H Uzun

Summary

Publications

  1. ncbi request reprint Paraoxonase, oxidized low density lipoprotein, monocyte chemoattractant protein-1 and adhesion molecules are associated with macrovascular complications in patients with type 2 diabetes mellitus
    V Sozer
    Department of Biochemistry Yildiz Technical University, Istanbul, Turkey
    Minerva Med 105:237-44. 2014
  2. ncbi request reprint Effects of hormone replacement therapy on plasma and tissue fibrinolytic activity in a rat model of surgically induced menopause
    Ata Topcuoglu
    Clin Invest Med 37:E85-92. 2014
  3. ncbi request reprint Melatonin ameliorates oxidative damage in hyperglycemia-induced liver injury
    Gulcan G Korkmaz
    Kirklareli University, School of Health, Kirklareli, Turkey
    Clin Invest Med 35:E370-7. 2012
  4. ncbi request reprint Circulating oxidized low-density lipoprotein and paraoxonase activity in preeclampsia
    H Uzun
    Department of Biochemistry, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
    Gynecol Obstet Invest 60:195-200. 2005
  5. ncbi request reprint Plasma protein carbonyl and thiol stress before and after laparoscopic gastric banding in morbidly obese patients
    Hafize Uzun
    Istanbul University, Cerrahpasa Medical Faculty, Department of Biochemistry, Turkey
    Obes Surg 17:1367-73. 2007
  6. ncbi request reprint Serum cystatin C level as a potentially good marker for impaired kidney function
    Hafize Uzun
    Department of Biochemistry, Cerrahpasa Medicine Faculty, Istanbul University, Cerrahpasa Tip Fakultesi, Temel Bilimler Biokimya Anabilim Dali, 34303 Cerrahpasa Istanbul, Turkey
    Clin Biochem 38:792-8. 2005
  7. ncbi request reprint Changes in leptin, plasminogen activator factor and oxidative stress in morbidly obese patients following open and laparoscopic Swedish adjustable gastric banding
    Hafize Uzun
    Department of Biochemistry, Istanbul University, Cerrahphasa School of Medicine, Istanbul, Turkey
    Obes Surg 14:659-65. 2004
  8. ncbi request reprint Increased maternal serum and cord blood fibronectin concentrations in preeclampsia are associated with higher placental hyaluronic acid and hydroxyproline content
    Hafize Uzun
    Istanbul University, Cerrahpasa Medical Faculty, Department of Biochemistry, Istanbul, Turkey
    Hypertens Pregnancy 29:153-62. 2010
  9. ncbi request reprint Oxidative stress in white coat hypertension; role of paraoxonase
    H Uzun
    Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Turkey
    J Hum Hypertens 18:523-8. 2004
  10. ncbi request reprint Levels of paraoxonase, an index of antioxidant defense, in patients with active sarcoidosis
    H Uzun
    Department of Biochemistry, Istanbul University, Turkey
    Curr Med Res Opin 24:1651-7. 2008

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint Paraoxonase, oxidized low density lipoprotein, monocyte chemoattractant protein-1 and adhesion molecules are associated with macrovascular complications in patients with type 2 diabetes mellitus
    V Sozer
    Department of Biochemistry Yildiz Technical University, Istanbul, Turkey
    Minerva Med 105:237-44. 2014
    ....
  2. ncbi request reprint Effects of hormone replacement therapy on plasma and tissue fibrinolytic activity in a rat model of surgically induced menopause
    Ata Topcuoglu
    Clin Invest Med 37:E85-92. 2014
    ..The purpose of this study was to analyze the effects of estrogen deficiency and hormone replacement therapy (HRT) on fibrinolytic activity in a rat mode of surgically-induced menopause...
  3. ncbi request reprint Melatonin ameliorates oxidative damage in hyperglycemia-induced liver injury
    Gulcan G Korkmaz
    Kirklareli University, School of Health, Kirklareli, Turkey
    Clin Invest Med 35:E370-7. 2012
    ..Our aim was to clarify the effects of hyperglycemia and to administer melatonin on lipid peroxidation, protein oxidation and oxidative DNA damage in rat...
  4. ncbi request reprint Circulating oxidized low-density lipoprotein and paraoxonase activity in preeclampsia
    H Uzun
    Department of Biochemistry, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
    Gynecol Obstet Invest 60:195-200. 2005
    ..Elevated oxidative stress, oxLDL, dyslipidemia and decreased PON1 activities may cause vascular endothelial damage and contribute to the pathophysiology of preeclampsia...
  5. ncbi request reprint Plasma protein carbonyl and thiol stress before and after laparoscopic gastric banding in morbidly obese patients
    Hafize Uzun
    Istanbul University, Cerrahpasa Medical Faculty, Department of Biochemistry, Turkey
    Obes Surg 17:1367-73. 2007
    ..The aim of this study is to examine the relationship between oxidative plasma protein and thiol stress and weight loss after laparoscopic adjustable gastric banding (LAGB)...
  6. ncbi request reprint Serum cystatin C level as a potentially good marker for impaired kidney function
    Hafize Uzun
    Department of Biochemistry, Cerrahpasa Medicine Faculty, Istanbul University, Cerrahpasa Tip Fakultesi, Temel Bilimler Biokimya Anabilim Dali, 34303 Cerrahpasa Istanbul, Turkey
    Clin Biochem 38:792-8. 2005
    ..To evaluate the diagnostic significance of serum cystatin C levels in clinical practice...
