Lionel Van Holle
- Using time-to-onset for detecting safety signals in spontaneous reports of adverse events following immunization: a proof of concept studyLionel Van Holle
Safety and Observational Database Research, Epidemiology, GlaxoSmithKline Biologicals, Wavre, Belgium
Pharmacoepidemiol Drug Saf 21:603-10. 2012..In these analyses, time-to-onset (TTO; the time between vaccination and the onset of the adverse event) is rarely considered. Our objective is to assess the potential use of TTO to improve signal detection (SD)...