Lionel Van Holle

Summary

Publications

  1. ncbi request reprint Using time-to-onset for detecting safety signals in spontaneous reports of adverse events following immunization: a proof of concept study
    Lionel Van Holle
    Safety and Observational Database Research, Epidemiology, GlaxoSmithKline Biologicals, Wavre, Belgium
    Pharmacoepidemiol Drug Saf 21:603-10. 2012
  2. ncbi request reprint The upper bound to the Relative Reporting Ratio-a measure of the impact of the violation of hidden assumptions underlying some disproportionality methods used in signal detection
    Lionel Van Holle
    Vaccine Safety Research Group, Vaccine Clinical Safety and Pharmacovigilance, GlaxoSmithKline Vaccines, Wavre, Belgium
    Pharmacoepidemiol Drug Saf 23:787-94. 2014
  3. ncbi request reprint Signal detection based on time-to-onset: extending a new method from spontaneous reports to observational studies
    Lionel Van Holle
    Vaccines Clinical Safety and Pharmacovigilance, GlaxoSmithKline Vaccines, Wavre, Belgium
    Pharmacoepidemiol Drug Saf 23:849-58. 2014
  4. doi request reprint Signal detection on spontaneous reports of adverse events following immunisation: a comparison of the performance of a disproportionality-based algorithm and a time-to-onset-based algorithm
    Lionel Van Holle
    Vaccine Safety Research Group VSRG, Vaccines Clinical Safety and Pharmacovigilance VCSP, GlaxoSmithKline Vaccines, Wavre, Belgium
    Pharmacoepidemiol Drug Saf 23:178-85. 2014
  5. doi request reprint Optimization of a quantitative signal detection algorithm for spontaneous reports of adverse events post immunization
    Lionel Van Holle
    Vaccine Safety Research Group, Vaccine Clinical Safety and Pharmacovigilance, GlaxoSmithKline Biologicals SA, Wavre, Belgium
    Pharmacoepidemiol Drug Saf 22:477-87. 2013

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Using time-to-onset for detecting safety signals in spontaneous reports of adverse events following immunization: a proof of concept study
    Lionel Van Holle
    Safety and Observational Database Research, Epidemiology, GlaxoSmithKline Biologicals, Wavre, Belgium
    Pharmacoepidemiol Drug Saf 21:603-10. 2012
    ..In these analyses, time-to-onset (TTO; the time between vaccination and the onset of the adverse event) is rarely considered. Our objective is to assess the potential use of TTO to improve signal detection (SD)...
  2. ncbi request reprint The upper bound to the Relative Reporting Ratio-a measure of the impact of the violation of hidden assumptions underlying some disproportionality methods used in signal detection
    Lionel Van Holle
    Vaccine Safety Research Group, Vaccine Clinical Safety and Pharmacovigilance, GlaxoSmithKline Vaccines, Wavre, Belgium
    Pharmacoepidemiol Drug Saf 23:787-94. 2014
    ..Here, we provide the tools for allowing signal detection experts to assess the consequence of the violation of this assumption on their specific SRD...
  3. ncbi request reprint Signal detection based on time-to-onset: extending a new method from spontaneous reports to observational studies
    Lionel Van Holle
    Vaccines Clinical Safety and Pharmacovigilance, GlaxoSmithKline Vaccines, Wavre, Belgium
    Pharmacoepidemiol Drug Saf 23:849-58. 2014
    ..The aim of this study was to assess the added value of this new TTO signal detection method adapted to observational studies...
  4. doi request reprint Signal detection on spontaneous reports of adverse events following immunisation: a comparison of the performance of a disproportionality-based algorithm and a time-to-onset-based algorithm
    Lionel Van Holle
    Vaccine Safety Research Group VSRG, Vaccines Clinical Safety and Pharmacovigilance VCSP, GlaxoSmithKline Vaccines, Wavre, Belgium
    Pharmacoepidemiol Drug Saf 23:178-85. 2014
    ..Time-to-onset (TTO) methods measure how unexpected the TTO distribution of a vaccine-event pair is compared with what is expected from other vaccines and events. Our purpose is to compare the performance associated with each method...
  5. doi request reprint Optimization of a quantitative signal detection algorithm for spontaneous reports of adverse events post immunization
    Lionel Van Holle
    Vaccine Safety Research Group, Vaccine Clinical Safety and Pharmacovigilance, GlaxoSmithKline Biologicals SA, Wavre, Belgium
    Pharmacoepidemiol Drug Saf 22:477-87. 2013
    ..To optimize the efficiency of signal detection by maximizing the proportion of true positive (TP) signals among signals detected by a disproportionality algorithm...