  7. ncbi request reprint Changes in leptin, plasminogen activator factor and oxidative stress in morbidly obese patients following open and laparoscopic Swedish adjustable gastric banding
    Hafize Uzun
    Department of Biochemistry, Istanbul University, Cerrahphasa School of Medicine, Istanbul, Turkey
    Obes Surg 14:659-65. 2004
    ....
  8. ncbi request reprint Increased maternal serum and cord blood fibronectin concentrations in preeclampsia are associated with higher placental hyaluronic acid and hydroxyproline content
    Hafize Uzun
    Istanbul University, Cerrahpasa Medical Faculty, Department of Biochemistry, Istanbul, Turkey
    Hypertens Pregnancy 29:153-62. 2010
    ..The purpose of this study was to examine the relationship between maternal serum FN levels and the extracellular matrix molecule contents of placental tissue, such as FN, hyaluronic acid (HA) and hydroxyproline (HP) levels...
  9. ncbi request reprint Oxidative stress in white coat hypertension; role of paraoxonase
    H Uzun
    Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Turkey
    J Hum Hypertens 18:523-8. 2004
    ..008). Our data demonstrate that oxidative stress increase in WCH is associated with a decrease in PON1 activity. The reduction in PON1 activity may be one of the factors leading to an increase in oxidative status in WCH...
  10. ncbi request reprint Levels of paraoxonase, an index of antioxidant defense, in patients with active sarcoidosis
    H Uzun
    Department of Biochemistry, Istanbul University, Turkey
    Curr Med Res Opin 24:1651-7. 2008
    ..We aimed to evaluate the oxidant-antioxidant balance in the pathogenesis and activity of sarcoidosis and to search if the change in the level of PON can be taken as an activity marker...
  11. pmc Potential effects of L-NAME on alcohol-induced oxidative stress
    Hafize Uzun
    Department of Biochemistry, Istanbul University, Cerrahpata School of Medicine, Istanbul, Turkey
    World J Gastroenterol 11:600-4. 2005
    ..Nw- nitro-L-arginine methyl ester (L-NAME) is a non-selective inhibitor of NOS. We aimed to evaluate whether L-NAME treatment had protective effects against oxidative stress in rats intragastrically fed with ethanol during a 4 wk-period...
  12. ncbi request reprint The effects of sildenafil citrate on ischemic colonic anastomotic healing in rats: its relationship between nitric oxide and oxidative stress
    Hafize Uzun
    Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    World J Surg 32:2107-13. 2008
    ....
  13. ncbi request reprint Predictive value of clinical and laboratory indices at first assessment in women referred with suspected gestational hypertension
    Dilly O C Anumba
    Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom
    Hypertens Pregnancy 29:163-79. 2010
    ..To establish the predictive value of tests in women referred with suspected gestational hypertension (GH) for preeclampsia and other adverse outcomes...
  14. ncbi request reprint Endothelium and angiogenesis in white coat hypertension
    Y Karter
    Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    J Hum Hypertens 18:809-14. 2004
    ..86+/-0.67; P=0.077). Our data demonstrate that WCH is associated with endothelial dysfunction and abnormal angiogenesis. The degree of these changes is not as severe as observed in hypertensive population...
  15. doi request reprint The role of feed regulating peptides on weight loss in patients with pulmonary tuberculosis
    S Yurt
    Yedikule Chest Disease and Chest Surgery Education and Research Hospital, Istanbul, Turkey
    Clin Biochem 46:40-4. 2013
    ..Malnutrition is a prominent feature of tuberculosis (TB). The aim of our study was to explore the function of plasma regulatory proteins in pulmonary TB and to investigate the relationship between these parameters and loss of body weight...
  16. ncbi request reprint Oxidative stress in human in sustained and white coat hypertension
    M Caner
    Department of Internal Medicine, Istanbul University, Cerrahpasa Medical Faculty, Isanbul, Turkey
    Int J Clin Pract 60:1565-71. 2006
    ..This may cause endothelial dysfunction just like in sustained hypertension. It may be necessary to add antioxidants to conventional antihypertensive therapy to balance the oxidative status in WCH...
  17. ncbi request reprint Effects of peritoneal-and hemodialysis on levels of plasma protein and lipid oxidation markers in diabetic patients
    V Sozer
    Department of Biochemistry, Yildiz Technical University, Istanbul, Turkey
    Minerva Med 104:75-84. 2013
    ..The aim of this paper was to evaluate the effects of dialysis procedures on oxidative stress in diabetic patients...
  18. ncbi request reprint Correlation of plasma and tissue oxidative stresses in intra-abdominal sepsis
    G M Koksal
    Department of Anaesthesiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    J Surg Res 122:180-3. 2004
    ....
  19. doi request reprint Effects of atorvastatin therapy on protein oxidation and oxidative DNA damage in hypercholesterolemic rabbits
    S Aydin
    Department of Biochemistry, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
    Pharmacol Res 59:242-7. 2009
    ..Our aim was to clarify the effects of hypercholesterolemic diet and administeration of atorvastatin on lipid peroxidation, protein oxidation and oxidative DNA damage in male New Zealand white rabbits...
  20. ncbi request reprint Evaluation of serum paraoxonase and arylesterase activities in subjects with asthma and chronic obstructive lung disease
    A Acay
    Istanbul Education and Research Hospital, Internal Medicine Clinic, Istanbul, Turkey
    Clin Lab 59:1331-7. 2013
    ..We carried out a study to assess if there is a difference between PON1 and AE activities and biochemical values between asthmatics and COPD patients and if there is a difference between comorbid or pure COPD patients...
