Victor V Uteshev

Summary

Publications

  1. doi request reprint The therapeutic promise of positive allosteric modulation of nicotinic receptors
    Victor V Uteshev
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA Electronic address
    Eur J Pharmacol 727:181-5. 2014
  2. pmc Somatic integration of single ion channel responses of α7 nicotinic acetylcholine receptors enhanced by PNU-120596
    Victor V Uteshev
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 7:e32951. 2012
  3. pmc α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum
    Victor V Uteshev
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Adv Exp Med Biol 740:603-38. 2012
  4. pmc Reduced GABA(A) receptor-mediated tonic inhibition in aged rat auditory thalamus
    Ben D Richardson
    Department of Pharmacology, School of Medicine, Southern Illinois University, Springfield, Illinois 62794, USA
    J Neurosci 33:1218-27a. 2013
  5. pmc A type-II positive allosteric modulator of α7 nAChRs reduces brain injury and improves neurological function after focal cerebral ischemia in rats
    Fen Sun
    University of North Texas Health Science Center, Department of Pharmacology and Neuroscience, Fort Worth, TX, USA
    PLoS ONE 8:e73581. 2013
  6. pmc A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia
    Bopanna I Kalappa
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, USA
    Br J Pharmacol 169:1862-78. 2013
  7. pmc Responsiveness to nicotine of neurons of the caudal nucleus of the solitary tract correlates with the neuronal projection target
    Lin Feng
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    J Neurophysiol 108:1884-94. 2012
  8. pmc Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596
    Bopanna I Kalappa
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 5:e13964. 2010
  9. pmc Mechanisms of facilitation of synaptic glutamate release by nicotinic agonists in the nucleus of the solitary tract
    Bopanna I Kalappa
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
    Am J Physiol Cell Physiol 301:C347-61. 2011
  10. pmc Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea]
    Alexander G Gusev
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    J Pharmacol Exp Ther 332:588-98. 2010

Collaborators

Detail Information

Publications13

  1. doi request reprint The therapeutic promise of positive allosteric modulation of nicotinic receptors
    Victor V Uteshev
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA Electronic address
    Eur J Pharmacol 727:181-5. 2014
    ..In this review, I will summarize the existing trends in therapeutic applications of nicotinic PAMs. ..
  2. pmc Somatic integration of single ion channel responses of α7 nicotinic acetylcholine receptors enhanced by PNU-120596
    Victor V Uteshev
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 7:e32951. 2012
    ..01 mV/µm). These research efforts could benefit optimization of potential α7-PAM-based therapies...
  3. pmc α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum
    Victor V Uteshev
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Adv Exp Med Biol 740:603-38. 2012
    ..In this review, the focus is placed on α7 nAChR-mediated currents and Ca(2+) influx and how this source of Ca(2+) entry compares to NMDA receptors in supporting cytosolic Ca(2+) homeostasis, neuronal function and survival...
  4. pmc Reduced GABA(A) receptor-mediated tonic inhibition in aged rat auditory thalamus
    Ben D Richardson
    Department of Pharmacology, School of Medicine, Southern Illinois University, Springfield, Illinois 62794, USA
    J Neurosci 33:1218-27a. 2013
    ..These data suggest that selective GABA(A)R subtype agonists or modulators might be used to augment MGB inhibitory neurotransmission, improving speech understanding, sensory gating, and slow-wave sleep for a subset of elderly individuals...
  5. pmc A type-II positive allosteric modulator of α7 nAChRs reduces brain injury and improves neurological function after focal cerebral ischemia in rats
    Fen Sun
    University of North Texas Health Science Center, Department of Pharmacology and Neuroscience, Fort Worth, TX, USA
    PLoS ONE 8:e73581. 2013
    ....
  6. pmc A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia
    Bopanna I Kalappa
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, USA
    Br J Pharmacol 169:1862-78. 2013
    ..This proof-of-concept study presents a novel neuroprotective paradigm that converts endogenous choline/ACh into potent neuroprotective agents in cerebral ischaemia by inhibiting α7 nAChR desensitization using PNU-120596...
  7. pmc Responsiveness to nicotine of neurons of the caudal nucleus of the solitary tract correlates with the neuronal projection target
    Lin Feng
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    J Neurophysiol 108:1884-94. 2012
    ..These results may support development of therapeutic strategies for selective targeting of specific autonomic pathways and impaired autonomic homeostasis...
  8. pmc Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596
    Bopanna I Kalappa
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 5:e13964. 2010
    ....
  9. pmc Mechanisms of facilitation of synaptic glutamate release by nicotinic agonists in the nucleus of the solitary tract
    Bopanna I Kalappa
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
    Am J Physiol Cell Physiol 301:C347-61. 2011
    ..Expanding the knowledge of mechanisms and pharmacology of nAChRs in the caudal NTS should benefit therapeutic approaches aimed at restoring impaired autonomic homeostasis...
  10. pmc Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea]
    Alexander G Gusev
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    J Pharmacol Exp Ther 332:588-98. 2010
    ..In certain neurological disorders, this activation may be therapeutically beneficial, more efficacious, and safer than treatments with nAChR agonists...
  11. pmc Evaluation of Ca2+ permeability of nicotinic acetylcholine receptors in hypothalamic histaminergic neurons
    Victor V Uteshev
    Southern Illinois University School of Medicine, Department of Pharmacology, Springfield, IL 62794, USA
    Acta Biochim Biophys Sin (Shanghai) 42:8-20. 2010
    ..Therefore, these results demonstrate that native TM nAChRs are highly Ca(2+) permeable, but approximately 1.4 fold less permeable to Ca(2+) than native hippocampal pyramidal NMDA receptors...
  12. pmc The dual effect of PNU-120596 on α7 nicotinic acetylcholine receptor channels
    Bopanna I Kalappa
    Southern Illinois University School of Medicine, Department of Pharmacology, MC 9629, PO Box 19629, Springfield, IL 62702, United States
    Eur J Pharmacol 718:226-34. 2013
    ....
  13. pmc Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus
    Ben D Richardson
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 6:e16508. 2011
    ..However, the presence of this unique type of inhibition has not been identified in auditory thalamus...