L Zhang

Summary

Country: USA

Publications

  1. ncbi [Influence of different doxorubicin-salt aggregates on the leakage of liposomal doxorubicin in vitro and long circulation in vivo]
    Lei Zhang
    School of Pharmacy, Fudan University, Fudan-Pharmaco Targeting Drug Research Center, Shanghai 200032, China
    Yao Xue Xue Bao 39:1018-22. 2004
  2. ncbi Electroporation-mediated topical delivery of vitamin C for cosmetic applications
    L Zhang
    Genetronics Inc, San Diego, CA 92121, USA
    Bioelectrochem Bioenerg 48:453-61. 1999
  3. ncbi Accelerated immune response to DNA vaccines
    Lei Zhang
    Genetronics, Inc, San Diego, California 92121, USA
    DNA Cell Biol 22:815-22. 2003
  4. ncbi Enhancement of the effectiveness of electroporation-augmented cutaneous DNA vaccination by a particulate adjuvant
    Lei Zhang
    Genetronics, Inc, 11199 Sorrento Valley Road, San Diego, CA 92121 1334, USA
    Bioelectrochemistry 63:369-73. 2004
  5. ncbi Enhanced delivery of naked DNA to the skin by non-invasive in vivo electroporation
    Lei Zhang
    Department of Research and Development, Genetronics, Inc, San Diego, CA 92121 1334, USA
    Biochim Biophys Acta 1572:1-9. 2002
  6. ncbi Clinical evaluation of safety and human tolerance of electrical sensation induced by electric fields with non-invasive electrodes
    L Zhang
    Genetronics, Inc, 11199 Sorrento Valley Rd, San Diego, CA 92121 1334, USA
    Bioelectrochemistry 56:233-6. 2002
  7. ncbi GPCR expression in tissues and cells: are the optimal receptors being used as drug targets?
    P A Insel
    Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
    Br J Pharmacol 165:1613-6. 2012
  8. ncbi Bcl-2 protects lymphoma cells from apoptosis but not growth arrest promoted by cAMP and dexamethasone
    L Zhang
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0636, USA
    Am J Physiol Cell Physiol 281:C1642-7. 2001
  9. ncbi Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger
    P A Insel
    Department of Pharmacology, University of California, San Diego, La Jolla, 92093 0636, USA
    Acta Physiol (Oxf) 204:277-87. 2012
  10. ncbi Adenoviral delivery of human CDC5 promotes G2/M progression and cell division in neonatal ventricular cardiomyocytes
    S D Williams
    Cardiovascular Research Institute, University of California, San Francisco, CA 92121, USA
    Gene Ther 13:837-43. 2006

Collaborators

Detail Information

Publications69

  1. ncbi [Influence of different doxorubicin-salt aggregates on the leakage of liposomal doxorubicin in vitro and long circulation in vivo]
    Lei Zhang
    School of Pharmacy, Fudan University, Fudan-Pharmaco Targeting Drug Research Center, Shanghai 200032, China
    Yao Xue Xue Bao 39:1018-22. 2004
    ..13, 23.31 and 29.79 h, respectively. CONCLUSION: Doxorubicin showed different stability in liposomes with different inner water phases, the weaker the acid in the inner water phase, the stabler the liposome...
  2. ncbi Electroporation-mediated topical delivery of vitamin C for cosmetic applications
    L Zhang
    Genetronics Inc, San Diego, CA 92121, USA
    Bioelectrochem Bioenerg 48:453-61. 1999
    ..Assuming that this fresh skin model and certain experimental conditions simulate projected in vivo applications, EMTD of Vit. C may represent an alternative method to ameliorate skin aging...
  3. ncbi Accelerated immune response to DNA vaccines
    Lei Zhang
    Genetronics, Inc, San Diego, California 92121, USA
    DNA Cell Biol 22:815-22. 2003
    ..This method may become valuable for developing prophylactic as well as therapeutic vaccines. The rapid response may be of particular interest in countering bio-terrorism...
  4. ncbi Enhancement of the effectiveness of electroporation-augmented cutaneous DNA vaccination by a particulate adjuvant
    Lei Zhang
    Genetronics, Inc, 11199 Sorrento Valley Road, San Diego, CA 92121 1334, USA
    Bioelectrochemistry 63:369-73. 2004
    ..This method may become important for the development of fast-acting therapeutic and prophylactic vaccines...