  21. ncbi request reprint Plasma ghrelin, leptin, and orexin-A levels and insulin resistance after laparoscopic gastric band applications in morbidly obese patients
    P Cigdem Arica
    Department of General Surgery, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
    Minerva Med 104:309-16. 2013
    ..The purpose of this study was to investigate the effects of a laparoscopic gastric band application on insulin resistance and the peptides involved in appetite in morbidly obese patients...
  22. ncbi request reprint Hypertension and hemostatic/fibrinolytic balance disorders
    O Tabak
    Department of Internal Medicine, Istanbul Education and Research Hospital, Istanbul, Turkey
    Clin Invest Med 32:E285. 2009
    ....
  23. doi request reprint Serum lipid hydroperoxide levels and paraoxonase activity in patients with lung, breast, and colorectal cancer
    H Balci
    Central Research Laboratory, Cerrahpasa Medical Faculty, University of Istanbul, Turkey
    J Clin Lab Anal 26:155-60. 2012
    ..The objectives of this article are to investigate the serum lipid hydroperoxide (LOOH) levels and paraoxonase-1 (PON1) and arylesterase (ARE) activity in patients with lung, breast, and colorectal cancer...
  24. ncbi request reprint Increased circulating concentrations of asymmetric dimethylarginine (ADMA) in white coat hypertension
    A Curgunlu
    Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    J Hum Hypertens 19:629-33. 2005
    ..Decreased NO and increased ADMA levels in WCH may indicate endothelial dysfunction. Our data indicate also that WCH represent an intermediate group between NT and HT when endothelial dysfunction is concerned...
  25. ncbi request reprint Lipid peroxidation and antioxidants in preeclampsia
    R Madazli
    Istanbul University, Cerrahpasa Medical Faculty, Department of Obstetrics and Gynecology, Turkey
    Eur J Obstet Gynecol Reprod Biol 85:205-8. 1999
    ..To determine the changes in plasma levels of lipid peroxide, vitamin E and vitamin C in women with preeclampsia and to investigate their relationship with diastolic blood pressure...
  26. ncbi request reprint The influence of omentectomy on the inflammatory phase of anastomotic healing
    M Paksoy
    Department of Surgery, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
    Hepatogastroenterology 48:1359-63. 2001
    ..CONCLUSIONS: Omentectomy may influence the outcome of the inflammatory phase of wound healing in rats. But systemic compensatory regulation of body can tolerate these detrimental effects and wound healing continues in its regular manner...
  27. ncbi request reprint The plasma and placental levels of malondialdehyde, glutathione and superoxide dismutase in pre-eclampsia
    R Madazli
    Department of Obstetrics and Gynaecology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
    J Obstet Gynaecol 22:477-80. 2002
    ..The magnitude of oxidative stress and antioxidant changes correlate well with diastolic blood pressure...
  28. ncbi request reprint Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats
    Veysel Tahan
    Department of Gastroenterology, Marmara University School of Medicine, Istanbul, Turkey
    J Pineal Res 46:401-7. 2009
    ..The drug ameliorated the grade of NASH. The present study suggests that melatonin functions as a potent antioxidant, anti-inflammatory and antiapoptotic agent in NASH and may be a therapeutic option...
  29. doi request reprint Serum thymidine kinase 1 activity in solid tumor (breast and colorectal cancer) patients treated with adjuvant chemotherapy
    M Bolayirli
    Central Biochemistry Laboratory, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey
    J Clin Lab Anal 27:220-6. 2013
    ..The aim of this study was to evaluate the changing of TK1 (where TK is thymidine kinase) activity before and after adjuvant chemotherapy in patients with breast and colorectal cancer...
  30. ncbi request reprint Prediction of preeclampsia with maternal mid-trimester placental growth factor, activin A, fibronectin and uterine artery Doppler velocimetry
    R Madazli
    Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty, University of Istanbul, 7 8 Kisim, L1 D, D 30, 34750 Ataköy, Istanbul, Turkey
    Int J Gynaecol Obstet 89:251-7. 2005
    ..And to evaluate and compare the clinical utility of these markers and uterine artery Doppler velocimetry in predicting preeclampsia...
  31. ncbi request reprint Effects of lipopolysaccharide on the blood-brain barrier permeability in prolonged nitric oxide blockade-induced hypertensive rats
    B Ahishali
    Department of Histology and Embryology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Int J Neurosci 115:151-68. 2005
    ....
  32. ncbi request reprint Influence of hypercholesterolemia and hypertension on the integrity of the blood-brain barrier in rats
    Rivaze Kalayci
    Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
    Int J Neurosci 119:1881-904. 2009
    ....
  33. doi request reprint The chance of gender dependency of oxidation of brain proteins in aged rats
    Hafize Uzun
    Istanbul University, Cerrahpasa Faculty of Medicine, Department of Biochemistry, 34303, Istanbul, Turkey
    Arch Gerontol Geriatr 50:16-9. 2010
    ..It has thus been found that gender indeed affects the oxidation of brain proteins and thus its aging; though the extent of the underlying mechanisms affecting brain aging and its etiology are still obscure...
  34. ncbi request reprint Melatonin reduces dimethylnitrosamine-induced liver fibrosis in rats
    Veysel Tahan
    Dpeartment of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    J Pineal Res 37:78-84. 2004
    ..In conclusion, the present study suggests that melatonin functions as a potent fibrosuppressant and antioxidant, and may be a therapeutic choice...
  35. ncbi request reprint Maternal and cord blood apelin, resistin and visfatin levels in gestational diabetes mellitus
    M Oncul
    Department of Obstetrics and Gynecology, Cerrahpasa Medical FacultyIstanbul University, Istanbul, Turkey
    Minerva Med 104:527-35. 2013
    ..Our results indicate that there is an increase in resistin concentrations and a decrease in visfatin concentrations in maternal serum and cord blood serum with GDM. ..
