bed rest and/or in other disuse states...
  35. ncbi request reprint Protein ingestion further augments S6K1 phosphorylation in skeletal muscle following resistance type exercise in males
    Rene Koopman
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht 6200 MD, The Netherlands
    J Nutr 137:1880-6. 2007
    ..45 +/- 0.07, P < 0.01) and remained elevated during recovery (P < 0.05). We conclude that the availability of dietary protein further enhances phosphorylation of S6K1 during recovery from resistance type exercise...
  36. ncbi request reprint Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects
    Rene Koopman
    Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 288:E645-53. 2005
    ..0820 +/- 0.0104%/h). We conclude that coingestion of protein and leucine stimulates muscle protein synthesis and optimizes whole body protein balance compared with the intake of carbohydrate only...
  37. doi request reprint Coingestion of carbohydrate and protein hydrolysate stimulates muscle protein synthesis during exercise in young men, with no further increase during subsequent overnight recovery
    Milou Beelen
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Nutr 138:2198-204. 2008
    ..Ingestion of protein with carbohydrate during and immediately after exercise improves whole-body protein synthesis but does not further augment muscle protein synthesis rates during 9 h of subsequent overnight recovery...
  38. ncbi request reprint Nutritional interventions to promote post-exercise muscle protein synthesis
    Rene Koopman
    Department of Movement Sciences, Maastricht University, Maastricht, The Netherlands
    Sports Med 37:895-906. 2007
    ..Exercise interventions combined with specific nutritional modulation provide an effective strategy to counteract or reduce the loss of skeletal muscle mass with aging...
  39. ncbi request reprint Effects of increasing insulin secretion on acute postexercise blood glucose disposal
    Brechje Kaastra
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Med Sci Sports Exerc 38:268-75. 2006
    ..Coingestion of protein and/or free amino acids with carbohydrate has been reported to accelerate postexercise muscle glycogen synthesis due to an increase in the insulin response...
  40. doi request reprint The single biopsy approach is reliable for the measurement of muscle protein synthesis rates in vivo in older men
    Nicholas A Burd
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre MUMC Maastricht, The Netherlands
    J Appl Physiol (1985) 113:896-902. 2012
    ....
  41. ncbi request reprint Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy males
    Rene Koopman
    Department of Human Biology, Maastricht University, P O Box 616, 6200, Maastricht, The Netherlands
    Eur J Appl Physiol 96:525-34. 2006
    ..We conclude that intramyocellular lipid and glycogen stores are readily used during resistance exercise and this is likely associated with the reported increase in whole-body insulin sensitivity following resistance exercise...
  42. ncbi request reprint Influence of prolonged endurance cycling and recovery diet on intramuscular triglyceride content in trained males
    Luc J C van Loon
    Department of Human Biology, Nutrition Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 285:E804-11. 2003
    ..Data obtained by quantitative fluorescence microscopy correspond well with MRS results, implying that both are valid methods to quantify IMTG content...
  43. doi request reprint Acute dietary protein intake restriction is associated with changes in myostatin expression after a single bout of resistance exercise in healthy young men
    Tim Snijders
    NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University, Maastricht, The Netherlands
    J Nutr 144:137-45. 2014
    ..This study demonstrates that dietary protein intake does not modulate the post-exercise increase in SC content but modifies myostatin expression in skeletal muscle tissue. This trial was registered at clinicaltrials.gov as NCT01220037. ..
  44. doi request reprint Astaxanthin supplementation does not augment fat use or improve endurance performance
    Peter T Res
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Med Sci Sports Exerc 45:1158-65. 2013
    ..Prolonged astaxanthin supplementation has been reported to increase fat oxidative capacity and improve running time to exhaustion in mice. These data suggest that astaxanthin may be applied as a potent ergogenic aid in humans...
  45. doi request reprint Eccentric exercise increases satellite cell content in type II muscle fibers
    Naomi M Cermak
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Med Sci Sports Exerc 45:230-7. 2013
    ..However, little is known about fiber type-specific changes in SC content and their activation status within 24 h of postexercise recovery...