  5. ncbi Enhanced delivery of naked DNA to the skin by non-invasive in vivo electroporation
    Lei Zhang
    Department of Research and Development, Genetronics, Inc, San Diego, CA 92121 1334, USA
    Biochim Biophys Acta 1572:1-9. 2002
    ..Our findings demonstrate the applicability of EP-enhanced DNA delivery to skin for gene therapy, DNA immunization and other areas...
  6. ncbi Clinical evaluation of safety and human tolerance of electrical sensation induced by electric fields with non-invasive electrodes
    L Zhang
    Genetronics, Inc, 11199 Sorrento Valley Rd, San Diego, CA 92121 1334, USA
    Bioelectrochemistry 56:233-6. 2002
    ..In previous animal experiments under analogous experimental conditions, the application of 50 V has been found effective for transdermal drug delivery into the penis...
  7. ncbi GPCR expression in tissues and cells: are the optimal receptors being used as drug targets?
    P A Insel
    Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
    Br J Pharmacol 165:1613-6. 2012
    ..Findings that define and characterize the most highly expressed GPCRs thus have important potential in terms of identifying new drug targets and novel therapies directed at a wide range of clinical disorders...
  8. ncbi Bcl-2 protects lymphoma cells from apoptosis but not growth arrest promoted by cAMP and dexamethasone
    L Zhang
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0636, USA
    Am J Physiol Cell Physiol 281:C1642-7. 2001
    ..The findings also indicate that glucocorticoid- and cAMP-mediated G(1) growth arrest is unaffected by Bcl-2 overexpression, even though increased Bcl-2 allows these lymphoma cells to resist necrosis and apoptosis...
  9. ncbi Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger
    P A Insel
    Department of Pharmacology, University of California, San Diego, La Jolla, 92093 0636, USA
    Acta Physiol (Oxf) 204:277-87. 2012
    ..In contrast, efforts to block PKA or stimulate Epac have the potential to be useful in diseases settings (such as heart failure) associated with cAMP-promoted apoptosis...
  10. ncbi Adenoviral delivery of human CDC5 promotes G2/M progression and cell division in neonatal ventricular cardiomyocytes
    S D Williams
    Cardiovascular Research Institute, University of California, San Francisco, CA 92121, USA
    Gene Ther 13:837-43. 2006
    ....
  11. ncbi Analysis of combinatorial chemistry samples by micellar electrokinetic chromatography
    P J Simms
    Department of Chemistry, Chugai Biopharmaceuticals, Inc, 6275 Nancy Ridge Drive, San Diego, California 92121, USA
    J Comb Chem 3:427-33. 2001
    ..The low background absorbency of the run buffer made for easy detection of compounds that absorbed at low UV wavelengths. The quick analysis time made this suitable for analysis of combinatorial chemistry samples...
  12. ncbi Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimurium
    H Kimura
    AntiCancer, Inc, San Diego, CA, USA
    Cell Prolif 43:41-8. 2010
    ..In this study, we measured antitumour efficacy of the Salmonella typhimurium A1-R tumour-targeting bacterium strain, administered systemically or intrathecally, to spinal cord cancer in orthotopic mouse models...
  13. ncbi SREBP-1c mediates the retinoid-dependent increase in fatty acid synthase promoter activity in HepG2
    Karim Roder
    School of Life Sciences, Heriot Watt University, Edinburgh, UK
    FEBS Lett 581:2715-20. 2007
    ..These data demonstrate that RXR ligands can stimulate the expression of a lipogenic gene solely by inducing transcription and cleavage of membrane-bound SREBP-1c...
  14. ncbi Immunogenicity of eight dormancy regulon-encoded proteins of Mycobacterium tuberculosis in DNA-vaccinated and tuberculosis-infected mice
    Virginie Roupie
    Mycobacterial Immunology, WIV Pasteur Institute Brussels, 642 Engelandstraat, B1180 Brussels, Belgium
    Infect Immun 75:941-9. 2007
    ..These findings have implications for proof-of-concept studies in mice mimicking tuberculosis (TB) latency models and their extrapolation to humans for potential new vaccination strategies against TB...
  15. ncbi T cell epitope-based peptide-DNA dual vaccine induces protective immunity against Schistosoma japonicum infection in C57BL/6J mice
    Lei Zhang
    Department of Pathogen Biology and Immunology, Jiangsu Province Laboratory of Pathogen Biology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu 210029, PR China
    Microbes Infect 10:251-9. 2008
    ..Together, these results suggest that P5 could be used as a vaccine immunogen for both worm killing and disease prevention against S. japonicum...