  36. doi request reprint Chronic emotional stress exposure increases infarct size in rats: the role of oxidative and nitrosative damage in response to sympathetic hyperactivity
    G Mercanoglu
    Yeditepe University, Faculty of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Methods Find Exp Clin Pharmacol 30:745-52. 2008
    ..Exaggerated sympathetic activity may be the major contributing factor. Oxidative and nitrosative damage in response to this sympathetic hyperactivity is the key mechanism...
  37. ncbi request reprint Effects of curcumin on tumour necrosis factor-alpha and interleukin-6 in the late phase of experimental acute pancreatitis
    A Gulcubuk
    Department of Pathology, Faculty of Veterinary Medicine, Istanbul University, 34320 Avcilar Istanbul, Turkey
    J Vet Med A Physiol Pathol Clin Med 53:49-54. 2006
    ..Curcumin has been shown to markedly reduce serum TNF-alpha and IL-6 levels in the late phase of AP, but failed in the prevention of tissue injury...
  38. doi request reprint Copper intoxication; antioxidant defenses and oxidative damage in rat brain
    Dervis Ozcelik
    Department of Biophysics, Cerrhpasa Medical Faculty, Istanbul University, 34303, Cerrahpasa, Istanbul, Turkey
    Biol Trace Elem Res 127:45-52. 2009
    ..001). The present results indicate that excessive Cu accumulation in the brain depressed SOD activities and GSH levels and resulted in high MDA levels in brain homogenate due to the lipid peroxidation induced by the Cu overload...
  39. ncbi request reprint Investigation of the dose-dependent neuroprotective effects of agmatine in experimental spinal cord injury: a prospective randomized and placebo-control trial
    Kadir Kotil
    Department of Neurosurgery, Haseki Educational and Research Hospital, Istanbul, Turkey
    J Neurosurg Spine 4:392-9. 2006
    ..The purpose of this study was to demonstrate the dose-dependent activity of agmatine, an inducible NOS (iNOS) inhibitor and selective NMDAR antagonist, on biochemical and functional recovery in an experimental rat SCI model...
  40. ncbi request reprint Copper-mediated oxidative stress in rat liver
    Dervis Ozcelik
    Department of Biophysics, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
    Biol Trace Elem Res 96:209-15. 2003
    ..It increases lipid peroxidation and depletes GSH reserves, which makes the organism more vulnerable to other oxidative challenges...
  41. doi request reprint Gender-dependent variations in systemic biomarkers of oxidative protein, DNA, and lipid damage in aged rats
    Ufuk Cakatay
    Istanbul Faculty of Medicine, Central Laboratory of Clinical Biochemistry, Istanbul University, Istanbul, Turkey
    Aging Male 13:51-8. 2010
    ..However, none of the studies specify the effect of gender. The purpose of this study is to clarify the ambiguity raised in preliminary reports as to gender dependency of oxidative damage in plasma...
  42. ncbi request reprint Gender difference as regards myocardial protein oxidation in aged rats: male rats have increased oxidative protein damage
    Refik Kayali
    Cerrahpasa Medical Faculty, Department of Pediatrics, Laboratory of Biochemistry, Istanbul University, Istanbul 34303, Turkey
    Biogerontology 8:653-61. 2007
    ..The gender factor responsible for such protein oxidation is unknown and controversial. Our aim was to reveal the difference between myocardial protein and lipid oxidation parameters of male and female aged rats...
  43. ncbi request reprint N-acetylcysteine attenuates alcohol-induced oxidative stess in rats
    Resat Ozaras
    Altimermer Cad 27 4, Kucukhamam, TR 34303 Fatih, Istanbul, Turkey
    World J Gastroenterol 9:791-4. 2003
    ..To investigate free-radical scavenger effect of n-acetylcysteine in rats intragastrically fed with ethanol...
  44. doi request reprint Ezetimibe therapy and its influence on oxidative stress and fibrinolytic activity
    Nurver Turfaner
    Cerrahpasa Medical Faculty, University of Istanbul, Turkey
    South Med J 103:428-33. 2010
    ..The effect of ezetimibe on blood lipids, oxidative stress, and fibrinolytic activity in hyperlipidemic patients was investigated after three months of therapy...
  45. ncbi request reprint N-acetylcysteine reduced the effect of ethanol on antioxidant system in rat plasma and brain tissue
    Seval Aydin
    Department of Biochemistry, Cerrahpasa Medical School, Istanbul, Turkey
    Tohoku J Exp Med 198:71-7. 2002
    ..Therefore we suggest that reactive free radicals are, at least partly, involved in the ethanol-induced injury of brain cells and NAC mitigate the toxic effects of ethanol on the oxidant-antioxidant system of rat plasma and brain...
  46. ncbi request reprint Plasma malondialdehyde, superoxide dismutase, sE-selectin, fibronectin, endothelin-1 and nitric oxide levels in women with preeclampsia
    Seval Aydin
    Department of Biochemistry, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
    Eur J Obstet Gynecol Reprod Biol 113:21-5. 2004
    ....
  47. ncbi request reprint Serum and cerebrospinal fluid concentrations of E-selectin in patients with aneurysmal subarachnoid hemorrhage
    T Tanriverdi
    Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    Braz J Med Biol Res 38:1703-10. 2005
    ....
  48. doi request reprint Clinical significance and prognostic value of serum sHER-2/neu levels in patients with solid tumors
    C Papila
    Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
    Med Oncol 26:151-6. 2009
    ..Further clinical validation is needed to confirm these findings...