  46. ncbi request reprint Coingestion of carbohydrate with protein does not further augment postexercise muscle protein synthesis
    Rene Koopman
    Department of Movement Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 293:E833-42. 2007
    ..11 +/- 0.01%/h in the PRO, PRO + LCHO, and PRO + HCHO experiments, respectively. In conclusion, coingestion of carbohydrate during recovery does not further stimulate postexercise muscle protein synthesis when ample protein is ingested...
  47. ncbi request reprint Nitrate supplementation's improvement of 10-km time-trial performance in trained cyclists
    Naomi M Cermak
    Department of Human Movement Sciences, Maastricht University Medical Centre, Maastricht, The Netherlands
    Int J Sport Nutr Exerc Metab 22:64-71. 2012
    ..Six days of nitrate supplementation reduced VO₂ during submaximal exercise and improved time-trial performance in trained cyclists...
  48. ncbi request reprint The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle
    Chamindie Punyadeera
    Department of Pathology, Research Institute GROW, Maastricht University, Maastricht, The Netherlands
    Eur J Endocrinol 152:427-36. 2005
    ..Furthermore, we aimed to detect and locate adiponectin in skeletal muscle tissue...
  49. doi request reprint Role of dietary protein in post-exercise muscle reconditioning
    Luc J C van Loon
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Nestle Nutr Inst Workshop Ser 75:73-83. 2013
    ..Future research should focus on the impact of the timing of protein provision throughout the day on the adaptive response to more prolonged exercise training...
  50. ncbi request reprint Creatine supplementation increases glycogen storage but not GLUT-4 expression in human skeletal muscle
    Luc J C van Loon
    Nutrition Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Clin Sci (Lond) 106:99-106. 2004
    ..In addition, neither muscle GS-1 nor Gln-1 mRNA expression was affected. We conclude that creatine ingestion itself stimulates muscle glycogen storage, but does not affect muscle GLUT-4 expression...
  51. doi request reprint Reduced glycaemic and insulinaemic responses following trehalose ingestion: implications for postprandial substrate use
    Judith G P van Can
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Br J Nutr 102:1395-9. 2009
    ..These differences were accompanied with a reduced carbohydrate oxidation after trehalose when ingested as a drink, whilst no significant differences in fat oxidation between drink were observed...
  52. ncbi request reprint Use of intramuscular triacylglycerol as a substrate source during exercise in humans
    Luc J C van Loon
    Nutrition Research Institute Maastricht NUTRIM Dept of Human Biology, Maastricht Univ, PO Box 616, 6200 MD Maastricht, The Netherlands
    J Appl Physiol (1985) 97:1170-87. 2004
    ....
  53. ncbi request reprint Increase in S6K1 phosphorylation in human skeletal muscle following resistance exercise occurs mainly in type II muscle fibers
    Rene Koopman
    Dept of Human Biology, Maastricht Univ, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 290:E1245-52. 2006
    ..We conclude that resistance exercise effectively increases the phosphorylation of S6K1 on Thr421/Ser424, which is not associated with a substantial increase in S6 phosphorylation in a fasted state...
  54. doi request reprint Muscle disuse atrophy is not accompanied by changes in skeletal muscle satellite cell content
    Tim Snijders
    Department of Human Movement Sciences, School for Nutrition, Toxicology and Metabolism NUTRIM, Maastricht University, Maastricht, The Netherlands
    Clin Sci (Lond) 126:557-66. 2014
    ..The loss in muscle mass was attributed to both type I and type II muscle fibre atrophy, and was not accompanied by a decline in satellite cell content...
  55. doi request reprint Concluding remarks: nutritional strategies to support the adaptive response to prolonged exercise training
    Luc J C van Loon
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Nestle Nutr Inst Workshop Ser 75:135-41. 2013
    ..Here, we provide an overview on the properties of various nutritional interventions that may be useful to support the adaptive response to exercise training and competition and, as such, to augment exercise training efficiency...