  16. ncbi [Inhibitory effects of transfected Bcl-XL antisense oligodeoxynucleotide on proliferation of esophageal cancer cells and growth of human esophageal carcinoma in nude mice]
    Lei Zhang
    Department of Pathology, First Affiliated Hospital, Zhengzhou University, Henan Key Laboratory of Tumor Pathology, Zhengzhou 450052, China
    Zhonghua Bing Li Xue Za Zhi 34:402-6. 2005
    ..The suppression of Bcl-XL expression by ASODN may offer both a therapeutic approach and an important theoretic foundation for gene therapy against esophageal carcinoma...
  17. ncbi The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers
    Rulun Zhou
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, Maryland 20852, USA
    J Neurosci 25:4493-502. 2005
    ....
  18. ncbi Gene transfer of an engineered transcription factor promoting expression of VEGF-A protects against experimental diabetic neuropathy
    Sally A Price
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Diabetes 55:1847-54. 2006
    ..These data suggest that VEGF-A-activating ZFP-TFs may ultimately be of clinical utility in the treatment of this disease...
  19. ncbi Optimal transfection with the HK polymer depends on its degree of branching and the pH of endocytic vesicles
    Qing-Rong Chen
    Department of Pathology, University of Maryland Baltimore, MSTF Building, 10 South Pine Street, Baltimore, MD 21201, USA
    Nucleic Acids Res 30:1338-45. 2002
    ..The interplay between optimal HK polymers and the endosomal pH may lead to improved gene-delivery polymers tailored to a particular cell...
  20. ncbi [Study the mechanisms and inducing transplantation immune tolerance of FTY720]
    Lei Zhang
    Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
    Zhonghua Wai Ke Za Zhi 41:773-7. 2003
    ..We originally designed the regime of FTY720 monotherapy, which started pre-operationally and maintained for a short period of time, and induced stable tolerance the allo-graft in mouse...
  21. ncbi DNA delivery to cells in culture using peptides
    Lei Zhang
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
    Methods Mol Biol 245:33-52. 2004
  22. ncbi P-selectin primes leukocyte integrin activation during inflammation
    Hai bo Wang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Nat Immunol 8:882-92. 2007
    ..Our data demonstrate the functional importance of this newly identified signaling pathway mediated by P-selectin glycoprotein ligand 1...
  23. ncbi Big tumor regression induced by GM-CSF gene-modified 3LL tumor cells via facilitating DC maturation and deviation toward CD11c+CD8alpha+ subset
    Yi Lin
    Department of Immunology, Institute for Immunobiology, Shanghai Medical College of Fudan University, Shanghai, P R China
    DNA Cell Biol 26:863-72. 2007
    ..Our research indicated that GM-CSF could optimize the immune microenvironment in the tumor site, which provides a potent approach for immunotherapy of tumors...
  24. ncbi In vivo dedifferentiation of human epidermal cells
    Haihong Li
    Mental Health Center, Shantou University Medical College, Guangdong Province, and Wound Healing and Cell Biology Laboratory, Burns Institute, The First Affiliated Hospital 304th Hospital, Beijing 100037, PR China
    Cell Biol Int 31:1436-41. 2007
    ..The results collectively indicated that some of the differentiated cells in engrafted epidermal sheets dedifferentiated into stem cells or stem cells-like in vivo, which offer us new evidence and insights into the dedifferentiation...
  25. ncbi A dominant negative mutant beta 2-microglobulin blocks the extracellular folding of a major histocompatibility complex class I heavy chain
    Dawn M Hill
    Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 278:5630-8. 2003
    ..Our data support an initial interaction of beta 2m with the MHC1 alpha 3 domain in MHC1 folding. In addition, the dominant negative mutant beta 2m can block T-cell functional responses to antigenic peptide and MHC1...
  26. ncbi Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis
    Paul A Baldock
    Bone and Mineral Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Biol Chem 282:19092-102. 2007
    ..Thus Y1 receptor pathways act powerfully to inhibit bone production and adiposity by nonhypothalamic pathways, with potentially direct effects on bone tissue through a single pathway with Y2 receptors...