  49. ncbi request reprint Time-level relationship for nitric oxide and the protective effects of aminoguanidine in experimental spinal cord injury
    O Soy
    Department of Neurosurgery, Taksim Education and Research Hospital, Istanbul, Turkey
    Acta Neurochir (Wien) 146:1329-35; discussion 1335-6. 2004
    ..In this experimental study, the time-level relationship of the nitric oxide and the neuroprotective effects of aminoguanidine were investigated in a rat spinal cord trauma model...
  50. ncbi request reprint The incidence of placental abnormalities, maternal and cord plasma malondialdehyde and vascular endothelial growth factor levels in women with gestational diabetes mellitus and nondiabetic controls
    Riza Madazli
    Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
    Gynecol Obstet Invest 65:227-32. 2008
    ....
  51. doi request reprint Effect of mycophenolate mofetil on cerulein-induced acute pancreatitis
    B Tasdogan
    Kartal Research and Education Hospital, Istanbul, Turkey
    Eur Surg Res 45:146-50. 2010
    ..The aim of this study was to determine the effects of mycophenolate mofetil (MMF) on acute pancreatitis with evaluation of biochemical and histopathological findings...
  52. ncbi request reprint Changes in malondialdehyde levels in bronchoalveolar fluid and serum by the treatment of asthma with inhaled steroid and beta2-agonist
    R Ozaras
    Internal Medicine, Istanbul University, Turkey
    Respirology 5:289-92. 2000
    ..We aimed to measure the level of malondialdehyde (MDA), which is a marker of lipid peroxidation, a free radical-mediated process, before and after a well-accepted treatment of asthma...
  53. ncbi request reprint Evaluation of apoptosis in cerebrospinal fluid of patients with severe head injury
    M Uzan
    Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    Acta Neurochir (Wien) 148:1157-64; discussion. 2006
    ....
  54. ncbi request reprint The effects of sevoflurane and desflurane on lipid peroxidation during laparoscopic cholecystectomy
    G M Koksal
    Istanbul University Cerrahpasa Medical Faculty, Department of Anaesthesiology, Istanbul, Turkey
    Eur J Anaesthesiol 21:217-20. 2004
    ..To compare the effects of sevoflurane and desflurane anaesthesia on lipid peroxidation...
  55. ncbi request reprint Excision and marsupialization versus sinus excision for the treatment of limited chronic pilonidal disease: a prospective, randomized trial
    M Oncel
    Department of Colorectal Surgery, Cleveland Clinic Foundation, 9500 Euclid Avenue A30, Cleveland, OH 44195, USA
    Tech Coloproctol 6:165-9. 2002
    ..The sinus excision technique can be performed as an out-patient procedure in most cases, and seems to be associated with better patient satisfaction...
  56. ncbi request reprint The role of nitric oxide on bone metabolism in ovariectomized rats following chronic ethanol intake
    Gonul Simsek
    Istanbul University, Cerrahpasa Medical Faculty, Department of Physiology, Cerrahpasa, Istanbul, Turkey
    Life Sci 76:1965-74. 2005
    ..Also, there was a significant decrease in ALT, AST, ALP, b-ALP, and GGT levels. NO increase due to alcohol intake may function as a protective mechanism preventing bone resorption in cases of estrogen insufficiency...
  57. ncbi request reprint Plasma and placental levels of interleukin-10, transforming growth factor-beta1, and epithelial-cadherin in preeclampsia
    Ali Benian
    Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
    Obstet Gynecol 100:327-31. 2002
    ..To investigate the plasma and placental levels of interleukin-10 (IL-10), transforming growth factor-beta1 (TGF-beta1), and epithelial-cadherin (E-cadherin) in normotensive and preeclamptic pregnancies...
  58. doi request reprint Effect of vitamin C on oxidative liver injury due to isoniazid in rats
    Yakup Ergul
    Department of Pediatrics, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
    Pediatr Int 52:69-74. 2010
    ..The aim of the present study was to investigate the effect of different doses of vitamin C on oxidative liver injury due to isoniazid (INH) in rats...
  59. ncbi request reprint The effects of hyperbaric oxygen treatment on oxidant and antioxidants levels during liver regeneration in rats
    Tülin Ayşe Ozden
    Institute of Child Health, Trace Element Unit, Istanbul University, Capa, Turkey
    Tohoku J Exp Med 203:253-65. 2004
    ..These results indicate that HBO treatment has beneficial effects on liver regeneration by decreasing MDA and by increasing antioxidant activities. We therefore suggest that HBO therapy may be useful after liver resection...
  60. pmc The relationships of leptin, adiponectin levels and paraoxonase activity with metabolic and cardiovascular risk factors in females treated with psychiatric drugs
    Aliye Ozenoglu
    Department of Psychiatry, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
    Clinics (Sao Paulo) 63:651-60. 2008
    ..The aim of this study was to investigate serum leptin, adiponectin and paraoxonase1 levels in adult females receiving pharmacotherapy for various psychiatric disorders...
  61. ncbi request reprint Depression, nutritional status, and serum cytokines in peritoneal dialysis patients: is there a relationship?
    Betul Kalender
    Department of Nephrology, Medical Faculty, University of Kocaeli, Kocaeli, Turkey
    Perit Dial Int 27:593-5. 2007
  62. ncbi request reprint Plasma adhesion and inflammation markers: asymmetrical dimethyl-L-arginine and secretory phospholipase A2 concentrations before and after laparoscopic gastric banding in morbidly obese patients
    Dildar Konukoglu
    Istanbul University, Cerrahpasa Medical Faculty, Department of Biochemistry, Istanbul, Turkey
    Obes Surg 17:672-8. 2007
    ..The aim of this study was to examine the relationship between subclinical inflammation and weight loss by laparoscopic adjustable gastric banding (LAGB)...