  56. doi request reprint Reduced satellite cell numbers with spinal cord injury and aging in humans
    Lex B Verdijk
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Human Movement Sciences, Maastricht University Medical Centre, Maastricht, The Netherlands
    Med Sci Sports Exerc 44:2322-30. 2012
    ..Despite obvious similarities in atrophy between both models, differences in muscle fiber size and satellite cell content may exist on a muscle fiber type-specific level...
  57. ncbi request reprint Responses to acute exercise in type 2 diabetes, with an emphasis on metabolism and interaction with oral hypoglycemic agents and food intake
    Henrik Galbo
    Copenhagen Muscle Research Centre CMRC and Department of Rheumatology, Bispebjerg Hospital, Copenhagen, Denmark, and Department of Movement Sciences, Nutrition and Toxicology Research Institute, Maastricht University, The Netherlands
    Appl Physiol Nutr Metab 32:567-75. 2007
    ..Finally, in people with type 2 DM, after a high-fat meal, prolonged moderate exercise reduces the exaggerated increases in plasma concentrations of triglycerides contained in chylomicrons and very low-density lipoproteins...
  58. doi request reprint Characteristics of muscle fiber type are predictive of skeletal muscle mass and strength in elderly men
    Lex B Verdijk
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    J Am Geriatr Soc 58:2069-75. 2010
    ..To investigate the relationship between skeletal muscle fiber type-specific characteristics, circulating hormone concentrations, and skeletal muscle mass and strength in older men...
  59. pmc Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: a randomized trial
    Lieke J J Klinkenberg
    Department of Clinical Chemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University Medical Center MUMC, Maastricht, The Netherlands
    PLoS ONE 8:e79280. 2013
    ..Therefore, the aim of this study was to assess the effect of 4 week astaxanthin supplementation (a potent cartenoid antioxidant) on antioxidant capacity and exercise-induced cardiac troponin release in cyclists...
  60. ncbi request reprint Optimizing the therapeutic benefits of exercise in Type 2 diabetes
    Stephan F E Praet
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    J Appl Physiol (1985) 103:1113-20. 2007
    ..A multidisciplinary individualized approach and continued exercise training under personal supervision is essential to enhance compliance and allow long-term health benefits of an exercise intervention program...
  61. doi request reprint Exercise and 24-h glycemic control: equal effects for all type 2 diabetes patients?
    Jan Willem van Dijk
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Med Sci Sports Exerc 45:628-35. 2013
    ..Moreover, we examined whether individual responses to exercise were related to subjects' baseline characteristics, including age, body mass index, diabetes duration, exercise performance, medication, and HbA1c content...
  62. ncbi request reprint Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients
    Kristof Vanschoonbeek
    Department of Human Biology, Nutrition and Toxicology Research Institute, Maastricht University, Maastricht, The Netherlands
    J Nutr 136:977-80. 2006
    ..More research on the proposed health benefits of cinnamon supplementation is warranted before health claims should be made...
  63. doi request reprint The reliability of using the single-biopsy approach to assess basal muscle protein synthesis rates in vivo in humans
    Nicholas A Burd
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre MUMC, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Metabolism 61:931-6. 2012
    ..Our data demonstrate that the single-biopsy approach, irrespective of whether the biopsy is obtained at 2 or 4 hours, can be used as a surrogate for the sequential-biopsy approach to determine basal muscle protein synthesis in a group...
  64. pmc Post-exercise protein synthesis rates are only marginally higher in type I compared with type II muscle fibres following resistance-type exercise
    Rene Koopman
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Eur J Appl Physiol 111:1871-8. 2011
    ..05), whereby rates of mixed muscle protein were 0.091 ± 0.005%/h. Muscle protein synthesis rates following resistance-type exercise are only marginally higher in type I compared with type II muscle fibres...
  65. doi request reprint Anabolic resistance of muscle protein synthesis with aging
    Nicholas A Burd
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Exerc Sport Sci Rev 41:169-73. 2013
    ..Thus, the level of habitual physical activity may be fundamental to maintain the anabolic responsiveness to protein intake with aging. ..
