Somatic integration of single ion channel responses of α7 nicotinic acetylcholine receptors enhanced by PNU-120596Victor V Uteshev
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
PLoS ONE 7:e32951. 2012
..01 mV/µm). These research efforts could benefit optimization of potential α7-PAM-based therapies...
- α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum
Victor V Uteshev
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
Adv Exp Med Biol 740:603-38. 2012
..In this review, the focus is placed on α7 nAChR-mediated currents and Ca(2+) influx and how this source of Ca(2+) entry compares to NMDA receptors in supporting cytosolic Ca(2+) homeostasis, neuronal function and survival...
Reduced GABA(A) receptor-mediated tonic inhibition in aged rat auditory thalamusBen D Richardson
Department of Pharmacology, School of Medicine, Southern Illinois University, Springfield, Illinois 62794, USA
J Neurosci 33:1218-27a. 2013
..These data suggest that selective GABA(A)R subtype agonists or modulators might be used to augment MGB inhibitory neurotransmission, improving speech understanding, sensory gating, and slow-wave sleep for a subset of elderly individuals...
- Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596
Bopanna I Kalappa
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
PLoS ONE 5:e13964. 2010
....
- Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea]
Alexander G Gusev
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
J Pharmacol Exp Ther 332:588-98. 2010
..In certain neurological disorders, this activation may be therapeutically beneficial, more efficacious, and safer than treatments with nAChR agonists...
- Mechanisms of facilitation of synaptic glutamate release by nicotinic agonists in the nucleus of the solitary tract
Bopanna I Kalappa
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
Am J Physiol Cell Physiol 301:C347-61. 2011
..Expanding the knowledge of mechanisms and pharmacology of nAChRs in the caudal NTS should benefit therapeutic approaches aimed at restoring impaired autonomic homeostasis...
- Evaluation of Ca2+ permeability of nicotinic acetylcholine receptors in hypothalamic histaminergic neurons
Victor V Uteshev
Southern Illinois University School of Medicine, Department of Pharmacology, Springfield, IL 62794, USA
Acta Biochim Biophys Sin (Shanghai) 42:8-20. 2010
..Therefore, these results demonstrate that native TM nAChRs are highly Ca(2+) permeable, but approximately 1.4 fold less permeable to Ca(2+) than native hippocampal pyramidal NMDA receptors...
- Responsiveness to nicotine of neurons of the caudal nucleus of the solitary tract correlates with the neuronal projection target
Lin Feng
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, USA
J Neurophysiol 108:1884-94. 2012
..These results may support development of therapeutic strategies for selective targeting of specific autonomic pathways and impaired autonomic homeostasis...
- Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus
Ben D Richardson
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
PLoS ONE 6:e16508. 2011
..However, the presence of this unique type of inhibition has not been identified in auditory thalamus...