  27. ncbi Sonoporation is an efficient tool for intracellular fluorescent dextran delivery and one-step double-crossover mutant construction in Fusobacterium nucleatum
    Yiping W Han
    Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106 4905, USA
    Appl Environ Microbiol 73:3677-83. 2007
    ..Since sonoporation has consistently generated one-step double-crossover mutants in F. nucleatum by use of intact suicide plasmids, this technology may be developed into an efficient tool for streamlining mutant construction in bacteria...
  28. ncbi Multilinear discriminant analysis for face recognition
    Shuicheng Yan
    Microsoft Research Asia, Beijing 100080, China
    IEEE Trans Image Process 16:212-20. 2007
    ....
  29. ncbi Stability of a transdermal salmon calcitonin formulation
    Shu-Lun Chang
    Department of Pharmacal Sciences, School of Pharmacy, Auburn University, Auburn, Alabama, USA
    Drug Deliv 10:41-5. 2003
    ..The formulation was stable under electric field, but there was a loss due to adsorption if salt bridges were used...
  30. ncbi Schistosoma japonicum egg antigens stimulate CD4 CD25 T cells and modulate airway inflammation in a murine model of asthma
    Jianghua Yang
    Department of Infectious Diseases, First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China
    Immunology 120:8-18. 2007
    ..These results reveal a novel form of protection against asthma and suggest a mechanistic explanation for the protective effect of helminth infection on the development of allergy...
  31. ncbi Tropane alkaloids production in transgenic Hyoscyamus niger hairy root cultures over-expressing putrescine N-methyltransferase is methyl jasmonate-dependent
    Lei Zhang
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan SJTU Nottingham Plant Biotechnology R and D Center, Fudan University, Shanghai 200433, People s Republic of China
    Planta 225:887-96. 2007
    ..Exposure to MeJA strongly stimulated both polyamine and tropane biosynthesis pathways and elicitation led to more or less enhanced production simultaneously...
  32. ncbi Modulation of expression of somatostatin receptor subtypes in Graves' ophthalmopathy orbits: relevance to novel analogs
    Irina Cozma
    School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Am J Physiol Endocrinol Metab 293:E1630-5. 2007
    ..Ex vivo analysis of orbital tissues reveals upregulation of SSTR1 and -2 in a group of GO patients. Adipogenesis, a process occurring in GO orbits, provides one possible explanation for some of the observed increase...
  33. ncbi Characterization of a partially protective B-cell epitope within the 62 kDa antigen of Schistosoma japonicum
    Lei Zhang
    Department of Pathogen Biology and Immunology, Jiangsu Province Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing 210029, China
    Acta Biochim Biophys Sin (Shanghai) 39:770-8. 2007
    ..japonicum. These results indicated that the epitope B3 from S. japonicum 62-kDa antigen might act as a candidate immunogen for future epitope vaccine investigation...
  34. ncbi Electrically modulated transdermal delivery of fentanyl
    Rajkumar Conjeevaram
    Dept Pharmaceutical Sciences, School of Pharmacy, Mercer University, Atlanta, Georgia 30341, USA
    Pharm Res 19:440-4. 2002
    ..CONCLUSIONS: Electrically assisted transdermal delivery of fentanyl significantly increased transport compared to passive delivery. Also, rapid and modulated delivery was shown to be feasible by programming the electrical parameters...
  35. ncbi GluR1 controls dendrite growth through its binding partner, SAP97
    Weiguo Zhou
    Department of Pediatrics, Division of Neurology, Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:10220-33. 2008
    ..Our findings suggest that the C-terminal 7 aa of GluR1 are essential for bringing SAP97 to the plasma membrane, where it acts to translate the activity of AMPA receptors into dendrite growth...
  36. ncbi A therapeutic SIV DNA vaccine elicits T-cell immune responses, but no sustained control of viremia in SIVmac239-infected rhesus macaques
    Jan zur Megede
    Novartis Vaccines and Diagnostics Inc, Emeryville, California, USA
    AIDS Res Hum Retroviruses 24:1103-16. 2008
    ..However, plasma RNA viral loads rebounded after ART termination to similar levels in all three groups, but remained below 10(5) copies/ml until the end of the study, which could be a late effect of the triple drug therapy...
  37. ncbi Deletion of the msdS/AfmsdC gene induces abnormal polarity and septation in Aspergillus fumigatus
    Yanjie Li
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China
    Microbiology 154:1960-72. 2008
    ..Although the mechanism by which the N-glycan processing affects polarity and septation is unclear, our results show that msdS is involved in polarity and septation in A. fumigatus...
