Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storageKosaku Uyeda
Department of Biochemistry, Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, 75216, USA
Biochem Pharmacol 63:2075-80. 2002
..ChREBP is able to control transcription of lipogenic enzyme genes in response to nutritional and hormonal inputs, and may play an important role in disease states such as diabetes, obesity, and hypertension...
Importin-alpha protein binding to a nuclear localization signal of carbohydrate response element-binding protein (ChREBP)Qiang Ge
Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
J Biol Chem 286:28119-27. 2011
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- Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation
Haruhiko Sakiyama
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 283:24899-908. 2008
..These results suggest that interactions with importin alpha and 14-3-3 regulate movement of ChREBP into and out of the nucleus, respectively, and that these interactions are regulated by the ChREBP phosphorylation status...
- Carbohydrate-response element-binding protein deletion alters substrate utilization producing an energy-deficient liver
Shawn C Burgess
Department of Biochemistry, Advanced Imaging Research Center, University of Texas Southwestern Medical School and Veterans Affairs, 5323 Harry Hines Blvd, Dallas, TX 75390 8854, USA
J Biol Chem 283:1670-8. 2008
..Overall, the shift from fat utilization to pyruvate and lactate utilization resulted in a decrease in the energy of ATP hydrolysis and a hypo-energetic state in the livers of ChREBP(-/-) mice...
- Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase
Takumi Kawaguchi
Department of Biochemistry, Dallas Veterans Affairs Medical Center and University of Texas Southwestern Medical Center, Dallas, Texas 75223, USA
J Biol Chem 277:3829-35. 2002
..AMPK was activated by the increased AMP that was generated by the fatty acid activation...
- Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice
Katsumi Iizuka
Department of Biochemistry, University of Texas Southwestern Medical School, Dallas, TX 75216, USA
Am J Physiol Endocrinol Metab 291:E358-64. 2006
..The results of this study suggest that inactivation of ChREBP expression not only reduces fat synthesis and obesity in ob/ob mice but also results in improved glucose tolerance and appetite control...
- Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
Katsumi Iizuka
Department of Biochemistry, University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
Proc Natl Acad Sci U S A 101:7281-6. 2004
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- Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver
Tsutomu Kabashima
Dallas Veterans Affairs Medical Center and Department of Biochemistry, University of Texas Southwestern Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
Proc Natl Acad Sci U S A 100:5107-12. 2003
..Thus, we propose that the same Xu5P-activated PPase controls both acute and long-term regulation of glucose metabolism and fat synthesis...
- Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription
Seiji Ishii
Departments of Biochemistry and Internal Medicine, University of Texas Southwestern Medical School, 4500 South Lancaster Road, Dallas, TX 75216, USA
Proc Natl Acad Sci U S A 101:15597-602. 2004
..In vivo binding of ChREBP to ACC, FAS, and LPK gene promoters in intact liver nuclei from rats fed a high-carbohydrate diet was demonstrated by using a formaldehyde crosslinking and chromatin immunoprecipitation procedure...
- Identification of Translin/Trax complex as a glucose response element binding protein in liver
Ru Feng Wu
Department of Internal Medicine, University of Texas Southwestern and The Dallas Veterans Affairs Medical Center, Box 151, 4500 S Lancaster Rd, Dallas, TX 75216, USA
Biochim Biophys Acta 1624:29-35. 2003
..Our findings indicate that the Translin/Trax complex constitutes the previously described GRBP, and that this complex binds the GRE of the L-PK gene with high affinity. The precise physiologic role of GRBP, however, remains unclear...
- Identification and characterization of the hypoxia-responsive element of the human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene
Masashi Fukasawa
Department of Microbiology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
J Biochem 136:273-7. 2004
..These results suggest that the sequence 5'-ACGTGNNNNACGTG-3' in the HP2K enhancer is the authentic HRE consensus motif that mediates increased transcription, under hypoxic conditions, via HIF-1...
- Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis
Kosaku Uyeda
Dallas Veterans Affairs Medical Center, Dallas, Texas 75390, USA
Cell Metab 4:107-10. 2006
..Further understanding of this metabolic cascade should provide insights on conditions such as fatty liver, obesity, and the metabolic syndrome...
- Increased hepatic fructose 2,6-bisphosphate after an oral glucose load does not affect gluconeogenesis
Eunsook S Jin
The Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
J Biol Chem 278:28427-33. 2003
..Liver glycogen repletion was also brisk throughout the study period, reaching approximately 30 micromol/g at 3 h. These data demonstrate that Fru-2,6-P2 does not inhibit gluconeogenesis significantly in vivo...