  63. ncbi request reprint The effect of halofuginone, a specific inhibitor of collagen type 1 synthesis, in the prevention of pancreatic fibrosis in an experimental model of severe hyperstimulation and obstruction pancreatitis
    Adem Karatas
    Department of General Surgery, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
    J Surg Res 148:7-12. 2008
    ..The aim of this paper is to assess the effects of halofuginone, a specific inhibitor of synthesis of collagen Type 1, on fibrogenetic process in an experimental model of early pancreatic fibrosis...
  64. doi request reprint The role of matrix metalloproteinases in recurrent tonsillitis
    Engin Acioglu
    Department of Otolaryngology, Istanbul Training and Research Hospital, Turkey
    Int J Pediatr Otorhinolaryngol 74:535-9. 2010
    ....
  65. ncbi request reprint The biochemical analysis of tympanosclerotic plaques
    Fehmi Doner
    Department of Otolaryngology, Medical Faculty, Suleyman Demirel University, Isparta, Turkey
    Otolaryngol Head Neck Surg 128:742-5. 2003
    ..We conducted a biochemical analysis of tympanosclerotic (TS) plaques...
  66. ncbi request reprint Serum paraoxonase (a high-density lipoprotein-associated lipophilic antioxidant) activity and lipid profile in experimental acute pancreatitis
    Ethem Unal
    Department of Surgery, Haydarpasa Numune Research and Training Hospital, Haydarpasa, Istanbul, Turkey
    Pancreas 31:84-7. 2005
    ..This study was designed to determine the serum lipid profile and the activity of paraoxonase (PON1, the lipophilic antioxidant component of high-density lipoprotein [HDL]-cholesterol) in acute pancreatitis...
  67. ncbi request reprint Effects of iloprost on visual evoked potentials and brain tissue oxidative stress after bilateral common carotid artery occlusion
    Erman Aytac
    Istanbul University, Cerrahpasa Medical Faculty, Department of Physiology, Cerrahpasa, Istanbul, Turkey
    Prostaglandins Leukot Essent Fatty Acids 74:373-8. 2006
    ..Low Cu-Zn SOD levels and impaired VEPs remained after iloprost treatment. Iloprost treatment may protect the brain tissue from oxidative damage during cerebral hypoperfusion...
  68. ncbi request reprint Effects of gender on stress ulcer formation in rats
    Ezel Uslu
    Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Bahcesehir, Turkey
    Tohoku J Exp Med 197:17-26. 2002
    ..Sex differences do not interfere stress ulcer formation. SOD activity in rat gastric tissue has varied significantly by hormonal milieu...
  69. ncbi request reprint Circulating levels of adiponectin, orexin-A, ghrelin and the antioxidant paraoxonase-1 in metabolic syndrome
    O Tabak
    Istanbul Education and Research Hospital Internal Medicine Clinic, Istanbul, Turkey
    Minerva Med 103:323-9. 2012
    ..We measured and compared plasma concentrations of adiponectin, orexin-A, ghrelin and the antioxidant paraoxonase-1 (PON1) between patients with metabolic syndrome (MS) and healthy controls...
  70. ncbi request reprint An alternative sutureless repair technique with amelogenin for duodenal perforation
    A Karatas
    Department of General Surgery, Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey
    Acta Chir Belg 112:121-5. 2012
    ..The aim of this study is to introduce a new technique for the closure of duodenal perforation using a novel recombinant enamel protein called amelogenin...
  71. ncbi request reprint Lichtenstein or darn procedure in inguinal hernia repair: a prospective randomized comparative study
    H F Kucuk
    Kartal Research and Education Hospital, Petrol is mh Sh Dursun Bakan Sk Hilal Sit A Blok D 21, 34862 Kartal, Istanbul, Turkey
    Hernia 14:357-60. 2010
    ..The aim of this study was to assess the outcome of patients with inguinal hernia where the Moloney darn or Lichtenstein procedure was used as the surgical choice...
  72. ncbi request reprint Placental stem cell markers in pre-eclampsia
    Ali Benian
    Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    Int J Gynaecol Obstet 100:228-33. 2008
    ..To investigate the placental CD34, CD44, and leukemia inhibitory factor (LIF) levels in normotensive and pre-eclamptic women...
  73. doi request reprint Gender-dependent oxidative variations in liver of aged rats
    Seval Aydin
    Cerrahpasa Faculty of Medicine, Department of Biochemistry, Istanbul University, Istanbul, Turkey
    Biogerontology 11:335-46. 2010
    ..Our results demonstrated greater susceptibility to hepatic oxidative damage in females than in males. This appears to contradict the general assumption that females are less susceptible to oxidative injury than males are...
  74. doi request reprint The effects of resveratrol on vasospasm after experimental subarachnoidal hemorrhage in rats
    Alper Karaoglan
    Department of Neurosurgery, Taksim Education and Research Hospital, Istanbul, Turkey
    Surg Neurol 70:337-43. 2008
    ..We investigated the efficacy of resveratrol, a stilbene polyphenol and tyrosine kinase inhibitor that occurs naturally in grapes and red wine, in a murine basilar artery vasospasm model...
  75. doi request reprint Donor heart preservation with iloprost supplemented St. Thomas Hospital cardioplegic solution in isolated rat hearts
    Burcak Deniz Dedeoglu
    Department of Pharmacology, Cerrahpasa Medical Faculty, Istanbul University, Turkey
    Prostaglandins Leukot Essent Fatty Acids 78:415-21. 2008
    ..According to our results, iloprost supplementation had mild but significant improvement in postischemic values in mechanical and oxidative stress parameters, resulting in better heart preservation...