  38. ncbi Why 1-NH and 3-NH protons of D-biotin exhibit different activities in aqueous solution
    Lei Zhang
    Department of Chemistry, Zhejiang University, Hangzhou 310027, China
    J Phys Chem B 112:8779-82. 2008
    ..The behavior of biotin in aqueous solution may be helpful for better understanding the unusual strong biotin-(strept)avidin binding...
  39. ncbi Starvation influences allatotropin gene expression and juvenile hormone titer in the female adult oriental armyworm, Mythimna separata
    Lei Zhang
    State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing, PR China
    Arch Insect Biochem Physiol 68:63-70. 2008
    ..We infer that AT is the important regulator of JH levels. A model for the shifting of migrants into resident morphs in the OAW is proposed...
  40. ncbi Direct electrochemistry of cytochrome c at ordered macroporous active carbon electrode
    Lei Zhang
    Department of Chemistry, College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234, China
    Biosens Bioelectron 23:1610-5. 2008
    ..The steady-state current response increases linearly with H(2)O(2) concentration from 2.0x10(-5) to 2.4x10(-4)moll(-1). The detection limit (3sigma) for determination of H(2)O(2) has been found to be 1.46x10(-5)moll(-1)...
  41. ncbi Specific detection of the endogenous transient receptor potential (TRP)-1 protein in liver and airway smooth muscle cells using immunoprecipitation and Western-blot analysis
    Hwei Ling Ong
    Department of Medical Biochemistry, School of Medicine, Faculty of Health Sciences, Flinders University, GPO Box 2100, Adelaide, South Australia 5001, Australia
    Biochem J 364:641-8. 2002
    ....
  42. ncbi The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
    Lei Zhang
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 14:377-87. 2008
    ..Finally, Sd recruits Yki to the enhancer of the pathway-responsive gene diap1, suggesting that diap1 is a direct transcriptional target of the Hpo pathway...
  43. ncbi J2 prolongs the corneal allograft survival through inhibition of the CD4+ T cell-mediated response in vivo
    He Xiao
    Department of Molecular Immunology, Institute of Basic Medical Sciences, 100850, Beijing, China
    Transpl Immunol 18:130-7. 2007
    ..All these results suggest that J2 is a potential lead for the development of new immunosuppressive agents to prevent the corneal allograft rejection...
  44. ncbi An edge-guided image interpolation algorithm via directional filtering and data fusion
    Lei Zhang
    Department of Computing, The Hong Kong Polytechnic University, Kowloon, Hong Kong
    IEEE Trans Image Process 15:2226-38. 2006
    ..Experiments show that the new interpolation techniques can preserve edge sharpness and reduce ringing artifacts...
  45. ncbi Potent inhibition of the CD4-dependent T cell response by J2, a novel nonpeptide organic ligand of CD4 D1
    He Xiao
    Department of Molecular Immunology, Institute of Basic Medical Sciences, Taiping Road 27, 100850 Beijing, China
    Mol Immunol 44:784-95. 2007
    ..All the results demonstrated the therapeutic potential of this compound as a novel immunosuppressive agent...
  46. ncbi Establishment and partial characterization of five malignant glioma cell lines
    Lei Zhang
    Department of Neurosurgery, University of Yamanashi Faculty of Medicine, Yamanashi, Japan
    Neuropathology 25:136-43. 2005
    ..These newly established malignant glioma cell lines can be used for further analysis of the mechanisms of tumor growth and progression...
  47. ncbi Dopamine-induced synaptic depression in the parabrachial nucleus is independent of CTX- and PTX-sensitive G-proteins, PKA and PLC signalling pathways
    Xihua Chen
    Division of Basic Medical Sciences, Memorial University of Newfoundland, 300 Prince Philip Drive, St John s, Newfoundland, Canada A1B 3V6
    Brain Res 995:236-46. 2004
    ..Furthermore, it does not employ the adenylyl cyclase-cAMP-PKA cascade, the phospholipase C signalling pathway and NMDA receptor-coupled mechanisms to depress excitatory synaptic transmission in the PBN...
