Kosaku Uyeda

Summary

Publications

  1. ncbi request reprint Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage
    Kosaku Uyeda
    Department of Biochemistry, Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, 75216, USA
    Biochem Pharmacol 63:2075-80. 2002
  2. pmc Importin-alpha protein binding to a nuclear localization signal of carbohydrate response element-binding protein (ChREBP)
    Qiang Ge
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 286:28119-27. 2011
  3. pmc Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation
    Haruhiko Sakiyama
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 283:24899-908. 2008
  4. pmc Structural characterization of a unique interface between carbohydrate response element-binding protein (ChREBP) and 14-3-3β protein
    Qiang Ge
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 287:41914-21. 2012
  5. ncbi request reprint Carbohydrate-response element-binding protein deletion alters substrate utilization producing an energy-deficient liver
    Shawn C Burgess
    Department of Biochemistry, Advanced Imaging Research Center, University of Texas Southwestern Medical School and Veterans Affairs, 5323 Harry Hines Blvd, Dallas, TX 75390 8854, USA
    J Biol Chem 283:1670-8. 2008
  6. ncbi request reprint Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase
    Takumi Kawaguchi
    Department of Biochemistry, Dallas Veterans Affairs Medical Center and University of Texas Southwestern Medical Center, Dallas, Texas 75223, USA
    J Biol Chem 277:3829-35. 2002
  7. ncbi request reprint Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice
    Katsumi Iizuka
    Department of Biochemistry, University of Texas Southwestern Medical School, Dallas, TX 75216, USA
    Am J Physiol Endocrinol Metab 291:E358-64. 2006
  8. pmc Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
    Katsumi Iizuka
    Department of Biochemistry, University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Proc Natl Acad Sci U S A 101:7281-6. 2004
  9. pmc Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription
    Seiji Ishii
    Departments of Biochemistry and Internal Medicine, University of Texas Southwestern Medical School, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Proc Natl Acad Sci U S A 101:15597-602. 2004
  10. pmc Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver
    Tsutomu Kabashima
    Dallas Veterans Affairs Medical Center and Department of Biochemistry, University of Texas Southwestern Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Proc Natl Acad Sci U S A 100:5107-12. 2003

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage
    Kosaku Uyeda
    Department of Biochemistry, Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, 75216, USA
    Biochem Pharmacol 63:2075-80. 2002
    ..ChREBP is able to control transcription of lipogenic enzyme genes in response to nutritional and hormonal inputs, and may play an important role in disease states such as diabetes, obesity, and hypertension...
  2. pmc Importin-alpha protein binding to a nuclear localization signal of carbohydrate response element-binding protein (ChREBP)
    Qiang Ge
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 286:28119-27. 2011
    ....
  3. pmc Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation
    Haruhiko Sakiyama
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 283:24899-908. 2008
    ..These results suggest that interactions with importin alpha and 14-3-3 regulate movement of ChREBP into and out of the nucleus, respectively, and that these interactions are regulated by the ChREBP phosphorylation status...
  4. pmc Structural characterization of a unique interface between carbohydrate response element-binding protein (ChREBP) and 14-3-3β protein
    Qiang Ge
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 287:41914-21. 2012
    ....
  5. ncbi request reprint Carbohydrate-response element-binding protein deletion alters substrate utilization producing an energy-deficient liver
    Shawn C Burgess
    Department of Biochemistry, Advanced Imaging Research Center, University of Texas Southwestern Medical School and Veterans Affairs, 5323 Harry Hines Blvd, Dallas, TX 75390 8854, USA
    J Biol Chem 283:1670-8. 2008
    ..Overall, the shift from fat utilization to pyruvate and lactate utilization resulted in a decrease in the energy of ATP hydrolysis and a hypo-energetic state in the livers of ChREBP(-/-) mice...
  6. ncbi request reprint Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase
    Takumi Kawaguchi
    Department of Biochemistry, Dallas Veterans Affairs Medical Center and University of Texas Southwestern Medical Center, Dallas, Texas 75223, USA
    J Biol Chem 277:3829-35. 2002
    ..AMPK was activated by the increased AMP that was generated by the fatty acid activation...
  7. ncbi request reprint Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice
    Katsumi Iizuka
    Department of Biochemistry, University of Texas Southwestern Medical School, Dallas, TX 75216, USA
    Am J Physiol Endocrinol Metab 291:E358-64. 2006
    ..The results of this study suggest that inactivation of ChREBP expression not only reduces fat synthesis and obesity in ob/ob mice but also results in improved glucose tolerance and appetite control...
  8. pmc Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
    Katsumi Iizuka
    Department of Biochemistry, University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Proc Natl Acad Sci U S A 101:7281-6. 2004
    ....
  9. pmc Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription
    Seiji Ishii
    Departments of Biochemistry and Internal Medicine, University of Texas Southwestern Medical School, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Proc Natl Acad Sci U S A 101:15597-602. 2004
    ..In vivo binding of ChREBP to ACC, FAS, and LPK gene promoters in intact liver nuclei from rats fed a high-carbohydrate diet was demonstrated by using a formaldehyde crosslinking and chromatin immunoprecipitation procedure...
  10. pmc Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver
    Tsutomu Kabashima
    Dallas Veterans Affairs Medical Center and Department of Biochemistry, University of Texas Southwestern Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Proc Natl Acad Sci U S A 100:5107-12. 2003
    ..Thus, we propose that the same Xu5P-activated PPase controls both acute and long-term regulation of glucose metabolism and fat synthesis...
  11. ncbi request reprint Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis
    Kosaku Uyeda
    Dallas Veterans Affairs Medical Center, Dallas, Texas 75390, USA
    Cell Metab 4:107-10. 2006
    ..Further understanding of this metabolic cascade should provide insights on conditions such as fatty liver, obesity, and the metabolic syndrome...
  12. ncbi request reprint Identification of Translin/Trax complex as a glucose response element binding protein in liver
    Ru Feng Wu
    Department of Internal Medicine, University of Texas Southwestern and The Dallas Veterans Affairs Medical Center, Box 151, 4500 S Lancaster Rd, Dallas, TX 75216, USA
    Biochim Biophys Acta 1624:29-35. 2003
    ..Our findings indicate that the Translin/Trax complex constitutes the previously described GRBP, and that this complex binds the GRE of the L-PK gene with high affinity. The precise physiologic role of GRBP, however, remains unclear...
  13. ncbi request reprint Increased hepatic fructose 2,6-bisphosphate after an oral glucose load does not affect gluconeogenesis
    Eunsook S Jin
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 278:28427-33. 2003
    ..Liver glycogen repletion was also brisk throughout the study period, reaching approximately 30 micromol/g at 3 h. These data demonstrate that Fru-2,6-P2 does not inhibit gluconeogenesis significantly in vivo...
  14. ncbi request reprint Identification and characterization of the hypoxia-responsive element of the human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene
    Masashi Fukasawa
    Department of Microbiology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Biochem 136:273-7. 2004
    ..These results suggest that the sequence 5'-ACGTGNNNNACGTG-3' in the HP2K enhancer is the authentic HRE consensus motif that mediates increased transcription, under hypoxic conditions, via HIF-1...