  76. ncbi request reprint Pathologic alterations detected in acute pancreatitis induced by sodium taurocholate in rats and therapeutic effects of curcumin, ciprofloxacin and metronidazole combination
    Ahmet Gülçubuk
    Department of Pathology, Faculty of Veterinary Medicine, Istanbul University, Istanbul, Turkey
    Pancreatology 5:345-53. 2005
    ..The objective of this study therefore was to investigate the effectiveness of ciprofloxacin and metronidazole combination and curcumin together in the treatment of acute pancreatitis...
  77. ncbi request reprint Effects of lipopolysaccharide on blood-brain barrier permeability during pentylenetetrazole-induced epileptic seizures in rats
    Nadir Arican
    Department of Forensic Medicine, Istanbul Faculty of Medicine, Istanbul University, Capa 34390, Istanbul, Turkey
    Life Sci 79:1-7. 2006
    ..We suggest that LPS may provide protective effects on the BBB integrity during epileptic seizures through transcellular pathway, since the paracellular route remained unaffected by LPS and LPS plus PTZ...
  78. ncbi request reprint Neuroprotective effects of GYKI 52466 on experimental spinal cord injury in rats
    Ahmet Colak
    Neurosurgery and Pathology Clinics, Taksim Education and Research Hospital, Istanbul, Turkey
    J Neurosurg 98:275-81. 2003
    ..The authors investigated the neuroprotective effects of GYKI 52466, a 2,3-benzodiazepine that is a selective and potent AMPA receptor antagonist, in a rat spinal cord trauma model...
  79. ncbi request reprint Results of tetanus vaccination in sarcoidosis
    E C Seyhan
    Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Istanbul, Turkey
    Sarcoidosis Vasc Diffuse Lung Dis 29:3-10. 2012
    ..We evaluated humoral immunity by vaccinating patients with sarcoidosis against tetanus...
  80. ncbi request reprint Effects of seprafilm and heparin in combination on intra-abdominal adhesions
    L Kaptanoglu
    Kartal Research and Education Hospital, Istanbul, Turkey
    Eur Surg Res 41:203-7. 2008
    ..The aim of this study was to assess the effects of heparin and Seprafilm, which is considered the gold standard, on the prevention of intra-abdominal adhesions...
  81. ncbi request reprint Potential role of matrix metalloproteinase-2,-9 and tissue inhibitors of metalloproteinase-1,-2 in exudative pleural effusions
    S Vatansever
    Istanbul University, Istanbul Medical Faculty, Department of Internal Medicine, Istanbul, Turkey
    Clin Invest Med 32:E293-300. 2009
    ..To investigate diagnostic values of pleural fluid matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitors of metalloproteinase-1 (TIMP-1) and TIMP-2 measurements in tuberculous pleurisy(TP) and malignat pleurisy (MP)...
  82. ncbi request reprint Vascular endothelial growth factor in adnexal masses
    F Demirkiran
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    Int J Gynaecol Obstet 83:53-8. 2003
    ..To determine cyst fluid and serum vascular endothelial growth factor (VEGF) concentrations in patients with ovarian masses and to investigate the efficiency of this modulator in the clinical management of cystic pelvic masses...
  83. ncbi request reprint Rosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis
    Veysel Tahan
    Department of Gastroenterology, Marmara University School of Medicine, Istanbul, Turkey
    Dig Dis Sci 52:3465-72. 2007
    ..Our preliminary study is the first to show the anti-inflammatory effects of rosiglitazone in NASH. Rosiglitazone's effect on cytokines may be a key mechanism of its anti-inflammatory effect in NASH...
  84. ncbi request reprint The effects of the immunomodulators on the colonic anastomosis in an experimental model of intraperitoneal sepsis
    Erdal Ergin
    Department of General Surgery, Cerrahpasa Medical School of Istanbul University, Istanbul, Turkey
    Hepatogastroenterology 51:439-42. 2004
    ..The present study examined the effects of G-CSF and Levamisole used as immunomodulators on the colonic anastomosis healing in the presence of an intraabdominal infection...
  85. ncbi request reprint Osteoporotic cytokines and bone metabolism on rats with induced hyperthyroidism; changes as a result of reversal to euthyroidism
    Gonul Simsek
    Istanbul University, Turkey
    Chin J Physiol 46:181-6. 2003
    ..05). Our findings showed that the deleterious effect on bone metabolism in hyperthyroidism might be mediated by cytokines and the increased bone turnover in hyperthyroidism failed to decrease despite euthyroidism...
  86. ncbi request reprint Effects of osteoporotic cytokines in ovary-intact and ovariectomised rats with induced hyperthyroidism; is skeletal responsiveness to thyroid hormone altered in estrogen deficiency?
    Gonul Simsek
    Department of Physiology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Tohoku J Exp Med 201:81-9. 2003
    ..In sham-operated rats there was no change in any of the parameters compared with initial values. Thyroid hormones may not be effective on bone metabolism in estrogen deficiency...
  87. ncbi request reprint Mechanical bowel preparation with different solutions in rats with selective left colonic ischemia and reperfusion injury
    Bilgi Baca
    Department of Surgery, Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey
    Am J Surg 196:418-24. 2008
    ..The aim of this study was to evaluate the effects of preoperative mechanical bowel preparation (MBP) on colonic ischemia/reperfusion (I/R) injury...