  48. ncbi Gene transcription profile in mice vaccinated with ultraviolet-attenuated cercariae of Schistosoma japonicum reveals molecules contributing to elevated IFN-gamma levels
    Xiang Zhu
    Department of Pathogenic Biology, Nanjing Medical University, Nanjing 210029, China
    Acta Biochim Biophys Sin (Shanghai) 37:254-64. 2005
    ..A comprehensive understanding of the immune mechanisms of attenuated cercariae-induced protection may contribute to developing efficient vaccination strategies against S. japonicum, especially during the early stage of infection...
  49. ncbi Co-expression and immunity of Legionella pneumophila mip gene and immunoadjuvant ctxB gene
    Tao Wang
    School of Preclinical and Forensic Medicine of West China, Sichuan University, Chengdu, China
    Acta Biochim Biophys Sin (Shanghai) 37:199-204. 2005
    ..01). The results indicated that the ctxB gene enhanced the humoral and cellular immune response to the mip gene immunization. These findings provide experimental evidence to support the development of the L. pneumophila DNA vaccine...
  50. ncbi [Enhancing antitumor activity of tumor-draining lymph node cells by autologous dendritic cells]
    Zheng Peng
    Department of General Surgery, General Hospital of PLA, Beijing 100853, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:595-7. 2004
    ..To enhance antitumor activity of tumor-draining lymph node(TDLN) cells by autologous dendritic cells(DCs) in-vitro...
  51. ncbi Expression of vascular endothelial growth factor gene in primary cultured rat hepatocytes
    Jin Lin Wang
    Department of Hepatobiliary Surgery, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou 510120, China
    Hepatobiliary Pancreat Dis Int 3:444-7. 2004
    ..This study was designed to investigate the VEGF121 transfection and expression in primary cultured rat hepatocyte...
  52. ncbi Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis
    Yanlei Hao
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4405, USA
    J Neurosci 24:6590-9. 2004
    ..This cascade of events provides a potential mechanism whereby mood stabilizers alleviate cerebral morphometric deficits associated with manic-depressive illness...
  53. ncbi pH-dependent conformational changes of ferricytochrome c induced by electrode surface microstructure
    Xiue Jiang
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China
    Biophys Chem 110:203-11. 2004
    ....
  54. ncbi Expression of cysteinyl leukotriene receptor 1 in human traumatic brain injury and brain tumors
    Wei-ping Zhang
    Department of Pharmacology, School of Medicine, Zhejiang University, 353, Yan An Road, Hangzhou 310031, PR China
    Neurosci Lett 363:247-51. 2004
    ..CysLT(1) was also detected in astrocytoma, ganglioglioma and metastatic adenocarcinoma, and the expression in the neuron- and glial-appearing cells around brain tumors increased robustly...
  55. ncbi [Cloning and expression of immunoadjuvant molecule--CTB gene]
    Tao Wang
    Department of Parasitology, West China Medical Center, Sichuan University, Chengdu 610041, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 21:255-8. 2004
    ....
  56. ncbi Attachment of gold nanoparticles to glassy carbon electrode and its application for the direct electrochemistry and electrocatalytic behavior of hemoglobin
    Lei Zhang
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China
    Biosens Bioelectron 21:337-45. 2005
    ..The steady-state current response increases linearly with hydrogen peroxide concentration from 2.0 x 10(-6) to 2.4 x 10(-4) M. The detection limit (3sigma) for hydrogen peroxide is 9.1 x 10(-7) M...
  57. ncbi [Effects of high dose glucose-insulin-potassium infusion on myocardial injury and serum sFas/ sFasL concentration in acute myocardial infarction]
    Lei Zhang
    Department of Cardiology, Capital University Affiliating Beijing Chaoyang Hospital, Beijing 100020, China
    Zhonghua Nei Ke Za Zhi 44:499-502. 2005
    ..CONCLUSION Owing to cardioprotective effects reported here and by others, a high-dose GIK infusion co-administered with the timely establishment of perfusion should be strongly considered as a treatment of choice for AMI...
  58. ncbi A colloidal Au monolayer modulates the conformation and orientation of a protein at the electrode/solution interface
    Xiue Jiang
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin, 130022, China
    Chemphyschem 6:1613-21. 2005
    ..Finally, a possible model for the adsorption orientation of cyt c at the colloidal-Au-modified electrode/solution interface is proposed...