  66. doi request reprint The impact of sarcopenia and exercise training on skeletal muscle satellite cells
    Tim Snijders
    Department of Human Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands
    Ageing Res Rev 8:328-38. 2009
    ..This review discusses the contribution of skeletal muscle SC in the age-related loss of muscle mass and the efficacy of exercise training as a means to attenuate and/or reverse this process...
  67. doi request reprint Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients
    Jan Willem van Dijk
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Diabetes Res Clin Pract 93:31-7. 2011
    ..Therefore, we assessed the prevalence of hyperglycemia throughout the day in type 2 diabetes patients and healthy controls under standardized dietary, but otherwise free-living conditions...
  68. doi request reprint The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type II muscle fiber size
    Rachel Nilwik
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Exp Gerontol 48:492-8. 2013
    ..The loss of skeletal muscle mass with aging has been attributed to a decline in muscle fiber number and muscle fiber size...
  69. doi request reprint Nutritional strategies to attenuate muscle disuse atrophy
    Benjamin T Wall
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht 6200 MD, The Netherlands
    Nutr Rev 71:195-208. 2013
    ..Such information will provide novel targets for nutritional interventions to further attenuate muscle disuse atrophy and, as such, support healthy aging...
  70. doi request reprint Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis
    Naomi M Cermak
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, Netherlands
    Am J Clin Nutr 96:1454-64. 2012
    ..However, there is much discrepancy in the literature regarding the proposed benefits of protein supplementation during prolonged resistance-type exercise training in younger and older populations...
  71. ncbi request reprint Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state
    Luc J C van Loon
    Department of Movement Sciences, Nutrition Research Institute Maastricht, Maastricht University, 616, 6200, Maastricht, MD, The Netherlands
    Pflugers Arch 451:606-16. 2006
    ..Interventions to augment mitochondrial density and/or function are likely to improve the balance between FA uptake and oxidation and should be applied to prevent and/or treat insulin resistance...
  72. ncbi request reprint A single session of resistance exercise induces oxidative damage in untrained men
    Saskia J Rietjens
    Department of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands
    Med Sci Sports Exerc 39:2145-51. 2007
    ..The aim of the present study was to investigate the effects of a single session of resistance exercise on antioxidant capacity, oxidative damage, and inflammation...
  73. ncbi request reprint Carbohydrate mouth rinsing in the fed state: lack of enhancement of time-trial performance
    Milou Beelen
    Nutrition and Toxicology Research Institute, Maastricht, Maastricht University, The Netherlands
    Int J Sport Nutr Exerc Metab 19:400-9. 2009
    ..Carbohydrate mouth rinsing does not improve time-trial performance when exercise is performed in a practical, postprandial setting...
  74. doi request reprint Aging, exercise, and muscle protein metabolism
    Rene Koopman
    Department of Human Movement Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Appl Physiol (1985) 106:2040-8. 2009
    ..The latter is needed to define more effective strategies that will maximize the therapeutic benefits of lifestyle intervention in the elderly...
  75. doi request reprint Continuous endurance-type exercise training does not modulate satellite cell content in obese type 2 diabetes patients
    Tim Snijders
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, P O Box 616, Maastricht 6200 MD, The Netherlands
    Muscle Nerve 43:393-401. 2011
    ..No change in SC content was observed after exercise training. Continuous endurance-type exercise training lowers fat mass, but it does not increase leg lean mass and/or modulate muscle fiber characteristics in type 2 diabetes patients...
  76. doi request reprint Low-intensity exercise reduces the prevalence of hyperglycemia in type 2 diabetes
    Ralph J F Manders
    Department of Human Movement Sciences NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Med Sci Sports Exerc 42:219-25. 2010
    ..Therapeutic targets should aim to reduce postprandial blood glucose excursions. Exercise prescription can effectively improve glucose homeostasis and reduce the risk of cardiovascular complications...
  77. ncbi request reprint Amino acid ingestion strongly enhances insulin secretion in patients with long-term type 2 diabetes
    Luc J C van Loon
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetes Care 26:625-30. 2003
    ..In this study, we aimed to investigate the insulinotropic capacity of this mixture in long-term type 2 diabetic patients...