  88. doi request reprint Relation of plasma protein oxidation parameters and paraoxonase activity in the ageing population
    Ufuk Cakatay
    Isatanbul University, Isatanbul Faculty of Medicine, Istanbul, Turkey
    Clin Exp Med 8:51-7. 2008
    ....
  89. doi request reprint Iloprost pretreatment before unilateral nephrectomy: an experimental study in rats
    Erman Aytac
    Department of General Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    Asian J Surg 31:69-74. 2008
    ..To evaluate the effects of iloprost administration before unilateral nephrectomy on postoperative interleukin-6 (IL-6), nitric oxide (NO), and oxidant/antioxidant status...
  90. ncbi request reprint The oxidant-antioxidant balance in systemic sclerosis cases with interstitial lung involvement
    Benan Musellim
    Department of Pulmonary Diseases, Istanbul University, Cerrahpasa Medical Faculty, Adnan Kahveci Bulvari Rontgen sokak, No 34 23 Bahcelievler, 34180, Istanbul, Turkey
    Rheumatol Int 27:163-7. 2006
    ..05). In our study, the oxidant burden in SS patients with interstitial lung involvement was found to be increased; however no correlation was detected between the severity of lung involvement and oxidant-antioxidant levels...
  91. ncbi request reprint The influence of hemodialysis on serum sialic acid levels in chronic renal failure
    E Uslu
    Department of Biochemistry, Cerrahpasa Medical School, Istanbul University, Çınar 8, Villa 9, Bahcesehir, Tel 90 212 669 0408 Fax 90 212 247 3993 e mail TR İstanbul
    Clin Exp Nephrol 6:154-7. 2002
    ..Serum sialic acid level is minimally influenced by hemodialysis performed with a hemophane membrane. ..
  92. ncbi request reprint Relation of protein oxidation parameters and disease activity in patients with Behçet's disease
    S Ozyazgan
    Department of Medical Pharmacology and Clinical Pharmacology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Clin Lab 59:819-25. 2013
    ....
  93. ncbi request reprint An evaluation of low molecular weight heparin and hyperbaric oxygen treatment in the prevention of intra-abdominal adhesions and wound healing
    Soykan Arikan
    General Surgery Clinic, Haseki Education and Research Hospital, Istanbul, Turkey
    Am J Surg 189:155-60. 2005
    ..To prevent adhesions, an experimental study was planned to designate the effects of low molecular weight (LMW) heparins and hyperbaric oxygen (HBO) therapy both on the formation of adhesions and wound healing...
  94. ncbi request reprint YKL-40 levels in the cerebrospinal fluid and serum of patients with aneurysmal subarachnoid hemorrhage: preliminary results
    Mehmet Yasar Kaynar
    Department of Neurosurgery Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
    J Clin Neurosci 12:754-7. 2005
    ..The authors believe that YKL-40 is expressed in cerebrospinal fluid due to stress on neural structures while a damaged blood-brain barrier allows entry of neutrophils and macrophages from the systemic circulation...
  95. ncbi request reprint Relative erythrocytosis of patients with end stage renal failure undergoing CAPD
    Mehmet Riza Altiparmak
    Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
    Ren Fail 24:29-35. 2002
    ..Patients treated with continuous ambulatory peritoneal dialysis (CAPD) having relative erythrocytosis were studied in order to determine the factors that would be responsible...
  96. ncbi request reprint Effects of atorvastatin on blood-brain barrier permeability during L-NAME hypertension followed by angiotensin-II in rats
    Rivaze Kalayci
    Research Institute for Experimental Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Brain Res 1042:184-93. 2005
    ....
  97. ncbi request reprint Systemic inflammatory response after laparoscopic and open application of adjustable banding for morbidly obese patients
    Kagan Zengin
    Department of General Surgery, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
    Obes Surg 12:276-9. 2002
    ..The aim of this study was to investigate the systemic inflammatory response, after laparoscopic and open stoma-adjustable silicone band application, which is thought to be mediated by cytokines...
  98. ncbi request reprint Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus
    Omur Tabak
    Istanbul Education and Research Hospital, Internal Medicine Clinic, Istanbul, Turkey
    Clin Invest Med 34:E163-71. 2011
    ..The purpose of this study was to determine the effects of diabetic complications on oxidation of proteins, lipids, and DNA and to investigate the relationship between oxidative damage markers and clinical parameters...
  99. ncbi request reprint The effects of nebivolol on apoptosis in a rat infarct model
    Guldem Mercanoglu
    Department of Pharmacology, Faculty of Pharmacy, Yeditepe University, Kayisdagi, Istanbul, Turkey
    Circ J 72:660-70. 2008
    ..In the present study, nitric oxide (NO) was investigated to see if it mediated effects of nebivolol on apoptosis in the rat myocardial infarction (MI) model...
  100. doi request reprint Hyperhomocysteinemia in inflammatory bowel disease patients without past intestinal resections: correlations with cobalamin, pyridoxine, folate concentrations, acute phase reactants, disease activity, and prior thromboembolic complications
    Yusuf Erzin
    Department of Gastroenterology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
    J Clin Gastroenterol 42:481-6. 2008
    ..The aim of this study was to identify the prevalence, risk factors of hyperhomocysteinemia and its correlation with prior thromboembolic events in an IBD cohort without past intestinal resections...
  101. ncbi request reprint Urinary N-acetyl-beta-D-glucosaminidase levels in patients with laryngeal squamous cell carcinoma
    Fatih Oktem
    Department of Biochemistry, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
    J Otolaryngol 36:233-9. 2007
    ..This study aimed to assess the clinical value of measuring urinary N-acetyl-beta-d-glucosaminidase (U-NAG) levels in patients with laryngeal squamous cell carcinoma...