  59. ncbi Short- and long-term regulation of adenylyl cyclase activity by delta-opioid receptor are mediated by Galphai2 in neuroblastoma N2A cells
    Lei Zhang
    Department of Pharmacology, Medical School, University of Minnesota, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Mol Pharmacol 69:1810-9. 2006
    ..These data suggest that Galpha(i2) serves as the signaling molecule in both DOR-mediated short- and long-term regulation of adenylyl cyclase activity...
  60. ncbi Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival
    Bing Sheng Li
    Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4130, USA
    J Biol Chem 278:35702-9. 2003
    ..These findings suggest that Cdk5 may exert a key role in promoting neuronal survival by regulating Akt activity through the neuregulin/PI 3-kinase signaling pathway...
  61. ncbi Output convergence analysis for a class of delayed recurrent neural networks with time-varying inputs
    Zhang Yi
    Computational Intelligence Laboratory, School of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China
    IEEE Trans Syst Man Cybern B Cybern 36:87-95. 2006
    ..This class of neural networks has been found many successful applications in solving some optimization problems. Some sufficient conditions to guarantee output convergence of the networks are derived...
  62. ncbi Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation
    Amin Majdalawieh
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Sir Charles Tupper Medical Building, Halifax, NS, Canada B3H 1X5
    Proc Natl Acad Sci U S A 103:2346-51. 2006
    ..Thereby, we speculate that AEBP1 may be critically implicated in the development of atherosclerosis, and it may serve as a molecular target toward developing antiinflammatory, antiatherogenic therapeutic approaches...
  63. ncbi A genetic model for muscle-eye-brain disease in mice lacking protein O-mannose 1,2-N-acetylglucosaminyltransferase (POMGnT1)
    Jianmin Liu
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, 650 E Adams Street, Syracuse, NY 13210, USA
    Mech Dev 123:228-40. 2006
    ..The present study provides the first genetic animal model to further dissect the roles of POMGnT1 in MEB disease...
  64. ncbi Anti-oxidative effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf in chronic bronchitis rats
    Yan Huang
    School of Pharmacy, Anhui Medical University, Hefei, Anhui Province, China 230032
    Life Sci 78:2749-57. 2006
    ..These results suggest that TAL inhibits HO-1 expression and MDA production and up-regulates SOD expression in AM from CB rats, which might be one of molecular mechanisms of its anti-inflammatory effects in CB rats...
  65. ncbi Cloning and sequence analysis of myostatin promoter in sheep
    Rong Du
    Shanxi Agricultural University, College of Animal Science and Technology, Taigu, Shanxi 030801, PR China
    DNA Seq 16:412-7. 2005
    ..Some of the motifs are conserved as compared to with that in the goat, bovine and porcine myostatin promoters. However, some differences were also found...
  66. ncbi Expression of Drosophila Ca2+ permeable transient receptor potential-like channel protein in a prostate cancer cell line decreases cell survival
    Lei Zhang
    Department of Medical Biochemistry, School of Medicine, Faculty of Health Sciences, Flinders University, GPO Box 2100, Adelaide, South Australia 5001, Australia
    Cancer Gene Ther 10:611-25. 2003
    ..This finding suggests a novel approach to modify the growth of prostate cancer cells that fail to undergo apoptosis following androgen ablation therapy...
  67. ncbi Identification of gene markers based on well validated and subcategorized stressed animals for potential clinical applications in PTSD
    Lei Zhang
    Department of Psychiatry, USUHS, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
    Med Hypotheses 66:309-14. 2006
    ..The validity and practicability of this hypothesis and the strategy for its testing have been supported by our preliminary laboratory data...
  68. ncbi Expression of heparanase mRNA in anti-sense oligonucleotide-transfected human esophageal cancer EC9706 cells
    Kui Sheng Chen
    Department of Pathology, The First Affiliated Hospital, Zhengzhou University, Key Laboratory of Henan Tumor Pathology, Zhengzhou 450052, Henan Province, China
    World J Gastroenterol 11:4916-7. 2005
    ..To investigate the effects of anti-sense oligonucleotides (ASODNs) on mRNA expression of heparanase in human esophageal cancer EC9706 cells...
  69. ncbi Induction of angiogenesis in a mouse model using engineered transcription factors
    Edward J Rebar
    Sangamo BioSciences, Richmond, California, USA
    Nat Med 8:1427-32. 2002
    ..These data establish, for the first time, that specifically designed transcription factors can regulate an endogenous gene in vivo and evoke a potentially therapeutic biophysiologic effect...