Research Grants9

  1. Carbohydrate Regulation of Hepatic Gene Expression
    Kosaku Uyeda; Fiscal Year: 2010
    ..This knowledge will provide information that may be useful in developing strategies for the prevention and treatment of obesity. ..
  2. STRUCTURAL ANALYSIS OF 6-PF-2-K/FRU-2,6-P2ASE ISOZYMES
    Kosaku Uyeda; Fiscal Year: 1999
    ..In addition, they will crystallize and solve the structure of the liver, heart, and placenta isozymes, in both their phosphorylated and unphosphorylated states. ..
  3. STRUCTURAL ANALYSIS OF 6-PF-2-K/FRU-2,6-P2ASE ISOZYMES
    Kosaku Uyeda; Fiscal Year: 2000
    ..In addition, they will crystallize and solve the structure of the liver, heart, and placenta isozymes, in both their phosphorylated and unphosphorylated states. ..
  4. STRUCTURAL ANALYSIS OF 6-PF-2-K/FRU-2,6-P2ASE ISOZYMES
    Kosaku Uyeda; Fiscal Year: 2001
    ..In addition, they will crystallize and solve the structure of the liver, heart, and placenta isozymes, in both their phosphorylated and unphosphorylated states. ..
  5. STRUCTURAL ANALYSIS OF 6-PF-2-K/FRU-2,6-P2ASE ISOZYMES
    Kosaku Uyeda; Fiscal Year: 2002
    ..In addition, they will crystallize and solve the structure of the liver, heart, and placenta isozymes, in both their phosphorylated and unphosphorylated states. ..
  6. Carbohydrate Regulation of Hepatic Gene Expression
    Kosaku Uyeda; Fiscal Year: 2004
    ..Other possibility is to produce a combination of ChREBP-/- and SREBP-/- that inhibit the major portion of lipogenesis in liver. ..
  7. Carbohydrate Regulation of Hepatic Gene Expression
    Kosaku Uyeda; Fiscal Year: 2005
    ..Other possibility is to produce a combination of ChREBP-/- and SREBP-/- that inhibit the major portion of lipogenesis in liver. ..
  8. Carbohydrate Regulation of Hepatic Gene Expression
    Kosaku Uyeda; Fiscal Year: 2006
    ..Other possibility is to produce a combination of ChREBP-/- and SREBP-/- that inhibit the major portion of lipogenesis in liver. ..
  9. Carbohydrate Regulation of Hepatic Gene Expression
    Kosaku Uyeda; Fiscal Year: 2007
    ..Other possibility is to produce a combination of ChREBP-/- and SREBP-/- that inhibit the major portion of lipogenesis in liver. ..