  78. doi request reprint Skeletal muscle lipase content and activity in obesity and type 2 diabetes
    Johan W E Jocken
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Centre, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 95:5449-53. 2010
    ..The obese insulin-resistant state is characterized by elevated lipid storage in skeletal muscle tissue...
  79. doi request reprint A single bout of exercise activates skeletal muscle satellite cells during subsequent overnight recovery
    Tim Snijders
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Exp Physiol 97:762-73. 2012
    ..A single bout of exercise activates both type I and II skeletal muscle fibre SCs within a single night of postexercise recovery, preceding the subsequent increase in SC content...
  80. ncbi request reprint Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes
    Luc J C van Loon
    Department of Movement Sciences, Nutrition Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 287:E558-65. 2004
    ..Because structural characteristics and intramyocellular distribution of lipid aggregates seem to be similar between groups, we conclude that elevated IMCL deposits are unlikely to be directly responsible for inducing insulin resistance...
  81. doi request reprint Patients with type 2 diabetes show a greater decline in muscle mass, muscle strength, and functional capacity with aging
    Marika Leenders
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    J Am Med Dir Assoc 14:585-92. 2013
    ..It has been suggested that the development of type 2 diabetes results in a more rapid decline in muscle mass, strength, and functional capacity...
  82. ncbi request reprint Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly
    Lex B Verdijk
    Dept of Movement Sciences, Faculty of Health Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 292:E151-7. 2007
    ..The decline in SC content might be an important factor in the etiology of type II muscle fiber atrophy, which accompanies the loss of skeletal muscle with aging...
  83. ncbi request reprint Protein supplementation during resistance-type exercise training in the elderly
    Marika Leenders
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    Med Sci Sports Exerc 45:542-52. 2013
    ..We assessed whether dietary protein supplementation can further augment the adaptive response to prolonged resistance-type exercise training in healthy elderly men and women...
  84. ncbi request reprint Untreated classical galactosemia patient with mild phenotype
    Bianca Panis
    Department of Pediatrics, University Hospital Maastricht, Maastricht, The Netherlands
    Mol Genet Metab 89:277-9. 2006
    ..Moreover he has a normal galactose intake from the age of 3 years. This case is probably an example of the important role of yet unknown susceptibility and or modifier genes...
  85. ncbi request reprint Intramyocellular triacylglycerol as a substrate source during exercise
    Luc J C van Loon
    Nutrition Research Institute Maastricht NUTRIM, Departments of Movement Sciences and Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Proc Nutr Soc 63:301-7. 2004
    ....
  86. ncbi request reprint The use of the [1,2-13C]acetate recovery factor in metabolic research
    Luc J C van Loon
    Nutrition Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Appl Physiol 89:377-83. 2003
    ..Therefore, theoretical acetate recovery factors taken from previous literature are not generally applicable...
  87. doi request reprint Poly (ADP-ribose) polymerase-1-inhibiting flavonoids attenuate cytokine release in blood from male patients with chronic obstructive pulmonary disease or type 2 diabetes
    Antje R Weseler
    Department of Health Risk Analysis and Toxicology, Maastricht University Medical Centre, Maastricht 6200 MD, The Netherlands
    J Nutr 139:952-7. 2009
    ....
  88. ncbi request reprint The role of membrane fatty-acid transporters in regulating skeletal muscle substrate use during exercise
    Maurice M A L Pelsers
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Sports Med 38:387-99. 2008
    ..This article will provide an overview on the effects of diet, acute exercise and exercise training on the expression and/or translocation of the various LCFA transporters in skeletal muscle tissue (FAT/CD36, FABPpm, FATP)...
  89. ncbi request reprint Thermoregulation during exercise in the heat: strategies for maintaining health and performance
    Daniel Wendt
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Sports Med 37:669-82. 2007
    ..The latter should contain moderate amounts of glucose and sodium, which improve both water absorption and retention...
  90. ncbi request reprint Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans
    Luc J C van Loon
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Clin Sci (Lond) 104:153-62. 2003
    ..In addition, our findings suggest that prolonged creatine ingestion induces an increase in fat-free mass...